• Journal of Microbiology and Biotechnology
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• v.18 no.5
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• pp.897-900
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• 2008

Various sequences of pH change were applied in a batch bioreactor to investigate pH shock effects on geldanamycin production by Streptomyces hygroscopicus subsp. duamyceticus JCM4427. In the control culture where the pH was not controlled, the maximum geldanamycin concentration was 414 mg/l. With the pHS1 mode of pH shock, that is, an abrupt pH change from pH 6.5 to pH 5.0 and then being maintained at around pH 5.0 afterward, 768 mg/l of geldanamycin was produced. With pHS2, in which the pH was changed sequentially from pH 6.7 to pH 5.0 and then back to pH 6.0, 429 mg/l of geldanamycin was produced. With pHS3 having a sequential pH change from pH 6.0 to pH 4.0 and then back to pH 6.5 followed by the third pH shock to pH 5.5, no geldanamycin production was observed. Considering that the productivity with pHS1 was about two-fold of that of the control culture with no pH control, we concluded that a more sophisticated manipulation of pH would further promote geldanamycin production.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.2
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• pp.220-225
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• 2002

To determine the anti-stress effect of KCG(加味天麻鉤藤飮) extract on sprague-dawley rats. we conducted a research about the change of weight, activity, reactivity, c-fos protein, cytotoxicity against PC12 cell line and heal shock protein. 1) KCG extract siginificantly inhibited the decrease of body weight induced by stress, compared with the control group. 2) KCG extract had no siginificant effect in the activity and reactivity of rats between the control and the experimental groups. 3) KCG extract siginificantly restrained c-fos protein manifestation, compared with the control group. 4) KCG extract siginificantly restrained heat shock protein, compared with the control group. These results suggested that KCG might be usefully anti-stress effect.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2011.04a
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• pp.648-654
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• 2011

The feed-water piping system constitutes a complex flow impedance network incorporating dynamic transfer characteristics which will amplify some pulsation frequencies. Understanding pressure pulsation waves for the feed-water recirculation piping system with cavitation problem of flow control valve is very important to prevent acoustic resonance. Feed water recirculation piping system is excited by potential sources of the shock pulse waves by cavitation of flow control valve. The pulsation becomes the source of structural vibration at the piping system. If it coincides with the natural frequency of the pipe system, excessive vibration results. High-level vibration due to the pressure pulsation affects the reliability of the plant piping system. This paper discusses the piping vibration due to the effect of shock pulsation by the cavitation of the flow control valves for the recirculation piping of feed-water pump system in combined cycle power plants.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2006.11a
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• pp.327-330
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• 2006

Numerical study on the passive control of the oblique shock wave/turbulent boundary-layer interaction control utilizing slotted plates over a cavity has been carried out. Numerical results have been compared with the experimental observations, such as pitot/wall surface pressures and Schlieren flow visualizations, obtained for the same boundary conditions. It was found that the present numerical results shows a good agreement with experimental data. Further, the effect of different slot configurations including various number, location and angle of slots on the characteristics of the interactions are also tested, focusing on the variation of the piot pressure and the boundary-layer characteristics downstream of the interaction and the recirculating mass flux through cavity.

• Journal of the Korean Society for Precision Engineering
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• v.17 no.2
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• pp.97-104
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• 2000

Pneumatic cylinder is widely used for mechanical handling systems. Often, the impact occurs at the both ends points of pneumatic cylinder and generates destructive shock with in the structural operating members of the machine or equipment. To reduce the damage of system, therefore, shock absorbing devices are required. Cushioning of pneumatic cylinders at one or both ends of piston stroke is used to reduce the shock and vibration. The cylinder body have to withstand under high velocity and load. In this research, the pneumatic cushioning cylinder moving tests have been conducted for different load mass and supply pressure. The velocity of pneumatic cylinder actuation system with multiple orifice cushion sleeve which is set vertically controled with meter-in/out system. This study examines the dynamic characteristics of pneumatic cylinder with cushion devices. It turns out that the cushion pressure is mainly a function of the external load rather than the supply pressure. The cushion region characteristics was also revealed in the meter-in system.

