• The Korean Journal of Food And Nutrition
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• v.20 no.3
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• pp.259-264
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• 2007

Ginger(Zingiber officinale Roscoe) has been used as a raw material in many various traditional preparations since the ancient times. As a component of traditional health products, ginger is known to be effective as an appetite enhancer, and has anti-cold and anti-inflammatory activities. This study was performed to investigate the immunomodulative effects of Zingiber officinale Roscoe in mice, using ex vivo experiments. In order to elucidate ginger's immunomodulative effects of Ginger, water extracts were orally administered to mice, and isolated macrophages were used as the experimental model. To identify the ex vivo effects, six to seven week old Balb/c mice were fed a chow diet ad libitum and the ginger water extracts were administered orally every other day for two or four weeks at two different concentrations(50 and 500 mg/kg b.w.). The results show that IL-IO and $IFN-{\gamma}$ were detected in the 500 mg/kg b.w. supplemented group with LPS stimulation in all cases. Also, the $IFN-{\gamma}$ /IL-10 ratio ranged from 3~5 with mitogen stimulation such as Con A and LPS. In conclusion, this study suggests that ginger extracts may enhance the immune function by regulating the cytokine(IL-10 and $IFN-{\gamma}$) production capacity of activated macrophages in mice.

• Smart Structures and Systems
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• v.24 no.1
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• pp.95-110
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• 2019

The semi-active impact damper (SAID) is proposed to improve the damping efficiency of traditional passive impact dampers. In order to investigate its damping mechanism and vibration control effects on realistic engineering structures, a 20-story nonlinear benchmark building is used as the main structure. The studies on system parameters, including the mass ratio, damping ratio, rigid coefficient, and the intensity of excitation are carried out, and their effects both on linear and nonlinear indexes are evaluated. The damping mechanism is herein further investigated and some suggestions for the design in high-rise buildings are also proposed. To validate the superiority of SAID, an optimal passive particle impact damper ($PID_{opt}$) is also investigated as a control group, in which the parameters of the SAID remain the same, and the optimal parameters of the $PID_{opt}$ are designed by differential evolution algorithm based on a reduced-order model. The numerical simulation shows that the SAID has better control effects than that of the optimized passive particle impact damper, not only for linear indexes (e.g., root mean square response), but also for nonlinear indexes (e.g., component energy consumption and hinge joint curvature).

• Structural Monitoring and Maintenance
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• v.7 no.4
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• pp.367-392
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• 2020

The specific characteristics of near-field earthquake records can lead to different dynamic responses of bridges compared to far-field records. However, the effect of near-field strong ground motion has often been neglected in the seismic performance assessment of the bridges. Furthermore, damage to horizontally curved multi-frame RC box-girder bridges in the past earthquakes has intensified the potential of seismic vulnerability of these structures due to their distinctive dynamic behavior. Based on the nonlinear time history analyses in OpenSEES, this article, assesses the effects of near-field versus far-field earthquakes on the seismic performance of horizontally curved multi-frame RC box-girder bridges by accounting the vertical component of the earthquake records. Analytical seismic fragility curves have been derived thru considering uncertainties in the earthquake records, material and geometric properties of bridges. The findings indicate that near-field effects reasonably increase the seismic vulnerability in this bridge sub-class. The results pave the way for future regional risk assessments regarding the importance of either including or excluding near-field effects on the seismic performance of horizontally curved bridges.

• Journal of Microbiology and Biotechnology
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• v.32 no.3
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• pp.324-332
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• 2022

The incidence of stress-related type 2 diabetes (stress-T2D), which is aggravated by physiological stress, is increasing annually. The effects of Lactobacillus, a key component of probiotics, have been widely studied in diabetes; however, studies on the effects of postbiotics are still limited. Here, we aimed to examine the mechanism through which heat-killed Lactiplantibacillus plantarum LRCC5314 (HK-LRCC5314) alleviates stress-T2D in a cold-induced stress-T2D C57BL/6 mouse model. HK-LRCC5314 markedly decreased body weight gain, adipose tissue (neck, subcutaneous, and epididymal) weight, and fasting glucose levels. In the adipose tissue, mRNA expression levels of stress-T2D associated factors (NPY, Y2R, GLUT4, adiponectin, and leptin) and pro-inflammatory factors (TNF-α, IL-6, and CCL-2) were also altered. Furthermore, HK-LRCC5314 increased the abundance of Barnesiella, Alistipes, and butyrate-producing bacteria, including Akkermansia, in feces and decreased the abundance of Ruminococcus, Dorea, and Clostridium. Thus, these findings suggest that HK-LRCC5314 exerts protective effects against stress-T2D via gut microbiome modulation, suggesting its potential as a supplement for managing stress-T2D.

