• 지역사회간호학회지
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• 제4권1호
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• pp.14-24
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• 1993

The Purpose of this study was to explore the condition of periodic medical examination and the health care services of industries in order to offer some basic data on developing industrial nursing care. To achieve this goal a self - administered questionnaire (developed by the academic affairs of community health nursing) was provieded to the nurses in 56 industries from Dec. 10, 1992 to Jan. 20, 1993. The statistical computer package, SPSS, was used to manipulate the data along with T-test and ANOVA. The results were as follows : 1. General characteristics: The greater part of the industries were manufacturing company, and below 300 employees of industry were 55.4%. The shift system was mostly one shift(66.1%) and three shift(23.2%), and 50.0% them organized the Industrial Safety and Health Commitee. Average a number of employees was 631 person. 2. Periodic Medical Examination: Most of the workers were receiving periodic medical examination from the designated hospital (95.71%). From the about 12.89% were gone through a colse medical examination. In colse medical examination 58.41% were decided 'C' and 36.73% were decided 'D'. About 6.23% off those who had any clinical findings were work-time shortening(7.84%), work-transition(8.12%), recoverating at home. The majority of the workers receive the result of the periodic medical examination individually (78.5%). 3. Special medical examination: The rate of those who are receiving special medical examination were 76.82% and about 8.24% were decided 'C' and 1.23% were decided 'D' Those who had any health problems were receiving follow-up checking (9.10%) and medical treatment while working (15.04%). The health managers in the company can consult (85.7%) those who had any suspicious sign and symptoms of occupational disease. 4. Health care services: The average score of health care services were 17.57 point out of 28 point, and the score was lower in health assessment and environmental hygiene than medical diagnosis and health education. There were significant differences in environmental hygine (F=3.72, P=0.017), health care services(F=3.94, P=0.013) according to the size of the size of the industries The other's significancy is not shown by any type of industrial nurse. The level of health care services were higher in the wokers who had better health and showed no singificant differences(T=-0.73, P=0.470).

• 지역사회간호학회지
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• 제4권1호
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• pp.58-66
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• 1993

The purpose of this study was to explore the condition of periodic medical examination, and health care services in industries. This will offer some basic data in developing industrial nursing care requirements. To achieve this goal a self-administered questionnaire (developed by the academic affairs of community health nursing) was provided to the nurses working in 40 industries from Dec 20, 1992 to Jan 20, 1993. The statistical computer package SAS, along with t-test, and ANOVA was used to manipulate the date. The results were as follows : 1. General Characteristics: The greater part of the industries studied were manufacturing company, with over 500 employees. The shift system was used with most companies using one or three shifts, and 75.0% of them were organized with Industrial Safety and Health Committees. 2. Periodic Medical Examination : Most of the workers were receiving periodic medical examination from a designated hospital (96.7%). Of those 15.8% had a close medical examination. In the medical examination 9.4% were evaluated at 'C' and 3.8 were evaluated at 'D'. About 55.0% of those workers received the result of the periodic medical examination individually(95.0%). 3. Special Medical Examination : The rate of those who were receiving special medical examination was 98.4% and about 11.7% were evaluated at 'C' and 3.9% were evaluated at 'D'. Those who had any health problems (54.2%) were receiving follow-up care, 52.4% of them had medical treatment while working. The health care managers in the company consulted 97.1% of them who had any suspicious signs and symptoms of occupational diseases. 4. Health Care Services : The average score of health care services was 13.8 out of a possible 28 point. The score of health education and health assessment, was lower than medical diagnosis and environmental hygiene. There were no significant differences in health care services according to the size of the industries(F=.95, P=.429). The score of health care services was higher in the worker who had better health and showed significant differences (F=4.50, p=.025).

• 대한치과보철학회지
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• 제54권2호
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• pp.132-139
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• 2016

교합의 점진적인 마모는 연령이 증가함에 따라 진행되는 정상적인 과정이다. 하지만 교합면의 마모가 과도하게 진행되어 수직 교합 고경이 감소하고 교합 평면이 붕괴된 경우에는 병적인 치수 상태, 교합 부조화, 기능적 장애 및 심미적인 문제가 나타날 수 있다. 치아를 수복할 공간이 부족하거나 교합 관계를 수정하기 위해서는 수직 교합 고경의 변경이 필요하다. 수직 고경을 변화시킬 경우, 수복 치료를 시작하기 전에 신중한 진단이 필수적이며 1 - 3개월 간 임시 수복물을 이용하여 근 신경계의 적응 범위를 벗어나지 않는지 평가를 한 후 최종 수복을 하여야 한다. 본 증례의 환자는 다수 치아들의 심한 마모가 있는 78세 남성 환자로서 수직 교합 고경의 평가 후 상악 전치부의 심미적인 외형 확보 및 교합관계, 교합평면의 개선을 위하여 최소한의 수직교합고경의 거상을 통하여 임시치아를 제작, 약 12주간의 적응기간 후 최종수복물을 제작하였다. 최종 수복물 장착 후 1년여의 경과 관찰 결과 새로 형성한 교합이 안정적으로 유지되었으며 특이할만한 합병증은 없었다. 이러한 일련의 치료과정을 통해 심미적, 기능적으로 만족할 만한 결과를 얻었기에 이를 보고하는 바이다.

