• Proceedings of the Ginseng society Conference
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• 1990.06a
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• pp.15-19
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• 1990

We have been isolating various physiologically active substances from non-saponin fraction of Korean Red Ginseng These are adenosine, gyro-glutamic acid, dencichine and acidic polysaccharide. Adenosine and gyro-glutamic acid are loom to inhibit epinephrine-induced lipolysis in fat cells and stimulate the insulin-mediated lipogenesis. In addition to these actions, adenosine was found to inhibit both norepinephrine- and histamine-induced aorta constriction, and pyre·glutamic acid inhibits angiotensin-converting enzyme. Dencichine stimulated histamine-induced aorta constriction. Finally, acidic polysaccharide was found to inhibit both lipolytic and anorexigenic actions of Toxohormone-L. Based on these experimental results, I presented a brief review on these compounds isolated from non- saponin fraction of Korea Red Ginseng. Keywords Panax ginseng, Korean red ginseng, adenosine, pyroglutamic acid, dencichine, acidic polysac- charide, lipolysis, lipogenesis, angiotensin-converting enzyme, toxohormone-L.

• Journal of Korean Academy of Rural Health Nursing
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• v.5 no.2
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• pp.92-101
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• 2010

Purpose: This study was conducted to develop a self-efficacy promotion program and to identify the effects of the program on degree of urinary incontinence, self-efficacy and quality of life in women with urinary incontinence. Method: The study used a pre-experimental design. Twenty participants were recruited from a nursing home located in Gwangju City and included residents, employees, and volunteer workers with urinary incontinence. Participants were surveyed from September 21 to November 2, 2005. The program treatment was provided to participants once a week for 6 weeks. Results: Frequency, amount, and situation scores for urinary incontinence, maximum and mean vaginal constriction pressure, vaginal constriction time, and nocturnal frequency were significantly improved after participating in the program (p<0.05). However, there was no significant pre- and posttest difference in frequency of daily urination (p=0.097). The degree of self-efficacy and quality of life for participants in the self-efficacy promotion program at posttest were significantly higher compared to the pretest scores (p<0.05). Conclusions: The results of the study indicate that a self-efficacy promotion program can be implemented for women with urinary incontinence in community health centers or nursing homes in order to reduce their incontinence symptoms, and increase self-efficacy and quality of life.

• Phonetics and Speech Sciences
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• v.3 no.4
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• pp.33-43
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• 2011

The present study investigates supralaryngeal articulatory characteristics of denti-alveolar (coronal) stops /t, $t^h$, $t^*$/ and /n/ in /aCa/ context in Seoul Korean. An Electromagnetic Articulograph (EMA, Carstens) was used to explore kinematics of the consonants by examining the kinematic data of the tongue tip (the primary articulator for the coronal consonants), along with some additional supplementary position data of the tongue body, the tongue dorsum and the jaw. The results showed that the constriction duration was the most robust articulatory correlates of the three-way stop contrast with a pattern of /t/$t^h$/$t^*$/. The contrast was further reinforced by the tongue body position (higher for /$t^h$, $t^*$/) and the tongue tip opening displacement (less displaced for /$t^h$, $t^*$/). The articulation of /n/ was quite similar to that of the lenis /t/ in terms of the constriction duration, and it was different from the oral stops in that it was produced with larger tongue tip displacement and lower jaw position than the oral stops, indicating its weak articulatory nature. The results are also discussed in comparison with those of bilabial stops with implications that the three-way contrast may be kinematically expressed differently depending on the physiological constraints imposed on the primary articulator (the tongue tip versus the lips). The present study, therefore, provides new articulatory (kinematic) data of denti-alveolar consonants in Korean, and demonstrates that the three-way stops, that have been known to differ primarily in their laryngeal settings, are indeed produced with kinematic distinctions at the supralaryngeal level.

• Restorative Dentistry and Endodontics
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• v.21 no.1
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• pp.150-160
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• 1996

The present study was to evaluate the accuracy of the frequency dependent type apex locator, Root-ZX. The subjects included 505 root canals of 238 teeth treated by the Department of Conservative Dentistry, and 22 human premolars which were schduled to be extracted for the orthodontic reasons. The results were as follows ; 1. The working lengths determined by Root-ZX were compared with radiographic readings. Of the total 505 root canals, 66 % showed coincidence within ${\pm}0.5mm$ and the average readings of Root-ZX were $0.13mm{\pm}1.05$ longer than those of radiographic readings. 2. The length difference between the file tip determined by Root-ZX and the apical constriction in extracted teeth were measured. Of the total 24 root canals, 70.8 % showed coincidence within ${\pm}0.5mm$ and the average readings of Root-ZX were $0.12mm{\pm}0.50$beyond the apical constriction. 3. The vitality of the teeth did not show any statistical difference(p>0.05) in the accuracy of the Root-ZX readings. The presence of the periapical lesions, however, significantly lowered the percentage of ${\pm}0.5mm$ accuracy in Root-ZX measurements.(p<0.05). In the presence of periapical lesions, the percentage within ${\pm}0.5mm$ was significantly lower.

