• The Journal of Pediatrics of Korean Medicine
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• v.35 no.3
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• pp.118-127
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• 2021

Objective The purpose of this study was to confirm the effect of Scutellaria baicalensis extract on skin damage recovery and inflammation relief in atopic dermatitis-induced mice through Endocannabinoid system (ECS) control. Methods 6-week-old Balb/C mice were divided into control group (Ctrl), atopic dermatitis induced group (ADE), palmitoylethanolamide (PEA) administered group after atopic dermatitis induced (PEAT), and Scutellaria baicalensis extract administered group after atopic dermatitis induced (SBT). Seven animals were assigned for each group. After drug administration for 3 weeks after inducing atopic dermatitis, Claudin and 8-OHdG were observed to confirm the recovery of the skin damage in each group. To confirm ECS regulation, CB1, CB2, and GPR55 were observed. To confirm the anti-inflammatory effect, Fc ε receptor, and MMP-9 was observed. Results Claudin positive reaction was significantly increased in SBT compared to ADE and PEAT. 8-OHdG positive reaction was significantly decreased in SBT compared to ADE and PEAT. CB1, CB2, and GPR55 positive responses were significantly increased in SBT compared to ADE and PEAT. Fc ε receptor and MMP-9 positivity were significantly decreased in SBT compared to ADE and PEAT. Conclusion It was confirmed that the Scutellaria baicalensis extract can reduce the inflammation of atopic dermatitis by restoring the structural damage of the skin lipid barrier through ECS activity.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.35 no.10
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• pp.83-90
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• 2019

The purpose of the present study is to confirm, through quantitative indices, changes arising with the implementation of urban regeneration projects, with a specific focus on the case of Dongnam-gu, Cheonan, one of the 13 priority rgions in urban regeneration. By utilizing quantitative data including resident population, floating population, revenue, number of small business persons, number of startup companies, and number of licensed buildings, the study confirmed changes in Dongnam-gu and other urban regeneration areas. The study compared monitoring results and implemented project policies to confirm changes within the area as a result of project implementation. Additionally, resident perception toward business districts was surveyed to confirm changes in perception and opinion, and monitoring indices were used to confirm changes as a result of project implementation. Accordingly, the study presented a plan to carry out the assessment of urban regeneration projects, which can be employed as data for conducting future urban regeneration projects. Urban regeneration projects are carried out for the long-term. Therefore, based on monitoring and investigative data, they require constant policy suggestions and periodic monitoring in accordance with changes resulting from project implementation. With regards to the effective range of urban regeneration projects, the study confirmed the possibility of an effect not only in the area of project implementation but also in surrounding areas. However, because the study merely confirms changes in Dongnam-gu, Cheonan, additional research is necessary to ascertain assessment plans suitable to the different types and regional characteristics of urban regeneration projects.

• Korea Trade Review
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• v.43 no.3
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• pp.199-218
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• 2018

The force majeure in the international sale of goods has been widely used regarding liability and settlement of disputes in the event of breach of contract due to circumstances beyond the control of the parties. The purpose of this study is to examine the judgment criteria and cases concerning on force majeure in the application of FTA preferential tariffs. In order to achieve this purpose, this paper uses a literature review and case analysis on exceptional circumstances under the Korea·ASEAN FTA and the Korea·EU FTA. This study, this paper provides several implications for companies seeking preferential tariffs regarding the Korea·ASEAN FTA and the Korea·EU FTA. Korean companies are subject to the following: confirm the denial article of FTA preferential tariffs stipulated in the Korea·ASEAN FTA and the Korea·EU FTA, consider the judgment criteria on exceptional circumstances of customs authorities, confirm the extension criteria on the validity period of certificate of origin, confirm the reply criteria of verification result of the customs authorities of the exporting country, and confirm the violation of the principle of good faith for unrequested action on reply of verification result of customs authorities.

