• 한국방사선학회논문지
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• 제18권2호
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• pp.179-185
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• 2024

DECT의 다양한 에너지 스펙트럼 영상 구현기능을 적용하여 조영제와 석회화의 정량적 구분 가능성을 알아보기 위해 CNR과 SNR을 비교하여 화질의 변화를 분석하고, 기존 방법인 2회 스캔 적용 시와 실험에서 적용한 VNC 영상 구현 1회 스캔 시 선량 감소수준을 알아보았다. 그 결과 70 keV 영역에서 조영제와 석회화가 가장 잘 구분되었고, CNR, SNR도 우수하였으며 스캔 선량은 약 26.5% 감소효과가 있었다. 따라서 DECT 적용은 에너지별 가상 분광 영상 구현으로 석회화의 명암을 형성하여 시각적 그리고 정량적 구분에 매우 유의미한 결과를 도출할 수 있었다. 향후 환자의 나이, 성별 및 체형 등을 고려한 임상 연구를 시행하여 결과를 도출한다면 혈관 내 조영제가 유입된 상태에서도 석회화 정량 분석이 가능하여 환자의 검사 선량과 다 회 검사에 대한 부담감 감소에 큰 효과가 있을 것으로 사료된다.

• 대한방사선기술학회지:방사선기술과학
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• 제39권1호
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• pp.71-79
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• 2016

본 연구는 전산화단층검사(computed tomography; CT)에서 저농도 조영제와 저관전압 기법이 선량과 영상에 미치는 유용성을 팬텀으로 평가하였다. 조영제 농도별로 희석정도를 달리하여 실험팬텀에 삽입 후 관전압과 관전류를 단계적으로 변화하여 촬영하였고, 획득된 팬텀영상을 통해 선량과 HU를 평가하였다. 그 결과 표준조건(350 mgI/ml, 120 kV)보다 저농도 조영제와 저관전압 조건(300 mgI/ml, 100 kV)설정이 체적 선량평가(CTDIvol; computed tomography dose $index_{vol}$)에서 평균 21% 감소하였다. SNR은 저농도 조영제와 저관전압 조건이 팬텀에서 측정한 모든 깊이(center, 4.5cm, 2.25cm)의 조영제와 생리식염수를 1:10, 1:20으로 희석한 실험에서 각각 12.2(26%), 6.2(17%) 증가하였다. CNR은 각각 11.5(32%), 6.3(26%) 증가하였다. CT 검사에서 조영제 부작용 감소를 위한 저농도 조영제의 사용과 피폭선량 감소를 위한 저관전압 사용으로 영상에서 높은 감약계수를 통한 다양한 연구가 필요할 것으로 사료된다.

• 대한방사선기술학회지:방사선기술과학
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• 제41권2호
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• pp.103-107
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• 2018

In MR, the iodine CT contrast medium reduces the T1 and T2 relaxation times of the substance, resulting in a change in signal intensity. This study aimed to measure the relaxation rate of MR contrast medium with or without diluting CT contrast medium and analyzed the effect of CT contrast medium. Undiluted Gadoteridol solution was diluted with saline to prepare MR contrast medium phantoms with various levels of Gadoteridol concentrations. Moreover, undiluted Iomeprol was mixed with the prepared MR contrast medium phantoms at 1:1 ratio to make MR contrast medium phantoms with containing CT contrast medium for the experiment. T1 and T2 mappings were conducted to quantitatively evaluate the relaxation time and relaxation rate of these phantoms. The results showed that the T1 and T2 relaxation time and relaxation rate of MR contrast medium diluted with CT contrast medium were significantly (p<0.05) shorter than those of MR contrast medium not diluted with CT contrast medium. The results of this study imply that, when MR contrast medium shall be used after injecting CT contrast medium, CT contrast medium should be discharged enough. Moreover, it would be desirable to conduct CT test after taking MRI test in order to reduce the effects of CT contrast medium on MR contrast medium.

• 대한기계학회논문집B
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• 제28권12호
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• pp.1528-1534
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• 2004

The combination of ultrasound echo images with digital particle image velocimetry (DPIV) methods has resulted in a two-dimensional, two-component velocity field measurement technique appropriate for opaque flow conditions including blood flow in clinical applications. Advanced PIV processing algorithms including an iterative scheme and window offsetting were used to increase spatial resolution. The optimum concentration of the ultrasound contrast agent used for seeding was explored. Velocity validation tests in fully developed laminar pipe flow result of echo PIV showed good agreement with both optical PIV measurements and the known analytic solution based on a volume flow measurement.

• Investigative Magnetic Resonance Imaging
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• 제19권1호
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• pp.52-55
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• 2015

Supradiaphragmatic liver is a rare condition. Establishing an accurate preoperative diagnosis is difficult. Operative exploration is necessary to differentiate this lesion from intrathoracic masses, such as a pleural based tumor, diaphragmatic tumor and peripheral lung tumor. However, with the aid of the hepatocyte-specific magnetic resonance imaging contrast agent, gadoxetic acid (Gd-EOB-DTPA), functional hepatocytes in the lesion can be identified in the hepatobiliary phase, potentially allowing an accurate and non-invasive diagnosis. We report a case of supradiaphragmatic liver diagnosed by Gd-EOB-DTPA-enhanced magnetic resonance imaging.

