• 국제학술발표논문집
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• The 3th International Conference on Construction Engineering and Project Management
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• pp.1075-1080
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• 2009

Recently, the building construction industry has been forced to cope with lack of skilled labor. A robot-based construction automation system should help overcome crucial troubles which may be caused by this phenomenon. In particular, it is vital to propose design for automation (DFA). Quality function deployment (QFD) is applied a systematic aid in determining the design reflecting customer's needs. This study employs the QFD approach to plan the component designs of an effective automation process, and presents the development process of DFA with an illustrative project. As a result, the study identifies the developers' design requirements for automated construction and weights them by their importance indices.

• International Journal of Stem Cells
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• 제16권4호
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• pp.376-384
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• 2023

The Wnt 𝛽-catenin signaling pathway is a highly conserved mechanism that plays a critical role from embryonic development and adult stem cell homeostasis. However, dysregulation of the Wnt pathway has been implicated in various diseases, including cancer. Therefore, multiple layers of regulatory mechanisms tightly control the activation and suppression of the Wnt signal. The E3 ubiquitin ligases RNF43 and ZNRF3, which are known negative regulators of the Wnt pathway, are critical component of Wnt signaling regulation. These E3 ubiquitin ligases control Wnt signaling by targeting the Wnt receptor Frizzled to induce ubiquitination-mediated endo-lysosomal degradation, thus controlling the activation of the Wnt signaling pathway. We also discuss the regulatory mechanisms, interactors, and evolution of RNF43 and ZNRF3. This review article summarizes recent findings on RNF43 and ZNRF3 and their potential implications for the development of therapeutic strategies to target the Wnt signaling pathway in various diseases, including cancer.

• 한국정보처리학회논문지
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• 제7권9호
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• pp.2846-2856
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• 2000

최근 웹 기술이 급속하게 발달함에 따라 웹 기반의 많은 에플리케이션이 개발되고 있다. 하지만 대부분의 웹 애플리케이션의 생성은 체계적인 프로세스 없이 개발자의 지식과 경험에 의존하여 개발되고 있다. 웹 기반의 응용시스템은 다양한 개발 기법이 요구되며 설계 및 개발 프로세스를 위해 풍부한 개발 방법론이 요구된다. 따라서, 본 논문에서는 추상화를 제공하지 않는 저수준 기술에 기반한 애플리케이션 개발을 개선하고 웹을 기반으로한 애플리케이션 구축을 위한 개발 프로세스를 제안한다. 또한, 웹 애플리케이션 개발 프로세스를 제시하며, 전자 문제은행 시스템(EPBS: Electronic Problem Bank System)에 이 프로세스를 적용하였다. 본 논문에서 제시한 웹 애플리케이션 개발 프로세스는 모델링을 위한 고수준의 추상화 정의를 가능하게 함으로써 역으로 개발을 통한 유지보수 정보획득으로 체계적 관리가 가능하며 모델 기반의 프로세스로써 이해하기 용이한 장점을 가진다. 또한, 분석과 설계 모델들은 이와 유사한 웹 애플리케이션 개발시 유용한 컴포넌트로써 재사용성을 기대할 수 있다.

• 수산해양교육연구
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• 제24권1호
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• pp.56-78
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• 2012

This study which is an alternative exploration for improving the quality level of instruction considering the perception of the teachers in early childhood education field on instructional design is to develop Differentiated Instructional Design Model coincides with the purpose of differentiated instruction curricula and with instructional design principles, and to find out whether the model has significant effect on development of teacher's professionalism. With these purposes, the perception of 343 teachers from early childhood education institutions are investigated, and after component variables are set by drawing the instructional design model available in early childhood education field and reviewing the literature of differentiated instruction model, the Differentiated Instructional design Model for Early Childhood are developed based on FGI(Focus Group Interview) expert evaluation. The experimental study of 88 teachers working in childcare facilities was implemented for effectiveness verification. As a result, first, most teachers consider the priority on making the lesson plans as the development of early childhood and Kindergarten Educational Subjects, and they realize the development of instructional design model which contributes on lesson planning and implementation is much needed. Second, the Differentiated Instructional design Model for Early Childhood are developed, which consists of the cyclic process - pre-lesson phase, lesson implementation phase, and assessment phase -based on development characteristics of early childhood. Third, the experiment of the developed model showed that the scores of experimental group is significantly higher than those of comparative group in knowledge and technique development aspect, and self-understanding development aspect among the aspects of development of teacher's professionalism.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2022년도 추계학술대회
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• pp.305-305
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• 2022

