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http://dx.doi.org/10.5012/bkcs.2011.32.11.3928

Characterization of Antibacterial Activity and Synergistic Effect of Cationic Antibacterial Peptide-resin Conjugates  

Kim, Jeong-Min (Bioorganic Chemistry Lab., Department of Chemistry, Inha University)
Jang, Su-Jung (Bioorganic Chemistry Lab., Department of Chemistry, Inha University)
Yang, Mi-Hwa (Bioorganic Chemistry Lab., Department of Chemistry, Inha University)
Cho, Hyeong-Jin (Bioorganic Chemistry Lab., Department of Chemistry, Inha University)
Lee, Keun-Hyeung (Bioorganic Chemistry Lab., Department of Chemistry, Inha University)
Publication Information
Bulletin of the Korean Chemical Society / v.32, no.11, 2011 , pp. 3928-3932 More about this Journal
Abstract
We synthesized peptide-resin conjugates (1 and 2) by immobilizing ${\beta}$-sheet antibacterial peptide and ${\alpha}$ helical antibacterial peptide on PEG-PS resin, respectively. Conjugate 1 showed considerable antibacterial activity in various conditions, whereas conjugate 2 did not exhibit antibacterial activity. The growths of various bacteria were inhibited by conjugate 1 even at lower concentrations than MIC. Conjugate 1 killed bacteria at MIC and had a potent synergistic effect with current antibacterial agents such as vancomycin and tetracycline, respectively. Overall results indicate that polymer surface modification using antibacterial ${\beta}$ sheet peptide is a powerful way to prevent microbial contamination on polymer surfaces.
Keywords
Cationic antibacterial peptide; Antibacterial polymer; Surface modification; Synergistic effect; Antibacterial resin;
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