• Journal of Life Science
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• v.7 no.4
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• pp.276-281
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• 1997

This study was investigated to determine whether nicotine causes the morphological changes and expression of heat shock protein(HSP) 70 in the central nervous system of rat embryo. The pregnant rats were injected s.c. twice daily with 3 mg nicotine per 100g body weight from day 0 to 14 of gestation and embryos were removed on gestation day 15. As morphological changes, retardation of cell proliferaton was observed in the telencephalon of nicotine-treated groups and no changes in the other region were found. Minimal HSP 70 was expressed over chole central nervous system was similar between control and nicotine-treated group, the expression of blood cells in the meinges and chroid plexus was significantly greater in nicotine-treated group than in control.

• Journal of Institute of Control, Robotics and Systems
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• v.1 no.1
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• pp.38-42
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• 1995

This paper presents a target scoring method using shock wave signals, which are generated from the supersonic speed of a projectile. The shock wave is detected from three acoustic sensors located in the target plane and the difference of the delay times are measured. The target coordinates are calculated from the effective propagation of velocity (EPV) and the delay times of the shock wave; and the EPV is from the projectile velocity and the delay time. With a comparison between the measurement result and the known coordinates, the accuracy and the usefulness of the proposed scheme is validated.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.64 no.1
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• pp.136-142
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• 2015

In the paper, a design method of knee and pelvis joint in the biped robot is proposed for shock absorption and gravity compensation. Similarly to the human's body, the knee joints of the biped robot support most body weight and get a shock from the landing motion of the foot on the floor. The torque of joint motor is also increased sharply to keep the balance of the robot. Knee and pelvis joints with the spring are designed to compensate the gravity force and reduce the contact shock of the robot. To verify the efficiency of the proposed design method, we develope a biped robot with the joint mechanism using springs. At first, we experiment with the developed robot on the static motions such as the bent-knee posture both without load and with load on the flat ground, and the balance posture on the incline plane. The current of knee joint is measured to analyze the impact force and energy consumption of the joint motors. Also, we observe the motor current of knee and pelvis joints for the walking motion of the biped robot. The current responses of joint motors show that the proposed method has an effect on shock reduction and gravity compensation, and improve the energy efficiency of walking motions for the biped robot.

• Journal of Advanced Marine Engineering and Technology
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• v.23 no.6
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• pp.794-805
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• 1999

Pneumatic cushioning cylinders are commonly employed for vibration and shock control. A mathematical simulation model of a double acting pneumatic cushioning cylinder designed to absorb shock loads is presented which is based on the following assumptions; ideal equation of state isentropic flow through a port conservation of mass polytropic thermodynamics single degree of freedom piston dynamics and energy equivalent linear damping. These differential equation can be solved through numerical integration using the fourth order Runge-Kutta method. An experimental study was conducted to validate the results obtained by the numerical integra-tion technique. Simulated results show good agreement with experimental data. The computer simulation model presented here has been extremely useful not only in understanding the has been extremely useful not only in understanding the basic cushioning but also in evaluating different designs.

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.6
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• pp.469-476
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• 2012

2,3,7,8-Tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) is an environmental toxicant with a polyhalogenated aromatic hydrocarbon structure and is one of the most toxic man-made chemicals. Exposure to 2,3,7,8-TCDD induces reproductive toxicity, immunotoxicity, and hepatotoxicity. In this study, we evaluated how 2,3,7,8-TCDD-induced hepatotoxicity affect the expression of heat shock proteins and antioxidant enzymes using the real-time polymerase chain reaction (PCR) in rat. 2,3,7,8-TCDD increased heat shock protein (Hsp27, ${\alpha}$-B-crystallin, Mortalin, Hsp105, and Hsp90s) and antioxidant enzymes (SOD-3, GST and catalase) expression after a 1 day exposure in livers of rats, whereas heat shock protein (${\alpha}$-B-crystallin, Hsp90, and GRP78) and antioxidant enzymes (SOD-1, SOD-3, catalase, GST, and GPXs) expression decreased on day 2 and then slowly recovered back to control levels on day 8. These results suggest that heat shock proteins and antioxidant enzymes were induced as protective mechanisms against 2,3,7,8-TCDD induced hepatotoxicity, and that prolonged exposure depressed their levels, which recovered to control levels due to reduced 2,3,7,8-TCDD induced hepatotoxicity.