• Journal of Animal Science and Technology
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• 제64권3호
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• pp.588-598
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• 2022

Despite vaccination, equine influenza virus (EIV) and equine herpesvirus (EHV) infections still cause highly contagious respiratory diseases in horses. Recently, concurrent vaccination with EIV and EHV was suggested as a new approach; however, there have been no reports of concurrent vaccination with recombinant canarypox EIV and inactivated EHV vaccines. In this study, we aimed to compare the EIV-specific immune responses induced by concurrent administrations of a recombinant canarypox EIV vaccine and an inactivated bivalent EHV vaccine with those induced by a single recombinant canarypox EIV vaccine in experimental horse and mouse models. Serum and peripheral blood mononuclear cells (PBMCs) were collected from immunized animals after vaccination. EIV-specific serum antibody levels, serum hemagglutinin inhibition (HI) titers, and interferon-gamma (IFN-γ) levels were measured by enzyme-linked immunosorbent assay, HI assay, and quantitative polymerase chain reaction, respectively. Concurrent EIV and EHV vaccine administration significantly increased IFN-γ production, without compromising humoral responses. Our data demonstrate that concurrent vaccination with EIV and EHV vaccines can enhance EIV-specific cellular responses in horses.

• 품질경영학회지
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• 제26권4호
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• pp.219-238
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• 1998

The objective of this study was to establish a procedure of concurrent engineering which can be easily a, pp.icable in Korean industry. An investigation of various techniques of concurrent engineering was conducted. Problems of Korean companies which can be resolved by concurrent engineering techniques were identified. Techniques which can resolve these problems at the relatively low cost and without complicated computer facilities were selected and form a procedure for this study. The procedure was a, pp.ied to a manufacturing company for validation. It was found that this procedure can substantially reduce time and cost of R&D and manufacturing.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5747-5752
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• 2012

Purpose: The main objective of the present study was to evaluate the efficacy and toxicity of concurrent chemoradiotherapy followed by adjuvant chemotherapy compared with concurrent chemoradiotherapy alone in the treatment of locoregionally advanced nasopharyngeal carcinoma. Methods: The search strategy included Pubmed, Embase, the Cochrane Library, China National Knowledge Internet Web, Chinese Biomedical Database and Wanfang Database. We also searched reference lists of articles and the volumes of abstracts of scientific meetings. Randomized controlled trials (RCTs) that compared concurrent chemoradiotherapy followed by adjuvant chemotherapy with concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma were included. Meta-analysis was performed with RevMan 5.1.0. The Grading of Recommendations Assessment, Development, and Evaluation system (GRADE) was used to rate the level of evidence. Results: Five studies were included. Risk ratios of 1.02 (95%CI 0.89-1.15), 0.93 (95%CI 0.72-1.21), 1.07 (95%CI 0.87-1.32), 0.95 (95%CI 0.80-1.13) were observed for 3 years overall survival, 5 years failure-free survival, 5 years locoregional failure-free survival and 5 years distant metastasis failure-free survival. There were no treatment-related deaths in both groups of five studies. Hematologic and gastrointestinal toxicity were the most significant for patients during adjuvant chemotherapy. The level of evidence was low. Conclusion: Compared with concurrent chemoradiotherapy alone, concurrent chemotherapy followed by adjuvant chemotherapy did not improve prognosis. More toxicity was found during adjuvant chemotherapy.

