• IMMUNE NETWORK
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• v.3 no.3
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• pp.201-210
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• 2003

Objective: The role of prostaglandin $E_2$ (PGE2) in the etiopathogenesis of immune and inflammatory diseases has become the subject of recent debate. To determine the role of PGE2 in rheumatoid arthritis (RA), we tested the effect of exogenous PGE2 on the production of cyclooxygenase-2 (COX-2) by rheumatoid synoviocytes. Methods: Fibroblast-like synoviocytes (FLS) were prepared from the synovial tissues of RA patients, and cultured in the presence of PGE2. The COX-2 mRNA and protein expression levels were determined by RT-PCR and Western blot analysis, respectively. The PGE2 receptor subtypes in the FLS were analyzed by RT-PCR. Electrophoretic mobility shift assay (EMSA) was used to measure the NF-${\kappa}B$ binding activity for COX-2 transcription. The in vivoeffect of PGE2 on the development of arthritis was also tested in collagen induced arthritis (CIA) animals. Results: PGE2 ($10^{-11}$ to $10^{-5}M$) dose-dependently inhibited the expression of COX-2 mRNA and the COX-2 protein stimulated with IL-$1{\beta}$, but not COX-1 mRNA. NS-398, a selective COX-2 inhibitor, displayed an additive effect on PGE2-induced COX-2 downregulation. The FLS predominantly expressed the PGE2 receptor (EP) 2 and EP4, which mediated the COX-2 suppression by PGE2. Treatment with anti-IL-10 monoclonal antibodies partially reversed the PGE2-induced suppression of COX-2 mRNA, suggesting that IL-10 may be involved in modulating COX-2 by PGE2. Experiments using an inducer and an inhibitor of cyclic AMP (cAMP) suggest that cAMP is the major intracellular signal that mediates the regulatory effect of PGE2 on COX-2 expression. EMSA revealed that PGE2 inhibited the binding of NF-${\kappa}B$ in the COX-2 promoter via a cAMP dependent pathway. In addition, a subcutaneous injection of PGE2 twice daily for 2 weeks significantly reduced the incidence and severity of CIA as well as the production of IgG antibodies to type II collagen. Conclusion: Our data suggest that overproduced PGE2 in the RA joints may function as an autocrine regulator of its own synthesis by inhibiting COX-2 production and may, in part, play an anti-inflammatory role in the arthritic joints.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.9 no.3
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• pp.12-19
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• 2010

In road network, especially in urban area, inefficiency of travel time is caused by signal control and turn maneuver at intersection and this inefficiency has substantial effects on travel time. When searching for the shortest path, this inefficiency which is caused by turn maneuver must be considered. Therefore, travel time, vehicle volume and delay for each link were calculated by using simulation package, PARAMICS V5.2 for adaptation of turn penalty at 16 intersections of Gangnam-gu. Turn penalty was calculated respectively for each intersection. Within the same intersection, turn penalty differs by each approaching road and turn direction so the delay was calculated for each approaching road and turn direction. Shortest path dealing with 16 intersections searched by Dijkstra algorithm using travel time as cost, considering random turn penalty, and algorithm considering calculated turn penalty was compared and analyzed. The result shows that by considering turn penalty searching the shortest path can decrease the travel time can be decreased. Also, searching the shortest path which considers turn penalty can represent reality appropriately and the shortest path considering turn penalty can be utilized as an alternative.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.17 no.4
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• pp.86-98
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• 2018

Since 2015, the Korea Expressway Corporation has provided predicted travel time information, which is reproduced from DSRC systems over the extended expressway network in Korea. When it is open for public information, it helps travelers decide optimal routes while minimizing traffic congestions and travel cost. Although, sutiable evaluations to investigate the reliability of travel time forecast information have not been conducted so far. First of all, this study seeks to find out a measure of effectiveness to evaluate the reliability of travel time forecast via various literatures. Secondly, using the performance measurement, this study evaluates concurrent travel time forecast information in highway quantitatively and examines the forecast error by exploratory data analysis. It appears that most of highway lines provided reliable forecast information. However, we found significant over/under-forecast on a few links within several long lines and it turns out that such minor errors reduce overall reliability in travel time forecast of the corresponding highway lines. This study would help to build a priority for quality control of the travel time forecast information system, and highlight the importance of performing periodic and sustainable management for travel time forecast information.

