• 약학회지
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• 제27권3호
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• pp.185-205
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• 1983

Penicillins and cephalosporins are biosynthesized from L-.alpha.-aminoadipic acid, L-cysteine and L-valine. A tripeptide, LLD-$\delta$-($\alpha$-aminoadipyl)cysteinylvaline(LLD-ACV) was isolated from fermentation broths of Cephalosporium acremonium as well as of Penicillium chrysogenum and it was proved that the LL-$\delta$-($\alpha$-aminoadipyl cysteine was formed first in mycelia, to which valine would be connected to give LLD-ACV. However, several points are still unsolved; first, what mechanism is involved in the configurational change from L-valine to D-valine, second, what kind of cyclization mechanism gives a $\betha$-lactam ring and a thiazolidine ring and third, what is the pathways for the ring expansion from penicillins to cephalosporins. At present, it seems clear that LLD-ACV is cyclized to give isopenicillin N, which is transformed to penicillin N and further to cepbalosporin C. Other hydrophobic penicillins, including benzyl penicillin and penicillin V, are formed from isopenicillin N by acyl-exchange reactions catalyzed by penicillin transferase, rather than by acylation reaction on 6-aminopenicillanic acid(6-APA), which was isolated from the fermentation broth of P. chrysogenum and which would be formed by hydrolysis of $\delta-(\alpha$-amincadipyl)amido moiety at the C-6 position in isopenicillin N or penicillin N by penicillin acylase. Acylation of 6-APA is catalyzed also by penicillin acylase, but the reaction is proved not to be involved in penicillin biosynthesis. Understanding the biosynthesis of penicillins and cephalsoporins would provide solutions to increase in fermentation yields of penicillins, especially of cephalosporins and a solution to biological production of 7-aminocepbalosporanic acid (7-ACA) which is of importance in pharmaceutical industry. Still regulation mechanisms in penicillin and cephalosporin biosynthesis are unveiled at all.

• 한국안전학회지
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• 제27권2호
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• pp.13-19
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• 2012

The effectiveness of treeing resistance in low density polyethylene containing azocompounds were investigated under radiation environments. 4-(4-nitrophenylazo)-1-naphthol and 4-(4-nitrophenylazo) resorcinol were selected for treeing inhibitors. LDPE containing the additives were crosslinked with dicumyl peroxide, irradiated by $Co^{60}$ ${\gamma}$-ray in the presence of air at room temperature. Treeing inception voltage, AC breakdown strength measurements were carried out for electrical insulation characteristics, thermoluminescence and gel contents were analyzed as various irradiation doses also. LDPE with treeing inhibitors showed much better insulation characteristics than pure LDPE. It is interpreted that molecular structures, polar groups and the type of radicals connected on the benzene ring of the additives affected electrical characteristics. From the results, 4-(4-nitrophenylazo) resorcinol was the most effective upon the best treeing and radiation resistance.

• 대한수학회보
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• 제36권4호
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• pp.671-682
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• 1999

Using a base-point free version of the infinite symmetric product we define a fibrewise infinite symmetric product for any fibration $E\;\longrightarrow\;B$. The construction works for any commutative ring R with unit and is denoted by $R_f(E)\;l\ongrightarrow\;B$. For any pointed space B let $G_I(B)\;\longrightarrow\;B$ be the i-th Ganea fibration. Defining $M_R-cat(B):= inf{i\midR_f(G_i(B))\longrihghtarrow\;B$ admits a section} we obtain an approximation to the Lusternik-Schnirelmann category of B which satisfies .g.a product formula. In particular, if B is a 1-connected rational space of finite rational type, then $M_Q$-cat(B) coincides with the well-known (purely algebraically defined) M-category of B which in fact is equal to cat (B) by a result of K.Hess. All the constructions more generally apply to the Ganea category of maps.

• 한국실내디자인학회논문집
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• 제19호
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• pp.11-19
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• 1999

This study is about the Characteristics of the Medievalism expressed in the German Architectural Expressionism. The concept of Medievalism is an attitude to revive the social and physical settings on Middle Ages. The social situation and architectural style in the Middle Ages were similar to the German Expressionism in the early 20th-century. The Medieval Characteristics of the German Architectural Expressionism were expressed in two ways -first, organic or sculptural style and second, fantastic or Crystal style. The architects such as Hermann Finsterlin, Henry van de Velde, Erich Mendelsohn, Rudolf Steiner, Hugo H ring, Hans Poelzig belonged to the first tendency, and such as Paul Scheerbart, Bruno Taut, Otto Bartning, Dominikus B hm belonged to the second tendency. The Medieval concept of the German architectural Expressionism was succeeded to Modern Architecture in 1950-1960s'. The architects in 1950-1960's such as Hans Scharoun, Gottfried B hm, Alvar Aalto, J rn Utzon intended to express organic and fantastic mass which was closely connected with the Medival concept of the German architectural Expressionism.

