• Journal of the Korean Chemical Society
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• v.19 no.4
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• pp.233-239
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• 1975

The configuration of two oxime groups in cis-2-butenedialdioxime, unsymmetrical compound conjugated by three double bonds, is determined by a NMR study on the effects of the solvent, temperature and concentration; it is certain that, in solutions of usual conditions, the configuration exists as only "syn-syn". And the relative strengths of the hydrogen bond between these oxime groups and several solvents are compared and somc effects of the temperature and concentration are also considered. The several models of hydrogen bond between oxime and solvents are proposed; especially it is to be noted here that the hydrogen bond in pyridine solvent is not resulted from the interaction between a lone electron pair on nitrogen atom of pyridine and the hydroxyl proton of oxime, but the result of $\pi$-complex formed between the $\pi$-orbital of pyridine and the hydroxyl proton of the solute.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.26 no.4
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• pp.213-221
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• 2013

This paper introduces a mesh continuation scheme for a one-dimensional inverse medium problem to reconstruct the spatial distribution of elastic wave velocities in heterogeneous semi-infinite solid domains. To formulate the inverse problem, perfectly-matched-layers(PMLs) are introduced as wave-absorbing boundaries that surround the finite computational domain truncated from the originally semi-infinite extent. To tackle the inverse problem in the PML-truncated domain, a partial-differential-equations(PDE)-constrained optimization approach is utilized, where a least-squares misfit between calculated and measured surface responses is minimized under the constraint of PML-endowed wave equations. The optimization problem iteratively solves for the unknown wave velocities with their updates calculated by Fletcher-Reeves conjugate gradient algorithms. The optimization is performed using a mesh continuation scheme through which the wave velocity profile is reconstructed in successively denser mesh conditions. Numerical results showed the robust performance of the mesh continuation scheme in reconstructing target wave velocity profile in a layered heterogeneous solid domain.

• Korean Chemical Engineering Research
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• v.46 no.2
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• pp.211-216
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• 2008

Bufexamac which was used for treatment of atopic dermatitis is the drug which was made as the ointment. However, penetration rate of bufexamac was very low for the barrier effect of stratum corneum. Microneedle was used to increase transdermal delivery rate of the bufexamac. We tried to conjugate bufexamac and FITC for the detection of penetration rate of bufexamac. FITC-bufexamac was mixed in hydrogel for the treatment skin surface. Fluorescent spectrophotometer was used to analysis the concentration of FITC-bufexamac. Microscope using fluorescent filter was used to capture the image about location of FITC-bufexamac in the skin. We confirmed that permeation rate of bufexamac was increased with the treatment by microneedle and was increased by the increasing number treatment of microneedle.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.41 no.11
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• pp.43-51
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• 2004

In this paper, we propose a high-level optical encryption system, which is tolerant with noises and cropping, by encrypting the phase-encoded CGH pattern of original image with the phase-encoded Fresnel diffraction pattern of random key images. For encryption, the phase-encoded CGH pattern of original image is multiplied by conjugate components which are the phase-encoded Fresnel diffraction patterns of random key images. The original information can be reconstructed by multiplying encrypted image by phase-encoded Fresnel diffraction pattern of random key images and performing Fourier transform of the multiplication result. The proposed system is robust to noises and cropping due to characteristics of CGH pattern and can guarantee high-level encryption by using Fresnel diffraction information. We verified the validity of proposed system by computer simulations, numerical analysis of noises and cropping effect and optical experiment.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.16 no.12 s.103
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• pp.1206-1212
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• 2005

In this paper, we propose a novel antenna structure which uses the electric and magnetic currents so as to eliminate nulls on their radiation pattern. The tag antenna was matched to the conjugate impedance of the commercial tag chip using the modified double T matching network. The radiation efficiency is about $90\%$, and the bandwidth($S_{11}< -10 dB$) is 848${\~}$926 MHz. Also it shows the gain deviation between the maximum and minimum gains about 4 dB at any direction of the tag antenna at the operating frequency. The readable range of the tag is 1.7${\~}$2.4 m for an arbitrary rotation angle of the tag with a commercial tag chip.

• Biomedical Science Letters
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• v.5 no.1
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• pp.11-15
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• 1999

Thyroxine (3,5,3',5'-L-tetraiodothyronine; T$_4$) is the most commonly measured thyroid hermono for the diagnosis of various thyroid disorders. Although radioimmunoassay (RIA) is still considered as the reference technique for the measurement of T$_4$, it is generally regarded that RIA has its primary disadventages in handling the wastes and controling the human and material resources. Therefore, establishment of enzyme-linked immunosorbent assay (ELISA) has of great significance. To verify the usefulness of our enzyme immunoassay, we have obtained the standard dose response curve of T$_4$ in patient's sera which is inversely proportional to the amount of herseradish peroxidase (HRP) conjugated monoclonal antibody of T$_4$ bound to the wells. The correlation coefficient (r) between the ELISA and chemiluminescent assay was 0.444 (n=38). Thus we have investigated the establishment of rapid and sensitive competitive ELISA assay method for detection of T$_4$ in patient's sera.

