• 한국해안해양공학회지
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• 제19권3호
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• pp.194-204
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• 2007

흐름이 연직유공벽을 통과할 때 발생하는 수두손실을 수치해석과 수리실험을 통하여 고찰하였다. 수치 해석에 대해서는 유공벽 전 후의 검사체적에 연속방정식, 모멘텀 방정식, 그리고 에너지 방정식을 적용하였으며 주어진 하류 쪽 수심과 유속에 대하여 상류 쪽 수심 및 유공벽 수두손실을 계산할 수 있는 무차원 관계식을 유도 하였다. 수리실험은 단일유공판과 삼중유공판에 대하여 각각 수행하였다. 단일유공판에 대한 계산결과와 실험결과를 비교하여 유공부 오리피스에서 연직 선형 제트류의 수축계수가 개구율뿐만 아니라 하류 쪽 Froude 수에도 의존함을 밝혔으며, 실험결과에 근거하여 수두손실을 계산하기 위한 실험식을 제시하였다. 단일유공판의 실험식을 삼중유공판에 대하여 하류에서 상류 쪽으로 축차적으로 적용한 결과, 예측치와 실험결과가 대체적으로 잘 일치함을 확인하였다.

• 한국전문물리치료학회지
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• 제12권3호
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• pp.22-30
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• 2005

This study was designed to identify the effect of various decline boards and postures of lower extremities on surface electromyographic (EMG) activity of knee muscles during isometric single-leg decline squat exercises. The subjects were twenty young male adults who had not experienced any knee injury and their Q-angles were within a normal range. They were asked to perform single-leg decline squat exercises in five various conditions. The EMG activities of the gluteus maximus (GM), vastus lateralis (VL), vastus medialis (VMO), tibialis anterior (TA), and gastrocnemius (GCM) muscles were recorded in five various single-leg decline squat exercises by surface electrodes and normalized by maximal voluntary isometric contraction (MVIC) values. The normalized EMG activity levels were compared using one-way ANOVA with repeated measures. The results of this study were as follows: 1) Exercises 2 and 4 produced significantly greater EMG activity of VMO than did exercise 1 ($p_{adj}$<.05/10), 2) The VMO/VL ratio of EMG activity of exercise 4 was the highest, producing a significantly greater ratio than exercise 1 ($p_{adj}$<.05/10). These results show that single-leg lateral oblique decline squat exercise is the best exercise for selective strengthening of VMO, and the posture of the contralateral leg does also affect strengthening of VMO, but we'll need to research patellofemoral joint compression for clinical application of single-leg lateral oblique decline squat exercises.

• The Journal of Korean Physical Therapy
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• 제28권2호
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• pp.106-111
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• 2016

Purpose: The aim of this study is to determine the effect of glenohumeral (GH) rotation position in modified knee push-up plus exercise (MKPUP) by examining the surface electromyography (EMG) amplitude in serratus anterior (SA), pectoralis major (PM), and upper trapezius (UTz) and the activity ratio of each muscle. Methods: A total of 22 healthy subjects volunteered for the study. Each subject performed the MKPUP at $0^{\circ}$, $45^{\circ}$, and $90^{\circ}$ of GH joint internal rotation. EMG of the SA and PM, UTz was compared between GH rotation positions and each muscle activity ratio. EMG was used to measure the muscle activity in terms of ratios to maximal voluntary isometric contraction (MVIC). Results: The difference in EMG activity during the exercise in three GH joint internal rotation positions was observed with the SA and the PM. The greater the GH joint internal rotation angle was, the lower the activity of the PM. In contrast, the SA showed higher activity. However, the activity of UT was similar under all conditions. The ratio of the SA and the PM was considerably greater at $90^{\circ}$ GH joint internal rotation than at $0^{\circ}$ and $45^{\circ}$. Conclusion: When excessive activation of the PM or imbalanced activation between the PM and the SA occurs, the MKPUP exercise is most effective at $90^{\circ}$ of GH joint internal rotation. Use of this position would be a beneficial strategy for selective strengthening of the SA and minimizing PM activation.

• 대한수의학회지
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• 제22권1호
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• pp.1-8
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• 1982

