• Archives of Pharmacal Research
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• v.15 no.4
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• pp.275-282
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• 1992

The present work was designed to investigate the effects of barzilin on ConAinducedd TCGF release, responsiveness to standardd IL-2, and mitogens-induced proliferation of splenocyte when administered intraperitoneally to 8 week-old C57BL/6 mice for 2 consecutive days. Immunological tests were performed 72 hours after the treatment of brailin. The administration of 50 mg/kg brazilin caused a noticeable increase in TCGF release and responsiveness to standard II-2 but inhibited mitogens-induced proliferation of splenocyte. These results that brazilin is able to modular immunological functions despite of its inhibitory effect on mitogen induced cell proliferation.

• Journal of the Korea Institute of Military Science and Technology
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• v.14 no.4
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• pp.676-683
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• 2011

In this paper, we propose a robust method which can detect and track a high-speed small approaching target in a cluttered environment for Korean Active Protection System. The proposed method uses a temporal and spatial filter, tracking filter to detect and track a single target in consecutive order. And it is comprised of a candidate target detection step, a prior target selection step and a target tracking. Field tests on real infrared image sequences show that the proposed method could stably track a high speed and small target in complex background and target occlusion.

• Journal of the Korean Data and Information Science Society
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• v.25 no.6
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• pp.1521-1530
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• 2014

The ROC analysis is considered for multiple class diagnosis. There exist many criteria to find optimal thresholds and measure the accuracy of diagnostic tests for k dimensional ROC analysis. In this paper, we proposed a diagnostic accuracy measure called the correct classification simple rate, which is defined as the summation of true rates for each classification distribution and expressed as a function of summation of sequential true rates for two consecutive distributions. This measure does not weight accuracy across categories by the category prevalence and is comparable across populations for multiple class diagnosis. It is found that this accuracy measure does not only have a relationship with Kolmogorov - Smirnov statistics, but also can be represented as a linear function of some optimal threshold criteria. With these facts, the suggested measure could be applied to test for comparing multiple distributions.

• Asia pacific journal of information systems
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• v.30 no.3
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• pp.457-496
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• 2020

This study aims to extensively analyze the performance of various Machine Learning (ML) techniques for predicting version to version change-proneness of source code Java files. 17 object-oriented metrics have been utilized in this work for predicting change-prone files using 31 ML techniques and the framework proposed has been implemented on various consecutive releases of two Java-based software projects available as plug-ins. 10-fold and inter-release validation methods have been employed to validate the models and statistical tests provide supplementary information regarding the reliability and significance of the results. The results of experiments conducted in this article indicate that the ML techniques perform differently under the different validation settings. The results also confirm the proficiency of the selected ML techniques in lieu of developing change-proneness prediction models which could aid the software engineers in the initial stages of software development for classifying change-prone Java files of a software, in turn aiding in the trend estimation of change-proneness over future versions.

• Journal of Applied Biological Chemistry
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• v.62 no.4
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• pp.355-359
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• 2019

In vivo micronucleus tests were performed to investigate the mutagenic potential of 4-butylaniline and N-butylaniline, which are used in dye intermediates and organic intermediates respectively. Groups of 5 male ICR mice were treated with vehicle or 4-butylaniline for 2 consecutive days by oral gavage at concentrations of 0 (control), 64, 160, 400, and 1000 mg/kg. Statistically significant and dose-dependent increases were found for micronuclei frequencies in male mice (p <0.05). These results suggest that 4-butylaniline can induce genetic effects in the micronuclei of male mouse bone marrow cells. Based on the positive results obtained in cytogenetic analyses of somatic cells in vivo, Globally Harmonized System of Classification and Labelling of Chemicals Category 2 was assigned. N-butylaniline was administered for 2 consecutive days by oral gavage to male ICR mice at dose of 0 (control), 64, 160, 400, and 800 mg/kg. N-butylaniline tested negative for micronuclei induction in mice, although N-butylaniline was associated with micronucleus induction at the highest dose. Based on the negative results obtained for cytogenetic analyses of somatic cells in vivo, "Not Classified" was assigned.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.22 no.2
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• pp.201-210
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• 1996