In this study, 139 Korean landrace sorghum germplasms collected in 10 different Korean regions were analyzed for tannin, total phenolic contents(TPC), and antioxidant activities using three assays including ABTS, DPPH, and FRAP. The Korean landrace sorghums showed significant variations of metabolite contents and antioxidant activities by collection regions. Gyeonggi sorghum had the highest tannin and TPC contents with 273.73%, 7.395mgGAE/g, respectively. Therefore, three assays of antioxidant activities of Gyeonggi sorghum, which is highly related to tannin and TPC, were also significantly higher than others. However, Gyeongnam sorghums showed the lowest tannin and TPC with 148.34% and 3.482mgGAE/g, thus, three antioxidnat activities showed the lowest levels. Three accessions(IT322580, IT340261 and IT329053) had the highest tannin levels over 400%, but, two accessions (IT322613, IT270366) showed less than 1% of tannin content. Four accessions (IT270349, IT286448, IT331878, and IT251882) showed the highest level of TPC over 9mgGAE/g. In this study, antioxidant activities with three assays were strongly related to tannins and TPC, and TPC showed higher significance than tannin with all three antioxidant activities. The germplasms with the highest overall antioxidant activity were IT270349, IT340261, and IT286448, which had the highest levels of tannin and TPC. The principal component analysis presented that 2 sub-populations were divided. Gyeonggi and Gangwon Yeongseo sorghums, which had high metabolite contents and antioxidant activity levels, were mainly included in group 1. Gyeongnam and Jeonnam sorghums, which had low metabolite and antioxidant activity levels, were mainly included in group 2. This results could contribute to discover breeding metarials for the development of functional sorghum varieties.

• 한국재료학회:학술대회논문집
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• 한국재료학회 2011년도 춘계학술발표대회
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• pp.5-5
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• 2011

