• Title/Summary/Keyword: Concordance Rate

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THE SHORT-TERM EFFECTS OF LOW-DOSE-RATE RADIATION ON EL4 LYMPHOMA CELL

  • Bong, Jin-Jong;Kang, Yu-Mi;Shin, Suk-Chul;Choi, Moo-Hyun;Choi, Seung-Jin;Lee, Kyung-Mi;Kim, Hee-Sun
    • Journal of Radiation Protection and Research
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    • v.37 no.2
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    • pp.56-62
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    • 2012
  • To determine the biological effects of low-dose-rate radiation ($^{137}Cs$, 2.95 mGy/h) on EL4 lymphoma cells during 24 h, we investigated the expression of genes related to apoptosis, cell cycle arrest, DNA repair, iron transport, and ribonucleotide reductase. EL4 cells were continuously exposed to low-dose-rate radiation (total dose: 70.8 mGy) for 24 h. We analyzed cell proliferation and apoptosis by trypan blue exclusion and flow cytometry, gene expression by real-time PCR, and protein levels with the apoptosis ELISA kit. Apoptosis increased in the Low-dose-rate irradiated cells, but cell number did not differ between non- (Non-IR) and Low-dose-rate irradiated (LDR-IR) cells. In concordance with apoptotic rate, the transcriptional activity of ATM, p53, p21, and Parp was upregulated in the LDR-IR cells. Similarly, Phospho-p53 (Ser15), cleaved caspase 3 (Asp175), and cleaved Parp (Asp214) expression was upregulated in the LDR-IR cells. No difference was observed in the mRNA expression of DNA repair-related genes (Msh2, Msh3, Wrn, Lig4, Neil3, ERCC8, and ERCC6) between Non-IR and LDR-IR cells. Interestingly, the mRNA of Trfc was upregulated in the LDR-IR cells. Therefore, we suggest that short-term Low-dose-rate radiation activates apoptosis in EL4 lymphoma cells.

EVALUATION OF MANDIBULAR CONDYLE POSITION IN TMJ TRANSCRANIAL RADIOGRAPH (악관절의 경두개 방사선사진에서 하악과두위 평가에 관한 연구)

  • Do Jeong-ju;Kim Eun-Kyung
    • Journal of Korean Academy of Oral and Maxillofacial Radiology
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    • v.22 no.1
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    • pp.67-75
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    • 1992
  • Transcranial radiograph is widely used in the diagnosis of craniomandibular disorder because it can be used by the dentist with relative ease in spite of image distortion. But correct information can be obtained only when one know the image change by projection angulation. The author compared the condyle position in the 3 groups of transcranial radiographs (horizontal angulation - 0°, 5°, individualized) with that in the individualized corrected lateral tomogram by objective and subjective evaluation methods. The results were as follows: 1. Among 3 transcranial groups, the condyle position in individualized group showed the highest concordance rate with that in the tomogram group in objective and subjective evaluation methods. 2. Correlation coefficient between individualized transcranial group and tomogram group in objective evaluation method was highest (P≤0.01). 3. Image clarity in individualized transcranial group was worse than that of the other two transcranial groups.

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Cytopathologic Diagnosis of Pulmonary Diseases by Transthoracic Fine Needle Aspiration Biopsy (경흉세침흡인 생검에 의한 폐질환의 세포병리학적 진단)

  • Park, In-Ae;Ham, Eui-Keun
    • The Korean Journal of Cytopathology
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    • v.1 no.1
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    • pp.27-35
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    • 1990
  • The authors report series of 360 cases of transthoracic fine-needle aspiration cytology (TFNA) from Oct. 1982, through Aug. 1986 at the Seoul National University Hospital. A diagnosis of neoplastic lesion was established in 50.3% of the cases. A non-neoplastic diagnosis was made in 38.5%, nondiagnostic one in 6.5% and inadequate one in 4.7% of the total. Statistical findings on cytological diagnoses were as follows. Specificity was 100% ; sensitivity, 92% ; predictive value for positive, 1.0 ; predictive value for negative, 0.9 ; concordance rate, 84.2% ; diagnostic accuracy in non-neoplastic lesion, 65.4%, and typing accuracy in malignant tumor, 0.77.

