• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 추계학술대회 논문집
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• pp.1303-1308
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• 2007

Recently, precast concrete tracks are replacing ballast track for efficient and economic maintenance of track. Precast concrete railroad tracks are manufactured in factory, and transported to railroad construction site for installation. Therefore, quality of precast concrete track itself should be sufficiently good. On the contrary to the convenient manufacturing of precast concrete track, the installation of a precast concrete track requires careful steps. Typically, a precast concrete track is placed on an approximately 15-cm thick lean concrete layer. A mortar is filled between lean concrete layer and precast concrete track to adjust the sloping angle of a precast concrete track for a safe train operation at a curvy section. Then, the use of filled mortarproduces a void underneath a precast concrete track, which is harmful to structural safety of a precast concrete track undercyclic loading. Therefore, it is essential to make sure that there is no void left beneath a precast concrete track after mortar filling. In the continuous resonance method, the amplitude of frequency response measured using an instrumented hammer and an accelerometer is plotted against a pseudo-depth, which is half of the wave velocity divided by frequency. The frequency response functions are measured at consecutive measurement locations, 6-cm interval between measurement points, and then combined together to generate a 2-D plot of frequency response. The sections with strong reflections or large amplitude of frequency response are suspicious areas with internal voids and unfilled areas. The 2-D frequency response plot was efficient in locating problematic sections just by examining the color shade of a visualized plot in 2-D format. Some of the problematic sections were drilled to make a visual inspection of mortar filling. The visual image of interface between mortar and precast concrete track was verified using the validity of the continuous resonance technique adopted in this research.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.171-176
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• 2016

Background: Much has been done to examine the psychological impact of cancer treatment, but it remains unclear to what extent anxiety and depression is related to symptom prevalence. The present study concerned the characteristics and frequency of distress as related to symptom prevalence in cancer patients undergoing chemotherapy in Malaysia. Materials and Methods: Participants were 303 consecutive adult cancer patients undergoing chemotherapy in an academic medical center. The short form Memorial Symptom Assessment Scale (MSAS-SF), which covers three domains of symptoms (global distress, physical- and psychological symptoms) was used to cross-sectionally measure symptom frequency and associated distress via self-reporting. One-way ANOVA and t-tests were used to test mean differences among MSAS-SF subscale scores. Results: Complete data were available for 303 patients. The mean number of symptoms was 14.5. The five most prevalent were fatigue, dry mouth, hair loss, drowsiness and lack of appetite. Overall, symptom burden and frequency were higher than in other published MSAS-SF studies. Higher symptom frequency was also found to be significantly related to greater distress in cancer patients undergoing chemotherapy. Conclusions: Patients undergoing chemotherapy suffer from multiple physical and psychological symptoms. Better symptom control or palliative care is needed. Greater frequency of reported symptoms may also indicate a subconscious bid by patients for care and reassurance - thus tailored intervention to manage distress should be offered.

• 대한관절경학회:학술대회논문집
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• 대한관절경학회 제21차 추계 학술대회
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• pp.153-153
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• 2009

The purpose of this study was to evaluate tibial tunnel widening prospectively after anterior cruciate ligament (ACL) reconstruction with hamstring tendon grafts using Rigidfix (DePuy Mitek, Raynham, MA) femoral fixation and Intrafix (DePuy Mitek) tibial fixation. 56 consecutive patients who underwent ACL reconstruction with a minimum of 2 years' postoperative evaluation were reviewed. On the anterior-posterior (AP) and lateral radiographs, the diameter of the tibial tunnel was measured at proximal, middle, and distal positions and the shape of the tibial tunnels were classified. Tunnel widening was defined as widening of greater than 2 mm. Group I was defined as cases with no tunnel widening and group II defined as cases with tunnel widening. Postoperative laxity evaluations were performed using Lachman test, pivot-shift test, and Instrumented laxity testing using the KT-1000 arthrometer. On the AP radiographs, the average diameter of the tibial tunnel increased 8.8% at 6 months and 8.5% at 12 months postoperatively compared to the immediate postoperative day. On the lateral radiographs, the average diameter of the tibial tunnel increased 7.2% at 6 months and 8.1% at 12 months year postoperatively compared to the immediate postoperative day. The tunnel shape evaluation revealed predominantly linear type in 53 patients (95%). Group I was 42 patients (75%) and group II was 14 (25%). The average KT-1000 measurement was 1.0~1.8 mm in group I and 2.1~2.8 mm in group II (p>0.05) The Lachman and pivot-shift showed tests no significant differences between the two groups. In conclusion, hamstring ACL reconstruction using Rigidfix and Intrafix fixation showed less widening of the tibial tunnels than observed in previously published studies.

