• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2003년도 춘계학술대회 논문집
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• pp.844-847
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• 2003

This thesis suggests design considerations and solutions for cam type transfer unit in which feed, lift, and clamp motions are occurred by cams. For fast transferring and avoiding cam breakage, each designed cam must satisfy the given specifications such like velocity, acceleration, jerk, pressure angle, ram thickness, and torque. To reduce absolute torque magnitude, conjugate cam is suggested. Conjugate cam eliminates the redundant pre-load by using complementary cam and follower to avoid jumping between them. The result from the prototype shows the reductions of the absolute torque value, and it indicates that conjugate cam could enhance the working speed of cam type transfer unit and extend of the life span of cam type transfer unit.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2002년도 학술대회지
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• pp.103-106
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• 2002

This paper presents an effective numerical method for analyzing three-dimensional unsteady conjugate heat transfer problems of a curved pipe subjected to infernally thermal stratification. In the present numerical analyses, the thermally stratified flows in the pipe are simulated using the standard $k-{\varepsilon}$turbulent model and the unsteady conjugate heat transfer is treated numerically with a simple and convenient numerical technique. The unsteady conjugate heat transfer analysis method is implemented in a finite volume thermal-hydraulic computer code based on a non-staggered grid arrangement, SIMPLEC algorithm and higher-order bounded convection scheme. Numerical calculations have been performed far the two cases of thermally stratified pipe flows where the surging directions are opposite each other i.e. In-surge and out-surge. The results show that the present numerical analysis method is effective to solve the unsteady flow and conjugate heat transfer in a curved pipe subjected to infernally thermal stratification.

• Journal of Pharmaceutical Investigation
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• 제40권4호
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• pp.219-223
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• 2010

The hyaluronic acid (HA) conjugate bearing $\alpha$-cyclodextrin ($\alpha$-CD) was synthesized as the potential carrier of poly(ethylene glycol) (PEG)-drug conjugates. The HA conjugate was prepared by the reaction between the carboxylic acid of HA and the primary amine of $\alpha$-CD in the presence of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and 1-hydroxybenzotriazole. The chemical structure of the conjugate was confirmed using $^1H$ NMR and FT-IR spectroscopy. The conjugate could form nano-sized particles in the presence of PEG by forming the inclusion complexes between $\alpha$-CD at the backbone of HA, which was demonstrated using electrophoretic light scattering and field emission transmission electron microscopy. It is anticipated that this novel kind of nanoparticles can serve as a useful delivery system for PEGylated drugs.

• 대한전자공학회논문지
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• 제25권9호
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• pp.1108-1114
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• 1988

Usng the P.Yeh's analytic method, we derive the condition for oscillation of a linear phase conjugate oscillator which consists of photorefractive medium and two conventional mirrors. From this general oscillation condition, we obtain the threshold oscillation conditon of a single phase conjugate resonator and the self-oscillation condition of photorefractive medium, then in special case (phase shift =90\ulcorner: no external dc electric field), oscillation conditions of the linear phase conjugate oscillator for any cavity length are derived. The results indicate that, unlike in a phase conjugate oscillator with Kerr-like medium, oscillation cannot occur at special cavity length for given couplinyg strengths.

• Archives of Pharmacal Research
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• 제13권2호
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• pp.147-150
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• 1990

Methotrexate (MTX)-poly-L-lysine (PLL) conjugate was relatively stable in phosphate buffer of pH 7.4 and in plasma. However, liver homogenate accelerated the release of MTX from the conjugate. Pharmacokinetics and tissue distribution of MTX were compared after intramuscular injection of MTX (treatment I) and MTX-PLL conjugate (treatment II), 10 mg/kg as free MTX to rabbits. The peak concentration of MTX in treatment II were significantly lower than those in treatment I. The amount of MTX excreted in 24-hr urine was significantly reduced in treatment II and it suggested that MTX be more metabolized in treatment II than in treatment I. The amounts of MTX remaining in each organ after 24-hr of intramuscular injection were not significantly different in both treatments.