• Child Health Nursing Research
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• 제7권4호
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• pp.421-433
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• 2001

The purpose of this phenomenological study was to understand the lived experience of mothers of children with muscular dystrophy. The participants were 11 mothers recruited by snowball sampling, who agreed with the objectives of the research and could verbally communicate with the researcher and who lived with their sons who had muscular dystrophy. Data collection was done through in-depth interviews with participants in their own homes. Each interview took 50 to 120 minutes. All of the interviews were audiotaped and then transcribed. Data were analyzed using Colaizzi's (1978) method of phenomenology. From the transcripts 109 significant sentences and phrases were selected and 13 clusters of themes were categorized from 67 significant statements. These results were integrated into the essential structure of the lived experience of mothers of children with muscular dystrophy. 1. Anxious and relying on chance due to indefinite diagnosis. 2. Only able to cry with shock because of son's fatal disease. 3. Seeing the future as dismal and feeling resentment that this disease in transmitted through the mother. 4. Feeling caught between a husband who is distancing himself from his family and the family which is disintegrating. 5. Feeling like a sinner for transmission of genetic disease(Feeling guilt for conceiving a son with a genetically transmitted fatal disease). 6. Empathizing with other suffers of muscular dystropy and their parents in their grief and helping to dissipate their heavy feelings. 7. Deciding to sacrifice self as a way of taking responsibility for giving birth to a handi-capped son. 8. Losing hope (feeling despair) as son's condition deteriorates in spite of all attempts to help him. 9. Wishing to die with son who becomes progressively immobile. 10. Accumulating Han*(한, 恨), because of rising Hwa(화, anger), and becoming sick both mentally and physically. 11. Seeing events as destiny and finding self-control through faith. 12. Finally, giving up sacrificing self for son and becoming concerned(involved) with other children in the family. 13. Feeling fear at son's impending death. This is the first research on the experience of Korean mothers of children with muscular dystrophy. In applying the phenomenology research method, this study not only helps health professionals understand the experience of these mothers in the Korean patriarchal social system, but the researcher, as a nurse, can share their agony and grief through identification of their inner world through in-depth personal interviews. The results obtained in this study will not only help in the development of family nursing practice for families with genetically transmitted diseases but also prepare basic data for family nursing practice in the Korean sociocultural context.

• Journal of Yeungnam Medical Science
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• 제8권2호
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• pp.24-34
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• 1991

1986년 1월부터 1988년 6월까지 30개월동안 '말이 늦다(언어발달지연)'는 것을 주소로 본원 소아과에 내원한 환아 중 언어발달지연의 진단기준에 부합하였던 52명의 아동을 대상으로 관찰하여 다음과 같은 성적을 얻었다. 1. 환아의 초진시 연령은 2-2.9세군이 16례 (30.8%), 3-3.9세군이 11례(21.2%)로 전체 환아의 반수 이상이 2-3.9세 사이에 내원했다. 2. 성별분포로는 남아가 39례, 여아가 13례로서 3:1의 비로 남아에서 많았다. 3. 원인은 지능발달지연이 28례(53.8%)로 가장 많았으며 그 외 발달성 언어장애가 12례(23.1%), 자폐증이 7례(13.5%)의 순으로 많았다. 4. 동반된 질환들로는 발음장애가 9례(17.3%)로 가장 많았고 사시가 5례(9.6%), 경련성질환이 4례(7.7%)에서 있었다. 5. 치료는 특수교육이 23례(44.2%), 언어치료가 12례(23.1%), 정신과적 자문이 7례(13.5%)에서 행해졌다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.1917-1923
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• 2016