The research and development of hybrid electric vehicle (HEV), plug-in hybrid electric vehicle (PHEV) and electric vehicle (EV) are intensified due to the energy crisis and environmental concerns. In order to meet the challenging requirements of powering HEV, PHEV and EV, the current lithium battery technology needs to be significantly improved in terms of the cost, safety, power and energy density, as well as the calendar and cycle life. One new technology being developed is the utilization of composite cathode by mixing two different types of insertion compounds [e.g., spinel $LiMn_2O_4$ and layered $LiMO_2$ (M=Ni, Co, and Mn)]. Recently, some studies on mixing two different types of cathode materials to make a composite cathode have been reported, which were aimed at reducing cost and improving self-discharge. Numata et al. reported that when stored in a sealed can together with electrolyte at $80^{\circ}C$ for 10 days, the concentrations of both HF and $Mn^{2+}$ were lower in the can containing $LiMn_2O_4$ blended with $LiNi_{0.8}Co_{0.2}O_2$ than that containing $LiMn_2O_4$ only. That reports clearly showed that this blending technique can prevent the decline in capacity caused by cycling or storage at elevated temperatures. However, not much work has been reported on the charge-discharge characteristics and related structural phase transitions for these composite cathodes. In this presentation, we will report our in situ x-ray diffraction studies on this mixed composite cathode material during charge-discharge cycling. The mixed cathodes were incorporated into in situ XRD cells with a Li foil anode, a Celgard separator, and a 1M $LiPF_6$ electrolyte in a 1 : 1 EC : DMC solvent (LP 30 from EM Industries, Inc.). For in situ XRD cell, Mylar windows were used as has been described in detail elsewhere. All of these in situ XRD spectra were collected on beam line X18A at National Synchrotron Light Source (NSLS) at Brookhaven National Laboratory using two different detectors. One is a conventional scintillation detector with data collection at 0.02 degree in two theta angle for each step. The other is a wide angle position sensitive detector (PSD). The wavelengths used were 1.1950 ${\AA}$ for the scintillation detector and 0.9999 A for the PSD. The newly installed PSD at beam line X18A of NSLS can collect XRD patterns as short as a few minutes covering $90^{\circ}$ of two theta angles simultaneously with good signal to noise ratio. It significantly reduced the data collection time for each scan, giving us a great advantage in studying the phase transition in real time. The two theta angles of all the XRD spectra presented in this paper have been recalculated and converted to corresponding angles for ${\lambda}=1.54\;{\AA}$, which is the wavelength of conventional x-ray tube source with Cu-$k{\alpha}$ radiation, for easy comparison with data in other literatures. The structural changes of the composite cathode made by mixing spinel $LiMn_2O_4$ and layered $Li-Ni_{1/3}Co_{1/3}Mn_{1/3}O_2$ in 1 : 1 wt% in both Li-half and Li-ion cells during charge/discharge are studied by in situ XRD. During the first charge up to ~5.2 V vs. $Li/Li^+$, the in situ XRD spectra for the composite cathode in the Li-half cell track the structural changes of each component. At the early stage of charge, the lithium extraction takes place in the $LiNi_{1/3}Co_{1/3}Mn_{1/3}O_2$ component only. When the cell voltage reaches at ~4.0 V vs. $Li/Li^+$, lithium extraction from the spinel $LiMn_2O_4$ component starts and becomes the major contributor for the cell capacity due to the higher rate capability of $LiMn_2O_4$. When the voltage passed 4.3 V, the major structural changes are from the $LiNi_{1/3}Co_{1/3}Mn_{1/3}O_2$ component, while the $LiMn_2O_4$ component is almost unchanged. In the Li-ion cell using a MCMB anode and a composite cathode cycled between 2.5 V and 4.2 V, the structural changes are dominated by the spinel $LiMn_2O_4$ component, with much less changes in the layered $LiNi_{1/3}Co_{1/3}Mn_{1/3}O_2$ component, comparing with the Li-half cell results. These results give us valuable information about the structural changes relating to the contributions of each individual component to the cell capacity at certain charge/discharge state, which are helpful in designing and optimizing the composite cathode using spinel- and layered-type materials for Li-ion battery research. More detailed discussion will be presented at the meeting.

• 한국정보과학회논문지:소프트웨어및응용
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• 제35권11호
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• pp.653-660
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• 2008

최근에 제시된 서비스 기반 컴퓨팅 패러다임에서의 서비스 기반 소프트웨어 개발을 지원하기 위한 체계적인 프로세스 모델에 대한 요구가 대두되고 있다. 기존에 제시된 Unified Software Development Process, UML Components 등의 방법론은 컴포넌트에 초점을 두고 만들어진 방법으로, 서비스의 정의, 바인딩, BPEL(Business Process Execution Language)을 이용한 서비스의 조합등과 같은 서비스 기반의 개발이 가지고 있는 특징을 반영하지 못하고 있다. 또한 서비스 기반의 개발 방법론으로 제시된 SOUP(Service Oriented Unified Process), SOMA(Service Oriented Modeling and Architecture) 등은 개념적인 절차가 위주로 되어 있지, 구체적인 가이드라인, 산출물 및 접근 방법을 명확히 제시하지 않는다. 그러므로 본 논문에서는 서비스 기반의 개발 패러다임을 지원하기 위한 체계화되고, 간소화된 프로세스 모델을 제시한다. 또한 OMG에서 제시한 SPEM(Software Process Engineering MetaModel)을 적용하여 프로세스 모델을 명시적으로 표현한다. 본 논문에서 제안된 프로세스 모델을 실제 서비스 기반의 개발에 적용함으로써 서비스 기반 소프트웨어 개발의 체계성 및 효율성을 증대시킬 수 있게 된다.

