• The Korean Journal of Physiology and Pharmacology
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• 제24권1호
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• pp.89-99
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• 2020

Although microscopic analysis of tissue slides has been the basis for disease diagnosis for decades, intra- and inter-observer variabilities remain issues to be resolved. The recent introduction of digital scanners has allowed for using deep learning in the analysis of tissue images because many whole slide images (WSIs) are accessible to researchers. In the present study, we investigated the possibility of a deep learning-based, fully automated, computer-aided diagnosis system with WSIs from a stomach adenocarcinoma dataset. Three different convolutional neural network architectures were tested to determine the better architecture for tissue classifier. Each network was trained to classify small tissue patches into normal or tumor. Based on the patch-level classification, tumor probability heatmaps can be overlaid on tissue images. We observed three different tissue patterns, including clear normal, clear tumor and ambiguous cases. We suggest that longer inspection time can be assigned to ambiguous cases compared to clear normal cases, increasing the accuracy and efficiency of histopathologic diagnosis by pre-evaluating the status of the WSIs. When the classifier was tested with completely different WSI dataset, the performance was not optimal because of the different tissue preparation quality. By including a small amount of data from the new dataset for training, the performance for the new dataset was much enhanced. These results indicated that WSI dataset should include tissues prepared from many different preparation conditions to construct a generalized tissue classifier. Thus, multi-national/multi-center dataset should be built for the application of deep learning in the real world medical practice.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2006년도 춘계 종합학술대회 논문집
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• pp.466-469
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• 2006

오늘날 현대는 정보사회로 이행하면서 기존의 매체에서 뉴미디어로의 매체전환을 시도하고 있다. 이러한 변화는 인쇄매체에서도 새로운 위협이 되고 있다. 전자출판(Computer Aided Publising)이라든지, 혹은 web 상의 소설, web 상의 잡지(Webzine) 등이 그러한 것들이며, 이러한 오늘날의 시대상황은 인쇄매체에 있어 더욱 새로운 변모를 요구하게 된다. 상품 경쟁력의 근원이 바로 디자인을 통한 문화 콘텐츠에 있음을 시사한다. 문화상품은 어떻게 하면 문화를 산업화 하는 것보다 구체적이고 현실적인 관점에서 경제적 차원의 전략적 개념으로 등장하고 있는 것이다. 기존 프린팅 미디어 기반의 디자인 제작 방법에 새로운 제작 방법을 접목하여 진보적 가치 창출 도구로 월드컵 문화콘텐츠 관련 상품디자인을 개발한 (주)셀파크 기업의 사례를 소개하고자 한다. 이를 통하여 기존의 디자인 회사에서 간과하기 쉬운 특허 등록을 통한 콘텐츠 디자인 상품 보호, 새로운 디자인 표현 방법으로 블루 오션시장을 창출한 사례를 연구하였다.

• The Journal of Advanced Prosthodontics
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• 제12권4호
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• pp.189-196
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• 2020

PURPOSE. The aim of the present study was to investigate the effects of surface treatments on the bond strengths between polymer-containing restorative materials and two dual-cure resin cements. MATERIALS AND METHODS. In the present study, rectangular samples prepared from Lava Ultimate (LU) and Vita Enamic (VE) blocks were used. The specimen surfaces were treated using CoJet sandblasting, 50 ㎛ Al₂O₃ sandblasting, % 9 HF (hydrofluoric) acid, ER,Cr:YSGG laser treatment, and Z-Prime. Dual-cure resin cements (TheraCem and 3M RelyX U 200) were applied on each specimen's treated surface. A micro-tensile device was used to evaluate shear bond strength. Statistical analysis was performed using the SAS 9.4v3. RESULTS. While the bond strength using TheraCem with LU or VE was not statistically significant (P=.164), the bond strength using U200 with VE was statistically significant (P=.006). In the TheraCem applied VE groups, Z-Prime and HF acid were statistically different from CoJet, Laser, and Sandblast groups. In comparison of TheraCem used LU group, there was a statistically significant difference between HF acid and other surface treatments. CONCLUSION. The bonding performance between the restorative materials and cements were material type-dependent and surface treatment had a large effect on the bond strength. Within the limitations of the study, the use of both U200 and TheraCem may be suggested if Z-prime was applied to intaglio surfaces of VE. The cementation of LU using TheraCem is suitable after HF acid conditioning of the restoration surfaces.

