• 한국지진공학회논문집
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• 제10권4호
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• pp.55-66
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• 2006

본 연구에서는 강성골격곡선으로부터 산정한 구조물의 초기 탄성진동주기 $T_1$와 응답스트럼으로부터 산정한 비선형 유사가속도 $A_{1y}/g$ 및 연성비 ${\mu}$를 사용하여, 반복적인 계산과정 없이 복합구조물의 내진성능을 평가하는 비선형직접스펙트럼법(NDSM)을 고려한다. 다양한 지진과 복합구조물에 대한 NDSM의 신뢰성과 실용성을 비선형시각이력해석(NRHA) 결과와 비교 검토하였다. 본 연구의 결론은 다음과 같다. (1) NDSM은 강성골격곡선으로부터 기본진동주기와 비선형 항복강도를 구하면, 비선형 응답스펙트럼으로부터 직접적으로 구조물의 비선형 최대응답을 산정할 수 있는 실용적인 방법으로 사료된다. (2) NDSM의 응답을 정산해와 비교한 결과, 대부분의 모델이 단순평균의 관점에서 전체 해석모델 중 3/4이 약 20% 이하의 오차를 나타내었고, 일반적으로 비선형시각이력해석의 응답보다 크게 산정되는 것으로 나타났다.

• 한국콘텐츠학회논문지
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• 제20권11호
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• pp.492-500
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• 2020

본 연구의 목적은 영어 읽기 불안 하위요소 간 상관관계와 인과관계를 분석하고 그 결과를 바탕으로 읽기 불안 요인이 학습에 미치는 부정적인 영향을 최소화할 수 있는 수업 설계와 교수 방법에 대한 방향성을 제시하여 효과적인 읽기 학습에 기여하는 것이다. 연구 참여자의 읽기 불안 정도는 설문지를 통해 측정하였고, SPSS 프로그램을 활용하여 설문 결과를 분석하였다. 본 연구를 통해 밝혀진 사실은 다음과 같다. 첫째, 평균 점수 이상·미만 향상집단 모두에서 영어 읽기 불안 하위요소 간 유의미한 상관관계가 나타났다. 두 번째, 두 집단 모두에서 자신감 결여 불안이 전체 읽기 불안에 가장 큰 영향을 주는 요인으로 나타났으며 다음으로는 장문 읽기, 평가 그리고 문법·어휘와 관련된 일반읽기 불안 순으로 전체 읽기 불안에 영향을 주는 것으로 나타났다. 본 연구 결과를 토대로 영어 읽기 교수 학습에 시사하는 바는 다음과 같다. 학습을 준비하는 교사나 학습의 주체인 학습자는 읽기 불안 요소가 서로 독립적으로 분리된 것이 아니라 상호 연관되어 있음을 인식하고, 교사는 학습자가 영어 읽기 학습에서 느끼는 불안감을 최소화할 수 있는 학습 환경을 제공함으로써 성공적인 읽기 학습의 가능성을 높일 수 있을 것으로 기대된다.

• 대한간호학회지
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• 제25권4호
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• pp.741-750
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• 1995

The purpose of this study was to develop a role conflict scale for nurses in hospitals. The process of study was as follows. The first step was the study of selected literature on role conflict in general and to translate into Korean language the role conflict and ambiguity scale developed by House. From this process, a scale for role conflict inventory-general was made by consulting with two professors majored in educational evaluation and one professor who is an authory on educational administration. In the second step, 24 clinical nurses were asked to describe the situations having job-related role conflict. In the third step, the role conflict inventory-specific was derived from the role conflict inventory -general, and data selected from the step two. The confidence and clarity of this role conflict inventory-specific was strengthed by consulting one clinical psychologist, two professors of nursing college and ten doctoral students of nursing. With this tool being tested, the results are summarized as follows. 1. Reliability Internal consistency reliability was tested by cronbach alpha, corrected item total correlation and correlation matrix. The cronbach alpha level was .94 and one item among 37 items was below .35 and the rest items were .42 above in the corrected item total correlation. There was no negative correlation in the correlation matrix. 2. Construct validity In the construct validity test, four factors have an eigen value 1.0 over, Factor 1 represented role ambiguity, composed of 15 items with .90 reliability level. Factor 2 represented deficiency of ability and skill, composed of 11 items with .90 of reliability level. Factor 3 represented working environment, composed of 6 items with .85 of reliability level. Final factor represented deficiency of job-related collaboration, composed of 5 items with .69 reliability level. These results contribute to measuring the level of role conflict for nurses, and to the managment of the nurses' role conflict.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.6997-7002
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• 2015

