• Journal of Oral Medicine and Pain
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• 제31권2호
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• pp.113-120
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• 2006

편평태선 환자의 미각기능과 치료에 따른 미각 기능의 변화를 알아보고자, 2005년 4월부터 2006년 2월까지 부산대학병원에 내원한 환자중에 구강검사를 통해 구강편평태선으로 진단되어진 환자를 실험군으로 선택하고, 2006년 2월에서 4월까지 충청북도 청주시 소재 00치과병원에 내원한 치과환자 중에 구강검사와 설문지를 사용하여, 미각에 영향을 미칠 수 있는 전신질환, 약물복용, 구강내 국소적 질환을 가지고 있지 않은 치과환자를 대조군으로 선택하여 전기미각역치를 측정한 후 다음과 같은 결과를 얻었다. 1. 구강편평태선환자군에서 대조군에 비해 전기미각역치는 낮은 경향을 보였다. 2. 여성에서는 구강편평태선환자군에서 전기미각역치가 낮은 경향을 보였지만, 남성에서는 높은 경향을 보였다. 3. 구강편평태선환자군의 다수의 병소가 있는 경우에는 혀끝, 혀 측방 중앙부위에서 높은 경향을 보였지만, 유곽유두, 연구개 부위에서는 오히려 낮은 경향을 보였다. 4. 구강편평태선환자군의 만성도에 따른 비교에서는 급성환자에서 혀끝, 혀 측방중앙부위에서 만성에서는 유곽유두부위, 연구개 부위에서 높은 경향을 보였다. 5. 구강편평태선환자군의 치료에 따른 전기미각역치는 모든 부위에서 낮은 경향을 보였고, NAS도 유의하게 감소하였다.

• Journal of Korean Neurosurgical Society
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• 제59권2호
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• pp.98-105
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• 2016

Objective : Lumbar disc herniation can induce sciatica by mechanical compression and/or chemical irritation. The aim of this study was to compare the effects of GCSB-5 (Shinbaro$^{(R)}$) and NSAIDs on pain-related behavior and on the expressions of microglia, astrocytes, CGRP, TRPV1, IL-6, and CX3CL1 in a rat model of lumbar disc herniation. Methods : 112 male Sprague-Dawley rats underwent implantation of nucleus pulposus to a dorsal root ganglion (DRG). Rats were divided into five groups as follows; a saline group (the vehicle control group) (n=27), a 10 mg/kg aceclofenac group (the aceclofenac group) (n=22), and 100, 300 or 600 mg/kg GCSB-5 groups (the GCSB-5 100, 300, or 600 groups) (n=21 for each group). Rats were tested for mechanical allodynia at 3 days after surgery and at 1 day, 3 days, 7 days, 14 days, 21 days, 28 days, 35 days, 42 days, 49 days, and 56 days after treatment commencement. Immunohistochemical staining of microglia (Iba1), astrocytes (GFAP), CGRP, and TRPV1, and PCR for IL-6 and CX3CL1 were performed on spinal dorsal horns and DRGs at 56 days after medication commencement. Results : After 56 days of GCSB-5 300 administration, mechanical withdrawal thresholds were significantly increased (p<0.05), and immunohistochemical expressions of Iba1, GFAP, CGRP, and TRPV1 were reduced than other groups, but this difference was not statistically significant. Conclusion : These results indicate GCSB-5 reduces mechanical allodynia and downregulates neuroglial activity and the expressions of CGRP and TRPV1 in the spinal segments of a rat model of lumbar disc herniation.

• International Journal of Oral Biology
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• 제35권3호
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• pp.83-89
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• 2010

We investigated the role of the central MAPK pathways in extra-territorial (referred) pain resulting from inflammation of the temporomandibular joint (TMJ). Experiments were carried out on male Sprague-Dawley rats weighing 220-280 g. Under anesthesia, these animals were injected with $50\;{\mu}L$ of complete Freund's adjuvant (CFA) into the TMJ using a Hamilton syringe. In the control group, saline was injected into the TMJ. To identify the extent of inflammation of the TMJ, Evans blue dye (0.1%, 5 mg/kg) was injected intravenously at 1, 3, 6, 9, 12 and 15 days after CFA injection. The concentration of Evans blue dye in the extracted TMJ tissue was found to be significantly higher in the CFA-treated animals than in the saline-treated group. Air-puff thresholds in the vibrissa pad area were evaluated 3 days before and at 3, 6, 9, 12, 15 and 18 days after CFA injection into the TMJ. Referred mechanical allodynia was established at 3 days, remained until 12 days, and recovered to preoperative levels at 18 days after CFA injection. This referred mechanical allodynia was observed in contralateral side area. To investigate the role of central MAPK pathways, MAPK inhibitors ($10\;{\mu}g$) were administrated intracisternally 9 days after CFA injection. SB203580, a p38 MAPK inhibitor, significantly attenuated referred mechanical allodynia, as compared with the vehicle group. PD98059, a MEK inhibitor, also reduced CFA-induced referred mechanical allodynia. These results suggest that TMJ inflammation produces extra-territorial mechanical allodynia, and that this is mediated by central MAPK pathways.

