• 한국식품위생안전성학회지
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• 제29권4호
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• pp.305-311
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• 2014

본 연구는 정량적 미생물 위해평가(Quantitative microbial risk assessment: QMRA)에 절대적으로 필요한 9종의 식중독 세균, 2종의 바이러스, 1종의 원생동물에 대한 최소 감염량(minimum infective dose)을 선정한 연구이다. 주요 식중독 미생물들의 최소 감염량을 선정하기 위하여, 1980년부터 2012년까지 PubMed, ScienceDirect database 등에서 주요 식중독 미생물들의 최소 감염량 및 위해평가 자료 82종을 수집하였다. 수집된 자료는 메타분석(mata-analysis)에서 사용되고 있는 relative frequency(fi, 상대빈도 값)를 계산하여 가장 적정한 최소 감염량을 추정 및 선정하였다. 주요 식중독 미생물들의 최소 감염량은, B. cereus $10^5cells/g$ (fi = 0.32), C. jejuni 500 cells/g (fi = 0.57), Cl. perfringens $10^7cells/g$ (fi = 0.56), Pathogenic E. coli 중 EHEC 10 cells/g (fi = 0.47), ETEC $10^8cells/g$ (fi = 0.71), EPEC $10^6cells/g$ (fi = 0.70), EIEC $10^6cells/g$ (fi = 0.60), L. monocytogenes $10^2{\sim}10^3cells/g$ (fi = 0.23), Salmonella spp. 10 cells/g (fi = 0.30), Shigella spp. 100 cells/g (fi = 0.32), S. aureus $10^5cells/g$ (fi = 0.45), V. parahaemolyticus $10^6cells/g$ (fi = 0.64), Hepatitis A virus $10{\sim}10^2particles/g$ (fi = 0.33), Noro virus 10 particles/g (fi = 0.71), C. pavum $10{\sim}10^2oocyst/g$ (fi = 0.33)으로 나타났다. 본 연구결과는 향후 국내 QMRA를 통한 위해수준 추정결과의 정확성을 향상시키는데 기여할 수 있을 것으로 기대된다.

• 한국가스학회지
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• 제22권6호
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• pp.44-51
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• 2018

LNG저장탱크가 노후화 됨에 따라 외벽 콘크리트에 균열, 철근부식 등 결함이 발생할 경우, 손상 종류 및 정도에 따라 구조물의 붕괴 등 대형사고 발생 위험이 존재하게 된다. LNG저장탱크는 2014년부터 정밀안전진단이 시작 되어 안전점검이 수행되고 있으며, 부재별 상태평가기준은 2016년 1월에 개정되어 적용하고 있다. 상태평가는 액화천연가스 저장탱크에 대한 외관 조사 및 재료시험 결과를 바탕으로 저장탱크에 대한 상태를 평가하는 것을 말하는 것으로 유지관리에 있어서 중요하다. 또한 각각의 LNG 저장탱크 대표상태를 나타내는 종합적 상태평가기준이 유지관리 시 중요하지만, LNG저장탱크 외조 콘크리트에 대한 관련 기준이 국내 외에 부재하여 상태평가 기준 개발 필요하다. 이 논문에서는 LNG 저장탱크 구조적 특성 검토, 부재별 상태평가 기준현황 분석, 부재별 가중치 부여를 통한 종합적 상태등급 산정 방안을 수립하였다. 부재별 가중치 산출은 AHP(Analytic Hierarchy process)기법을 이용하고 전문기관의 설문조사 등을 통해 종합적 상태평가 기준을 개발하였다.

• 문화기술의 융합
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• 제7권1호
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• pp.674-681
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• 2021

주요기반시설(critical infrastructure)을 대상으로 하는 사이버 공격이 증가하고 있다. 주요기반시설은 국가의 핵심 인프라이며 기반시설 간 상호의존성이 높은 특성을 가지고 있어서 일반적으로 사용되는 사이버 보안으로는 충분히 보호하기 어렵다. 특히 주요기반시설의 물리적 위험과 논리적 위험의 구분이 모호해지고 있어서 전체를 포괄하는 관점의 위험 관리가 이루어져야 한다. 이에 주요기반시설을 보다 적극적으로 보호하기 위한 방안으로 주요국에서는 보안내재화(SbD, security by design)를 적용하기 시작하였으며 보다 확대된 개념의 사전예방적보안(CSbD, cybersecurity by design)이 고려되고 있다. 이러한 사전예방적보안(CSbD)은 소프트웨어(SW) 안전 설계와 관리의 안정성 확보뿐만 아니라 물리적인 정치 및 기기(HW) 안전성과 사전 예방·차단 조치, 그리고 사이버회복탄력성(cyber resilience)까지 포함하는 포괄적인 보안 체계를 의미한다. 이에 본 연구는 미국과 싱가포르, 그리고 유럽에서 선도적으로 추진되고 있는 주요기반시설의 보안내재화(SbD) 방안들을 비교분석하고 주요기반시설에 대한 최적의 보안내재화(SbD) 적용 방안을 제시하고자 한다.