• 한국방사선학회논문지
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• 제16권2호
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• pp.103-113
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• 2022

이 논문에서는 결합된 PET(fluorodeoxyglucose, ¹⁸F-FDG)와 MRI(magnetic nanoparticles, MNP) 조영제를 동시 PET-MRI 스캔에 사용하기 위한 가교제로 N-(p-maleimidophenyl) isocyanate를 사용하여 합성하는 방안을 제안하였다. 실험은 신경교종 줄기 세포 마우스 모델에서 결합 조영제(¹⁸F-FDG로 표지된 MNP)를 주입하기 전후에 PET-MRI 이미지를 획득하고 평가하였다. 획득한 각 영상에 대해 관심영역(ROI)을 설정한 후, 분할하여 병변의 면적을 계산하였을 때 PET 영상이 MRI 영상보다 더 크고 정확했다. 특히 동시 PET-MRI 영상은 주변 연조직과 함께 정확한 병변을 묘사하였다. 평균 및 표준편차 값은 조영제 주입 여부에 관계없이 PET 영상 또는 PET-MRI 동시 영상보다 MRI 단독 영상에서 더 높게 나타났다. 또한 동시 PET-MRI 영상값이 PET 영상보다 평균 및 표준편차 값이 높게 나타났다. ¹⁸F-FDG 라벨링된 MNP 조영제와 동시 PET-MRI 영상을 표적 영상으로 사용하고 ¹⁸F- FDG 조영제만을 원본 이미지로 사용했을 때의 피크 신호 대 잡음비(PSNR) 값은 모든 실험에서 유의미 하게 나타났다. 결론적으로 동시 PET-MRI 영상에서 결합된 ¹⁸F-FDG 표지 MNP 조영제가 유용함을 확인하였다. 다양한 핵종을 사용할 수 있는 SPECT-MRI 영상 연구를 통해 진단과 치료를 동시에 할 수 있는 제제를 개발하기 위해서는 향후 연구가 필요할 것이다.

• Journal of Magnetics
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• 제21권1호
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• pp.115-124
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• 2016

The present study analyzes T1 TSE and T1 slice sel. IR (dark_fluid) signal strength according to the degree of gadolinium contrast agent dilution and analyzes the turbo factors with regard to changes in the maximum and overall signal strength to study correlations between changes and signal-to-noise ratios (SNRs) and compare peak-to-peak SNR (PSNR) enhancement in order to improve the quality of T1-weighted images. Enhancement TR (600 msec) evaluated to determine the T1 TSE turbo factor and obtain the maximum signal strength, T1WI were used sequentially to experiment with turbo factors_1-4. T1 slice sel. IR (dark-fluid) was used to sequentially test turbo factors_2-5 but not turbo factor_1 at a TR (1500 msec) and compare data at an increase in T1 of 900 msec. The T1 TSE was reduced according to the contrast agent concentration. Phantom signal strength increased, whereas turbo factors_1-4 exhibited maximum signal strength at a concentration of 3 mmol, followed by a gradual decrease. In the turbo factors_2-5, the signal strength increased sharply to maximum signal strength at 0.7 mmol, followed by a reduction. T1 TSE had a greater maximum signal strength than did T1 slice sel. IR (dark_fluid). A comparison of SNR found that T1 TSE imaging was superior (33.3 dB) in turbo factor_1 and T1 slice sel. IR (dark_fluid) was highest (33.9 dB) at turbo factor_5. A PSNR comparison analysis was not sufficient to distinguish between the images obtained with both techniques at 30 dB or higher under all experimental conditions.

• 대한방사선기술학회지:방사선기술과학
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• 제44권4호
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• pp.335-342
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• 2021

Studies on the side effects of contrast agents are being discussed based on various cases, but studies analyzing the chemical structure of the underlying contrast agents are difficult to understand as the manufacturers have not disclosed them. Therefore, in this study, the chemical structure of the contrast medium was analyzed using ¹H-NMR spectrometer for Omnipaque contrast medium prepared from Iohexol, which is a nonionic iodide contrast medium, Xenetix contrast medium from Iobitridol, and Iomeron contrast medium from Iomeprol. As a result, it was found that the Omnipaque contrast medium of Iohexol had 6 carboxyl groups, 3 carbonyl groups, 4 amine groups, 1 methyl group, and 2 cyano groups. It was found that the Xenetix contrast medium of the iobitridol formulation had 6 carboxyl groups, 3 carbonyl groups, 2 amine groups, and 4 cyano groups. It was found that the Iomeron contrast agent of the Iomeprol formulation had 5 carboxyl groups, 3 carbonyl groups, 4 amine groups, 1 methyl group, and 2 cyano groups. As shown in this study, the chemical structure of the non-ionic monomer contrast agent increases its affinity with water by binding a number of hydroxyl groups (OH) to the carboxyl group. It is necessary to accurately identify each of these factors and analyze the physical and chemical changes of the contrast medium according to various environmental factors.

• Korean Journal of Radiology
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• 제22권5호
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• pp.677-687
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• 2021

Microvascular ultrasound (US) techniques are advanced Doppler techniques that provide high sensitivity and spatial resolution for detailed visualization of low-flow vessels. Microvascular US imaging can be applied to breast lesion evaluation with or without US contrast agents. Microvascular US imaging without a contrast agent uses a sophisticated wall filtering system to selectively obtain low-flow Doppler signals from overlapped artifacts. Microvascular US imaging with second-generation contrast agents amplifies flow signals and makes them last longer, which facilitates hemodynamic evaluation of breast lesions. In this review article, we will introduce various microvascular US techniques, explain their clinical applications in breast cancer diagnosis and radiologic-histopathologic correlation, and provide a summary of a recent radiogenomic study using microvascular US.

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2003년도 제8차 학술대회 초록집
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• pp.93-93
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• 2003

To test the feasibility of rBF and rBVin the assessment of R004 sarcomas of the rat and to compare the results obtained by using Gd-DTPA and Gadomer-17 as a MR contrast agent, on the basis of the histological findings of tumor necrosis.