• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3629-3633
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• 2014

Background: Glioblastoma (GBM) is an immunosuppressive tumor whose median survival time is only 12-15 months, and patients with GBM have a uniformly poor prognosis. It is known that heredity contributes to formation of glioma, but there are few genetic studies concerning GBM. Materials and Methods: We genotyped six tagging SNPs (tSNP) in Han Chinese GBM and control patients. We used Microsoft Excel and SPSS 16.0 statistical package for statistical analysis and SNP Stats to test for associations between certain tSNPs and risk of GBM in five different models. ORs and 95%CIs were calculated for unconditional logistic-regression analysis with adjustment for age and gender. The SHEsis software platform was applied for analysis of linkage disequilibrium, haplotype construction, and genetic associations at polymorphism loci. Results: We found rs891835 in CCDC26 to be associated with GBM susceptibility at a level of p=0.009. The following genotypes of rs891835 were found to be associated with GBM risk in four different models of gene action: i) genotype GT (OR=2.26; 95%CI, 1.29-3.97; p=0.019) or GG (OR=1.33; 95%CI, 0.23-7.81; p=0.019) in the codominant model; ii) genotypes GT and GG (OR=2.18; 95%CI, 1.26-3.78; p=0.0061) in the dominant model; iii) GT (OR=2.24; 95%CI, 1.28-3.92; p=0.0053) in the overdominant model; iv) the allele G of rs891835 (OR=1.85; 95%CI, 1.14-3.00; p=0.015) in the additive model. In addition, "CG" and "CGGAG" were found by haplotype analysis to be associated with increased GBM risk. In contrast, genotype GG of CCDC26 rs6470745 was associated with decreased GBM risk (OR=0.34; 95%CI, 0.12-1.01; p=0.029) in the recessive model. Conclusions: Our results, combined with those from previous studies, suggest a potential genetic contribution of CCDC26 to GBM progression among Han Chinese.

• Journal of the Korean Society of Costume
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• v.13
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• pp.51-72
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• 1989

In this thesis, I examined the mental, philosophical aspects and the aesthetic sense of our ancestors through the study of the patterns pictured in the mural paintings of Koguryo dynasty's old tomb. To view the mode of construction in Koguryo dynasty from present angle, the detailed analysis of the patterns was done. As a result, I could fully understand the formative consciousness of our nation. 1. I defined the process of transition of the mural paintings by putting some 70 mural aintings into the form of a diagram. 2. The cultural aspects of the mural paintings in Koguryo dynasty were characterized by the fusion of our primitive religion and Buddhism, Confucianism and Taoism which were introduced from China. From this fact, I could inferred that Koguryo people were giving off the strong desire for the faith by means of the mural paintings. Further more I found that configuration of the patterns such as religious elements. 3. The types of the patterns were classified into four types, this is, geometric type, natural type, cultural type and abstract type, Among these types, geometric type and natural type were nonsymbolic in nature but became cultured and abstracted in course of time. cultural pattern and abstract pattern got the symbolic meaning in the long run. Of all the constitution of the patterns represented in the mural paintings such as repeat constitution, left and right symmetric constitution, top and bottom symmetric constitution and rotary symmetric constitution, the left and right symmetric constitution was mainly used and some monotony of left and right symmetric constitution. The analysis of motif which was got from the mode of the patterns showed that the mixing of symbolic and nonsymbolic patterns made it possible to regard the separate symbol as compound in nonsymbolic patterns and the combination between nonsymbolic patterns ensured the understanding of other patterns in certain cases. Our ancestors made great efforts to transmit certain meaning symbolically. Also to heighten the symbolism, they drew the meangless patterns firstly and then appended meaning to those patterns secondly. Furthermore, they offered the background to the patterns comblined with symbolism, so that meaning transmission was clarified at last. As mentioned above, the patterns shown in the mural paintings of Koguryo dynasty's old tomb were characterized by natural beauty. And natural beauty was found out clearly in the form and constitution of the patterns. Therefore I concluded that our nation's religious, philosophical tradition was acted on the patterns strongly.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.12 no.1
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• pp.142-184
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• 2008