• The Journal of Korean Physical Therapy
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• 제6권1호
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• pp.85-93
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• 1994

The purposes of this study were 1) to examine the effects of microcurrent electrical neuromuscular stimulation 2) to compare surface electrode with needle electrode at somatic acupuncture points on experimental pain threshold measured at the distal end of the radius 3) to determine the changes in effect over time. A total of sixty healthy adult male and female subjects were assigned randomly to one of two experimental group or to a control group. Group 1(n=20) received MENS(Microcurrent Electrical Neuromuscular Stimulation) with surface electrode. Group 2(n=20) received HENS with needle electrode. Group 3(n=20) received no MENS. It measured experimental pain threshold at the wrist on pretreatment, 0 min after treatment. 15 min after treatment, 30 min after treatment in two experimental group. The results were as follows: 1. Experimental pain thresholds were higher in males than females(P<0.01). 2. Only the experimental group exhibited a significant increased in pain threshold after MENS treatment(P<0.05). 3. Surface electrode group increased significant pain threshold 0 min, 15 min after treatment, but greatly decrease 30 min after treatment. 4. Needle electrode group increased significant pain threshold 0 min, 15 min after treatment, but decrease 30 min after treatment. The results suggest that MENS applied to appropriate somatic acupuncture point can increase pain threshold. Further research is needed to assess the effects of greatly variety intensity of MENS of pain sufferes.

• The Korean Journal of Pain
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• 제23권3호
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• pp.186-189
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• 2010

Background: Neuropathic pain resulting from diverse causes is a chronic condition for which effective treatment is lacking. The goal of this study was to test whether dexamethasone exerts a preemptive analgesic effect with bupivacaine when injected perineurally in the spared nerve injury model. Methods: Fifty rats were randomly divided into five groups. Group 1 (control) was ligated but received no drugs. Group 2 was perineurally infiltrated (tibial and common peroneal nerves) with 0.4% bupivacaine (0.2 ml) and dexamethasone (0.8 mg) 10 minutes before surgery. Group 3 was infiltrated with 0.4% bupivacaine (0.2 ml) and dexamethasone (0.8 mg) after surgery. Group 4 was infiltrated with normal saline (0.2 ml) and dexamethasone (0.8 mg) 10 minutes before surgery. Group 5 was infiltrated with only 0.4% bupivacaine (0.2 ml) before surgery. Rat paw withdrawal thresholds were measured using the von Frey hair test before surgery as a baseline measurement and on postoperative days 3, 6, 9, 12, 15, 18 and 21. Results: In the group injected preoperatively with dexamethasone and bupivacaine, mechanical allodynia did not develop and mechanical threshold forces were significantly different compared with other groups, especially between postoperative days 3 and 9 (P < 0.05). Conclusions: In conclusion, preoperative infiltration of both dexamethasone and bupivacaine showed a significantly better analgesic effect than did infiltration of bupivacaine or dexamethasone alone in the spared nerve injury model, especially early on after surgery.

• The Korean Journal of Pain
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• 제23권3호
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• pp.166-171
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• 2010

Background: Neuropathic pain resulting from diverse causes is a chronic condition for which effective treatment is lacking. The goal of this study was to test whether dexamethasone exerts a preemptive analgesic effect with bupivacaine when injected perineurally in the spared nerve injury model. Methods: Fifty rats were randomly divided into five groups. Group 1 (control) was ligated but received no drugs. Group 2 was perineurally infiltrated (tibial and common peroneal nerves) with 0.4% bupivacaine (0.2 ml) and dexamethasone (0.8 mg) 10 minutes before surgery. Group 3 was infiltrated with 0.4% bupivacaine (0.2 ml) and dexamethasone (0.8 mg) after surgery. Group 4 was infiltrated with normal saline (0.2 ml) and dexamethasone (0.8 mg) 10 minutes before surgery. Group 5 was infiltrated with only 0.4% bupivacaine (0.2 ml) before surgery. Rat paw withdrawal thresholds were measured using the von Frey hair test before surgery as a baseline measurement and on postoperative days 3, 6, 9, 12, 15, 18 and 21. Results: In the group injected preoperatively with dexamethasone and bupivacaine, mechanical allodynia did not develop and mechanical threshold forces were significantly different compared with other groups, especially between postoperative days 3 and 9 (P < 0.05). Conclusions: In conclusion, preoperative infiltration of both dexamethasone and bupivacaine showed a significantly better analgesic effect than did infiltration of bupivacaine or dexamethasone alone in the spared nerve injury model, especially early on after surgery.