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Development of a Hydrological Drought Index Considering Water Availability (수자원 가용능력을 고려한 수문학적 가뭄지수의 개발)

  • Park, Min-Ji;Shin, Hyung-Jin;Choi, Young-Don;Park, Jae-Young;Kim, Seong-Joon
    • Journal of The Korean Society of Agricultural Engineers
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    • v.53 no.6
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    • pp.165-170
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    • 2011
  • Recently natural disasters such as the frequency and intensity of drought have been increasing as a result of climate change. This study suggests a drought index, WADI (Water Availability Drought Index), that considers water availability using 6 components (water intake, groundwater level, agricultural reservoir water level, dam inflow, streamflow, and precipitation) using the Z score and data monitoring on a nationwide level. SPI (Standardized Precipitation Index) was applied in coastal area. For the severe droughts of 2001 spring and 2008 autumn, the index was evaluated by comparison with reported damage areas. suggested to combine The spatial concordance rate of WADI in 2001 and 2008 for estimation of the degree of drought severity was 50 % and 24 % compared to the actual recorded data respectively.

A Study on Children's Family Drawings by Attachment Classification (아동기 애착 유형에 따른 아동의 가족화 연구)

  • Jin, Mi Kyoung;Lee, Kyung Sook
    • Korean Journal of Child Studies
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    • v.28 no.4
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    • pp.187-196
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    • 2007
  • This study evaluated attachment representation of school aged children, its relation to classification of family drawings, and their association with children's perceptions about families. The attachment representation of 43 children 6-9 years of age was evaluated by the Manchester Attachment Story Task (Green, Stanley, & Goldwyn, 2003) children's family drawings were classified by Fury's Family Drawing Scales (1996). Results showed that 12 children (28%) were avoidant, 23 (54%) secure, 4 (9%) resistant, and 4 (9%) were disorganized. Classification of childhood attachment representation showed a high concordance rate (86%) with family drawings. Securely Attached children showed positive perceptions such as family pride/happiness and vitality/creativity while Insecure children showed negative perceptions like emotional distance, tension and bizarreness.

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Analysis of Test-retest Reliability of Individual Items in a Preliminary From of Child-rearing Attitude Scale (양육태도검사 예비형의 문항검사―재검사 신뢰도의 분석)

  • 차재호
    • Journal of the Korean Home Economics Association
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    • v.20 no.2
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    • pp.135-140
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    • 1982
  • As a step preliminary to the factor-analysis of a child-rearing attitude scale under construction, its preliminary form containing a total of 368 self-answered questions was administerd to 88 married women with one or more children in the grade school age. all graduates of colleges and in possession of a home telephone and a house, twice from one week apart. The test-retest correlation coefficients, calculated for each test item based on the subject's choice among the three response alternatives on two test ocasions, ranged from .80 to .10. The cut-off point of r=.41 or lower led to the elimination of 48 items. As a point of incidental interest, the rate of response concordance. The namber of subjects giving the same categroy response on two occasions was calculated for each item and it was correlated with its test. retest correlation coefficient. The two different indices of item test-retest reliability were found not related to each other. Empirical evidence, as well as rational justifications, was presented to show that the correlation coefficient is the better of the tow indices of item test-retest reliability.

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Development of Methods to lmprove the Reliability of ELECTRE (복합기준 평가방법 ELECTRE의 신뢰도 증진을 위한 방안 연구)