Predictive tests for the identification of contact sensitizing chemicals have been developed. We measured the sensitization potential with three predictive tests, the in vitro and the in vivo Local Lymph Node Assay(LLNA), ELISA to detect interferon-gamma(IFN-${\gamma}$) from supernatant and flow cytometry to detect change of cell surface proteins, using draining lymph nodes of mice. BALB/c mice were exposed to various chemicals or vehicles on the ears daily for 3 consecutive days in all experiments. With some exceptions of propyl paraben, neomycin sulfate, the in vivo LLNA was able to detect the sensitizing capacity of test chemicals and was more sensitive than the in vitro LLNA for chemicals used in the present study. In another experiment, contact sensitivity was assessed by the ELISA to detect IFN-Υ from the supernatants of the cultured LNCs after sensitization with chemicals. There was a good correlation between the LLNA and the IFN-Υ production for test chemicals. We also examined the change of cell surface proteins on LNCs after sensitization by flow cytometry for some cell adhesion molecules(ICAM-1, E-cadherine, B7 molecule), T cell markers(CD3, CD4, CD8, T$\alpha$$\beta$,T${\gamma}$$\delta$) and B cell markers(LR1, CD45R, I-Ad). The number of ICAM-1 positive cells and B cells in LNCs were increased after sensitization with DNCB, TNCB, isoeugenol and 25%, 50% cinnamic aldehyde compared with that of vehicle as a control. In conclusion, the in vivo LLNA could provide more sensitive screening test for moderate to strong sensitizers and some weak sensitizers including cosmetic raw materials than the in vitro LLNA. The production of IFN-Υ by allergen-activated LNCs might be a values indicators without radioisotopes for the identification of contact allergens. Detection of allergens by testing the increase of ICAM-1 positive cells and B cells in LNCs by flow cytometry might be used as a test method to detect allergens.

• Journal of Korea Association of Health Promotion
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• v.3 no.2
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• pp.121-136
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• 2005

Background/Aims The liver funtion tests(LFTs), such as aspartate aminotransferase(AST), alanine amino-transferase(ALT), r -glutamyl transferase( r -GT), have been widely used for screening tests but their low positive predictive value can cause many false positive results. To evaluate the clinical usefulness of these tests, we analyzed serial LFT results of single factory workers and compared the risk factor's in groups divided by the serial LFT results. Methods From June 2001 to October 2001, 1223 consecutive healthy workers in a single factory were enrolled and questionnaire, LFT and liver ultrasonography were performed. Previous LFT results were collected from Annual Health Examination Survey. According to the abnormalities in serial LFT, participants were classified into three groups (abnormal-in-both, alternating normal-in-both) and the risk factors were compared among these groups using multiple logistic regression Results The prevalence of LFT abnormality in a single test was 16.8% but, in serial LFT, only 5% of participants showed consistent abnormality. The risk factors for abnormal-in-both group, compared with alternating group, were liver ultrasonography abnormality such as fatty liver(odds ratio, 2.2; p=0.026) and heavy alcohol intake (more than 210g/week) (odds ratio, 7.2;P=0.064). HBsAg was not significant risk factor for any of the three groups. ConclusionIn factory workers with serial LFT abnormality, alcoholic liver disease could be the principal cause of abnormal LFT. Even if HBsAg were positive in patients with abnormal LFT, there is a possibility of another causes for LFT abnormalities such as alcoholic liver disease and nonalcoholic steatosis or steatohepatitis

• PNF and Movement
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• v.17 no.2
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• pp.167-175
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• 2019

