• 생약학회지
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• 제52권2호
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• pp.112-117
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• 2021

Helianthus annuus L. has been reported with various pharmacological activities such as antibacterial, antidiabetic, and antioxidant effects. According to recent studies, H. annuus L. is known to contain components such as phenolic compounds, flavonoids, alkaloids, sesquiterpenoids, and lignans. The seeds of H. annuus L. have been reported to contain chlorogenic acid and di-O-caffeoylquinic acid as major components. However, studies on the main components and content of leaves of H. annuus L. are still incomplete. Therefore, in this study, the contents of four major components of H. annuus L. were evaluated by simultaneous quantitative analysis with high performance liquid chromatography (HPLC)-diode array detector (DAD). The isolated four compounds Caffeoylquinic acid(CQA), 3,4-dicaffeoylquinic acid(3,4-DCQA), 3,5-dicaffeoylquinic acid(3,5-DCQA) and 4,5-dicaffeoylquinic acid(4,5-DCQA) were shown in a large linearity with a correlation coefficient (R²) of 0.99. In addition, as a result of intra-inter day analysis of four major compounds by the analysis method of this study, the accuracy of 88.46% or more and less than 112.85% and excellent precision of less than 3% were shown, the content analysis showed CQA (0.383±0.018 mg/g), 3,4-DCQA (0.282±0.017 mg/g), 3,5-DCQA (1.109±0.068 mg/g), and 4,5-DCQA (0.673±0.020 mg/g).

• 한국터널지하공간학회 논문집
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• 제12권4호
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• pp.329-340
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• 2010

터널과 같은 지하공동 구조물의 역학적 거동은 지반의 복잡성 및 불확실성으로 인해 예측이 매우 어렵다. 터널굴착에 따른 거동 예측은 주로 모형실험이나 수치해석을 이용한 방법을 사용한다. 그러나 모형실험은 현장조건을 재현하기 어렵고, 수치해석 또한 적합한 구성 모델의 선정과 입력인자를 구하기가 매우 힘들다. 본 연구는 국내 화강암 풍화토 지반에 건설되는 터널의 천단침하와 내공변위에 대한 계측자료와 RMR을 근거로 하여 회귀분석방법을 사용하여 천단침하와 내공변위를 예측하였다. 계측자료를 분석한 결과 터널 굴착에 따른 천단침하는 굴착 초기인 약 20일 이내에 총 변위 변화량의 약 70~80%가 발생되었다. 천단침하와 내공변위를 예측한 결과, 지수함수가 대수함수보다 비교적 계측값에 잘 일치하였다. 또한 RMR값과 각 단면의 변위를 비교하여 상관관계식을 얻었다.

• 대한한의학방제학회지
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• 제28권4호
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• pp.313-325
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• 2020

Objectives : To explore the associated potential pathways and molecular targets of Hwangryunhaedok-tang(HHT) by the approaches of network pharmacology and bioinformatics in traditional chinese medicine(TCM). Methods : Hwangryunhaedok-tang constituent drugs(Coptidis Rhizoma, CR; Scutellariae Radix, SR; Phellodendri Cortex, PC; Gardeniae Fructus, GF) and their processing types were searched from TCM systems pharmacology(TCMSP). The databases of TCMSP, Kyoto Encyclopedia of Genes and Genomes(KEGG), MCODE and STRING were used to gather information. The network of bioactive ingredients and target gene was constructed by Cytoscape software(version 3.8). Results : A total of 94 HHT active compounds(CR, 12; SR, 35; PC, 33; GF, 14, respectively) were found, and HHT were identified by TCMSP. Applications of KEGG and MCODE analysis indicates that total of 6 bioactive ingredients in the top 10% ranking were obtained and 32 diseases of HHT were screened. The molecular pathway analysis revealed that HHT exerts cancer, inflammation and cerebrovascular diseases effects by acting on several signaling pathway. In addition, HHT found that three genes(e.g. SPIN1, TRIM25, and APP) correlate with the aforementioned diseases. Conclusions : This study showed that network pharmacology analysis is useful to elucidate the complex mechanisms of action of HHT.

