Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Evaluation of concurrent immunizations with equine influenza virus and strangles vaccines

  • Dong-Ha Lee (Racing Resources Management Team, Jeju, Korea Racing Authority) ;
  • Kyungmin Jang (Racing Resources Management Team, Jeju, Korea Racing Authority) ;
  • Taemook Park (Racing Resources Management Team, Jeju, Korea Racing Authority) ;
  • Youngjong Kim (Racing Resources Management Team, Jeju, Korea Racing Authority) ;
  • Kyoung Hwan Kim (Racing Resources Management Team, Jeju, Korea Racing Authority) ;
  • Eun-bee Lee (Department of Veterinary Medicine, College of Veterinary Medicine, Jeju National University) ;
  • Young Beom Kwak (Racing laboratory, Jeju, Korea Racing Authority) ;
  • Eun-Ju Ko (Department of Veterinary Medicine, College of Veterinary Medicine, Jeju National University)
  • Received : 2023.11.12
  • Accepted : 2023.12.07
  • Published : 2023.12.30
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Abstract

Despite regular vaccinations, equine influenza virus (EIV) and Streptococcus equi subsp. equi (strangles) are the cause of highly contagious respiratory infections in horses. Many recent studies have reported that the concurrent administration of two vaccines could simplify horse management and minimize veterinary expenses. However, there is little information available regarding the efficacy of concurrent vaccinations against EIV and strangles. In this study, we evaluated EIV-specific antibody responses following the single EIV vaccination with the recombinant viral-vectored EIV vaccine or concurrent vaccination with the EIV and inactivated strangles vaccines. Blood samples were collected at 1-, 2-, 4-, and 8 weeks post-immunization (wpi) from each group. EIV-specific antibodies were evaluated by enzyme-linked immunosorbent assay (ELISA) and hemagglutination inhibition (HAI) assay. Both single and concurrent vaccination showed similar levels of EIV-specific serum immunoglobulin g (IgG) at 1 and 2 wpi. However, at 4 to 8 wpi, the EIV-only vaccination group showed significantly higher serum IgG levels than those from the concurrently vaccinated group. The HAI titers showed similar trends as the ELISA data, except at 8 wpi when both groups presented HAI titers with no significant differences. These data demonstrate that the concurrent vaccination against EIV and strangles could compromise the humoral immune response to equine influenza between vaccination intervals, which suggests the use of the consecutive vaccination protocol for EIV and strangles rather than concurrent vaccination.

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References

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