Background: There was seldom study about method that diagnose 8 Constitution beside method of pulse diagnosis in 8 Constitution Medicine. Objectives: This study is to make out 8 Constitution Medicine Diagnosis Expert System Development used CBR(Case based Reasoning). Methods: First, at case base construction process we constructed case base for CBR embodiment because gathering 925 cases all to patient who constitution is verified, and second, at study model establishment process superior expert system development by purpose CBR of reasoning process dividing fundamental type CBR that spend basis data value and expert type I II III CBR that reflect weight in basis data value according to advice expert opinion, and third, system embodiment process explained about way to give process and weight that diagnose constitution through Nearest Neighbor Method sampling process of CBR techniques, and fourth, at system estimation process we selected superior CBR model because comparing and estimate the diagnosis rate of expert system with fundamental type system (GECBR) model and expert type I II III CBR system (AVCBR, AACBR, AGCBR) model that reflect expert opinion in fundamental type system. GECBR and AGCBR chose on superior study model. Through such 4 study process, we developed 8 constitution diagnosis expert system lastly. Results: 1. When we select GECBR that is fundamental type by reasoning system, diagnosis rate 78.91% of 8 constitution diagnosis expert system is expected, and the constitution diagnosis rate Hepatonia 90.4%, Cholecystonia 63.0%, Pancreotonia 91.1%, Gastrotonia 0%, Pulmotonia 71.2%, Colonotonia 74.4%, Renotonia 37.5%, Vesicotonia 67.1% expect. 2. When we select AGCBR that is expert type III by reasoning system, diagnosis rate 77.51% of 8 constitution diagnosis expert system is expected, and the constitution diagnosis rate Hepatonia 93.4%, Cholecystonia 58.5%, Pancreotonia 91.1%, Gastrotonia 0%, Pulmotonia 73.1%, Colonotonia 64.4%, Renotonia 41.7%, Vesicotonia 72.2% expect. Conclusion: Based on this study, 8 constitution diagnosis expert system may give help to diagnose 8 constitution, and it is going to utilize as objective estimation tool of 8 constitution diagnosis, and further study for 8 Constitution Medicine Diagnosis Expert System Development used CBR(Case based Reasoning) is needed to supplement this study.

• Korean Journal of Remote Sensing
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• v.33 no.5_3
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• pp.763-771
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• 2017

The purpose of this paper is to review the background and purpose of the special issue on Theory of Environment Geospatial Information and Its Applications in Korean Journal of Remote Sensing. The significance of the paper was also discussed. Environmental information refers to environment related information (literature, statistics, images, etc.) in a comprehensive manner. Such environmental information as a local change or issue of the environment is defined as environmental spatial information by developing in a spatial form. Remote sensing data is very useful as direct or indirect data including environmental spatial information on wide-area and local environment. Various applications will be possible not only in the environmental field through several improvements. For this purpose, first, refining and scientificization of technology to build environmental spatial information could be performed. Second, the application field can be expanded by developing the concept and contents of existing environmental spatial information. The third method is continuous increase of the application of existing environmental spatial information. In this paper, the direction of development was examined that reflects recent changes of environmental spatial information such as conversion of data formats and integration with ICT (Information and Communications Technologies). In particular, the basic technology for the construction of environmental spatial information was reviewed through various papers. Through the studies related to the above, utilization of domestic environmental spatial information would be diversified. Also, the development of environment policy and efficient management of environmental factors could be possible.

• Analytical Science and Technology
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• v.16 no.5
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• pp.1041-1051
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• 2003

Neutron induced prompt gamma activation analysis (PGAA) offers a nondestructive, sensitive and relatively rapid method for the determination of trace and major elements and is proven to be convenient for online analysis of minerals, metals, coal, cement, petrochemical, coating, paper as well as many other materials and products. The technique has found many uses in medicine, industry, research, security and the detection of contraband items. This report reviews the present status and future trends of the PGAA techniques. Requirements for the system are neutron source, high resolution HPGe detectors with a high-voltage power supply, an amplifier, analog-to-digital converter, and a multichannel analyzer for the detection and measurement of prompt ${\gamma}$-ray emit form the neutron capture elements. Introducing a ${\gamma}$-${\gamma}$ coincidence system also improves the quality of the ${\gamma}$-ray spectrum by suppressing the background created from the Compton scattering of high energy prompt ${\gamma}$-rays. A PGAA system using a $^{252}Cf$ neutron source is currently under construction for the on-line measurement of several elements in aqueous samples at KAERI. The system can be applied for the detection of chemical weapons and explosives as well as various narcotics.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.6 no.4
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• pp.265-282
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• 2008

Based on the site characterization works in a low and intermediate level waste(LILW) repository site, the numerical simulations for groundwater flow were carried out in order to understand the groundwater flow system of repository site. To accomplish the groundwater flow modeling in the repository site, the discrete fracture network(DFN) model was constructed using the characteristics of fracture zones and background fractures. At result, the total 10 different hydraulic conductivity(K) fields were obtained from DFN model stochastically and K distributions of constructed mesh were inputted into the 10 cases of groundwater flow simulations in FEFLOW. From the total 10 numerical simulation results, the simulated groundwater levels were strongly governed by topography and the groundwater fluxes were governed by locally existed high permeable fracture zones in repository depth. Especially, the groundwater table was predicted to have several tens meters below the groundwater table compared with the undisturbed condition around disposal silo after construction of underground facilities. After closure of disposal facilities, the groundwater level would be almost recovered within 1 year and have a tendency to keep a steady state of groundwater level in 2 year.