• Structural Engineering and Mechanics
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• 제18권5호
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• pp.645-669
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• 2004

In seismic analysis of moment-resisting frames, beam-column connections are often modeled with rigid joint zones. However, it has been demonstrated that, in ductile reinforced concrete (RC) moment-resisting frames designed based on current codes (to say nothing of older non-ductile frames), the joint zones are in fact not rigid, but rather undergo significant shear deformations that contribute greatly to global drift. Therefore, the "rigid joint" assumption may result in misinterpretation of the global performance characteristics of frames and could consequently lead to miscalculation of strength and ductility demands on constituent frame members. The primary objective of this paper is to propose a rational method for estimating the hysteretic joint shear behavior of RC connections and for incorporating this behavior into frame analysis. The authors tested four RC edge beam-column-slab connection subassemblies subjected to earthquake-type lateral loading; hysteretic joint shear behavior is investigated based on these tests and other laboratory tests reported in the literature. An analytical scheme employing the modified compression field theory (MCFT) is developed to approximate joint shear stress vs. joint shear strain response. A connection model capable of explicitly considering hysteretic joint shear behavior is then formulated for nonlinear structural analysis. In the model, a joint is represented by rigid elements located along the joint edges and nonlinear rotational springs embedded in one of the four hinges linking adjacent rigid elements. The connection model is able to well represent the experimental hysteretic joint shear behavior and overall load-displacement response of connection subassemblies.

• 한국물환경학회지
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• 제21권6호
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• pp.651-658
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• 2005

The Non-parametric Analysis is powerful in data test especially for the non- normality water quality data. The data at three monitoring stations of the Tam-Jin River were evaluated for their normality using Skewness, Q-Q plot and Shapiro-Willks tests. Various constituent of water quality data including temperature, pH, DO, SS, BOD, COD, TN and TP in the period of January 1994 to December 2004 were used as dataset. Shapiro-Willks normality test was carried out for a test 5% significance level. Most water quality data except DO at monitoring stations 1 and 2 showed that data does not normally distributed. It is indicating that non-parametric method must be used for a water quality data. Therefore, a homogeneity was conducted by Mann-Whitney U test (p<0.05). Two stations were paired in three pairs of such stations. Differences between stations 1, 2 and stations 1, 3 for pH, BOD, COD, TN and TP were meaningful, but Tam-Jin 2 and 3 stations did not meaningful. In addition, a narrow gap of the water quality ranges is not a difference. Categories in which all three pairs of stations (1 and 2, 2 and 3, 1 and 3) in the Tam-Jin River showed difference in water quality were analyzed on TN and TP. The results of in this research suggest a right analysis in the homogeneity test of water quality data and a reasonable management of pollutant sources.

• Journal of Gastric Cancer
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• 제17권4호
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• pp.342-353
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• 2017

Purpose: This study evaluated the changes in nutritional status based on quality of life (QoL) item-level analysis to determine whether individual QoL responses might facilitate personal clinical impact. Materials and Methods: This study retrospectively evaluated QoL data obtained by the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Core 30 (QLQ-C30) and Quality of Life Questionnaire-Stomach (QLQ-STO22) as well as metabolic-nutritional data obtained by bioelectrical impedance analysis and blood tests. Patients were assessed preoperatively and at the 5-year follow-up. QoL was analyzed at the level of the constituent items. The patients were categorized into vulnerable and non-vulnerable QoL groups for each scale based on their responses to the QoL items and changes in the metabolic-nutritional indices were compared. Results: Multiple shortcomings in the metabolic-nutritional indices were observed in the vulnerable groups for nausea/vomiting (waist-hip ratio, degree of obesity), dyspnea (hemoglobin, iron), constipation (body fat mass, percent body fat), dysphagia (body fat mass, percent body fat), reflux (body weight, hemoglobin), dry mouth (percent body fat, waist-hip ratio), and taste (body weight, total body water, soft lean mass, body fat mass). The shortcomings in a single index were observed in the vulnerable groups for emotional functioning and pain (EORTC QLQ-C30) and for eating restrictions (EORTC QLQ-STO22). Conclusions: Long-term postoperative QoL deterioration in emotional functioning, nausea/vomiting, pain, dyspnea, constipation, dysphagia, reflux, eating restrictions, dry mouth, and taste were associated with nutritional shortcomings. QoL item-level analysis, instead of scale-level analysis, may help to facilitate personalized treatment for individual QoL respondents.

