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http://dx.doi.org/10.3344/kjp.2010.23.3.166

Effect of Perioperative Perineural Injection of Dexamethasone and Bupivacaine on a Rat Spared Nerve Injury Model  

Lee, Jeong-Beom (Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine)
Choi, Seong-Soo (Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine)
Ahn, Eun-Hye (Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine)
Hahm, Kyung-Don (Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine)
Suh, Jeong-Hun (Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine)
Leem, Jung-Gil (Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine)
Shin, Jin-Woo (Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine)
Publication Information
The Korean Journal of Pain / v.23, no.3, 2010 , pp. 166-171 More about this Journal
Abstract
Background: Neuropathic pain resulting from diverse causes is a chronic condition for which effective treatment is lacking. The goal of this study was to test whether dexamethasone exerts a preemptive analgesic effect with bupivacaine when injected perineurally in the spared nerve injury model. Methods: Fifty rats were randomly divided into five groups. Group 1 (control) was ligated but received no drugs. Group 2 was perineurally infiltrated (tibial and common peroneal nerves) with 0.4% bupivacaine (0.2 ml) and dexamethasone (0.8 mg) 10 minutes before surgery. Group 3 was infiltrated with 0.4% bupivacaine (0.2 ml) and dexamethasone (0.8 mg) after surgery. Group 4 was infiltrated with normal saline (0.2 ml) and dexamethasone (0.8 mg) 10 minutes before surgery. Group 5 was infiltrated with only 0.4% bupivacaine (0.2 ml) before surgery. Rat paw withdrawal thresholds were measured using the von Frey hair test before surgery as a baseline measurement and on postoperative days 3, 6, 9, 12, 15, 18 and 21. Results: In the group injected preoperatively with dexamethasone and bupivacaine, mechanical allodynia did not develop and mechanical threshold forces were significantly different compared with other groups, especially between postoperative days 3 and 9 (P < 0.05). Conclusions: In conclusion, preoperative infiltration of both dexamethasone and bupivacaine showed a significantly better analgesic effect than did infiltration of bupivacaine or dexamethasone alone in the spared nerve injury model, especially early on after surgery.
Keywords
bupivacaine; dexamethasone; perineural injection; preemptive analgesia; spared nerve injury model;
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