[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.4333/KPS.2010.40.4.219

Synthesis and Characterization of Hyaluronic Acid-α-Cyclodextrin Conjugate as the Potential Carrier of PEGylated Drugs

Sivasubramanian, Maharajan (Department of Advanced Polymer and Chemical Engineering, Kyung Hee University)
Park, Jae-Hyung (Department of Advanced Polymer and Chemical Engineering, Kyung Hee University)

Publication Information

Journal of Pharmaceutical Investigation / v.40, no.4, 2010 , pp. 219-223 More about this Journal

Abstract

The hyaluronic acid (HA) conjugate bearing $\alpha$ -cyclodextrin ( $\alpha$ -CD) was synthesized as the potential carrier of poly(ethylene glycol) (PEG)-drug conjugates. The HA conjugate was prepared by the reaction between the carboxylic acid of HA and the primary amine of $\alpha$ -CD in the presence of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and 1-hydroxybenzotriazole. The chemical structure of the conjugate was confirmed using $^1H$ NMR and FT-IR spectroscopy. The conjugate could form nano-sized particles in the presence of PEG by forming the inclusion complexes between $\alpha$ -CD at the backbone of HA, which was demonstrated using electrophoretic light scattering and field emission transmission electron microscopy. It is anticipated that this novel kind of nanoparticles can serve as a useful delivery system for PEGylated drugs.

Keywords

Hyaluronic acid; $\alpha$ -cyclodextrin; PEG; nanoparticles;

Citations & Related Records

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