• The Journal of Pediatrics of Korean Medicine
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• v.22 no.3
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• pp.83-94
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• 2008

Objectives : The purpose of this study is to confirm severe problem caused by using a modified RUCAM scale than that officially recognized to diagnose liver injury induced by herbal medicine. Materials and Methods : Cases with liver injury induced by herbal medicine received to a related institute from January 2004 to December 2007 were collected and evaluated by the original scale and modified scale. Results : 1. Based on this study, we couldn't clinicaly confirm that the case was not excluded by the relieved first item basis of modified RUCAM scale which has to be excluded by the first item basis of orginal RUCAM scale. 2. By modified 6th item, one score was added to the total score. 3. By adding 8th item, it gaind one point to the whole the total score. Conclusions : In this study, we can clinically confirm that the modified RUCAM　application to case with liver injury induced by herbal medicine is a severe problem.

• The Journal of Pediatrics of Korean Medicine
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• v.35 no.3
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• pp.128-137
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• 2021

Objective The purpose of this study was to confirm the effectiveness of coptidis rhizoma extract-ceramide complex on skin barrier, transepidermal water loss (TEWL) and pH reduction, and inflammation of the skin. Methods Coptidis rhizoma extract-ceramide complex was applied in 6-week-old Balb/C mice after dermatitis was induced. To confirm the skin condition changes, TEWL and pH were observed, and filaggrin in the stratum corneum of the skin was observed. Kallikrein-related peptidase (KLK) 7, Protease activated receptor (PAR)-2, Thymic stromal lymphopoietin (TSLP), and IL-4 were observed in the stratum corneum to confirm the changes in the inflammatory response. Results Filaggrin positive reaction was increased in the experiment group compared to the control group. TEWL and pH were lower in the experiment group compared to the control group. KLK7, PAR2, TSLP, and IL-4 positive responses were decreased in the experiment group compared to the control group. Conclusions It was confirmed that the coptidis rhizoma extract-ceramide complex can relieve the inflammatory response of atopic dermatitis by restoring the skin lipid barrier damage.

• The Journal of Pediatrics of Korean Medicine
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• v.38 no.1
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• pp.37-45
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• 2024

Objectives The aim of this study was to determine the inhibitory effects of Bangpungtongsungsan extract (BTS) on fat accumulation in high-fat diet-induced young obese mice. Methods The extract was administered to 3-week-old C57BL/6 male mice fed with a high-fat diet. The experimental groups were divided into a control group (Ctrl), high-fat diet group (HFDF), and BTS treated group after high fat diet feeding (BTST), with 10 mice assigned to each group. Lipid synthesis was observed to confirm the inhibition of fat synthesis. Changes in body weight, body fat percentage, and total cholesterol in the blood were observed to confirm weight control. Peroxisome proliferator-activated receptor gamma (PPAR-γ) and sterol regulatory element-binding protein (SREBP)-1 positivity was observed to confirm the inhibition of fat accumulation in liver tissue. Results Bangpungtongsungsan significantly inhibited lipid synthesis. Changes in body weight, body fat percentage, and total cholesterol in the blood were significantly lower in BTST rats than in HFDF rats. PPAR-γ and SREBP-1 positivity were significantly lower in BTST rats compared to HFDF rats. Conclusions This study confirms the potential of BTST to inhibit fat accumulation in obesity.

• Journal of Korean Academy of Nursing
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• v.15 no.1
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• pp.5-16
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• 1985