• Journal of Ginseng Research
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• v.14 no.2
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• pp.157-161
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• 1990

We have been isolating various physiologically active substances from non-saponin fraction of Korean Red Ginseng. These are adenosine, pyre-glutamic acid, dencichine and acidic polysaccharide. Adenosine and pyre-glutamic acid are known to inhibit epinephrine-induced lipolysis in fat cells and stimulate the insulin-mediated lipogenesis. In addition to these actions, adenosine was found to inhibit both norepinephrine- and histamine-induced aorta constriction, and pyre·glutamic acid inhibits angiotensin-converting enzyme. Dencichine stimulated histamine-induced aorta constriction. Finally, acidic polysaccharide was found to inhibit both lipolytic and anorexigenic actions of Toxohormone-L. Based on these experimental results, I presented a briefreview on these compounds isolated from non-saponin fraction of Korea Red Ginseng.

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.1
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• pp.59-64
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• 2012

Hypoxic pulmonary vasoconstriction (HPV) is physiologically important response for preventing mismatching between ventilation and perfusion in lungs. The HPV of isolated pulmonary arteries (HPV-PA) usually require a partial pretone by thromboxane agonist (U46619). Because the HPV of ventilated/perfused lungs (HPV-lung) can be triggered without pretone conditioning, we suspected that a putative tissue factor might be responsible for the pretone of HPV. Here we investigated whether HPV can be also observed in precision-cut lung slices (PCLS) from rats. The HPV in PCLS also required partial contraction by U46619. In addition, $K^+$ channel blockers (4AP and TEA) required U46619-pretone to induce significant contraction of PA in PCLS. In contrast, the airways in PCLS showed reversible contraction in response to the $K^+$ channel blockers without pretone conditioning. Also, the airways showed no hypoxic constriction but a relaxation under the partial pretone by U46619. The airways in PCLS showed reliable, concentration-dependent contraction by metacholine ($EC_{50}$, ~210 nM). In summary, the HPV in PCLS is more similar to isolated PA than V/P lungs. The metacholineinduced constriction of bronchioles suggested that the PLCS might be also useful for studying airway physiology in situ.

• Phonetics and Speech Sciences
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• v.7 no.1
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• pp.151-163
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• 2015

In this study, we aim to describe kinematic characteristics of Korean /l/-flapping in two speech rates (fast vs. comfortable). Production data was collected from seven native speakers of Seoul Korean (four females and three males) using electromagnetic midsagittal articulometry (EMMA), which provided two dimensional data on the x-y plane. We examined kinematic properties of the vertical/horizontal tongue tip gesture, the vertical/horizontal (rear) tongue body gesture, and the jaw gesture in an /i/-/i/ context. Gestural landmarks of the vertical tongue tip gesture are directly measured. This serves as the actual anchoring time points to which relevant measures of other trajectories referred. The study focuses on velocity profiles, closing/opening spatiotemporal properties, constriction duration, and constriction minima were analyzed. The results are summarized as follows. First, gradiently distributed spatiotemporal values of the vertical tongue tip gesture were on a continuum. This shows more of a reduction in fast speech rate, but no single instance of categorical reduction (deletion). Second, Korean /l/-flapping predominantly exhibited a backward sliding tongue tip movement, in 83% of production, which is apparently distinguished from forward sliding movement in English. Lastly, there was an indication of vocalic reduction in fast rate, truncating spatial displacement of the jaw and the tongue body, although we did not observe positional variations with speech rate. The present study shows that Korean /l/-flapping is characterized by mixed articulatory properties with respect to flapping sounds of other languages such as English and Xiangxiang Chinese. Korean /l/ flapping demonstrates a language-universal property, such as the gradient nature of its flapping sounds that is compatible with other languages. On the other hand, Korean /l/-flapping also shows a language-particular property, particularly distinguished from English, in that a backward gliding movement occurs during the tongue tip closing movement. Although, there was no vocalic reduction in V2 observed in terms of jaw and tongue body height, spatial displacement of these articulators still suggests truncation in fast speech rate.