  • 이인성
    • Journal of the Korean Institute of Landscape Architecture
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    • v.23 no.1
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    • pp.23-38
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    • 1995
  • ELEECTRE is a less demanding and potentially Bffective multiattribute evaluation method for pre-editing proeedure. The method, however, was developed based on probabilistic mathematicsand its reliability has never'been emprieally tested. This article examined the reliability of ELECTRo under various conditions of linear and non-linear utility func- tions using a Monte-Carlo shnulation, and found the method eausea a considerably high rate of error. To enhance the reliability of ELECTRE, two ways of modi(ication - adjust- ment of threshold values of concordance and discordance matrices, and adjustment of the required nunlber of probably-dominant alternatives to eliminate a probably-dominated alternative - were suggested, and their effctiveness was also tesed by a Monte-Carlo simulation. The simulation result chows that these modifications cponsiderably improve the reliability of ELECTRE, and yet maintain a reasonably high level of efficiency. Through these modifications, ELECTRE can be used as an efficient and feliable pre-editing method. Ways to implement ELECTRE in the construction of plainning decision support systens were discussed. The impli(els combination of this method and other multiattribute evaluation methods will help to create more effective decision suport systems.

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Kinect Sensor- based LMA Motion Recognition Model Development

  • Hong, Sung Hee
    • International Journal of Advanced Culture Technology
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    • v.9 no.3
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    • pp.367-372
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    • 2021
  • The purpose of this study is to suggest that the movement expression activity of intellectually disabled people is effective in the learning process of LMA motion recognition based on Kinect sensor. We performed an ICT motion recognition games for intellectually disabled based on movement learning of LMA. The characteristics of the movement through Laban's LMA include the change of time in which movement occurs through the human body that recognizes space and the tension or relaxation of emotion expression. The design and implementation of the motion recognition model will be described, and the possibility of using the proposed motion recognition model is verified through a simple experiment. As a result of the experiment, 24 movement expression activities conducted through 10 learning sessions of 5 participants showed a concordance rate of 53.4% or more of the total average. Learning motion games that appear in response to changes in motion had a good effect on positive learning emotions. As a result of study, learning motion games that appear in response to changes in motion had a good effect on positive learning emotions

Geant 4 Monte Carlo simulation for I-125 brachytherapy

  • Jie Liu;M.E. Medhat;A.M.M. Elsayed
    • Nuclear Engineering and Technology
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    • v.56 no.7
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    • pp.2516-2523
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    • 2024
  • This study aims to validate the dosimetric characteristics of Low Dose Rate (LDR) I-125 source Geant4-based Monte Carlo code. According to the recommendation of the American Association of Physicists in Medicine (AAPM) task group report (TG-43), the dosimetric parameters of a new brachytherapy source should be verified either experimentally or theoretically before clinical procedures. The simulation studies are very important since this procedure delivers a high dose of radiation to the tumor with only a minimal dose affecting the surrounding tissues. GEANT4 Monte Carlo simulation toolkit associated brachytherapy example was modified, adapted and several updated techniques have been developed to facilitate and smooth radiotherapy techniques. The great concordance of the current study results with the consensus data and with the results of other MC based studies is promising. It implies that Geant4-based Monte Carlo simulation has the potential to be used as a reliable and standard simulation code in the field of brachytherapy for verification and treatment planning purposes.

Performance Analysis of PE-GOX Hybrid Rocket Motor Part I : Regression Rate Characteristics (PE-GOX 하이브리드 로켓 모터의 성능 예측 Part I : 후퇴율 특성)

  • Youn, Chang-Jin;Song, Na-Young;Yoo, Woo-Jun;Jeon, Chang-Soo;Kim, Jin-Kon;Sung, Hong-Gae;Moon, Hee-Jang
    • Journal of the Korean Society of Propulsion Engineers
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    • v.11 no.2
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    • pp.71-78
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    • 2007
  • An experimental investigation was conducted to clarify the combustion characteristics of Polyethylene-GOX(PE-GOX) hybrid motor using a single-port fuel grain configuration. Data from the experiments were analyzed to evaluate the length-averaged regression rate of PE-GOX propellants. Based on the existing theories, the empirical regression rate formulas provided from Marxman[3,4] and Altman[14] showed good concordance with the PE-GOX experiments. The accuracy of the regression rate was then evaluated and compared with the measured one. As a result, Marxman's model was somewhat more precise than Altman's model in these experiments. Moreover, the consideration of the empirical regression rate showed that O/F ratio has minor variation due to the quasi constant inflow of the fuel during motor firing.