Purpose: This study aims to determine the effect of Jeonbuk tri-pull taping and proprioceptive neuromuscular facilitation (PNF) exercise on the shoulder's active range of motion, pain, subluxation, upper extremity function, and activities of daily living in patients with stroke. Methods: In this study, Jeonbuk tri-pull taping and PNF exercise were applied to three patients with stroke and subluxation. The tape was removed and new tape applied for two days every Monday, Wednesday, and Friday over six consecutive weeks. PNF exercise was applied five times a week for six weeks. To measure the range of motion, a smart phone clinometer application was used, and the degree of pain was measured using a visual analogue scale (VAS). A jig measuring method was employed to measure the distance of subluxation. The Fugl-Meyer Assessment (FMA) was used to evaluate arm function, and the modified Barthel Index (MBI) was employed to evaluate the activities of daily living. Results: The shoulder's active range of motion was improved in the patients compared to the range of pre-tests, and the pain and subluxation distance were reduced compared to those of pre-tests. Arm function and activities of daily living were increased compared to those of pre-tests. Conclusion: The study results verified that Jeonbuk tri-pull taping and PNF exercise are useful when applied to patients with subluxation and stroke.

• Geomechanics and Engineering
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• v.27 no.5
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• pp.447-463
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• 2021

Caisson-type structures are widely used as quay walls in coastal areas. In Korea, for a long time, many caisson-type quay walls have been constructed with a low front water depth. These facilities can no longer meet the requirements of current development. This study developed a new technology for deepening existing caisson-type quay walls using grouting and rubble mound excavation to economically reuse them. With this technology, quay walls could be renovated by injecting grout into the rubble mound beneath the front toe of the caisson to secure its structure. Subsequently, a portion of the rubble mound was excavated to increase the front water depth. This paper reports the results of an investigation of the seismic behavior of a renovated quay wall in comparison to that of an existing quay wall using centrifuge tests and numerical simulations. Two centrifuge model tests at a scale of 1/120 were conducted on the quay walls before and after renovation. During the experiments, the displacements, accelerations, and earth pressures were measured under five consecutive earthquake input motions with increasing magnitudes. In addition, systematic numerical analyses of the centrifuge model tests were also conducted with the PLAXIS 2D finite element (FE) program using a nonlinear elastoplastic constitutive model. The displacements of the caisson, response accelerations, deformed shape of the quay wall, and earth pressures were investigated in detail based on a comparison of the numerical and experimental results. The results demonstrated that the motion of the caisson changed after renovation, and its displacement decreased significantly. The comparison between the FE models and centrifuge test results showed good agreement. This indicated that renovation was technically feasible, and it could be considered to study further by testbed before applying in practice.

• Neonatal Medicine
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• v.18 no.2
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• pp.301-309
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• 2011

Purpose: Point-of-care tests (POCTs) have the potential to significantly influence management of neonates. The aim of this study was to assess the clinical usefulness of the POCT chemistry analyzer in a neonatal intensive care unit (NICU). Methods: Blood samples of neonates admitted to the NICU were tested using a POCT chemistry analyzer (Piccolo Xpress Chemistry Analyzer, Abaxis, Union City, CA, USA) and a central laboratory chemical analyzer (Chemistry analyzer 7600-110, Hitachi Ltd., Tokyo, Japan) from March to September, 2010. Correlation of 15 analytes between the POCT and the central laboratory machine was evaluated. For consistency of the POCT, three consecutive samplings were performed. Differences among the three tests were recorded. The causes of performance errors were checked through log files. Results: One hundred of 112 pairs of tests for accuracy performed in 54 neonates showed a high correlation between the two machines. Twelve performance errors occurred during the 112 tests. The most common error was insufficient sample error. Eighteen triplet tests performed in 18 patients for consistency revealed a difference range of 3-10%, which was considered to be acceptable. No error occurred during the 54 tests. Conclusion: The POCT is capable of analyzing multiple analytes with a minimal amount of whole blood in a short time. The few performance errors noted presently are likely preventable. This POCT is concluded to be suitable for use as a simple and rapid diagnostic method in the NICU with a minimal amount of blood collected in a less invasive manner.