This study examined the effects of husband's supportive behavior reinforcement education on stress relief of primigravidas. The purpose was to reinforce husbands' supportive behavior and relieve primigravidas' stress. The purposes of this study were to determine lactors influencing Primigravidas' stress and the effect of husbands' supportive behavior reinforcement education on stress relief of primigravidas. The subjects, consisting of 140 primigravidas who registered or visited in three obstetrics and gynecology clinics in J city, were divided into at random experimental and control groups. Data were collectpe from April To July, 1984 through interviews during hospital visits, and by questionaires. The husbands' supportive behavior reinforcement education and the measurement tools were developed by the investigator from the literature and during pilot study: the instruments to measure primigravidas' stress and husbands' supportive behavior were tested for reliability and validity. Personality characteristisc were measured by Chestnuts' Stress Management instrument. T-test, ANOVA, ω², and Pearson Correlation were used in analysing the data to confirm the intensity of the influence and the relation between general characteristics and primigravidas' stress. Pearson correlation and Stepwise Multiple Regression were used to confirm the predictors of primigravidas' stress. Independent variables were compared by means of t-test and χ³-test to confirm significant discrepancy of experimental and control groups. T-test, paired t-test, pearson correlation were used in analyzing the data to confirm the effect of husband's supportive behavior reinforcement education on stress relief of primigravidas. The results of the study are summarized. Results from analyzing the effect of husbands' supportive behavior reinforcement education: There was no significant difference between the general characteristics of the experimental and control groups. And husbands' supportive behavior, personality, marital Satisfaction, natural abortion variables influenced at primigravidas' stress. A hypothetical test by comparative analysis of the measurement of primigravidas' stress and husbands' support behavior between the experimental and the control group before and after the experiment to confirm the effect of husbands' supportive behavior reinforcement education resulted in the following: The first hypothesis that husbands' supportive behavior reinforcement education will increase husbands' support behavior to relieve primigravidas' stress was supported. The second hypothesis that husbands' supportive behavior reinforcement education will relieve primigravidas' stress was supported. As a result, it u·as shown that husbands' supportive behavior reinforcement education relieved primigravidas' stress, and the hypotheses were supported. The third hypothesis that the higher the degree of husbands' supportive behavior, the lower the primigravidas' stress was supported. It was concluded that husbands' supportive behavior reinforcemen education increase husbands' supportive behavior and relieves Primigravidas' stress.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.46 no.3
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• pp.253-263
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• 2020

Reactive oxygen species (ROS) plays an important role in maintaining homeostasis. However, excessive ROS production damages cellular components such as proteins, lipids, and nucleic acids and promotes skin aging. In this study, we confirmed the antioxidant effect of CSYJE to prevent excessive oxidative stress. First, DPPH and ABTS assays were performed to confirm the antioxidant effect of CSYJE and the radical scavenging activity was confirmed depending on the concentration. As a result of performing the MTT assay to confirm the cell viability, it was confirmed that there was no cytotoxicity at a concentration of 1,000 ㎍/mL. As a result of western blotting to confirm the expression levels of the antioxidant-related proteins nuclear-E2-related factor 2 (Nrf2) and Heme oxygenase-1 (HO-1), it was confirmed that the expression was increased in a concentration-dependent manner. After inducing ROS with lipopolysaccharide (LPS), an intracellular ROS-causing substance, DCF-DA was performed to confirm the inhibitory effect of ROS production, and the inhibition of ROS production was confirmed to concentration-dependent. Real-time RT-PCR was performed to confirm the mRNA expression level of inflammatory cytokines and inflammatory mediator caused by ROS generation, mRNA expression was reduced in a dose dependent manner. Therefore, this study confirmed the antioxidant effect of CSYJE through the Nrf2/HO-1 signaling pathway, which suggests that CSYJE can be used as an antioxidant cosmetic material by inhibiting free radicals.

• Journal of Institute of Control, Robotics and Systems
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• v.10 no.12
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• pp.1271-1279
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• 2004

A new bio-mimetic actuator is proposed. The actuator realizes bidirectional actuation since it is with a stretched film antagonistically configured with compliant electrodes. Also, it is distinguished from existing actuators with respect to the controllability of its compliance. Bidirectional actuation and compliance controllability are important characteristics for the artificial muscle actuator and the proposed one accomplishes these requirements without any mechanical substitute or complicated algorithms. In this paper its basic concepts and working principles are introduced with static and dynamic analysis. Control strategies for displacement as well as stiffness are introduced and experimental results are given to confirm the effectiveness of the proposed methods. In addition, an example of robotic actuating devices is given to confirm the usefulness of the proposed actuator.

• Journal of Digital Convergence
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• v.6 no.4
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• pp.91-104
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• 2008

This study notes the growing importance of online community as a means of building customer relationships. The author aims to identify how to communicate in an online community on preannounced new products, and test social influence that influence word-of-mouth of consumers, and confirm moderate effect of market maven between social influence and word-of-mouth activity in on-line community. The main findings are that social influence such as internalization and conformity positively influence word-of-mouth communication on online community. And moderate effect of market maven confirm between social influence(internalization and confirmity) and word-of-mouth activity.