• 혜화의학회지
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• 제21권1호
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• pp.11-21
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• 2012

New onset diabetes is a major complication after kidney transplantation. However, the natural course of posttransplantation diabetes mellitus (PTDM) remains unclear. The aim of this study was to demonstrate the detailed natural courses of PTDM according to the onset and persistency of hyperglycemia, and to investigate risk factors for development of different courses of PTDM in renal allograft recipients. The purpose of this study is to develop novel immune suppressants for PTDM using of action mechanism of them. The use of immunosuppressive drugs in transplanted patients is associated with the development of diabetes, possibly due to ${\beta}$-cell toxicity. To better understand the mechanisms leading to post-transplant diabetes, we investigated the actions of prolonged exposure of ${\beta}$-cells to therapeutical levels of tacrolimus (FK506) or cyclosporin A(CsA). The immunosuppressive drug cyclosporine(CsA) is a potent agent widely used after organ transplantations and various autoimmune disorders. After using CsA, some patients suffer severe complications including renal and vascular toxicity. The renal or vascular toxicity is influenced by the degree of the endothelial damage. FK506(tacrolimus) is a widely used immunosuppressive agent in the treatment of various medical conditions, including autoimmune disease, bone marrow and organ transplantations. We found some interesting clusters and confirmed the feasibility of cDNA microarray in the study of Immunosuppressant. In this study, we investigated gene expression patterns induced by Immunosuppressant in RIN-m5F of rat insulinoma cell line. Gene expressions evaluated using cDNA microarry in two clusters were increased or decreased. this study provides comprehensive comparison of the patterns of gene expression changes induced by CsA and FK506 in ${\beta}$-cells. This study could establish that the mode of action mechanism by which currently used insulin inhibitors inducing PTDM could be elucidated at least in part, which raises the possibility that novel immune suppressive PTDM can be developed. The molecular biological study on PTDM will also contribute the progress in diabetes research field as well as in that of PTDM.

• Journal of Trauma and Injury
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• 제33권1호
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• pp.18-22
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• 2020

Purpose: Damage control laparotomy has contributed to improved survival rates for severe abdominal injuries. A large part of severe abdominal injury occurs with a concomitant pelvic bone fracture. The safety and effectiveness of internal fixation of pelvic bone fracture(s) has not been established. The aim of the present study was to evaluate infection risk in the pelvic surgical site in patients who underwent emergent abdominal surgery. Methods: This single-center retrospective observational study was based on data collected from a prospectively maintained registry between January 2015 and June 2019. Patients who underwent laparotomy and pelvic internal fixation were included. Individuals <18 and ≥80 years of age, those with no microbiological investigations, and those who underwent one-stage abdominal surgery were excluded. Comprehensive statistical comparative analysis was not performed due to the small number of enrolled patients. Results: A total of six patients met the inclusion criteria, and the most common injury mechanism was anterior-posterior compression (67%). The average duration of open abdomen was 98 hours (range, 44-98), and the time interval between abdominal closure and pelvic surgery was 98 hours. One patient (16.7%) died due to multi-organ dysfunction syndrome. Micro-organisms were identified in the abdominal surgical site in five patients (83%), with no micro-organisms in pelvic surgical sites. There was no unplanned implant removal. Conclusions: Internal fixation of pelvic bone fracture(s) could be performed in the state of open abdomen, and the advantages of early fixation may countervail the risks for cross contamination.

• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2577-2581
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• 2012

Objective: To conduct a meta-analysis to investigate the value of EBV DNA in diagnosis of nasopharyngeal cancer (NPC) in Asian populations, and provide important evidence for screening. Methods: Prospective or respective case-control or cohort studies regarding the detection role of EBV DNA for NPC were included in our study. We conducted a comprehensive literature search in PubMed, EMBASE, and the Chinese Biomedical Database (CBM database between January 1980 and March 2012. Results: A total of 18 studies with 1492 NPC cases and 2641 health controls were included. Almost of the included studies were conducted in China, and only one other conducted in Thailand. The overall results demonstrated that the pooled sensitivity, specificity, positive likelihood (+LR) and negative likelihood (-LR) were 0.73 (0.71-0.75), 0.89 (0.88-0.90), 8.84 (5.65-13.84) and 0.19(0.11-0.32), respectively. The overall EBV DNA detection showed the largest area of 0.932 under the summary receiver operator curve (SROC). The accuracy of detection by plasma for NPC (0.86) was higher than in serum (0.81), with largest areas under the SROC of 0.97 and 0.91, respectively. Conclusion: Our results demonstrated the EBV DNA detection in plasma or serum has high sensitivity and specificity in diagnosis of NPC, especially in Chinese populations with a high risk of cancer.