The effect of acetylcholine, oxytocin and prostaglandin $F_{2{\alpha}}$ ($PGF_{2{\alpha}}$) on cyclic nucleotide levels in estrogen-primed rabbit whole uterus were studied in the presence and absence of 1-methyl-3-isobutyl xanthine (MIX), a phosphodiestrase inhibitor, and indomethacin, a prostagandin inhibitor. In the absence of MIX, acetylcholine increased guanosine 3', 5'-cyclic monophosphate (cGMP), but had no effect on adenosine 3', 5'-cyclic monophosphate (cAMP) levels. In contrast, oxytocin had no influence on cGMP, but decreased cAMP levels. $PGF_{2{\alpha}}$ increased cGMP and decreased cAMP levels. MIX increased both cAMP and cGMP levels. Oxytocin and $PGF_{2{\alpha}}$ further increased cGMP levels, indicating activation of guanylate cyclase activity. The ratio of cAMP/cGMP was decreased by uterine stinulants both in presence and absence of MIX. Indomethacin elevated cAMP and cGMP revels. The effects of uterine stimulants in the presence of indomethacin on cyclic nucleotide levels were varied from tissue to tisse. In general, oxytocin decreased cGMP and $PGF_{2{\alpha}}$ increased cAMP/cGMP levels, but the effects were statisically nonsignicficant. The cAMP/cGMP ratio was increased by uterine stimulant in the presence of indomethacin. In conclusion, uterine stimulants eased cAMP/cGMP ratio which indicates that the uterine stimulants have opposing effects on adenylate cyclase and guanylate cyclase activities. The endometrium plays a role in the regulation of cyclic nucleotide levels and uterine contraction by means of PG synthesis. Indomethacin has an unknown activities besides both of PG synthetase and phosphodiesterase inhibitions.

• 대한기계학회논문집B
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• 제20권5호
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• pp.1603-1612
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• 1996

The pressure loss coefficient of Newtonian and non-Newtonian fluids such as water, aqueous solutions of Carbopol-934 and Separan AP-273 and blood in the stenotic tubes are determined experimentally and numerically. The numerical analyses for flows of non-Newtonian fluids in the stenotic tubes are conducted by the finite element method. The effect of the contraction ratio and the ratio of length to diameter on the pressure drop are investigated by the experiments and numerical analysis. The pressure loss coefficients are significantly dependent upon the Reynolds number in the laminar flow regime. As Reynolds number increases, the pressure loss coefficients of both Newtonian and non-Newtonian fluids decrease in the laminar flow regime. As the ratio of length to diameter increases the maximum pressure loss coefficient increases in the laminar flow regime for both Newtonian and non-Newtonian fluids. Newtonian fuid shows the highest values of pressure loss coefficient and blood the next, followed by Carbopol solution and Separan solution in order. Experimental results are used to verify the numerical analyses for flows of Newtonian and non-Newtonian fluids. Numerical results for the maximum pressure loss coefficient in the stenotic tubes are in fairly good agreement with the experimental results. The relative differences between the numerical and experimental results of the pressure loss coefficients in the laminar flow regime range from 0.5% to 14.8%.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.360-362
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• 2002

Myocardial tagging technique such as spatial modulation of magnetization (SPAMM) allows the study of myocardial motion with high accuracy. Tagging contrast of such a tagging images can affect to the accuracy of the estimation of tag intersection in order to analyze the myocardial motion. Tagging contrast can be affected by tagline spacing. The aim of this study was to investigate the relationship between tagline spacing of SPAMM image and tagging contrast-to-noise ratio (CNR) experimentally. One healthy volunteer was undergone electrocardiographically triggered MR imaging with SPAMM-based tagging pulse sequence at a 1.5T MR scanner (Gyroscan Intera, Philips Medical System, Netherland). Horizontally modulated stripe patterns were imposed with a range from 3.6mm to 9.6mm of tagline spacing. Images of the left ventricle (LV) wall were acquired at the mid-ventricle level during cardiac cycle with FEEPI (TR/TE/FA=5.8/2.2/10). Tagging CNR for each image was calculated with a software which developed in our group. During contraction, tagging CNR was more rapidly decreased in case of short tagline spacing than in case of long tagline spacing. In the same heart phase, CNR was increased corresponding with tag line spacing. Especially, at the fully contracted heart phase, CNR was more rapidly increased than the other heart phases as a function of tagline spacing.

• 한국항공우주학회지
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• 제32권5호
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• pp.91-96
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• 2004

액체로켓 엔진에 사용되는 가스발생기를 최적설계 하였다. 추진제는 RP-1/LOx 이고, open cycle터보펌프 시스템을 사용하였으며, 가스발생기는 농후 (fuel-rich) 연소를 적용하였다. 최적설계의 목적함수는 주연소설의 비추력의 최대화이고 설계 제한조건은 가스발생기 연소 실온도와 터빈-펌프의 출력일치이다. 가스 발생기의 설계에 사용된 설계변수는 가스발생기 유량, O/F비, 터빈 노즐 입구 각, 부분분사비, 그리고 터빈 원주속도이며 이들을 이용하여 가스발생기의 열역학적 성능을 계산하였다. 그리고 설계 제한조건을 만족하면서 목적함수를 최대화 할 수 있는 가스발생기의 크기와 성능조건을 확인하였다. 설계된 가스발생기 기본형상은 연소시험에 적용된 후 최종적으로 결정된다.

