• Biomedical Science Letters
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• v.8 no.2
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• 2002

• Journal of the Korean Mathematical Society
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• v.30 no.1
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• pp.63-77
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• 1993

• Proceedings of the PSK Conference
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• 2000.04a
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• pp.48-52
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• 2000

• Archives of Pharmacal Research
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• v.16 no.4
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• pp.347-348
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• 1993

• Kyungpook Mathematical Journal
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• v.35 no.1
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• pp.33-38
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• 1995

• Bulletin of the Korean Chemical Society
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• v.18 no.8
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• pp.907-910
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• 1997

• Bulletin of the Korean Chemical Society
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• v.20 no.2
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• pp.250-252
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• 1999

• Proceedings of the PSK Conference
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• 2001.10a
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• pp.314.1-314.1
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• 2001

• Bulletin of the Korean Chemical Society
• /
• v.32 no.11
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• pp.3928-3932
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• 2011

We synthesized peptide-resin conjugates (1 and 2) by immobilizing ${\beta}$-sheet antibacterial peptide and ${\alpha}$ helical antibacterial peptide on PEG-PS resin, respectively. Conjugate 1 showed considerable antibacterial activity in various conditions, whereas conjugate 2 did not exhibit antibacterial activity. The growths of various bacteria were inhibited by conjugate 1 even at lower concentrations than MIC. Conjugate 1 killed bacteria at MIC and had a potent synergistic effect with current antibacterial agents such as vancomycin and tetracycline, respectively. Overall results indicate that polymer surface modification using antibacterial ${\beta}$ sheet peptide is a powerful way to prevent microbial contamination on polymer surfaces.

• Bulletin of the Korean Chemical Society
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• v.33 no.9
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• pp.3004-3008
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• 2012

Small molecule conjugated peptides were prepared by solid-phase synthesis as potential novel whitening agents, and their melanogenesis inhibitory activities were investigated. The conjugated small molecules were well-known materials as tyrosinase inhibitors, and peptides were selected from the sequences that are known to antagonize melanocortin receptor 1 (MC1R). Most of small molecules-peptide conjugates showed superior melanin inhibition activity to kojic acid and arbutin. Among these, almost all compounds have -AR- sequence. From this study, we concluded that the small molecule conjugated peptides containing -AR- sequence have melanogenesis inhibitory activities and have potential to be used as novel whitening agents.