• Journal of Animal Science and Technology
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• v.64 no.3
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• pp.588-598
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• 2022

Despite vaccination, equine influenza virus (EIV) and equine herpesvirus (EHV) infections still cause highly contagious respiratory diseases in horses. Recently, concurrent vaccination with EIV and EHV was suggested as a new approach; however, there have been no reports of concurrent vaccination with recombinant canarypox EIV and inactivated EHV vaccines. In this study, we aimed to compare the EIV-specific immune responses induced by concurrent administrations of a recombinant canarypox EIV vaccine and an inactivated bivalent EHV vaccine with those induced by a single recombinant canarypox EIV vaccine in experimental horse and mouse models. Serum and peripheral blood mononuclear cells (PBMCs) were collected from immunized animals after vaccination. EIV-specific serum antibody levels, serum hemagglutinin inhibition (HI) titers, and interferon-gamma (IFN-γ) levels were measured by enzyme-linked immunosorbent assay, HI assay, and quantitative polymerase chain reaction, respectively. Concurrent EIV and EHV vaccine administration significantly increased IFN-γ production, without compromising humoral responses. Our data demonstrate that concurrent vaccination with EIV and EHV vaccines can enhance EIV-specific cellular responses in horses.

• Journal of Korean Society for Quality Management
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• v.26 no.4
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• pp.219-238
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• 1998

The objective of this study was to establish a procedure of concurrent engineering which can be easily a, pp.icable in Korean industry. An investigation of various techniques of concurrent engineering was conducted. Problems of Korean companies which can be resolved by concurrent engineering techniques were identified. Techniques which can resolve these problems at the relatively low cost and without complicated computer facilities were selected and form a procedure for this study. The procedure was a, pp.ied to a manufacturing company for validation. It was found that this procedure can substantially reduce time and cost of R&D and manufacturing.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5747-5752
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• 2012

Purpose: The main objective of the present study was to evaluate the efficacy and toxicity of concurrent chemoradiotherapy followed by adjuvant chemotherapy compared with concurrent chemoradiotherapy alone in the treatment of locoregionally advanced nasopharyngeal carcinoma. Methods: The search strategy included Pubmed, Embase, the Cochrane Library, China National Knowledge Internet Web, Chinese Biomedical Database and Wanfang Database. We also searched reference lists of articles and the volumes of abstracts of scientific meetings. Randomized controlled trials (RCTs) that compared concurrent chemoradiotherapy followed by adjuvant chemotherapy with concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma were included. Meta-analysis was performed with RevMan 5.1.0. The Grading of Recommendations Assessment, Development, and Evaluation system (GRADE) was used to rate the level of evidence. Results: Five studies were included. Risk ratios of 1.02 (95%CI 0.89-1.15), 0.93 (95%CI 0.72-1.21), 1.07 (95%CI 0.87-1.32), 0.95 (95%CI 0.80-1.13) were observed for 3 years overall survival, 5 years failure-free survival, 5 years locoregional failure-free survival and 5 years distant metastasis failure-free survival. There were no treatment-related deaths in both groups of five studies. Hematologic and gastrointestinal toxicity were the most significant for patients during adjuvant chemotherapy. The level of evidence was low. Conclusion: Compared with concurrent chemoradiotherapy alone, concurrent chemotherapy followed by adjuvant chemotherapy did not improve prognosis. More toxicity was found during adjuvant chemotherapy.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.3C
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• pp.157-162
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• 2011

For blind equalization of communication channels, concurrent equalization is useful to improve convergence characteristics. However, the concurrent equalization will result in limited performance enhancement by continuing concurrent adaptation with two algorithms after the equalizer converges to steady-state. In this paper, to improve the convergence characteristics and steady-state performance of the concurrent equalization, proposed is a new concurrent equalization technique with variable step-size parameter and weight-based tap coefficients update. The proposed concurrent vsCMA+DD equalization calculates weight factors using error signals of the variable step-size CMA (vsCMA) and DD (decision-directed) algorithm, and then updates the two equalizers based on the weights respectively. The proposed method, first, improves the error performance of the CMA by the vsCMA, and enhances the steady-state performance as well as the convergence speed further by the weight-based tap coefficients update. The performance improvement by the proposed scheme is verified through simulations.

• Radiation Oncology Journal
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• v.12 no.1
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• pp.99-107
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• 1994

Among the 63 patients with histopathologically proven primary squamous cell anal cancer who were managed in Presbyterian Medical Center and Yonsei University Cancer from Jan. 1971 to Dec. 1991, 34 patients, who were managed with surgery alone(abdominoperineal resection) or post-operative radiotherapy and concurrent chemoradiotherapy were analysed. With mean follow up time of 81.3 months, 30 Patients(88$ \% $) were followed up from 17 to 243 months. In methods, 10 patients were treated with surgery alone. 9 Patients were treated with combined surgery and postoperative radiotherapy(50$\∼$60 Gy in 28$\∼$30 fractions). 15 patients were treated with concurrent chemoradiotherapy. Chemotherapy (Mitomycin C 15 mg/squ, bolus injection day 1;5-FU, 750 mg/squ, 24hr infusion, day 1 to 5) and radiotherapy started the same day. A dose of 30 Gy was given to the tumor and to the pelvis including inguinal nodes, in 15 fractions. After 2 weeks a boost of radiotherapy(20 Gy) to the ano-perineal area and second cycle of chemotherapy completed the treatment. The overall 5-year survival rate was 56.2$ \% $. Concurrent chemoradiotherapy group was 70$ \% $ and surgery alone group was 16.7$ \% $. According to the cox proportional harzard model, there was significant difference between survival with concurrent chemoradiotherapy and surgery alone(p=0.0129), but post-operative radiotherapy was 64.8$ \% $, which was not stastically significant(p=0.1412). In concurrent chemoradiotherapy group, the anal funtion Preservation rate was 87$ \% $ and the severe complication rate(grade 3 stenosis and incontinence) was 13.3$ \% $. In conclusion, we conclude that the concurrent chemoradiotherapy may be effective treatment modality in patients with anal cancer.