Background: Lynch Syndrome (LS) is a familial cancer condition caused by germline mutations in DNA mismatch repair genes. Individuals with LS have a greatly increased risk of developing colorectal cancer (CRC) and it is therefore important to identify mutation carriers so they can undergo regular surveillance. Tumor DNA from LS patients characteristically shows microsatellite instability (MSI). Our aim here was to screen young CRC patients for MSI as a first step in the identification of unrecognized cases of LS in the Saudi population. Materials and Methods: Archival tumor tissue was obtained from 284 CRC patients treated at 4 institutes in Dammam and Riyadh between 2006 and 2015 and aged less than 60 years at diagnosis. MSI screening was performed using the BAT-26 microsatellite marker and positive cases confirmed using the pentaplex MSI analysis system. Positive cases were screened for BRAF mutations to exclude sporadic CRC and were evaluated for loss of expression of 4 DNA mismatch repair proteins using immunohistochemistry. Results: MSI was found in 33/284 (11.6%) cases, of which only one showed a BRAF mutation. Saudi MSI cases showed similar instability in the BAT-26 and BAT-25 markers to Australian MSI cases, but significantly lower frequencies of instability in 3 other microsatellite markers. Conclusions: MSI screening of young Saudi CRC patients reveals that approximately 1 in 9 are candidates for LS. Patients with MSI are strongly recommended to undergo genetic counselling and germline mutation testing for LS. Other affected family members can then be identified and offered regular surveillance for early detection of LS-associated cancers.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2185-2193
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• 2016

Background: The pathogenesis of sporadic colorectal cancer (CRC) is influenced by the patient genetic background and environmental factors. Based on prior understanding, these are classified in two major pathways of genetic instability. Microsatellite instability (MSI) and CPG island methylator phenotype (CIMP) are categorized as features of the hypermethylated prototype, and chromosomal instability (CIN) is known to be indicative of the non-hypermethylated category. Secreted frizzled related protein 2 (SFRP2), APC1A in WNT signaling pathway and the DNA repair gene, O6-methylguanine-DNA methyltransferase (MGMT), are frequently hypermethylated in colorectal cancer. Detection of methylated DNA as a biomarker by easy and inexpensive methods might improve the quality of life of patients with CRC via early detection of cancer or a precancerous condition. Aim: To evaluate the rate of SFRP2 and MGMT hypermethylation in both polyp tissue and serum of patients in south Iran as compared with matched control normal population corresponding samples. Materials and Methods: Methylation-specific PCR was used to detect hypermethylation in DNA extracted from 48 polypoid tissue samples and 25 healthy individuals. Results: Of total polyp samples, 89.5% had at least one promoter gene hypermethylation. The most frequent methylated locus was SFRP2 followed by MGMT-B (81.2 and 66.6 percent respectively). Serologic detection of hypermethylation was 95% sensitive as compared with polyp tissue. No hypermethylation was detected in normal tissue and serum and its detection in patients with polyps, especially of serrated type, was specific. Conclusions: Serologic investigation for detection of MGMT-B, SFRP2 hypermethylation could facilitate prioritization of high risk patients for colonoscopic polyp detection and excision.

• 대한한의학회지
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• 제17권2호
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• pp.100-116
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• 1996

Gastric cancer shows the most high friquency in cancers that occurs in Korea. The western medicine treatment for gastric cancer has radiation and surgery, chemical treatment. While, oriental medicine cures the gastric cancer by herb-drugs, acupunture , moxa and srigma. With just one way of treating gastric cancer can't be effective remedy. Because each medicine has a strength and weakness. Thus, it is effective treatment when two medicine combins and supplement each other. We got the following result about a trend of oriental and westernal combination treatment for gastric cancer through studing records. 1. The western medicine treats gastric cancer patient with surgery first and right after surgery. They need on assembly treatent such as chemical and immune treatment. In oriental medicine, they treats gastric cancer patients with differentiation of symptone and signs and treatment(辨證施治)[for example:incoordination between liver and stomach(肝胃不和), insufficiency of spleen and stomach(脾胃虛弱), stagnation of blood stasis and toxic agent(瘀毒內阻), deficiency of yin by stomach heat(胃熱傷陰), reinforcing both qi and blood(氣血雙虧), stagnation of damp-phlegm(痰濕凝結)] and cure for them by acupuncture and stigma, too. 2. In combination with oriental and western medical treatment principle of gastric cancer by each stage is as follows. First stage and second stage gastric cancer is cured with radical surgery mainly. After operation, the herb of invigoration of the spleen(健脾), coordination of the stomach(和胃), and smoothing the liver and regurating the circulation of qi(疏肝理氣), is used for good gastroenteric condition. The second stage patients can be concidered using in combination with chimical treatment. The third stage gastric cancer is treated with radical surgery or with temporizing surgery. After those surgery, herb-drugs treatment is used jointly. The fourth stage patients who have no extensively metastasis or local contraindication can undergo temporizing and curcuit surgical operation. Herb-drugs and chemical treatments are used together for patients after operating. If he has operating contraindication, he would be treated with herb-drugs and chemical treatment. 3. In case of using in combination with oriental and western medical treatment as follows. As for herb-drugs with chemical treatment, reinforcing both qi and blood(補益氣血), invigorate the spleen and the stomach(健脾和胃), reinforcing liver and kidney(滋補脾腎), clear out the heat and relieve the toxic agent(淸熱解毒), can be used and with radiation treatment, clear out the heat and relieve the toxic agent(淸熱解毒), promoting the production body fluid and moisturizing the vicera(生津潤燥), reinforcing both qi and blood(補益氣血), invigorate the spleen and the stomach (健脾和胃), reinforcing liver and kidney(滋補肝腎) etc, can be used. 4. According to the research of oriental and western medical combination treatment are the 5-year-survival degree with oriental and western medicine combination treatment was for better than that just with oriental or western medical treatment. Especially, it has good effect on the third, fourth stage gastric cancer. That is, the middle and the end of stage gastric cancer. 5. The merits of oriental and western medicine combination treatment are lengthers one's life and diminish the bad effect of chemical treatment and radiation treatment be near completion, prevent from relapsing, maintain the balance in their eveirenment of body and improve immunity.