• Journal of Korean Society for Geospatial Information Science
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• v.12 no.4 s.31
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• pp.45-51
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• 2004

Control stations managed by national and local governmes are associated with other survey work and constructing geography information and they are important assets in the national level as the positional standard of the country. Since these control points are managed as some type of register and the control points could not be easily updated due to the loss of control stations from construction work or urban development. Therefore, the users could not understand the present situation of the changed control stations. In this background, the aim of this study was to develop control station management system which the managers can use to efficiently maintain control points and to support the usage of the survey control points. For developing this system, we have designed input, update, network, analysis and statistic functions, and have constructed the system using Mapobject as main engine with other languages such as Visual C++ and Visual Basic. The graphic data used in this system are 1/5,000 digital map and digital cadastral map, and the attribute data of each control station are point name, map tile name, longitude and latitude coordinates, TM coordinates, surveying data with the format of year-month-day and control situation photos and so on. In the result of constructing this control station management system, we could achieve integrated management of graphic, attribute and positioning information of each control station.

• Journal of Science Education
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• v.34 no.1
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• pp.140-154
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• 2010

The core of subject matter education is determined by the choice of subject matter taught to students and by the organization of content according to educational objectives. The purpose of this research is to suggest ways to improve the present content of science education so as to prepare students and schools for a radically different future. We deduced the main issues the solution of which could lead to significant improvements in the contents of science education by analyzing previous studies and investigating the changes in content that were effected during curriculum revisions in the past. The main issues thus revealed through this study are as follows: the essence of the contents of subject matters in science education, the social and cultural background of change in the science curriculum, the rational steps on the way to choosing contents as part of the science curriculum, the processes of choosing the main contents of each subject, the international comparative study of contents, the updating of contents for the benefit of future society, and the reorganization of subject contents. In order to find a concrete improvement on the issues deduced, we organized an expert group. Then, we proceeded to collect and analyze the experts' opinions. A survey was administered to 19 science education experts working with universities and colleges of education. We examined their degree of agreement on the issues and problems, and on the steps that may be taken to us the improvements on these issues. we suggested that: collecting opinion and reaching an agreement on the essence of the contents of the subject matters in science education, the necessity to choose core contents within the scientific domain, developing a structure map in order to integrate and connect various subject domains, presenting explicitly the objective of inquiry by grades, moving toward integrating science contents, diversifying the construction of science textbooks.

• Geotechnical Engineering
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• v.10 no.2
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• pp.25-40
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• 1994

In order to investigate behavior of lateral flow by plasticity of soils and construction control due to it, in the case of unsymmetrical surcharge load on the soft soils, we examine the existing theoretical background, and compared and analysed the experimental results by model test. After model test fabricated by model test apparatus, which made full remolding samples of soft soils, we observed the state of behavior for deformation with increasing load step to constant time interval. The critical surcharge and ultimate capacity showed tendency to approach to the proposed value of Jaky and Meyerhof, and the lateral flow pressure of which the maximum value was acted on the depth calculated by z/H=0.26+1.71cu and one third value of the maximum lateral flow pressure acted on the ground surface, approach the trapezoid distribution And maximum lateral flow pressure will be calculated by proposed equation of Hong or simple equation which($\alpha=0.4$) the flow pressure coefficient . of proposed equation by Tschebotarioff exchanged to($\alpha=K_0$) . Basides, the failure surcharge by [(q/$y_m$)-q] and [$S_y-(y_m/S_y)$] showed the smaller than ultimate bearing capacity, especially failure criteria line of control diagram of [$S_y(y_m/S_y)$] will be calculated by following equation. $S_y.=3.15exp[-0.58(y_m/S_y)$

• Journal of Korea Port Economic Association
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• v.32 no.4
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• pp.109-126
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• 2016

This study investigates the initiatives of Gangwon sea routes based on precedent studies on the North Pole route to suggest a multi-modal buildup of transport logistics network of Gangwon harbors for the strengthening of logistics efficiency in the Korean Peninsula. The findings were: First, the government should expand railway infrastructure in Gangwon. Second, harbors in Gangwon should each have one speciality to strengthen connection with other harbors by using railway oriented background transportation network. Third, the government should develop industries of EFEZ(East coast Free Economic Zone) in the East Sea Coast in Gangwon to connect resources from the North Pole Sea. Fourth, the government should invite the base of Araon Ho's polar research vessel to play the role of the North Pole Sea route in the near future. Fifth, the government should strengthen the role of the Samcheock LNG base under construction. SIxth, environment-friendly transportation technology should be introduced to reduce carbon emission as much as possible. Lastly, an optimum North Pole logistics route should be developed to connect the Metropolitan area(Metropolitan Economic Zone), Gangwon roads and railway, Gangwon habor, Trans-Siberian Railway and thw North Pole route, and Europe, to strengthen national foreign trade power in the near future.