• Applied Microscopy
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• 제25권4호
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• pp.17-25
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• 1995

This paper aims to probe the cell differentiation and gene activity in early Oogenesis from Dendrolimus spectabilis Butler by transmission electron microscope. The 8 cystocytes are formed by mitosis of the Oogonia, and differentiated to the 1 Oocyte and 7 nurse cells. The oocyte and nurse cells are connected by ring canals, through which the cytoplasmic organelles such as mitochondria, free ribosomes, and electron dense granular materials are passed from nurse cells to o cyte. Many replication fork in the cystocyte nuclei and 2 transcriptional units of $2.7{\mu}m\;and\;0.36{\mu}m\;or\;0.5{\mu}m$ in the nurse cells are observed by the chromatin spreading technique. It is possible that transcriptional units are passed from nurse cells to Oocyte.

• JSTS:Journal of Semiconductor Technology and Science
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• 제15권6호
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• pp.615-628
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• 2015

CGRA (Coarse-Grained Reconfigurable Architecture) based multi-core architecture can be considered as a suitable solution for the fault-tolerant computing. However, there have been a few research projects based on fault-tolerant CGRA without exploiting the strengths of CGRA as well as their works are limited to single CGRA. Therefore, in this paper, we propose two approaches to enable exploiting the inherent redundancy and reconfigurability of the multi-CGRA for fault-recovery. One is a resilient inter-CGRA fabric that is ring-based sharing fabric (RSF) with minimal interconnection overhead. Another is a novel intra/inter-CGRA reconfiguration technique on RSF for maximizing utilization of the resources when faults occur. Experimental results show that the proposed approaches achieve up to 94% faulty recoverability with reducing area/delay/power by up to 15%/28.6%/31% when compared with completely connected fabric (CCF).

• 한국정밀공학회지
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• 제26권4호
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• pp.55-63
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• 2009

This paper reports on the theoretical and experimental study of the pressure ripples in a pressure unbalanced type vane pump which have widespread use in industry. Because they can infinitely vary the volume of the fluid pumped in the system by a control. Pressure ripples occur due to the flow ripples induced by geometry of side plate, leakage flow, reverse flow from the outlet volume produced by pressure difference between pumping chamber and outlet volume when the pumping chamber connected with the outlet volume. In this paper, we measured the pressure variation of a pumping chamber, reaction force on a cam ring, the mathematical model for analyzing the pressure ripples which included vane detachment and fluid inertia effects in notch area has been presented, and was applied to predict the level and the wave form of the pressure ripples according to operating conditions.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1988년도 전기.전자공학 학술대회 논문집
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• pp.157-160
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• 1988

This paper describes the development of the Interfacing unit between PSTN and interphone network. The designed and realised system detects the ring signal from PSTN and makes off-hook condition when it is detected. Then the caller can hear the response tone from the unit and the tones of the interphone network condition. The developed system receives the interphone number to which the caller wants to connect by MFC tones and drives Interphone switch matrix. Thus, a call is connected to the interphone user directly. The caller may press the interphone number up to 10 digits and the last two of which are recognized as valid ones. The caller must press the first digit within 20 seconds after system response.

• Bulletin of the Korean Chemical Society
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• 제5권1호
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• pp.23-26
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• 1984

The crystal structure of phthalylsulfacetamide, one of the long-acting 'sulfa' drugs, has been determined by the X-ray diffraction methods. The crystal is monoclinic with cell dimensions of a = 7.980(3), b = 12.784(2), c = 18.064(7) ${\AA}$ and ${\beta}$= $112.94(2)^{\circ}$, space group $P2_1$/c and Z = 4. The structure was solved by the direct methods and refined to R = 0.048. The sulfonylacetamide moiety is folded with respect to the central phenyl ring and the benzamide and benzoyl planes are nearly perpendicular to each other. This conformation is consistent with those of the relevant molecules containing the corresponding moieties. All of the molecules in the crystal lattice are connected by a three-dimensional hydrogen bonding network.

• Bulletin of the Korean Chemical Society
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• 제5권4호
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• pp.158-162
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• 1984

The crystal structure of chloramphenicol base, $C_9H_{l2}N_2O_4$, the deacylated base of antibiotic chloramphenicol, has been determined by X-ray diffraction techniques using diffractometer data obtained by the ${\omega}-2{\theta}$ scan technique with CuK${\alpha}$ radiation from a crystal with space group symmetry $P2_12_12_1$ and unit cell parameters a = 22.322(6), b = 7.535(6), c = 5.781(5) ${\AA}$. The structure was solved by direct methods and refined by full-matrix least-squares to a final R = 0.051 for the 573 observed reflections. The overall conformation of the base is quite different from those of the chloramphenicol congeners which are similar despite the presence of many rotatable single bonds. The propane chain in the base is bent with respect to the phenyl ring, while it is extended in the chloramphenicol congeners. There is no intramolecular hydrogen bond between the hydroxyl groups of the propanediol moiety. All of the molecules in the crystal lattice are connected by a three-dimensional hydrogen bonding network.