• 약학회지
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• 제45권3호
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• pp.302-309
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• 2001

Wheat germ agglutinin (WGA) pectin, which binds to human melanoma cell line, was conjugated with Praecoxin A using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide as a cross-linking agent. Physical mixture (PM) of WGA and Praecoxin A was also prepared by using a non-specific binding property of Praecoxin A to WGA. The WGA:Praecoxin A ratio in the conjugate and PM was approximately 1:18 and 1:20, respectively. The results of hemagglutination assay and enzyme-linked lectin assay indicated that the conjugate and PM maintained the lectin-like properties of the WGA. The binding ratio of conjugate was about 70% during 4-24 hr, but the most of Praecoxin A was released within 24 hr in the case of PM. These results lead to the conclusion that the conjugate is potentially useful for the formulation of injection that requires targeting for melanoma as well as sustained release at the site.

• Macromolecular Research
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• 제14권3호
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• pp.387-393
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• 2006

Nanoparticles of Poly(L-glutamic acid) (PG) conjugated to the anticancer drug paclitaxel and targeted moiety folic acid (FA) were synthesized and characterized in vitro. The nanoparticles were designed to take advantage of FA targeting to folate receptor (FR) positive cancer cells. The chemical composition of the conjugate was characterized by $^1H-NMR$, FTIR and UV/vis spectroscopy. The selective cytotoxicity of the FA-PG-paclitaxel conjugates was evaluated in FR positive cancer cells. The interaction of the conjugate was visualized by fluorescence microscopy with results confirming the successful preparation of the conjugate and the production of nanoparticles of about 200-300 nm in diameter. The amount of paclitaxel conjugated to FA-PG was 25% by weight. Cellular uptake of the conjugate was FA dependent, and the conjugate uptake was mediated specifically by the folate receptor. These results demonstrate the improved selective toxicity and effective delivery of an anticancer drug into FR bearing cells in vitro.

• 한국수학교육학회지시리즈B:순수및응용수학
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• 제22권1호
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• pp.25-34
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• 2015

In this paper we characterize the isogonal and isotomic conjugates of conic. Every conic can be expressed by a quadratic rational B$\acute{e}$zier curve having control polygon $b_0b_1b_2$ with weight w > 0. We show that the isotomic conjugate of parabola and hyperbola with respect to ${\Delta}b_0b_1b_2$ is ellipse, and that the isotomic conjugate of ellipse with the weight $w={\frac{1}{2}}$ is identical. We also find all cases of the isogonal conjugate of conic with respect to ${\Delta}b_0b_1b_2$. Our characterizations are derived easily due to the expression of conic by the quadratic rational B$\acute{e}$ezier curve in standard form.

• 산업식품공학
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• 제14권1호
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• pp.21-26
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• 2010

C-Reactive protein (CRP), which is an 118 kDa pentameric protein, was secreted by the liver is an important biomarker for coronary disease, hypertension and inflammation. In this study, a method for CRP detection exploiting quantum dot (Qdot)-antibody conjugate was developed according to an indirect-competitive immunosensing protocol. For this purpose, a streptavidin-bound $Qdot_{605}$ was linked with a separately prepared biotinylated monoclonal antirat CRP antibody to produce a Qdot-antibody conjugate. The immunosensing was performed at 0.1 and 20 nM of the coating antigen and conjugate, respectively. The current method was found very sensitive in CRP detection, judging from the concentration-dependent fluorescence emission.

• Bulletin of the Korean Chemical Society
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• 제17권11호
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• pp.1018-1022
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• 1996

Adenosine deaminase (ADA) has been utilized as the label in devising a potentiometric homogeneous assay for riboflavin and riboflavin binding protein (RBP). The proposed homogeneous assay method employs an ADA-biotin conjugate as the signal generator and an avidin-riboflavin conjugate as the signal modulator in the solution phase. The catalytic activity of the ADA-biotin conjugate is inhibited in the presence of an excess amount of the avidin-riboflavin conjugate, and the observed inhibition is reversed in an amount proportional to the concentration of RBP added. When the analyte riboflavin is added to this mixture of ADA-biotin, avidin-riboflavin and RBP, the activity of the enzyme conjugate is re-inhibited in an amount proportional to the concentration of riboflavin. Since the enzyme label used in this system is ADA, an ammonia-producing enzyme, a potentiometric rather than photometric detection scheme is used to monitor the enzymatic activity in the assay.