• Advances in Traditional Medicine
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• v.6 no.3
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• pp.186-195
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• 2006

The present study was carried out to determine the involvement of opioid and non-opioid receptor and the effect of pH and enzymes on the recently reported antinociceptive activity of aqueous extract of Corchorus olitorius (AECO) leaves using the abdominal constriction test. The extract was prepared by soaking the dried powdered leaves of Corchorus (C.) olitorius in distilled water overnight, and the supernatant obtained was considered as a stock solution with 100% concentration/ strength. The extract, administered subcutaneously in the concentrations/ strength of 10, 50 and 100%, was found to show a significant concentration-independent antinociception. The 50% concentration AECO were further used to study on the above mentioned parameters. The extract exhibited: significant (P < 0.05) decreased in activity when pre-treated (s.c.) against 10 mg/kg naloxonazine, bicuculine (10 mg/kg), phenoxybenzamine (10 mg/kg), 10 mg/kg pindolol, and 5 mg/kg mecamylamme, but not 10 mg/kg naltrindole, 10 mg/kg atropine, respectively; significant (P < 0.05) decreased in activity after pre-treatment against 10% a-amylase, but not 1 % protease or 10% lipase and; significant (P < 0.05) decreased in activity after exposure to alkaline condition (pH between 9 and 13) while maintaining the activity at acidic condition, respectively. The C. olitorius leaves antinociception, which involved, at least in part, activation of $\mu-opioid,\;\alpha-and\;\beta-adrenergic$, and nicotinic receptors, was found to decrease under alkaline condition and in the presence of $\alpha-amylase$.

• The Journal of Internal Korean Medicine
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• v.21 no.4
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• pp.621-631
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• 2000

Objective : In this study, the medicine herbs above were directly treated to cultured normal lung cells and lung carcinoma cells, and the effects were investigated to develope new cancer treatments with increased anti-cancer efficiency as well as decreased side-effects and to suggest more useful clinical therapies. Materials and Methods : In the experiment, WI-26 VA lung normal cell line and A-427 lung carcinoma cell line were cultured. To observe the morphological change of the treated cells, were subjected to Giemsa staining and observed under Reflected Fluorescence microscope. To examine whether cell death occurred, cells observed under Reflected Fluorescence microscope, To investigate the degree of cell death in the nucleus, cells were screened by Laser cytometry ACAS 570. Results : Samgibopye-tang(Shenqibufei-tang) stimulated not only the growth of the normal cells but also that of the carcinoma cells, Wikyeung-tang(Weijing-tang) induced morphological change such as cytoplasmic constriction in the normal cells and the carcinoma cells, but it did not show any strong inhibitory effect on the cell growth. Samso-eum(Shensu-yin) caused severe cell damage in both cell lines, Eunkyo San(Yinqiao-san) significantly damaged the nuclei and caused weak cytoplasmic constriction in both cell lines, Normal cells treated with Gilgyeung-tang(Jingeng-tang) did not show any significant morphological change while some Gilgyeung-tang(Jingeng-tang) treated carcinoma cells were observed to have a normal cell-like shape, interestingly, conclusions : As the results above, Samgibopye-tang(Shenqibufei-tang), Wikyeung-tang(Weijing-tang), and Gilgyeung-tang(Jingeng-tang) helped the growth of both cell lines, and especially Samgibopye-tang(Shenqibufei-tang) showed the best effect, However, Samso-eum(Shensuyin) and Eunkyo-san(Yinqiao-san) caused lethal damage in the normal cells and also showed strong toxicity in the carcinoma cells.

• Journal of Ocean Engineering and Technology
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• v.11 no.1
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• pp.65-73
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• 1997

The floating body discussed in this study is a 2-D rectangular floating unit supported by four vertical piles at its corners. Structures of this type are frequently seen as floating piers for the crafts in a small harbour. The movement in some modes of motion of such a flating body is fully or partially restrincted by the piles. The authors(Kim et al. 1994) carried out a series of model tests on its wave control function, its motion and the loads on piles. The experimental results showed that a certain degree of intial constriction force which clamps the floating unit in the horizontal direction can effectively reduce the body motion and wave energy without increasing mooring forces. This may be due to the friction forces occuring between the piles and the rollers installed in the mooring equipments on the floating unit. In this paper, we develop a numerical model for the prediction of wave transformation and floating body motions, where the friction force is idealized as the Coulomb friction and linearized into a damping force using the equivalent damping cofficient. This linearization is verified by comparing the results of motions between the linear and nonlinear analysis of the ezuations of motion. We further compare the caculation results by the linear model with the experimental results and discuss the effect of the friction force or the constriction force on body motions and wave energy dissipation.