• Restorative Dentistry and Endodontics
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• 제44권3호
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• pp.27.1-27.12
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• 2019

This case report describes a technique in which endodontic treatment and permanent indirect restoration were completed in the same clinical appointment with the aid of a computer-aided design/computer-aided manufacturing (CAD/CAM) system. Two patients were diagnosed with irreversible pulpitis of the mandibular first molar. After access preparation, root canals were located, irrigation was performed until bleeding ceased, and the coronal tooth structure was prepared for indirect restoration. Then, utilizing an interim 3-mm build-up of the endodontic access cavity, a hemi-arch digital scan was performed with an intraoral scanner. Subsequent to digital scanning, restoration design was performed simultaneously with the endodontic procedure. The root canals were shaped using the Race system under irrigation with 2.5% sodium hypochlorite followed by root canal filling. The pulp chamber was subsequently filled with a 3-mm-thick composite resin restoration mimicking the interim build-up previously utilized to facilitate block milling in the CAD/CAM system. Clinical try-in of the permanent onlay restoration was followed by acid etching, application of a 5th generation adhesive, and cementation of the indirect restoration. Once the restoration was cemented, rubber dam isolation was removed, followed by occlusal adjustment and polishing. After 2 years of follow-up, the restorations were esthetically and functionally satisfactory, without complications.

• 한국산업정보학회논문지
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• 제24권2호
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• pp.41-46
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• 2019

전력 시스템에서 직렬 보상기의 적용은 회로 차단기 과도 재기 전압 (Transient Recovery Voltage : TRV) 문제와 같은 다른 장치에 영향을 미친다. 본 논문에서는 TCSC (Thyristor-Controlled Series Capacitor)가 있는 경우와 없는 경우의 선로 차단기에 대한 TRV 효과를 시뮬레이션을 통해 분석하고, TCSC 설치로 인한 TRV 증가를 극복하는 효과적인 방법을 제안한다. 또한 금속 산화물 바리스터 (Metal Oxide Varistor : MOV)에 대한 제안된 보호의 영향에 대해서도 설명한다. 시뮬레이션 모델은 국내의 345 kV 송전선로를 사용하였다. 전력 시스템은 PSCAD (Power Systems Computer Aided Design) / EMTDC (Electro Magnetic Transient Direct Current)를 사용하여 모델링하였다. TRV는 송전선로 및 차단기 단자에서 단락 고장을 구현하여 분석하였고, MOV의 에너지는 보호 동작 알고리즘을 적용하여 해석하였다. 제안된 보호 방안을 적용하는 경우 TRV는 표준을 만족시키지만, 지연 시간이 증가함에 따라 MOV 에너지 용량의 증가하여야 한다. 이 결과를 적용하여 실제 전력 시스템에서 예상되는 전송 선로 고장 상태로 인한 TRV 문제를 해결할 수 있다.

• 대한치과기공학회지
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• 제42권4호
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• pp.326-333
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• 2020

Purpose: The purpose of this study was to evaluate the effects of various zirconia surface treatment methods on shear bond strength with resin cements. Methods: We prepared 120 cylindrical zirconia specimens (⌀10 mm×10 mm) using computer-aided design/computer-aided manufacturing (CAD/CAM). Each specimen was randomly subjected to one of four surface treatment conditions: (1) no treatment (control), (2) airborne-particle abrasion with 50 ㎛ of Al2O3 (A50), (3) airborne-particle abrasion with 125 ㎛ of Al2O3 (A125), and (4) ZrO2 slurry (ZA). Using a polytetrafluoroethylene mold (⌀6 mm×3 mm), we applied three resin cements (Panavia F 2.0, Super-Bond C&B, and Variolink N) to each specimen. The shear bond strength tests were performed in a universal testing machine. The surfaces of representative specimens of each group were evaluated under scanning electron microscope. We used one-way analysis of variance (ANOVA), two-way ANOVA, and post hoc Tukey honest significant difference test to analyze the data. Results: In the surface treatment method, the A50 group showed the highest bond strength, followed by A125, ZA, and control groups; however, no significant difference was observed between A50 and A125, A125 and ZA, and ZA and control (p>0.05). Among the resin cements, Super-Bond C&B showed the highest shear bond strength, followed by Panavia F 2.0 and Variolink N (p<0.05). Conclusion: Within the limitations of this study, application of airborne-particle abrasion and ZrO2 slurry improved the shear bond strength of resin cement on zirconia.

