• Journal of the Korean Society for Nondestructive Testing
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• v.29 no.4
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• pp.338-343
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• 2009

Tomography is the imaging method of cross sectional area using multi beam signals and is mainly applied to the medical diagnosis to acquire the image of the inside human body. This method is pretty meaningful in nondestructive evaluation field since the imaging of the inspection region can enhance the comprehension of the inspector. Recently, much attention has been paid to the guided wave for the diagnosis of platelike structures. So, in this work, a study on the imaging of the damage location in a plate was carried out on the basis of computer aided analysis of guided waves and tomographic imaging. To this end, boundary element method was employed to analyze the effect of the damage in plate on the propagation of the guided waves and the analytic results were applied to the tomographic imaging method to identify the damage location. Consequently, it was shown that the number of sensors heavily affect the inspection performance of the damage location.

• Progress in Medical Physics
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• v.27 no.4
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• pp.189-195
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• 2016

This paper aims to verify the clinical feasibility of a custom-made film created by a laser cutting tool for End-to-End (E2E) quality assurance in robotic intensity modulated radiation therapy system. The custom-made film was fabricated from the Gafchromic EBT3 film with the size of $8^{{\prime}{\prime}}{\times}10^{{\prime}{\prime}}$ using a drawing that is identical to the shape and scale of the original E2E film. The drawing was created by using a computer aided design program with the image file, which is obtained by scanning original E2E film. Beam delivery and evaluations were respectively performed with the original film and the custom-made film using fixed-cone collimator on three tracking modes: 6D skull (6DS), Xsight spine (XS), and Xsight lung (XL). The differences between total targeting errors of the original and custom-made films were recorded as 0.17 mm, 0.3 mm, and 0.17 mm at 6DS, XS, and XL tracking modes, respectively. This indicates that the custom-made film could yield nearly equivalent results to those of the original E2E film, given the uncertainties caused by distortions during film scanning and vibrations associated with film cutting. By confirming the clinical feasibility of a custom-made film for E2E testing, it can be expected that economic efficiency of the testing will increase accordingly.

• Journal of dental hygiene science
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• v.13 no.3
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• pp.290-295
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• 2013

The purpose of this study was to investigate the shear bond strength between various commercial all-ceramic system core and veneering ceramics, and evaluate the clinical stability by comparing the conventional metal ceramic system. The test samples were divided into three groups: Ni-Cr alloy (metal bond), yttria-stabilized, tetragonal zirconia polycrystal (Y-TZP) (zirconia bond), lithium disilicate (lithium disilicate bond). The veneering porcelain recommended by the manufacturer for each type of material was fired to the core. After firing, the specimens were subjected to shear force in a universal testing machine. Load was applied at a crosshead speed of 0.50 mm/min until failure. Average shear strengths (mega pascal) were analyzed with a one-way analysis of variance and the Tukey test (${\alpha}$=0.05). The mean shear bond strength${\pm}$SD in MPa was $44.79{\pm}2.31$ in the Ni-Cr alloy group, $28.32{\pm}4.41$ in the Y-TZP group, $15.91{\pm}1.39$ in the Lithium disilicate group. The ANOVA showed a significant difference among groups (p<0.05). None of the all-ceramic system core and veneering ceramics could attain the high bond strength values of the metal ceramic combination.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2005.05a
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• pp.854-861
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• 2005

The functional behavior of a portable consumer electronic (PCE) product is nearly all expressed with human-machine interaction (HMI) tasks. Although physical prototyping and computer aided design (CAD) software can show the appearance of the product, they cannot properly reflect its functional behavior. In this paper, we propose a virtual prototyping (VP) system that incorporates virtual reality and HMI functional simulation in order to enables users to capture not only the realistic look of a PCE product but also its functional behavior. We obtain geometric part models of the product and their assembly and kinematics information with the help of CAD and reverse engineering tools, and visualize them with various display tools. We adopt state transition methodology to capture the HMI functional behavior of the product into a state transition chart, which is later used to construct a finite state machine (FSM) for the functional simulation of the product. The FSM plays an important role to control the transition between states of the product. The proposed VP system receives input events such as mouse clicks on buttons and switches of the virtual prototype model, and it reacts to the events based on the FSM by activating associated activities. The VP system provides the realistic visualization of the product and the vivid simulation of its functional behavior. It can easily allow users to perform functional evaluation and usability testing. Moreover, it can greatly reduce communication errors occurring in a typical product development process. A case study about VP of an MP3 player is given to show the usefulness of the proposed VP system.

• Journal of Biomedical Engineering Research
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• v.37 no.5
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• pp.168-177
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• 2016

In this paper we present an implantable pressure sensor to measure real-time blood pressure by monitoring mechanical movement of artery. Sensor is composed of inductors (L) and capacitors (C) which are formed by microfabrication and direct bonding on two biocompatible substrates (quartz). When electrical potential is applied to the sensor, the inductors and capacitors generates a LC resonance circuit and produce characteristic resonant frequencies. Real-time variation of the resonant frequency is monitored by an external measurement system using inductive coupling. Structural and electrical simulation was performed by Computer Aided Engineering (CAE) programs, ANSYS and HFSS, to optimize geometry of sensor. Ultrafast laser (femto-second) cutting and MEMS process were executed as sensor fabrication methods with consideration of brittleness of the substrate and small radial artery size. After whole fabrication processes, we got sensors of $3mm{\times}15mm{\times}0.5mm$. Resonant frequency of the sensor was around 90 MHz at atmosphere (760 mmHg), and the sensor has good linearity without any hysteresis. Longterm (5 years) stability of the sensor was verified by thermal acceleration testing with Arrhenius model. Moreover, in-vitro cytotoxicity test was done to show biocompatiblity of the sensor and validation of real-time blood pressure measurement was verified with animal test by implant of the sensor. By integration with development of external interrogation system, the proposed sensor system will be a promising method to measure real-time blood pressure.