• 간호행정학회지
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• 제14권4호
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• pp.421-431
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• 2008

Purpose: Using comprehensive and valid instrument, MDS-HC 2.0, this study aimed to analyze the functional status and to evaluate the care needs of the community-dwelling disabled with cerebral impairment. Method: With a convenient sample of 88 disabled with cerebral impairment, the data were collected at a community health center located in rural area in Choongchung providence in August 2005. Subject's functional status and care needs were evaluated using Minimum Data Set-Home Care version 2.0. Result: Significant proportion of subjects were totally dependent for locomotion-outdoor (26.1%), personal hygiene (24.1%), bathing (24.1%). For IADLs, over 40% of subjects were totally dependent for ordinary house work, managing finances, or shopping. Top five ranked care needs were preventive health care measures (100%), communication disorders (71.6%), visual function (55.7%), health promotion (52.3%), and pressure ulcers (48.9%). The proportion of triggered clinical assessment protocols were significantly higher in disability level I group for the risk of institutionalization (p=<.001), communication disorders (p=.004), cognitive problems (p=.001), pressure ulcers (p=<.001), skin and foot conditions (p=.010), and urinary incontinence and indwelling catheters (p=<.001). Conclusions: It is necessary to provide community based rehabilitation services that are individualized for their service needs thus enhance optimal level of functioning.

• 지역사회간호학회지
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• 제29권1호
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• pp.108-119
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• 2018

Purpose: The purpose of this study is to estimate the prevalence of the metabolic syndrome in pre-menopausal housewives and to explore controllable and uncontrollable factors regarding metabolic syndrome. Methods: The study population of this cross-sectional survey was from the Korean Health and Nutrition Examination Survey (KHANES) 2010 through 2015, including the fifth and sixth population-based studies. The criteria for metabolic syndrome include waist circumference, blood pressure, fasting plasma glucose, triglyceride, high-density lipoprotein (HDL) based on Korean Clinical Practice Guideline for Metabolic Syndrome by the Korean Academy of Family Medicine 2015. Results: Among the 2,498 subjects, 247 subjects had metabolic syndrome and the prevalence was estimated to be 9.9%. The number of subjects who met the criterion of HDL was 936 (36.2%), which was the most prevalent among the criteria for metabolic syndrome. Statistically significant (p<.05) factors include age, livinghood benefit group, perceived health status, obesity, family history of DM, sleeping time, awareness of stress,leukocyte, and erythrocyte count. The odds ratio of obesity in the BMI ${\geq}25$ group was 12.59 times as high as that of the BMI <25 group (p<.001) for metabolic syndrome. Conclusion: The prevalence of metabolic syndrome in pre-menopausal housewives in the survey was not low, and it is necessary to develop and apply comprehensive health habit management programs to improve controllable factors including exercise and food intake.

• 한국융합학회논문지
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• 제2권1호
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• pp.21-29
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• 2011

이 연구의 목적은 2005년 우리나라 1개광역도 1개 군지역 2개면 5개리에 거주하는 주민에서의 우울증 요병율과 우울증 관련요인을 분석코자 시행되었다. 본 연구결과 전체 조사대상자의 15.0%가 우울증인 것으로 나타났다. 여자의 우울증 유병율이 19.3%로 남자의 우울증 유병율 8.4%보다 높게 나타났다. 다변수분석 결과 우울증과 관련이 있는 변수로는 일상생활에서 받는 스트레스 수준으로 즉, 스트레스를 많이 받는 사람에 비하여 보통인 사람이 0.11배 적게 받는 사람이 0.10배 유의하게 낮게 우울이 발생하는 것으로 나타났다 (p<0.01). 또한 65세이상 노인에서 다변량 로지스틱 회귀분석 실시결과, 직업이 농업인 경우에 비하여 무직이거나 기타 직종에 종사하고 있는 경우 우울증 발생이 9.58배 높았다. 또한 스트레스 정도에서는 스트레스를 일상생활 중 많이 느끼는 노인에 비하여 보통이나 적게 느끼는 경우 각각 0.05배, 0.11배 낮은 우울발생을 보였으며, 이는 통계적으로 유의하였다 (p<0.01).

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.149-153
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• 2016

Breast cancer is the most common cancer in Iran. In the recent years an upward trend has been observed in the Iranian population. Early detection by molecular approaches may reduce breast cancer morbidity and mortality. We provided consultation to 3,782 women diagnosed with early onset breast cancer during the past 15 years (1999-2014). To establish a data set for BRCA gene alterations of the Iranian families at risk, two hundred and fifty four women who met our criteria were analyzed. A total number of 46 alterations including 18 variants with unknown clinical significance (39.1%), 18 missense mutations (39.1%), 7 Indels (15.2%) and 3 large rearrangement sequences (6%) were identified. Further scanning of affected families revealed that 49% of healthy relatives harbor identical causative mutations. This is the first report of comprehensive BRCA analysis in Iranian women with early onset breast cancer. Our findings provide valuable molecular data to support physicians as well as patients for the best decision making on disease management.