• Journal of Biosystems Engineering
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• v.35 no.6
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• pp.401-407
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• 2010

In this study, computer simulations were conducted to assess the use of a circulating concurrent-flow dryer for rapeseed drying and to determined the effect of this drying method on the germination ratio of rapeseed after the drying process was complete. The simultaneous heat and mass transfer between air and rapeseed in a concurrent-flow dryer was examined by simulation. The drying simulation was based on several parameters with sequent time series. Equations concerning air psychrometrics, physical properties, thermal properties, equilibrium moisture content, thin layer drying of rapeseed, etc. were all combined to solve the simulation models. Based on energy and mass transfer in the concurrent-flow drying model, a simulation program for the circulating concurrent-flow rapeseed dryer was built along with a detailed description of the mathematical solution to the model. A pilot scale circulating concurrent-flow dryer(200 kg/batch) was used to verify the fitness of the simulation program. A comparison between the experimental data and the model predicted results was presented and discussed. The drying parameters and germination ratio were analyzed and the accuracy of the simulation program was evaluated. The simulation program proved to be reliable and was shown to be a convenient tool for predicting rapeseed drying and germination ratio of rapeseed in a concurrent-flow dryer.

• The Transactions of the Korea Information Processing Society
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• v.3 no.3
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• pp.617-630
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• 1996

In this paper, a shared-concurrent file system (S-CFS) is designed and implemented using conventional disks as disk arrays on a Workstation Cluster which can be used as a small-scale server. Since it is implemented on UNIX operating systems, S_CFS is not only portable and flexible but also efficient in resource usage because it does not require additional I/O nodes. The result of the research shows that on small-scale systems with enough disks, the performance of the concurrent file system on transaction processing applications is bounded by the bottleneck of CPUs computing powers while the performance of the concurrent file system on massive data I/Os is bounded by the time required to copy data between buffers. The concurrent file system,which has been implemented on a Workstation Cluster with 8 disks,shows a throughput of 388 tps in case of transaction processing applications and can provide the bandwidth of 15.8 Mbytes/sec in case of massive data processing applications. Moreover,the concurrent file system has been dsigned to enhance the throughput of applications requirring high performance I/O by controlling the paralleism of the concurrent file system on user's side.

• Korean Journal of Veterinary Service
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• v.46 no.4
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• pp.263-268
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• 2023

Despite regular vaccinations, equine influenza virus (EIV) and Streptococcus equi subsp. equi (strangles) are the cause of highly contagious respiratory infections in horses. Many recent studies have reported that the concurrent administration of two vaccines could simplify horse management and minimize veterinary expenses. However, there is little information available regarding the efficacy of concurrent vaccinations against EIV and strangles. In this study, we evaluated EIV-specific antibody responses following the single EIV vaccination with the recombinant viral-vectored EIV vaccine or concurrent vaccination with the EIV and inactivated strangles vaccines. Blood samples were collected at 1-, 2-, 4-, and 8 weeks post-immunization (wpi) from each group. EIV-specific antibodies were evaluated by enzyme-linked immunosorbent assay (ELISA) and hemagglutination inhibition (HAI) assay. Both single and concurrent vaccination showed similar levels of EIV-specific serum immunoglobulin g (IgG) at 1 and 2 wpi. However, at 4 to 8 wpi, the EIV-only vaccination group showed significantly higher serum IgG levels than those from the concurrently vaccinated group. The HAI titers showed similar trends as the ELISA data, except at 8 wpi when both groups presented HAI titers with no significant differences. These data demonstrate that the concurrent vaccination against EIV and strangles could compromise the humoral immune response to equine influenza between vaccination intervals, which suggests the use of the consecutive vaccination protocol for EIV and strangles rather than concurrent vaccination.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.19 no.38
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• pp.207-215
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• 1996

Concurrent Engineering is a concept to aim at product development lead-time in order to satisfy customer's changing tastes in n timely manner. This approach is concurrently integrating all participants and aspects of product design, development and manufacture. In this paper the concepts, framework, and success factor-teamwork- of concurrent engineering is presented.

• ETRI Journal
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• v.36 no.3
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• pp.374-384
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• 2014

To achieve high-speed (giga-bit) connectivity for short-range wireless multimedia applications, the millimeter-wave (mmWave) wireless personal area networks with directional antennas are gaining increased interest. Due to the use of directional antennas and mmWave communications, the probability of non-interfering transmissions increases in a localized region. Network throughput can be increased immensely by the concurrent time allocation of non-interfering transmissions. The problem of finding optimum time allocation for concurrent transmissions is an NP-hard problem. In this paper, we propose two enhanced versions of previously proposed multi-hop concurrent transmission (MHCT) schemes. To increase network capacity, the proposed schemes efficiently make use of the free holes in the time-allocation map of the MHCT scheme; thus, making it more compact.