• The Korean Journal of Pain
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• 제26권4호
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• pp.356-360
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• 2013

Background: Nerve injury sometimes leads to chronic neuropathic pain associated with neuroinflammation in the nervous system. In the case of chronic neuropathic pain, the inflammatory and algesic mediators become predominant and result in pain hypersensitivity following nervous system damage. It is well known that urinary trypsin inhibitor (ulinastatin, UTI) has an anti-inflammatory activity. Recently, the neuroprotective action of UTI on the nervous system after ischemic injury has been reported. Thus, we evaluated the neuroprotective effect of ulinastatin in a rat model of neuropathic pain. Methods: Neuropathic pain was induced with L5 spinal nerve ligation (SNL) in male Sprague-Dawley rats weighing 100-120 g. The rats were divided into 3 groups, with n = 8 in each group. The rats in the control group (group 1) were administered normal saline and those in group 2 were administered UTI (50,000 U/kg) intravenously through the tail vein for 3 days from the day of SNL. Rats in group 3 were administered UTI (50,000 U/kg) intravenously from the $5^{th}$ day after SNL. The paw withdrawal threshold was measured using the von Frey test for 3 days starting from the $5^{th}$ day after SNL. Results: The paw withdrawal thresholds were significantly increased in the rats of group 2 compared to the other groups (P < 0.05). Conclusions: Ulinastatin, which was administered for 3 days after SNL, increased the paw withdrawal threshold and it could have a neuroprotective effect in the rat model of neuropathic pain.

• 한국항행학회논문지
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• 제20권6호
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• pp.503-510
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• 2016

최근 이동형 글로벌 광대역 통신 및 위성기반의 양방향 인터넷 서비스에 대한 수요가 증가함에 따라 ESIM (earth station in motion)이라는 새로운 형태의 위성 터미널이 개발되고 있다. 이 서비스는 ITU-R Resolution 158(WRC-15)에서 FSS 업링크에 27.5-29.5 GHz 대역사용을 고려하고 있어 동일대역에서 1순위 업무로 분배된 FS와의 간섭분석에 대한 연구가 요구되고 있다. 이에 본 논문에서는 ESIM이 기존의 FS(fixed service)에 미치는 간섭영향을 안테나의 포인팅 에러와 방위각을 고려하여 4 가지 시나리오에 대해 분석하였다. 그 결과 에러 초과확률 5% 및 10% 기준에서 앙각이 $20^{\circ}{\sim}40^{\circ}$에 따라 두 시스템간의 분리거리는 32~52 km 정도 요구되고 있다. 이에 분리거리를 최소화하면서 동일대역의 FS를 보호하기 위해서는 안테나 포인팅 에러뿐만 아니라 이동 터미널의 방위각을 제어할 수 있어야 한다.

• 정보처리학회논문지B
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• 제9B권1호
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• pp.47-56
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• 2002

분산 멀티미디어 문서 시스템은 네트워크로 연결된 여러 서버에 있는 미디어들은 검색하여 제시된 시간 관계에 따라 미디어들을 프리젠테이션한다. 효과적인 프리젠테이션을 위해서는 동기화가 지원되어야 하며, 특히, 분산 환경에서의 프리젠테이션은 네트워크 대역폭과 지연시간 등에 의해 영항을 받기 때문에, 그러한 요소들이 고려되어 동기화가 지원되어야 한다. 본 연구에서는 분산 환경에서 프리젠테이션을 효과적으로 수행할 수 있는 분산 멀티미디어 프리젠테이션 시스템을 제안하고, 프리젠테이션을 위해 미디어들이 각 서버로부터 전송될 때 네트워크의 상태와 자원을 검사하여 그에 따른 변화를 서버에 피드백시켜, 서버로부터 전송되는 데이터의 양을 조절함으로서 동기화를 지원하기 위한 기법을 제안한다. 네트워크의 상태 변화를 효과적으로 파악하여 서버로 피드백하기 위해, 버퍼에 경계점을 설정하여 버퍼를 관리하는 기법과 서버로부터 패킷이 전송되는 시간과 클라이언트에 도착하는 시간의 차이를 체크하는 기법을 함께 사용하고 있다.

• 한국실내디자인학회논문집
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• 제22권5호
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• pp.302-310
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• 2013

Many museums have recently employed digital technologies in exhibition installations to provide visitors with interactive experiences with the installations, not just audiences. However, most of them have focused on the adoption of new prototypes or technologies, not considering user experiences of those systems carefully. This study developed an evaluation tool for usability of the tangible user interfaces and conducted a usability study on museum installations emphasizing user interaction and experience. The evaluation tool is composed of 5 features of tangible user interfaces such as tangible, interaction, convenience, representation, spatial interaction and social interaction, and 24 items. The museum we investigated is the Gwacheon National Science Museum, where 8 installations, classified 4 categories, were selected for the usability study. We recruited 6 undergraduate students, who were divided into 2 teams, each team having 3 students. Three students in a team manipulated and experience each installation together and reported their evaluation score through the questionnaire and interviews. The results showed that the score of the usability for the category 3, which requires students to move their bodies for the interaction, is the highest one because it features with spatial interaction. Students expressed much interest in the category 4, which utilizes users' other senses, however, the score of the usability is the lowest because the interaction is temporary and repetitive. Most installations are well designed in terms of control constraints, legibility, lower thresholds, participation encouragement, and open to the public, but pooly designed in terms of multiple access points, configurability, accurate movement, ambient media, and full-body interaction.