• Journal of Digital Contents Society
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• v.15 no.4
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• pp.513-520
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• 2014

The Smart Grid is next-generation power system materialized Convergence and Integration of power technologies and Information Technologies. And this system is the next generation power system optimizing energy efficiency via real-time information exchanges grafting the information technologies upon present power networks which are web-net. The introduction of smart grid can be embodied for latitude, distributed and cooperated network by inter-active exchange of energy information between electrical power provider and consumer previous uni-directional electrical power supplement. Therefore in this paper, we proposed Convergence technologies - Smart power grid, Smart Place, Smart Renewable and Smart Electricity Service - to make smart-grid succeed via analyzing the datum. And we scoped on Convergence and Integration technologies, which could be used for smart-power-grid that is most important factor to replace previous power industries. And we brought out the expecting industrialize timing and interesting aspects and analyzed the result with survey of professional worker from institute, research center, power plant and business of power industries. And proposed the essential policies for the government and power-control-business companies based on the datum and survey output.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.38A no.1
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• pp.68-78
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• 2013

In this paper, we propose an early spectrum sensing(ESS) as an advance preparation for radio-access trial, which enables multi-mode terminals to access the most appropriate radio-access system in a cloud-conceptual base station system where multiple radio access technologies(RATs) coexist. Prior to a random access to one of RATs, a multi-mode terminal conducts a spectrum sensing over entire frequency bands of whole RATs, then select the RAT with the lowest sensing power, that is likely to have the most available spectrum. Thus, an access failure caused by that the selected RAT has no available radio spectrum could be avoidable in advance. In computer simulation, we consider as various RATs as possible. First, circuit and packet systems are taken into consideration. In addition, the packet systems are classified according to the feasibility of carrier aggregation(CA). In case of terminal, three modes are considered with circuit-only, packet-only, and multi-mode. Subsequently, packet traffic is classified into real-time and non-real-time traffic with three different tolerable delay levels. The simulation includes a call process starting with a call generation and ending up with a resource allocation reflecting individual user's QoS requirements and evaluates the proposed scheme in terms of the successful access probability, system access time, system balancing factor and packet loss probability.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.7 no.1
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• pp.71-82
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• 1996

In this paper, the Doppler phase error due to the relative velocity between a satellite and the earth station in communications using a low earth orbit mobile satellite is detected. The performance of BPSK system in the presence of Rician fading with Doppler phase error and interference, noise is compared with that of the system disturbed by Doppler phase error and noise only. The expression of error rate performance of BPSK system is derived as the type of complementary error function. The numerical calculation of the induced equation are performed in terms of satellite-height, orbit-eccentricity, the velocity of the earth, Rician fading parameter, signal to interference rateio (SIR), the ratio of carrier frequency and base band bit rate. The main conclusion that can be drawn from this analysis is that Rician fading channel environment with Doppler phase error and interference effect yields severe performance degradation than Do- ppler phase error and noise effect in satellite communication channel. And using the numerical calculation, we give a quantitative insight how much the satellite communication channel parameters degrade the system performance. Furthermore it is shown that an appropriate transmission power control for the performance enhancement is beneficial to the new satellite communication system planning.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.7 no.2
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• pp.128-138
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• 1996