• Journal of Biomedical Engineering Research
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• v.38 no.1
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• pp.25-31
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• 2017

Testing TB in chest X-ray images is a typical method to diagnose presence and magnitude of PTB lesion. However, the method has limitation due to inter-reader variability. Therefore, it is essential to overcome this drawback with automatic interpretation. In this study, we propose a novel method for detection of PTB using SegNet, which is a deep learning architecture for semantic pixel wise image labelling. SegNet is composed of a stack of encoders followed by a corresponding decoder stack which feeds into a soft-max classification layer. We modified parameters of SegNet to change the number of classes from 12 to 2 (TB or none-TB) and applied the architecture to automatically interpret chest radiographs. 552 chest X-ray images, provided by The Korean Institute of Tuberculosis, used for training and test and we constructed a receiver operating characteristic (ROC) curve. As a consequence, the area under the curve (AUC) was 90.4% (95% CI:[85.1, 95.7]) with a classification accuracy of 84.3%. A sensitivity was 85.7% and specificity was 82.8% on 431 training images (TB 172, none-TB 259) and 121 test images (TB 63, none-TB 58). This results show that detecting PTB using SegNet is comparable to other PTB detection methods.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.12
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• pp.6114-6118
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• 2013

This study examined the ultrasonic pulse reflection method(UPRM) for testing each ultrasonic pulse waveform model(UPWM) based on weld defects. The sharp crack of a clear signal was generated. The echo height of the defective probes changed according to the location. In a long crack in a circle around the defective probes, the Swivel scanning echo height when using the particle was reduced drastically. The peaks in the echo were thin because the needle was pointed. The porosity defects arising from a single echo was sharp and crisp, but a number of pores of the collective reflection overlapped and ajagged echo was observed. Slag, slag inclusions, cracks, and defects at the Swivel scan of each particle using the echo shape showed difference in the degree. Cracks were revealed as sudden changes in the echo height of the slag inclusions: increase ${\rightarrow}$ decrease ${\rightarrow}$ increase ${\rightarrow}$ decrease. In addition, the location of a number of defects in the dense pore geometry, such as a typical echo sundry, revealed the shape in the slag. Poor penetration of the defect echo, revealed the cracks to have a sharp-edged, crack-like shape with an echo.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.15 no.12 s.91
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• pp.1123-1130
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• 2004

In this paper, a technique is presented f3r the design of a structurally simple narrow-band orthomode transducer (OMT) operating at 12/14 GHz frequency bands. The proposed OMT has such a structure that a horizontally polarized wave incident on the circular waveguide of the common port is directed to the rectangular waveguide of the straight port, while the vertically polarized wave is directed to the rectangular waveguide of the side port. Firstly methods are developed f3r designing individual parts of the OMT based on the waveguide theory and the theory of impedance matching. Secondly based on developed methods the whole OMT structure is designed using a commercial electromagnetic field analysis software. The validity of the proposed design technique is confirmed by fabricating and testing the designed OMT.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.2291-2295
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• 2016

Small molecule tyrosine kinase inhibitors targeting HER 2 receptors have emerged as an important therapeutic approach in inhibition of downstream proliferation and survival signals for the treatment of breast cancers. Recent drug discovery efforts have demonstrated that naturally occurring polyphenolic compounds like delphinidin have potential to inhibit proliferation and promote apoptosis of breast cancer cells by targeting HER2 receptors. While delphinidin may thus reduce tumour size, it is associated with serious side effects like dysphonia. Owing to the narrow therapeutic window of delphinidin, the present study aimed to identify high affinity compounds targeting HER2 with safer pharmacological profiles than delphinidin through virtual screening approaches. Delphinidin served as the query parent for identification of structurally similar compounds by Tanimoto-based similarity searching with a threshold of 95% against the PubChem database. The compounds retrieved were further subjected to Lipinski and Verber's filters to obtain drug like agents, then further filtered by diversity based screens with a cut off of 0.6. The compound with Pubchem ID: 91596862 was identified to have higher affinity than its parent. In addition it also proved to be non-toxic with a better ADMET profile and higher kinase activity. The compound identified in the study can be put to further in vitro drug testing to complement the present study.

• Journal of the Korea Safety Management & Science
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• v.16 no.2
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• pp.43-52
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• 2014

In weapon systems development, live fire tests have been frequently adopted to evaluate the performance of the systems under development. Therefore, it is necessary to ensure safety in the test ranges where the live fire tests can cause serious hazards. During the tests, a special care must be taken to protect the test and evaluation (T&E) personnel and also test assets from potential danger and hazards. Thus, the development and management of the range safety process is quite important in the tests of guided missiles and artillery considering the explosive power of the destruction. Note also that with a newly evolving era of weapon systems such as laser, EMP and non-lethal weapons, the test procedure for such systems is very complex. Therefore, keeping the safety level in the test ranges is getting more difficult due to the increased unpredictability for unknown hazards. The objective of this paper is to study on how to enhance the safety in the test ranges. To do so, an approach is proposed based on model-based systems engineering (MBSE). Specifically, a functional architecture is derived utilizing the MBSE method for the design of the range safety process under the condition that the derived architecture must satisfy both the complex test situation and the safety requirements. The architecture developed in the paper has also been investigated by simulation using a computer-aided systems engineering tool. The systematic application of this study in weapon live tests is expected to reduce unexpected hazards and test design time. Our approach is intended to be a trial to get closer to the recent theme in T&E community, "Testing at the speed of stakeholder's need and rapid requirement for rapid acquisition."