• 한국통신학회논문지
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• 제36권3C호
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• pp.157-162
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• 2011

동시 등화는 통신 채널을 블라인드 등화 시 수렵 특성 개선에 유용하다. 그러나 동시 등화는 등화기가 정상상태에 수렴한 후에도 동시 적응을 계속함으로써 성능 개선이 제한적이다. 본 논문에서는 동시 등화의 수렴 특성과 함께 정상상태 성능을 개선하기 위해, 가변 수렴상수와 가중치기반의 탭 계수 갱신을 적용하는 새로운 동시 등화 기법을 제안한다. 제안하는 동시 vsCMA+DD 등화는 가변 수렴상수 CMA(variable step-size CMA: vsCMA)와 판정의거 (decision-directed: DD) 알고리즘의 오차 신호를 사용하여 가중치를 산출하고, 이를 이용하여 두 등화기를 각각 가중 갱신한다. 제안 방법은 vsCMA에 의해 CMA의 오차 성능을 개선하고, 가중치기반의 탭 계수 갱신에 의해 수렴 속도와 정상상대 성능을 개선하였다. 모의실험을 통해 제안 방식의 성능 개선을 검증하였다.

• Radiation Oncology Journal
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• 제12권1호
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• pp.99-107
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• 1994

Among the 63 patients with histopathologically proven primary squamous cell anal cancer who were managed in Presbyterian Medical Center and Yonsei University Cancer from Jan. 1971 to Dec. 1991, 34 patients, who were managed with surgery alone(abdominoperineal resection) or post-operative radiotherapy and concurrent chemoradiotherapy were analysed. With mean follow up time of 81.3 months, 30 Patients(88$ \% $) were followed up from 17 to 243 months. In methods, 10 patients were treated with surgery alone. 9 Patients were treated with combined surgery and postoperative radiotherapy(50$\∼$60 Gy in 28$\∼$30 fractions). 15 patients were treated with concurrent chemoradiotherapy. Chemotherapy (Mitomycin C 15 mg/squ, bolus injection day 1;5-FU, 750 mg/squ, 24hr infusion, day 1 to 5) and radiotherapy started the same day. A dose of 30 Gy was given to the tumor and to the pelvis including inguinal nodes, in 15 fractions. After 2 weeks a boost of radiotherapy(20 Gy) to the ano-perineal area and second cycle of chemotherapy completed the treatment. The overall 5-year survival rate was 56.2$ \% $. Concurrent chemoradiotherapy group was 70$ \% $ and surgery alone group was 16.7$ \% $. According to the cox proportional harzard model, there was significant difference between survival with concurrent chemoradiotherapy and surgery alone(p=0.0129), but post-operative radiotherapy was 64.8$ \% $, which was not stastically significant(p=0.1412). In concurrent chemoradiotherapy group, the anal funtion Preservation rate was 87$ \% $ and the severe complication rate(grade 3 stenosis and incontinence) was 13.3$ \% $. In conclusion, we conclude that the concurrent chemoradiotherapy may be effective treatment modality in patients with anal cancer.

• Journal of Biosystems Engineering
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• 제35권6호
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• pp.401-407
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• 2010

In this study, computer simulations were conducted to assess the use of a circulating concurrent-flow dryer for rapeseed drying and to determined the effect of this drying method on the germination ratio of rapeseed after the drying process was complete. The simultaneous heat and mass transfer between air and rapeseed in a concurrent-flow dryer was examined by simulation. The drying simulation was based on several parameters with sequent time series. Equations concerning air psychrometrics, physical properties, thermal properties, equilibrium moisture content, thin layer drying of rapeseed, etc. were all combined to solve the simulation models. Based on energy and mass transfer in the concurrent-flow drying model, a simulation program for the circulating concurrent-flow rapeseed dryer was built along with a detailed description of the mathematical solution to the model. A pilot scale circulating concurrent-flow dryer(200 kg/batch) was used to verify the fitness of the simulation program. A comparison between the experimental data and the model predicted results was presented and discussed. The drying parameters and germination ratio were analyzed and the accuracy of the simulation program was evaluated. The simulation program proved to be reliable and was shown to be a convenient tool for predicting rapeseed drying and germination ratio of rapeseed in a concurrent-flow dryer.