• 수산해양기술연구
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• 제46권4호
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• pp.335-345
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• 2010

Species composition and seasonal variation of fish assemblage in Sacheon marine ranching, Korea were examined. Sampling was seasonally made by a shrimp trawl from February 2009 to November 2009. A total of 55 species were collected. Of these, five species was dominant species comprising 51.1% of the total number of individuals. Nine species represented 57.3% of the total biomass. While total abundance (number of individuals) was high in spring, total biomass and species richness (number of species) and diversity were high in autumn. Cluster analysis, based on seasonally abundance data of the 21 most common species, showed that the species were separated into 4 different groups. Group A composed of Pholis nebulosa, Pleuronectes yokohamae, Hypodytes rubripinnis, Hexagrammos otakii, Tridentiger trigonocephalus and Paracercis sexfasciata, which were year round residents, group B Congr myriaster, Leiognathus nuchalis, and Platycephalus indicus, which were abundant in autumn, group C Sillago japonica, Pseudaesopia japonica, Zoarces gilli, Pholis fangi, and Pleuronichthys cornutus which were abundant in spring, and group D Sillago sihama, Cociella sp., Johnius grypotus, Cynoglossus joyneri, Cynoglossus robustus, and Pennahia argentata, which were abundant in summer. Principal component analysis revealed that seasonal variation in the fish assemblage was attributed to the abundance of temporal species such as conger and sand smelt fishes, which were abundant in summer, due to seasonal variation of water temperature.

• 생약학회지
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• 제49권4호
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• pp.362-371
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• 2018

Hwanggeumjackyak-tang (HJT) composed of Scatellaria baicalensis Georgi, Paeonia Lactiflora and Glycyrrhizae uralensis Fischer is a traditional Korean herbal medicine widely used for acute enteritis. In order to develop the tablet formulation of HJT, evaluation of the flow properties, thickness, diameter, hardness, friability and disintegration was carried out on four HJT granules according to mixed content of seven additives. Simultaneous analysis used HPLC method was performed of HJT tablet and was determined of the seven marker components; Albiflorin, Paeoniflorin, Liquiritin, Baicalin, Baicalein, Glycyrrhizic acid and Wogonin. The biological activities were examined the effect of HJT on anti-oxidation and pro-inflammation mediated by LPS-stimulation. We confirmed that both of HJT-Decoction (HJT-D) and HJT-Formulation (HJT-F) have the similar contents on total polyphenol and flavonoid and inhibited the secretion of nitro oxide (NO), interleukin $(IL)-1{\beta}$,interleukin (IL)-6, tumor necrosis factor $(TNF)-{\alpha}$ and the expression of nitric oxide synthase (iNOS), $IL-1{\beta}$, IL-6, $TNF-{\alpha}$. Therefore, the developed formulation for tablet of HJT would provide chemically and biologically the same effect compared with decoction of HJT.

• 한국비블리아학회지
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• 제21권4호
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• pp.49-66
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• 2010

현대과학기술의 발전은 한 사회의 문화와 사회구성원간의 커뮤니케이션에 큰 영향을 미친다. 따라서 기존의 정보를 수집, 정리하여 이용자에게 제공하던 도서관은 현대사회의 변화에 발맞추어 다양한 역할을 부여받게 되었다. 최근 공공도서관 신축 또는 리모델링 수요의 급증이 예상되고 있지만 우리는 아직 도서관의 유형과 서비스 규모를 고려한 도서관 공간운영에 대한 모델이 없는 실정이다. 본 연구는 공공 도서관이 합리적이고 체계적인 공간운영을 하기 위하여 필요한 조건과 사례를 검토하고 공간구성의 현황과 문제점을 도출하여 해결대안이 될 수 있는 공간요소의 재구성을 통해 효율적인 운영을 위한 공간구성체계를 제시하는 것을 목적으로 한다. 따라서 본 연구에서는 급증하는 도서관의 조립과 리모델링 사업계획에서 참고할 수 있도록 도서관의 특성과 서비스 규모에 상응하는 합리적인 공간운영 표준모델의 개발을 위해, 첫째, 국내 공공도서관 공간구성 현황을 조사 분석하고 둘째, 국내 및 해외의 도서관 건축물 공간구성 사례 수집분석하며, 셋째, 향후 신축할 국내 공공도서관 건축물을 유형별로 정의하여 공간구성에 대한 합리적인 권장모델을 개발하여 제시하고자 한다.