Background: In cervical cancer patients it has been reported that there in a significant Ki-67/MIB-1 expression is correlated with survival in cervical cancer patients. However, the prognostic value is still not well understood. Materials and Methods: In the present meta-analysis the prognostic value of Ki-67/MIB-1 with regard to overall survival (OS) and disease-free survival (DFS) in cervical cancer was investigated. The databases of PubMed, ISI Web of Science, Cochrane Central Register of Controlled Trials, EMBASE, Science Direct and Wiley Online Library were used to identify appropriate literature. Results: In order to explore the relationship between Ki-67/MIB-1 and cervical cancer, we have included 13 studies covering 894 patients in the current meta-analysis. The effect of Ki-67/MIB-1 on OS for pooled random effects HR estimate was 1.63 (95%confidence interval (CI) 1.09-2.45; P<0.05). The pooled HR for DFS was 1.26 (95%CI 0.58-2.73; P>0.05) and the subgroup analysis indicated Ki-67/MIB1 was associated with DFS (HR=3.67, 95%CI 2.65-5.09) in Asians. Conclusions: According to this meta-analysis, Ki-67/MIB-1 has prognostic value for OS in patients suffering from cervical cancer. For better evaluation of the prognostic role of Ki-67/MIB-1 on DFS, studies with larger numbers of patients are needed to validate present findings in the future.

• Asian Pacific Journal of Cancer Prevention
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• 제13권1호
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• pp.103-110
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• 2012

Neoadjuvant chemotherapy for resectable esophageal carcinoma has been a focus of study, but no agreement has been reached on clinical randomized controlled trials and relevant systematic evaluation. The purpose of this study was to perform a meta-analysis on published randomized controlled trials (RCTs) that compared neoadjuvant chemotherapy and surgery with surgery alone for resectable esophageal carcinoma. Medline and manual searches was conducted in PubMed, ASCO (American Society of Clinical Oncology) meeting summary, Embase, the Cochrane Library (up to October 2010), Chinese Biomedical Literature Database, China National Knowledge Infrastructure, VIP Database, Wanfang Database. The selection contents were to identify all published and unpublished RCTs that compared neoadjuvant chemotherapy and surgery with surgery alone for resectable esophageal carcinoma. Sixteen RCTs which included 2,594 patients were selected. The risk ratio (RR) (95% confidence interval [CI]; P value), expressed as neoadjuvant chemotherapy and surgery versus surgery alone (treatment versus control), was 1.02 (0.95, 1.10; P=0.54) for 1-year survival, 1.29 (1.13, 1.47; P=0.0001) for 3-year survival, 1.31 (1.13, 1.51; P=0.0003) for 5-year survival, 1.00 (0.95, 1.04; P= 0.85) for rate of resection and 0.89 (0.64, 1.23; P=0.48) for operative mortality. The results showed that neoadjuvant chemotherapy for resectable esophageal carcinoma can raise the overall survival rate of patients with esophageal carcinoma, but it does not affect treatment-related mortality.

• 한국구조물진단유지관리공학회 논문집
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• 제23권6호
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• pp.132-140
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• 2019

본 연구는 철근콘크리트 단층 구조물의 구조 부재 위치에 대한 비파괴검사법을 이용한 추정 신뢰도를 알아보기 위해 기둥, 벽체, 보 및 슬래브로 구성된 실험체를 제작하고, 기존 추정식과 비교 과정에서 정확한 분석을 위해 오차율 비교와 모평균 구간 추정을 사용하여 통계적 접근을 통한 신뢰성을 분석하고자 한다. 그 결과, 초음파속도법을 이용하여 압축강도를 추정한 결과와 코어시험 결과를 비교한 전체 평균 오차율은 18.8%, 반발경도법을 이용하여 압축강도를 추정한 결과와 코어시험 결과를 비교한 전체 평균 오차율은 20.1%가 도출되어 현장 적용성을 확인하였다. 그리고 부재별 신뢰성 부분에서 초음파속도법과 반발경도법을 이용하여 신속하고 효율적인 구조물 안전진단을 하기 위해서 각각 벽체 부재와 보 부재를 중심으로 압축강도 추정 시 신뢰도 높은 결과를 도출되는 것을 확인하였다.

• 치위생과학회지
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• 제19권4호
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• pp.220-227
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• 2019