• 한국정보처리학회논문지
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• 제3권3호
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• pp.617-630
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• 1996

본 연구에서는 소규모 서버로 사용될 수 있는 Workstation Cluster환경에서 전통 적인 디스크들을 디스크 배열 처럼 사용할 수 잇는 병행 화일시스템(S-CFS)을 설계 하고 구현하였다. S-CFS는 범용의 UNIX 운영체제를 기반으로 구현되어서 융통성과 이식 성이 높으며 별도의 입출력 노드가 불필요하므로 시스템 자원을 효율적으로 사용한다. 성능 분석 결과에 위하며, 소규모 서버에서 디스크의 수가 충분 할 경우, 트랜잭션 처리 에서 병행 화일시스템의 성능은 CPU 계산 능력에 의하여제한받는 것으로 나타났으며 대용량 데이타 입출력에서는 성능이 버퍼 간의 데이타 복사시간에 의하여 제한받는 것으로 나다.Workstation Cluster 에서 구현된 병행 화일시스템은 8개의 디스크에서 트랜잭션 처리의 경우에는초당 388 트랜잭션의 처리율을 보였으며, 대용량 데이타의 경우에는 15.8 MBytes/sec 의 대역표을 보였다. 그리고 사용자가 병행 화일시스템의 병렬성을 제어할 수 있도록 설계함으로써 고속 입출력을 요구하는 사용자의 처리율을 높일 수 있도록 하였다.

• 한국동물위생학회지
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• 제46권4호
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• pp.263-268
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• 2023

Despite regular vaccinations, equine influenza virus (EIV) and Streptococcus equi subsp. equi (strangles) are the cause of highly contagious respiratory infections in horses. Many recent studies have reported that the concurrent administration of two vaccines could simplify horse management and minimize veterinary expenses. However, there is little information available regarding the efficacy of concurrent vaccinations against EIV and strangles. In this study, we evaluated EIV-specific antibody responses following the single EIV vaccination with the recombinant viral-vectored EIV vaccine or concurrent vaccination with the EIV and inactivated strangles vaccines. Blood samples were collected at 1-, 2-, 4-, and 8 weeks post-immunization (wpi) from each group. EIV-specific antibodies were evaluated by enzyme-linked immunosorbent assay (ELISA) and hemagglutination inhibition (HAI) assay. Both single and concurrent vaccination showed similar levels of EIV-specific serum immunoglobulin g (IgG) at 1 and 2 wpi. However, at 4 to 8 wpi, the EIV-only vaccination group showed significantly higher serum IgG levels than those from the concurrently vaccinated group. The HAI titers showed similar trends as the ELISA data, except at 8 wpi when both groups presented HAI titers with no significant differences. These data demonstrate that the concurrent vaccination against EIV and strangles could compromise the humoral immune response to equine influenza between vaccination intervals, which suggests the use of the consecutive vaccination protocol for EIV and strangles rather than concurrent vaccination.

• 산업경영시스템학회지
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• 제19권38호
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• pp.207-215
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• 1996

Concurrent Engineering is a concept to aim at product development lead-time in order to satisfy customer's changing tastes in n timely manner. This approach is concurrently integrating all participants and aspects of product design, development and manufacture. In this paper the concepts, framework, and success factor-teamwork- of concurrent engineering is presented.

• ETRI Journal
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• 제36권3호
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• pp.374-384
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• 2014

To achieve high-speed (giga-bit) connectivity for short-range wireless multimedia applications, the millimeter-wave (mmWave) wireless personal area networks with directional antennas are gaining increased interest. Due to the use of directional antennas and mmWave communications, the probability of non-interfering transmissions increases in a localized region. Network throughput can be increased immensely by the concurrent time allocation of non-interfering transmissions. The problem of finding optimum time allocation for concurrent transmissions is an NP-hard problem. In this paper, we propose two enhanced versions of previously proposed multi-hop concurrent transmission (MHCT) schemes. To increase network capacity, the proposed schemes efficiently make use of the free holes in the time-allocation map of the MHCT scheme; thus, making it more compact.