• Journal of Microbiology and Biotechnology
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• v.24 no.9
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• pp.1291-1299
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• 2014

Recently, multifunctional nanomaterials have been developed as nanotherapeutic agents for cellular imaging and targeted cancer treatment because of their ease of synthesis and low cytotoxicity. In this study, we developed a multifunctional, two-component nanorod consisting of gold (Au) and nickel (Ni) blocks that enables dual-fluorescence imaging and the targeted delivery of small interfering RNA (siRNA) to improve cancer treatment. Fluorescein isothiocyanate-labeled luteinizing hormone-releasing hormone (LHRH) peptides were attached to the surface of a Ni block via a histidine-tagged LHRH interaction to specifically bind to a breast cancer cell line, MCF-7. The Au block was modified with TAMRA-labeled thiolated siRNA in order to knock down the vascular endothelial growth factor protein to inhibit cancer growth. These two-component nanorods actively targeted and internalized into MCF-7 cells to induce apoptosis through RNA interference. This study demonstrates the feasibility of using two-component nanorods as a potential theranostic in breast cancer treatment, with capabilities in dual imaging and targeted gene delivery.

• Journal of the Korean Society of Systems Engineering
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• v.12 no.2
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• pp.69-80
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• 2016

The purpose of this study is to establish a component reutilization system in Nuclear Power Plant (NPP) by Object-Oriented Systems Engineering Method (OOSEM). Unified Modeling Language (UML) is mainly used for OOSEM. Operational Concept (OpsCon), Use cases, Structure Diagrams, and Behavior Diagrams are developed to analyze stakeholders needs, system requirements, logical architecture, and physical architecture. Based on the current decommissioning and purchasing system of the component, some activities from their systems were excepted and additional new activities were developed for a component reutilization system.

• Journal of Magnetics
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• v.11 no.4
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• pp.160-163
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• 2006

We have prepared crystalline Ag nanoparticles with an average size of 4 nm in diameter by using an inductively coupled plasma reactor equipped with the liquid nitrogen cooling system. Our magnetic data show that the nano-sized effect of Ag nanoparticles on the magnetic properties is ferromagnetic, instead of a diamagnetic component of the Ag bulk and a superparamagnetic component of magnetic nanoparticles. We have also studied the magnetic properties of Ag-Cu nanocomposites with an opposite concentration profile between surface and core. These comparisons indicate that the ferromagnetic component strongly depends on the surface of Ag nanoparticles, while the paramagnetic component is strongly affected by the outer oxide layer, with the background of a diamagnetic component from the core of Ag.

• Journal of the Korea Society of Computer and Information
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• v.12 no.5
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• pp.113-119
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• 2007

Framework has constructive and extendable code. It is consist of the variable design collections. In the aspect of the classes's collection, it is similar to the class library. but it is different to provide the architecture which is possible to develop the application rather than the collection of the simple classes. In framework it is very important factor to develop and control the component library. In this paper, we design the usable component model through defining the meta-relation between components and proposed the sample case using this model.

• Journal of Internet Computing and Services
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• v.8 no.6
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• pp.87-93
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• 2007

In the component based software development, it is very important to interface between modules of component. Almost of existing method, Connectors are deal with all communication channels between two or more components/interfaces by RPC(Remote procedure call) and event call. But these process has limits when component send a lot of request call to other component through connector. That is, we need more efficient interface method that connector can process multi request call. In this paper, I propose interaction scheduling algorithm using message queue in the connector. For this purpose, I use message buffer which operate to save and load message temporarily.

• The Transactions of the Korea Information Processing Society
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• v.7 no.5S
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• pp.1629-1637
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• 2000

With wide spending the Internet and Web techniques, we have recognized the necessary and commercial-value of electronic commerce system. Electronic commerce(EC) means the whole economical activities based on electronic medium. Both scalability and flexibility are fundamental attributes of EC system and interoperability among heterogeneous systems must be supported. So, for successful a developing of EC system, it is necessary to apply the CBD (Component Based Development) based on component assembling and customization. In this paper, we propose the method for identifying and specifying the components to construct the component based electronic commerce system. To do, we define the component/system architecture specified on EC domain, identified and classified the EC components with hierarchy relationship. Also, we suggested the specification notation and some examples.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.10 no.2
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• pp.73-82
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• 2004

Objectives : In order to develop the measuring tool of visual display terminal (VDT) syndrome and investigate the variables affecting the development of VDT syndrome. Methods : A questionnaire study accompanied with the evaluation of working environment was performed with 42 VDT users from banking operations. Results : As a results of analysis with data colleted by newly developed questionnaire, VDT syndrome included five factors named as eye-related component, and psychological component. general body discomfort component. musculoskeletal component, and skin-related component. The scores of eye-related symptoms was 15.17, scores of psychological symptoms was 7.36, scores of general body discomfort symptoms was 10.52, scores of musculoskeletal symptoms was 9.38, scores of skin-related symptoms was 3.67, and total scores was 46.10. Scores of 2.05 eye fatigue in the level of eye-related symptoms were higher significantly. Scores 50.52 of female was statistically higher than scores 41.67 of male. Conclusions : The subjective symptoms of VDT syndrome scores was significantly associated with gender and age.

• Journal of the Korean Society for Railway
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• v.7 no.4
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• pp.406-411
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• 2004

BOM(Bill of Materials) is a listing or description of raw materials, parts, and assemblies that define a product. In order to evaluate the performance of proposed BOM management system, which is very important to maintenance information system of urban transit. We develop component based BOM data and rule-set to design data structure that is mutually independent and integrated efficiently. It divides data whit management interface using component technology. The component based master BOM have advantage in database size and flexibility. Flexibility is measured as the number of updating records in accordance with added new product or engineering change. In database size, component based BOM is the best. we develop master BOM management system in web environment.

• Journal of the Korean Society for Precision Engineering
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• v.16 no.3 s.96
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• pp.222-232
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• 1999

This paper describes the development of a precision 3-component load cell with plate beams which may be used for measuring forces Fx, Fy and moment Mz simultaneously in industry. We have derived equations to predict the bending strains on the surface of the beams under forces or moment. We have also determined the attachment location of strain gages of each sensor and fabricated 3-component load cell. To evaluate the rated strain and interference error of each sensor, we have carried out characteristic test of precision 3-component load cell. It reveals that the rated strain calculated from the derived equations are good agreement with the results from Finite Element Method analysis.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2006.03a
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• pp.374-381
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• 2006

This study presents a new information model for building a database which is used for the Damage Calculation in a Road network after Seismic outbreak (DCRS). The component which is required for information system and data analysis is divided by four factors. Those are Ground Motion Component, Road Network Component, Fragile Structure Component, and Cost Component. These components have various manners and procedures that build informations by each systems. In this study, applying the domestic system resources and these four factors, we presented the integrated evaluating system. finally, we also present the prototype of DCRS based on the ArcGIS. It is expected that developed prototype can play a role in more improved DCRS by advanced study.