• Nutrition Research and Practice
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• 제8권1호
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• pp.59-65
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• 2014

There is currently no reference for intake of lysine for Chinese people; therefore, the present study was conducted to determine the lysine requirement of Chinese young male adults on a habitual Chinese mixed diet based on the modified indicator amino acid oxidation method. Seven young men with a mean age of $23.7{\pm}2.2$ years that were healthy based on questionnaire, physical examinations and screening tests were evaluated. Subjects were evaluated over five consecutive 7 day periods, during which time they were administered decreasing amounts of lysine via the diet (65, 55, 45, 35, $25mg{\cdot}kg^{-1}{\cdot}d^{-1}$). Subjects were allowed to adapt from day 1 to 6 and the isotopes were measured on day 7 in each period. The subjects' body weights, body compositions and plasma proteins were also examined during the study. Amino acid kinetics were measured based on the indicator amino acid oxidation technique using the $^{13}CO_2$ release rate and phenylalanine oxidation rate to estimate lysine requirements. Body weights, body compositions, and plasma proteins of subjects did not change significantly relative to those at baseline. The mean and the upper 95% CI of lysine requirements of Chinese habitual diets were determined to be 58.41 and $70.09mg{\cdot}kg^{-1}{\cdot}d^{-1}$, respectively, based on the $^{13}CO_2$ release rate and 54.28 and $65.14mg{\cdot}kg^{-1}{\cdot}d^{-1}$, respectively, based on the phenylalanine oxidation rate.

• 대한환경공학회지
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• 제27권8호
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• pp.852-858
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• 2005

대기질 예측 모델링은 대기질 관리의 유용한 도구이다. 특히, 도시지역에서 대기질은 건물과 자동차와 같은 국부적인 장애물에 의해 크게 영향을 받는다. 일반적으로 도로를 따라 건물이 연속적으로 형성되어있는 도시거리협곡에서의 대기질을 예측하고자 할 때 현재 이용 가능한 대기확산모델은 대기질을 정확하게 예측하는데 많은 한계점을 가지고 있다. 본 연구에서는 도시거리협곡에서 대기질 예측을 위한 경험적인 모델을 제안하고자 하였다. 이를 위해 풍동실험을 수행하고, 그 결과를 통계적으로 분석하였다. 풍동실험 결과 넓은 협곡인 경우와 도로축과 직각을 이루는 바람일 때 도시거리협곡의 대기질을 향상시키는데 유용하다는 것을 확인하였다. 또한, 제안한 모델을 이용한 모델 예측치는 풍동실험 결과와 상관성이 양호하게 나타났다.

• Archives of Plastic Surgery
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• 제41권5호
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• pp.535-541
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• 2014

Background Patients having unilateral breast reconstruction often require a second stage procedure on the contralateral breast to improve symmetry. In order to provide immediate symmetry and minimize the frequency and extent of secondary procedures, we began performing simultaneous contralateral balancing operations at the time of initial reconstruction. This study examines the indications, safety, and efficacy of this approach. Methods One-hundred and two consecutive breast reconstructions with simultaneous contralateral balancing procedures were identified. Data included patient age, body mass index (BMI), type of reconstruction and balancing procedure, specimen weight, transfusion requirement, complications and additional surgery under anesthesia. Unpaired t-tests were used to compare BMI, specimen weight and need for non-autologous transfusion. Results Average patient age was 48 years. The majority had autologous tissue-only reconstructions (94%) and the rest prosthesis-based reconstructions (6%). Balancing procedures included reduction mammoplasty (50%), mastopexy (49%), and augmentation mammoplasty (1%). Average BMI was 27 and average reduction specimen was 340 grams. Non-autologous blood transfusion rate was 9%. There was no relationship between BMI or reduction specimen weight and need for transfusion. We performed secondary surgery in 24% of the autologous group and 100% of the prosthesis group. Revision rate for symmetry was 13% in the autologous group and 17% in the prosthesis group. Conclusions Performing balancing at the time of breast reconstruction is safe and most effective in autologous reconstructions, where 87% did not require a second operation for symmetry.

• Biomolecules & Therapeutics
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• 제22권3호
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• pp.213-222
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• 2014

Abnormal adaptation of the stress-response system following traumatic stress can lead to alterations in the hypothalamic-pituitaryadrenal (HPA) axis that may contribute to the development of post-traumatic stress disorder (PTSD). The present study used several behavioral tests to investigate the anxiolytic-like and antidepressant activity of L-tetrahydropalmatine (L-THP) in an experimental rat model of anxiety and depression induced by single prolonged stress (SPS), an animal model of PTSD. Male rats were treated intraperitoneally (i.p.) with vehicle or varied doses of THP 30 min prior to SPS for 8 consecutive days. Daily THP (50 mg/kg) administration significantly increased the number and duration of open arm visits in the elevated plus maze (EPM) test, reduced the anxiety index, increased the risk assessment, and increased the number of head dips over the borders of the open arms after SPS. THP was also associated with increased time spent at the center of the open field, reduced grooming behaviors in the EPM test, and reduced time spent immobile in the forced swimming test (FST). It also blocked the decrease in neuropeptide Y (NPY) and the increase in corticotrophin-releasing factor (CRF) expression in the hypothalamus. This is the first study to determine that THP exerts pronounced anxiolytic-like and antidepressant effects on the development of the behavioral and biochemical symptoms associated with PTSD, indicating its prophylactic potential. Thus, THP reversed several behavioral impairments triggered by the traumatic stress of SPS and is a potential non-invasive therapeutic intervention for PTSD.