In this paper, the Doppler phase error due to the relative velocity between a satellite and the earth station in communications using a low earth orbit mobile satellite is detected. The performance of BPSK system in the presence of Rician fading channel environment with Doppler phase error, inter- ference and noise is compared with that of the system disturbed by Doppler phase error and noise only, And adopted coding techniques are Hamming, BCH, RS and convolution codes. The expression of error rate performance of BPSK system is derived as the type of complementary error function. The main conclusion that can be drawn from this analysis is that Rician fading channel environment with Do- ppler phase error and interference, noise effect yields severe performance degradation then Doppler phase error and noise effect in satellite communication channel. The conclusion can be drawn from this analysis is that using coding technique then noncoding. And using the numerical calculation, we give a quantitative insight how much the satellite communication channel parameters degrade the system per- formance. Furthermore it is shown that an appropriate transmission power control for the performance enhancement is beneficial to the new satellite communication system planning.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.4
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• pp.1413-1424
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• 2013

Recently, the frequency of severe storms increases in Korea. Severe storms occurring in a short time cause huge losses of both life and property. A considerable research has been performed for the flood control system development based on an accurate stream discharge prediction. A physical model is mainly used for flood forecasting and warning. Physical rainfall-runoff models used for the conventional flood forecasting process require extensive information and data, and include uncertainties which can possibly accumulate errors during modelling processes. ANFIS, a data driven model combining neural network and fuzzy technique, can decrease the amount of physical data required for the construction of a conventional physical models and easily construct and evaluate a flood forecasting model by utilizing only rainfall and water level data. A data driven model, however, has a disadvantage that it does not provide the mathematical and physical correlations between input and output data of the model. The characteristics of a data driven model according to functional options and input data such as the change of clustering radius and training data length used in the ANFIS model were analyzed in this study. In addition, the applicability of ANFIS was evaluated through comparison with the results of HEC-HMS which is widely used for rainfall-runoff model in Korea. The neuro-fuzzy technique was applied to a Cheongmicheon Basin in the South Han River using the observed precipitation and stream level data from 2007 to 2011.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.10 no.3
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• pp.1-8
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• 2011

The parking guidance system can increase driver's convenience with detailed parking information service, but it continuously consumes electrical energy with large amount of sensors, displays and control modules. With the increase of the demand for green and sustainable building design, it becomes a meaningful issue for parking guidance system to reduce operating power. This paper presents the preliminary design and estimated results of a parking guidance system which is optimized to reduce the power consumption mainly on detectors and displays. The system design is based on commercial wireless parking detectors, wireless-loop-detector and earth-magnetic-detector. We have performed system architecture design, communication network design, parking information service scenario planning, battery life regulation and at last operating power estimation. With the 7 years of battery replace cycle, the estimated result for power consumption of designed system was 0.33W/slot, which is 13% of the traditional system's estimation result. The estimated annual maintain cost was similar to the traditional ultrasonic sensor based system's. The low power operable designed system can be expected to reduce CO2 emission.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.16 no.5
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• pp.39-48
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• 2016

One of the major trends of automotive networking architecture is the introduction of automotive Ethernet. Ethernet is already used in single automotive applications (e.g. to connect high-data-rate sources as video cameras), it is expected that the ongoing standardization at IEEE (IEEE802.3bw - 100BASE-T1, respectively IEEE P802.3bp - 1000BASE-T1) will lead to a much broader adoption in future. Those applications will not be limited to simple point-to-point connections, but may affect Electric/Electronic(EE) Architectures as a whole. It is agreed that IP based traffic via Ethernet could be secured by application of well-established IP security protocols (e.g., IPSec, TLS) combined with additional components like, e.g., automotive firewall or IDS. In the case of safety and real-time related applications on resource constraint devices, the IP based communication is not the favorite option to be used with complicated and performance demanding TLS or IPSec. Those applications will be foreseeable incorporate Layer-2 based communication protocols as, e.g., currently standardized at IEEE[13]. The present paper reflects the state-of-the-art communication concepts with respect to security and identifies architectural challenges and potential solutions for future Ethernet Switch-based EE-Architectures. It also gives an overview and provide insights into the ongoing security relevant standardization activities concerning automotive Ethernet. Furthermore, the properties of non-automotive Ethernet security mechanisms as, e.g., IEEE 802.1AE aka. MACsec or 802.1X Port-based Network Access Control, will be evaluated and the applicability for automotive applications will be assessed.