• 한국조리학회지
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• 제20권3호
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• pp.186-200
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• 2014

외식기업 종사자를 대상으로 멘토링 역할이 감정표현 및 자아존중감에 미치는 영향 관계을 알아보기 위하여 설문지를 이용하여 조사하였다. 수집한 통계처리 및 분석방법은 SPSS 18.0와 AMOS을 이용하여 빈도분석, 탐색적, 확인적 요인분석, 상관관계분석, 구조방정식 모형을 실시한 결과 첫째, 멘토와 멘티 간의 공감대와 협조관계가 형성되어 개인적인 조언, 상담, 지원 등 심리적인 스트레스의 해소 방안으로 멘토링 역할이 조직의 목표에 중요한 것으로 나타났다. 둘째, 멘토링 역할은 조직성과 및 팀웍을 형성하는데 심리적 영향력이 멘토의 역할에 따라 조직적응 능력에 긍정적인 것으로 나타났다. 셋째, 팀내에서 조직의 갈등은 구성원의 의사소통이나 상호작용 속에서 감정표현은 자아존중감에 영향이 있는 것으로 나타났다. 외식 업무 특성상 인적자원 의존도가 높은 산업으로서 조직에서 발생할 수 있는 심리적인 스트레스로 인한 직원들 간의 갈등 관계를 해소할 수 있는 멘토와 멘티 간의 긴밀한 공감대와 협조 관계가 형성되어 조직의 목표를 달성하고 높은 수준의 서비스를 제공할 수 있는 것을 알 수 있다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1998년도 하계학술대회 논문집 C
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• pp.1220-1223
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• 1998

High Power Laboratory is the facility for building to simulate the various phenomena generated from electric systems of the real world and to test making and breaking capability, switching capability and durability of circuit breaker, switchgear and other electric utilities, moreover, load equipments which contain capacitor bank is installed for studying the diverse effects originated from the constituent of load through entire systems or receiving end. Such factors, abnormal voltage or current, can be serious in electrical systems, especially, in the case caused by capacitive components such as overvoltage or inrushcurrent, the problems may be more fatal to the systems. In this paper, the optimal design of capacitor bank which will be equipped in High Power Laboratory, which is for simulating as closely as the practical phenomena resulted from the capacitive currents, and the verification aided by computer simulations are presented. For this, analysis of the circuit characteristics according to the standards which can be criteria of the capacitive current tests and the test circuit configuration in accordance with the analysis are proposed in prelude. In the body of the paper the optimal design of capacitor bank has been obtained on the basis of all conditions mentioned above and the test circuit configuration with LGIS test requirements. furthermore, analysis and verification for the design are derived by EMTP. finally, evaluation for the capacitor bank design and further study plan are concluded.

• 한국수학교육학회지시리즈E:수학교육논문집
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• 제36권2호
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• pp.201-227
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• 2022

한국 고등학교 학생들에게 적합한 수학불안 요인 측정도구를 개발하기 위하여 요인 탐색, 문항 개발, 타당도 및 신뢰도 검증의 단계로 연구를 실시하였다. 이를 위하여 문헌분석을 통해 기 개발되어 사용되어온 문항을 수정 보완하고, 학생들을 대상으로 한 개방형 조사를 통해 사교육 및 수학 교수 방법에 대한 시대적 배경을 반영한 신규 문항을 추가하였다. 개발된 측정문항에 대한 탐색적 요인분석과 확인적 요인분석을 통해 타당도를 검증하였으며, 연구 결과, 수학교과의 특성에 기인하는 불안 요인이 구체화되었고, 모둠학습이나 발표수업 등과 같은 교수학습 방법 등이 반영되었다.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제29권3호
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• pp.7-15
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• 2023

Purpose: This study was conducted with the aim of presenting spatial planning directions for evacuation spaces based on an analysis of the performance of horizontal evacuation during the early stages of fire incidents in a geriatric hospital. Methods: Based on a review of previous studies, the research model was designed by establishing occupancy conditions, evacuation, and fire scenarios. The analysis model was developed by considering vulnerable areas in terms of evacuation movement and analyzing the results of evacuation performance. Furthermore, the study analyzed the improvement in evacuation performance by arranging refuge areas. Results: The results of the study are as follows. Firstly, vulnerability spots were identified in terms of evacuation performance by schematizing Required Safe Egress Time, Available Safe Egress Time, and their differences. Secondly, the Required Safe Egress Time in the adjacent public spaces along the escape routes of occupants was found to be higher compared to the Available Safe Egress Time. Thirdly, the results of the correlation analysis between the difference in Available Safe Egress Time and Required Safe Egress Time during the early stages of a fire, as well as their constituent factors, demonstrated that user congestion is a more significant factor in compromising evacuation safety than the physical changes in the fire condition. Fourthly, the analysis of evacuation time was conducted by designating refuge areas where occupants can evacuate within a sufficient timeframe. This led to a decrease in the Required Safe Egress Time. Implications: This study is expected to be used as data on the direction of evacuation space planning to improve the evacuation performance of Geriatric Hospital.