• BMB Reports
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• v.31 no.5
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• pp.519-523
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• 1998

We have previously reported that anti-glucose-6-phosphate dehydrogenase (G6PD) serum raised against native G6PD (nG6PD) enzyme recognized nG6PD antigen poorly in competitive enzyme-linked immunosorbent assay (ELISA) (Kim, 1997). In the present study, we investigated whether anti-G6PD serum raised against nG6PD can react with denatured G6PD effectively in competitive ELISA. We used partially active G6PD (paG6PD) by repeated freeze-thawing or SDS-denatured G6PD (SDS-G6PD) as both immobilized and soluble antigens, and anti-G6PD serum raised against nG6PD for competitive ELISA. The polystyrene cuvettes coated with either paG6PD or SDS-G6PD were challenged with a mixture of a limiting amount of anti-G6PD serum and various doses of paG6PD or SDS-G6PD as competitors, followed by incubation with alkaline phosphatase-anti-IgG conjugate. The competitive ELISA with paG6PD or SDS-G6PD antigen exhibited the sigmoidal dose-response curve characteristic of competition immunoassays. Furthermore, Triton-denatured G6PD (Triton-G6PD) was used in competitive ELISA. The paG6PD, SDS-G6PD, or Triton-G6PD used as competitors increased the inhibition of antibody binding to immobilized either of nG6PD or denatured G6PD compared with nG6PD competitor. The inhibition by denatured G6PD competitors was more pronounced at high competitor concentrations than at low counterparts. We conclude that anti-G6PD serum raised against nG6PD can effectively react with denatured G6PD in competitive ELISA and that our anti-G6PD serum recognizes denatured enzymes better than active enzymes.

• Journal of Korean Society for Geospatial Information Science
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• v.7 no.2 s.14
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• pp.47-56
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• 1999

In this study, tie point observation in aerial triangulation was automated by the image processing methods. The technique includes boundary extraction and We matching processes. The procedures were applied to extract points of Interest and to find their conjugate points in the other images. The image coordinates of the identified points were then used to compute their absolute coordinates. An algorithm was developed in this study for the automation of observation in aerial triangulation, which is a manual process of selecting a tie point and recording the image coordinate of the selected point. The developed algorithm automates this process through the application of a mathematical operator to extract points of interest from an arbitrary image. The root m square error of image coordinates of the developed algorithm is $6.8{\mu}m$, which is close to that of the present analytical method. In a manual environment, the accuracy of the result of a photogrammetric process is heavily dependant on the level of skill and experience of the human operator. No such problem exists in an automated system. Also, as a result of the automated system, the time spent in the observation process could be reduced by a factor of 61.2%, thereby reducing the overall cost.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2002.09a
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• pp.367-369
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• 2002

We have designed ramp profile excitation pulse based on the Shinnar-Le Roux (SLR) algorithm. The algorithm provides many advantages to pulse designers. The first advantage is the freedom of deciding the amplitudes, frequencies, and ripple sizes of stopband, passband, and transition band of pulse profile. The second advantage is the freedom of deciding the pulse phase, more specifically, minimum phase, linear phase, maximum phase, and any phase between them. The minimum phase pulse is the best choice in the case of 3D TOF, because it minimizes the echo time, which implies the best image quality in the same MR examination condition. In addition, the half echo technique is slightly modified in our case. In general, using the half echo technique means that the acquired data size is half and the rest part can be filled with complex conjugate of acquired data. But in our case, the echo center is just shifted to left, which implies the reduction of echo time, and the acquired data size is the same as the one without using the half echo technique. In this case, the increase of right part of data leads to improvement of the resolution and the decrease of left part of data leads to decrease of signal to noise ratio. Since in the case of 3D TOF, the signal to noise ratio is sufficiently high and the resolution is more important than signal to noise ratio, the proposed method appears to be significantly affective and gives rise to the improved high resolution angiograms.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6403-6407
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• 2012

Detoxifying enzymes are present in most epithelial cells of the human gastrointestinal tract where they protect against xenobiotics which may cause cancer. Induction of examples such as glutathione S-transferase (GST) and its thiol conjugate, glutathione (GSH) as well as NAD(P)H: quinoneoxidoreductase (NQO1) facilitate the excretion of carcinogens and thus preventing colon carcinogenesis. Pterostilbene, an analogue of resveratrol, has demonstrated numerous pharmacological activities linked with chemoprevention. This study was conducted to investigate the potential of pterostilbene as a chemopreventive agent using the HT-29 colon cancer cell line to study the modulation of GST and NQO1 activities as well as the GSH level. Initially, our group, established the optimum dose of 24 hours pterostilbene treatment using MTT assays. Then, effects of pterostilbene ($0-50{\mu}M$) on GST and NQO1 activity and GSH levels were determined using GST, NQO1 and Ellman assays, respectively. MTT assay of pterostilbene ($0-100{\mu}M$) showed no cytotoxicity toward the HT-29 cell line. Treatment increased GST activity in the cell line significantly (p<0.05) at 12.5 and $25.0{\mu}M$. In addition, treatment at $50{\mu}M$ increased the GSH level significantly (p<0.05). Pterostilbene also enhanced NQO1 activity significantly (p<0.05) at $12.5{\mu}M$ and $50{\mu}M$. Hence, pterostilbene is a potential chemopreventive agent capable of modulation of detoxifiying enzyme levels in HT-29 cells.