• Clinical and Experimental Pediatrics
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• 제52권5호
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• pp.622-626
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• 2009

키쿠치(Kikuchi) 병, 키쿠치-후지모토(Kikuchi-Fujimoto) 병, 혹은 조직구 괴사성 림프선염은 1972년 일본에서 키쿠치와 후지모토 두 사람에 의해 처음 기술되었으며 흔히 아시아 지역에서 30세 미만의 여성들을 주로 침범하는 자가 관해 질환으로 기술되어져왔다. 이 질환의 병인은 여전히 잘 알려져 있지 않으나 감염성(EBV, HHV-6 and -8, HTLV-1, cytomegalovirus, varicella-zoster virus, tuberculosis, toxoplasmosis, yersiniosis, cat scratch disease), 자가면역성(SLE, Kawasaki disease), 그리고 종양성 질환(lymphoma)이 포함되는 것으로 간주된다. 가장 흔한 임상증상은 발열과 통증 없는 경부 림프선염이다. 진단은 생검을 통한 조직병리학적으로 하게 되는데, 주로 풍부한 핵파괴(karyorrhexis)를 가진 피질 주위 지역에서 나타나는 국소 괴사, 괴사 지역 주위로 비정형적인 단핵구들의 집합, 중성구 및 형질 세포의 결핍, 그리고 대개 림프절 캡슐의 보존 등으로 특징 지워진다. 절대적인 치료법은 없어 대증 치료를 하게 되며 치료 없이도 대개 1-6개월 안에 자가 관해되고 재발률도 3.3%에 불과하다. 키쿠치-후지모토 병의 합병증으로 피부, 심장, 골수 등을 침범할 수 있으며 간질환, 무균성 뇌수막염, 간비비대 등이 발생할 수 있으나 드물다. 본 증례에서는 입원 당시 결핵성 임파선염과 뇌수막염으로 오인되었던 무균성 뇌수막염을 동반한 키쿠치-후지모토 병을 경험하였기에 이에 보고하는 바이다.

• 한국산학기술학회논문지
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• 제18권10호
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• pp.63-68
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• 2017

무인 운전 도시 철도시스템은 기관사 없이 열차를 운행 할 수 있는 장점을 갖지만, 이례상황 발생 시 유인운전의 기관사처럼 즉각적인 고장상태 파악, 관제보고, 수동조치가 어렵다. 따라서, 본선 운행 동안 차량 고장 / 상태 정보를 실시간으로 검지하여 차량기지 입고 시에 효율적으로 정비할 수 있는 유지보수 정보시스템의 구축이 필요하다. 본 논문에서는 무선통신망을 활용한 열차제어시스템, 관제 - 열차제어 정보시스템 콘솔 및 차량기지 유지보수 정보시스템간의 인터페이스를 실시간으로 구현하는 개념설계 방안을 제안하였다. 우선적으로 운행 중 발생되는 800,000 건/일의 많은 열차 상태 정보를 전송하기 위하여 본 연구에서 제안한 데이터 처리 알고리즘을 이용하여 56byte의 데이터 테이블로 수집한다. 이러한 상태 정보를 4자리의 헥사 코드화하여 분류하고, 본선 운행 동안 실시간으로 전동차 상태와 고장정보를 맵핑함으로서, 차량기지 내에 차량 유지보수 정보시스템에 전송한다. 또한 열차제어 정보시스템과 차량기지 유지보수 정보시스템 간에 실시간으로 송 / 수신 데이터의 전송을 각각 확인하고, 이로부터 현장에서 사용하도록 고장정보 화면구현을 구현하였다.