• 대한약리학회지
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• 제32권1호
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• pp.39-49
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• 1996

본 실험에서는 흰쥐의 뇌 기저동맥을 이용하여 $K^+$과 U46619에 의한 수축과 세포내 $Ca^{2+}$의 변동을 관찰하고, 이들 반응을 CGRP 전처치시 나타나는 반응과 비교하였다. CGRP (30과 100 nM)는 U46619에 의하여 야기된 수축반응과 세포내 $Ca^{2+}$의 증가반응을 억제시켰으나, $K^+$ (90 mM)에 의하여 나타나는 반응에는 영향을 미치지 아니하였다. 게다가, U46619에 의하여 야기되는 장력에 대하여 세포내 $Ca^{2+}$의 변동 $(F_{340}/F_{380})$을 도표화하여 세포내 $Ca^{2+}$ 농도와 장력의 발생과의 상관관계를 검토하고, 이들 결과를 CGRP 전처치시 나타나는 결과와 비교하였다. CGRP (30과 100 nM) 전처치군에서 얻어진 직선이 오른쪽으로 치우치지는 않으면서 아래쪽으로 이동하는 점으로 볼 때, CGRP가 $Ca^{2+}$에 대한 수축기구의 감수성에는 영향을 미치지 않으면서 세포내 $Ca^{2+}$ 농도를 저하시킴에 의하여 U46619에 의한 근수축반응을 억제시키는 것으로 보여진다. 이러한 CGRP의 효과는 CGRP1 수용체 길항제인 CGRP$(8{\sim}37)$ 분획(100 nM)의 전처치시 현저히 억제되었다. CGRP에 의한 수축력과 세포내 $Ca^{2+}$의 저하는 large conductance $Ca^{2+}$에 의하여 활성화되는 $K^+$ 통로 봉쇄제인 charybdotoxin (100 nM)과 iberiotoxin (100 nM)의 전처치에 의하여 완전하게 역전되었으나, small conductance $Ca^{2+}$에 의하여 활성화되는 $K^+$ 통로 봉쇄제인 apamin (300 nM)과 ATP에 감수성이 높은 $K^+$ 통로 봉쇄제인 glibenclamide (1 ${\mu}M$)에 의해서는 영향을 받지 아니하였다. 이상의 결과로 볼 때 CGRP1 수용체는 $Ca^{2+}$에 의하여 활성화되는 $K^+$ 통로를 개방시킴으로 세포내 $Ca^{2+}$을 감소시켜 뇌 기저동맥의 이완반응을 매개하는 것으로 사료된다.

• 대한한방내과학회지
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• 제35권4호
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• pp.439-447
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• 2014

Objectives: The aim of this study was to investigate whether 1) variation of bowel sounds recorded stably through an electronic stethoscope in a sound insulation box can be related with that of gastric contraction and 2) if they are thus useful tool in the measurement of the gastric contractility in awake rats or not. Methods: Electrical potentials of both electronic stethoscope of bowel sound and force transducer were recorded simultaneously and continuously in the sound insulation box for the starting 30 min of basal state, and then 30 min of 0.2 ml normal saline administration, finally 30 min of 0.2 ml mosapride citrate solution (100 mg/Kg) in rats. Each motility index of normal saline or mosapride citrate treatment was presented with ratio against the basal state by using integrated electrical potentials. Results: A pattern of significance of gastric contractility between bowel sound and force transducer was showed analogously. Conclusions: The amplitude of bowel sounds recorded by the electronic stethoscope related with the intensity of gastric contractions. This confirms that a sound insulation box and electronic stethoscope are useful tools in the measurement of the gastric contractility of awake rats.

• The Journal of Korean Physical Therapy
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• 제28권2호
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• pp.65-70
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• 2016

Purpose: The aim of this study was to determine the effects of electromyographic (EMG)-Biofeedback using closed kinetic chain exercise (EB-CKCE) on quadriceps angle (Q-angle) and quadriceps muscle activation and muscle activation ratio in subjects with patellofemoral pain syndrome and to provide fundamental information on rehabilitation exercise in patellofemoral pain syndrome. Methods: Thirty participants who met the criteria were included. The subjects were randomly divided into three groups: control group (Group I, n=10), semi-squat exercise group (Group II, n=10), and EMG-Biofeedback using closed kinetic chain exercise group (Group III, n=10). Intervention was provided to each group for eight weeks (three times per week; 30 minutes per day). Subjects were measured on Q-angle and quadriceps muscle activation. Results: Significant difference in Q-angle and quadriceps muscle activation was observed in groups II and III compared with control group I (p<0.01). Results of post-hoc analysis showed a significant difference in Q-angle and quadriceps muscle activation in on group III compared with groups I and II. Conclusion: Findings of this study suggest that closed kinetic chain exercise using EMG-Biofeedback that provides real-time biofeedback information on muscle contraction may have a beneficial effect on improvement of Q-angle and quadriceps muscle activation in patellofemoral pain syndrome.