• 한방비만학회지
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• 제15권2호
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• pp.153-161
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• 2015

감로수는 궁중음료인 제호탕과 동의보감의 생맥산에서 유래한 절식보조음료이다. 감로수를 이용한 절식요법의 보완과 향후 예정된 임상시험을 위한 임상지표 선정을 위해 정상인 1예, 비만인 1예, 고도비만인 1예를 대상으로 10일간의 절식요법 전, 후로 증례를 관찰하였다. 절식 후 체중은 평균 -6.3%, 체지방은 평균 -6.5%, 근육은 평균 -6.6% 감소하였고, 영양지표에 해당하는 RBC, hemoglobin, hematocrit, T-protein, albumin의 수치는 증가하였고 염증지표에 해당하는 hs- CRP, CRP, ESR, WBC 수치는 감소하였다. 절식 후에도 간기능, 신기능, 전해질수치는 정상수준을 유지하였고, 산화스트레스는 감소하였으며, 항산화력이 증가하는 결과를 나타내었다. 피로도는 절식 전보다 다소 개선되었고, 절식기 동안 불면 이외에 별다른 불편증상을 호소하지 않았다. 다만 혈중 빌리루빈수치 상승, 케톤 증가로 인한 체액의 약산성화는 절식요법을 시행함에 있어 추후 보완해야 할 사안이라 생각된다. 결론적으로 감로수의 디톡스 프로파일은 적합하며 관찰된 결과는 후속연구에 고려될 것이다.

• 수산해양교육연구
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• 제22권1호
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• pp.123-140
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• 2010

The Purpose of this study was to examine the effects of self-growth group counseling on self-esteem and life satisfaction of university students. For this study the following hypotheses were established. First, does the self-growth group counseling enhance significantly the participants' self-esteem? Second, does the self-growth group counseling enhance significantly the participants's life satisfaction? Those who participated in this study were 22 University students which are in D University in Busan. Ten participants were assigned in the experimental group and twelve in the control group. The experimental group participated in the self-growth group counseling one session a week for 12 consecutive weeks held by counseling center for D University students. The instruments used in this study were Self-Esteem Scale and life satisfaction Scale. The data was analysed by ANCOVA. The average, standard deviation, and estimated marginal means were calculated and the differences between the pre and post-tests calculated, processed by SPSS 12.0. The major findings of this study can be summarized as follows: First, the self-growth group counseling is effective to enhance significantly the level of self-esteem of University students. Second, the self-growth group counseling is also effective to enhance the level of life satisfaction of University students. Based on the results, the self-growth group counseling was suggested as a means to help University students enhance their self-esteem and life satisfaction.

• Journal of Ginseng Research
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• 제39권2호
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• pp.148-154
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• 2015

Background: Ginseng is known to have antiapoptotic, anti-inflammatory, and antioxidant effects. The present study investigated a possible role of Korean Red Ginseng (KRG) in suppressing dopaminergic neuronal cell death and the cleavage of p35 to p25 in the substantia nigra (SN) and striatum (ST) using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease mouse model. Methods: Ten-week-old male C57BL/6 mice were injected intraperitoneally with 30 mg/kg of MPTP at 24-h intervals for 5 d, and then administered KRG (1 mg/kg, 10 mg/kg, or 100 mg/kg) once a day for 12 consecutive days from the first injection. Pole tests were performed to assess the motor function of the mice, dopaminergic neuronal survival in the SN and ST was evaluated using tyrosine hydroxylase-immunohistochemistry, and the expressions of cyclin-dependent kinase 5 (Cdk5), p35, and p25 in the SN and ST were measured using Western blotting. Results: MPTP administration caused behavioral impairment, dopaminergic neuronal death, increased Cdk5 and p25 expression, and decreased p35 expression in the nigrostriatal system of mice, whereas KRG dose-dependently alleviated these MPTP-induced changes. Conclusion: These results indicate that KRG can inhibit MPTP-induced dopaminergic neuronal death and suppress the cleavage of p35 to p25 in the SN and the ST, suggesting a possible role for KRG in the treatment of Parkinson's disease.