Background: This descriptive study aimed to examine the relationship between the 4C core competencies and work ability among dental hygienists. Methods: From November 2018 to January 2019, data were collected-from 190 dental hygienists workong in dental clinics in Busan, Ulsan, and Gyeongsangnam province using structured questionnaires. For the general characteristics of the dental hygienists, frequency and percentage were calculated, and the level of the 4C core competencies and work ability of dental hygienists was calculated using means and standard deviations. A multiple regression analysis was conducted to analyze the effects of the 4C core competencies on work ability. Results: The mean scores for the 4C core competency levels of the dental hygienists were as follows: communication ability 3.34, critical thinking ability 3.41, creative problem-solving 3.40, and collaborative self-efficacy 3.27. Meanwhile the mean score for work ability level was 3.65. The predictive factors influencing work ability were communication ability and cooperative self-efficacy (p<0.001), and the sub-factors of critical thinking ability that affect work ability were sound conferences (p<0.01), intellectual fairness (p<0.05), intellectual enthusiasm (p<0.05), and self-confidence (p<0.001). Finally, the sub-factors of creative problem-solving ability that affect work ability were planning and execution (p<0.01) and performance evaluation (p<0.05). Conclusion: The current study showed that education programs covering the core competencies of dental hygienists, rather than the existing theoretical education program, should be developed and implemented to enhance 4C core competencies that affect work ability.

• 한국임상약학회지
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• 제30권1호
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• pp.11-18
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• 2020

Background: Nivolumab and pembrolizumab are antagonists of the programmed death-ligand 1 (PD-L1) receptor that function as immuno-oncological agents. This study aimed to evaluate the safety and efficacy of nivolumab and pembrolizumab in elderly patients in outpatient settings. Methods: The safety and efficacy of nivolumab and pembrolizumab were compared retrospectively among patients at the Veterans Health Service (VHS) Medical Center in Seoul, South Korea, from September 1, 2017 to August 25, 2018. Results: Eighty-seven patients were selected for the study. The median progression-free survival was 63 days for nivolumab (95% confidence interval (CI), [14 to 282]) vs. 243 days for pembrolizumab (95% CI, [22 to 348]) (p =0.04). The objective response rate (ORR) was 0% in the nivolumab group vs 5.6% in the pembrolizumab group (p =0.310). All the patients exhibited treatment-related adverse effects. More than 89% of the patients exhibited diseases of the gastrointestinal (GI) tract. Pneumonia, of grades three or higher, was the most common adverse effect, followed by weakness and anorexia. Conclusions: There was no statistically significant difference between the nivolumab group and the pembrolizumab group with respect to the ORR. The incidence and severity of the adverse effects in this study were higher than those of previous studies; however, these adverse effects are generally manageable in a real-world clinical setting. Further randomized controlled studies will be necessary to confirm these results in elderly patients.

• 디지털콘텐츠학회 논문지
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• 제18권6호
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• pp.1049-1056
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• 2017

본 연구는 스피치교육의 효과를 측정하는데 있어 화자의 목소리의 변화에 주목하였다. 본 연구에서는 스피치교육을 통해 얻게 되는 실질적 효과 중 목소리의 변화를 보다 가시적이고, 과학적으로 평가하고자 하였다. 연구결과 모든 학습자의 목소리에서 스피치교육 전과는 다른 객관적인 변화를 찾을 수 있었다. 학습자 모두 공명, 음색, 발음의 정확성, 휴지 등 다양한 목소리 요소에서 점진적 기술향상이 이루어졌다. 즉, 스피치교육을 받기 전보다 목소리가 풍부해지고 발음이 정확하고, 휴지를 잘 활용하는 안정화된 결과를 볼 수 있었다. 이 연구결과를 통해 스피치훈련을 통해 목소리의 변화가 나타날 수 있는지 분석하고, 스피치 학습자들이 스피치교육에 적극 임해 스피치실력 향상의 결과를 얻을 수 있을 것으로 기대된다.

• 한국환경농학회지
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• 제37권2호
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• pp.97-103
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• 2018

BACKGROUND: Dissipation of acetamiprid and thiamethoxam in greenhouse grown chard samples was evaluated at 5 intervals including the pre-harvest interval after application. This study was conducted to determine the residue levels, the biological half-lives and dissipation rate of acetamiprid and thiamethoxam in chard under controlled conditions. METHODS AND RESULTS: Acetamiprid and thiamethoxam were applied in accordance with good agricultural practices for chard. Chard samples were collected at 0, 1, 2, 3, 5, 7, 10 and 14 days after application. Quantitaion was performed by HPLC-DAD system with C18 column. Limit of quantification (LOQ) of acetamiprid and thiamethoxam were both 0.02 mg/kg for chard. The recovery of acetamiprid and thiamethoxam were 77.8~107.5% and 94.3~108.6% at two concentration levels. The half-lives of pesticide dissipation in chard for two fields were 11.9 and 8.2 days for acetamiprid and 3.6 and 3.3 days for thiamethoxam respectively. The dissipation rate of acetamiprid and thiamethoxam were estimated according to the statistics method with a 95% confidence. CONCLUSION: Dissipation of acetamiprid and thiamethoxam in chard were determined under greenhouse. The concentration of acetamiprid and thiamethoxam in chards at 0 days after application were below specified by Korean MRL. Dissipation rate constant will be useful to set the pre-harvest residue limit for public health and consumer protection.