• 한국전기전자재료학회논문지
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• 제33권5호
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• pp.380-385
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• 2020

Over the past decade, small robots have been of particular interest in the engineering field. Among the various types of small robots, biomimetic robots, which mimic animals and insects, have been developed for special activities in areas where humans cannot physically access. The optimal motion of a walking robot can be determined by the characteristics of the traversed surface (e.g., roughness, curvature, slope, materials, etc.). This study proposes three types of piezoelectric structures using different driving mechanisms, depending on the application range of the small walking robots. Dynamic modeling using computer-aided engineering optimized the shape of the robot to maximize its moving characteristics, and the results were also verified through its fabrication and experimentation. Three types of robots, named by their actuator shapes as I, π, & T-shape, were proposed regarding application for small scale ambulatory robots to different terrain conditions. Among these, the T-shaped robots were shown to have a wide range of speeds (from 2 mm/s up to 255 mm/s) and good carrying capacity (up to 10 g at 50 mm/s) through driving experiments. Based on this study, we proposed possible application areas for the three types of walking robot actuators.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2003년도 The 8th Asian Symposium on Precision Forging ASPF
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• pp.115-122
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• 2003

This paper presents the development of a virtual forging factory framework. The technologies of virtual reality and relational database had been integrated in the developed framework using Microsoft $Windows^{(R)}$ programming as the main technique so as to emulate a physical forging factory. The developed virtual forging factory consists of forging cells and a forging cell is comprised of forging machine, forging die, and forging operations forming a forging production line. The technology of virtual reality had been successfully adopted in the production simulation of manufacturing such as CNC and robotics. However, the application in virtual forging factory seems to have not been studied yet. Potential application of a virtual forging factory can be beneficial to (1) computer aided instruction, (2) shorten the learning curve of a novice, (3) remote diagnosis and monitoring when remote monitoring and control technology and signal inspection is considered, (4) improve adverse forging environment when remote forging technology is applied, and (5) virtual reality application.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2014년도 춘계학술발표대회
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• pp.582-585
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• 2014

Visualization is a science which makes the invisible to visible through the techniques of experimental visualization and computer-aided visualization. This paper presents the practical aspects of visualization of multivariate dataset. In this paper, we will briefly discuss a previous research work and introduce a new visualization technique which will help us to design and develop a visualization tool for experimental visualization of multivariate dataset. Our newly developed visualization tool can be used in various domains. In this paper, we have chosen a software industry as an application domain and we used the multivariate dataset of software components computed by VizzMaintenance. VizzMaintenance is software analysis tool which give us multiple software metrics of open source Java based programs. Main objective of this research is to develop a new visualization tool for large multivariate dataset which will be more efficient and easy to perceive by viewer. Perception is very important for our research work and we have decided to test the perception level of our proposed visualization approach by researchers of our research lab.

• 대한장애인치과학회지
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• 제13권2호
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• pp.95-98
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• 2017

본 증례는 다운 증후군이 있는 환자의 구강 재건 시 CAD/CAM 시스템 사용의 이점을 모색해보았다. 다운 증후군 환자들의 경우, 보철물 파절의 위험성이 크며 불가피하게 보철물을 재제작할 경우, CAD/CAM 시스템의 기존 데이터를 이용하여 최소한의 기공 과정만 진행하여 보철물을 빠른 시일 내에 재제작할 수 있다. 결과적으로 이는 심미적 및 기능적 개선을 통해 삶의 질을 높일 수 있는 보철물 제작 시 환자의 불편감과 치과의사의 노력을 최소화하는 방법이다.