• International conference on construction engineering and project management
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• 2022.06a
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• pp.1032-1039
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• 2022

Evaluating infrastructure's impact on social equity is an emerging area of research in transportation construction engineering. Transportation agencies have been trying to include sustainable development. The three components of sustainable development are environmental protection, social equity, and economic development. Although social equity is one of the essential components of sustainable development, most transportation agencies do not consider this component. The research publications in this area are limited. The principal objective of this study is to synthesize existing studies related to the impact of transportation infrastructures on social equity. This study will also identify social equity indicators, the correlation between social equity and transportation infrastructures and their services, and the impact of transportation infrastructures' on social equity. In addition, this study will identify current issues of social equity and will provide some recommendations. This synthesis study revealed that transportation infrastructures impacted social equity in various ways. Some effects are positive, such as new job creation on the market. Other effects are adverse, such as diminishing socio-economic and environmental degradation. Studies also showed that the current practices evaluated infrastructures' impact on a case-by-case basis. The authors recommend adopting a multi-disciplinary holistic for assessing infrastructure's effects on social equity. The multi-disciplinary fields of study include civil engineers, construction engineers/managers, public policy researchers, environmentalists, and social scientists.

• Advances in concrete construction
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• v.15 no.5
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• pp.303-312
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• 2023

The present study investigates the effects of Cattaneo-Christov thermal effects of stagnation point in Walters-B nanofluid flow through lubrication of power-law fluid by taking the slip at the interfacial condition. For the solution, the governing partial differential equation is transformed into a series of non-linear ordinary differential equations. With the help of hybrid homotopy analysis method; that consists of both the homotopy analysis and shooting method these equations can be solved. The influence of different involved constraints on quantities of interest are sketched and discussed. The viscoelastic parameter, slip parameters on velocity component and temperature are analyzed. The velocity varies by increase in viscoelastic parameter in the presence of slip parameter. The slip on the surface has major effect and mask the effect of stagnation point for whole slip condition and throughout the surface velocity remained same. Matched the present solution with previously published data and observed good agreement. It can be seen that the slip effects dominates the effects of free stream and for the large values of viscoelastic parameter the temperature as well as the concentration profile both decreases.

• Asia Marketing Journal
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• v.13 no.3
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• pp.55-77
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• 2011

This study investigate the interaction effects of bundle price discount framing and message framing on consumer's attitude of bundle component. Although each effect of bundle price discount framing and message framing has been explored individually, few attempts have been made to invest them jointly. This study tests the interaction effects of bundle price discount framing and message framing on consumer's evaluation of bundle component. Moreover, this research focuses on consumer's evaluation of individual bundle component while the existing research on bundling primarily focused on consumer's evaluation of the bundle. Prior research suggests that consumers are sensitive to the framing of prices and discounts in the presentation of the bundle offer. For example, there is considerable evidence that partitioning or consolidating the prices of a bundle can influence the attractiveness of the bundle offer. Similarly, there is evidence that an equivalent price reduction to the overall bundle, one of the individual products in the bundle, or distributed among the individual products in the bundle can alter the perceived attractiveness of the offer (e.g. Chakravarti, Krish, Paul, and Srivastava 2002; Hamilton and Srivastava 2008; Janiszewski and Cunha 2004; Johnson, Herrmann and Bauer 1999; ; Morwitz, Greenleaf, and Johnson 1998; Yadav 1994; 1995). In line with these earlier research, this research suggests that the bundle type can influence the consumer's evaluation of bundle component. There are two types of bundle - mixed-leader bundle and mixed-joint bundle. In mixed-leader bundling, the price of one of the two products is discounted when the other product is purchased at the regular price. In mixed-joint bundling, a single price is set when the two product are purchased jointly. This study supposes that the teeth whitening product is the leader product in a mixed-leader bundle. So bundle price discount framing is manipulated such as "Buy the teeth whitening product (regular price \80,000) and get 50% discount on the functional toothpaste(regular price \40,000), special set price \100,000" or "Buy the functional toothpaste and the teeth whitening product as a set and get discount for the set, special set price \60,000". Message framing is manipulated through the product claims described in an advertising bill. The positive framing presents that "Over 95% of users achieved the expected 2-3 shades of improvement in two weeks" where as the negative framing presents "less than 5% of users did not achieve the expected 2-3 shades of improvement in two weeks". This study uses hypothetical brand name of the teeth whitening product and the functional toothpaste This study is based on a 2x2 factorial design with bundle discount framing (mixed-leader bundle vs. mixed-joint bundle) and massage framing (positive vs. negative). The dependant variables are consumer's perceived quality and attitude of the teeth whitening product The data reveals that two dependant variables are correlated, so the data is analyzed with two-way MANOVA. This research explores the significant interaction effect of bundle discount framing and message framing on consumer's perceived quality and attitude of the teeth whitening product. When the message framing is positive, consumer's perceived quality and attitude of the teeth whitening product is higher in mixed-leader bundle than mixed-joint bundle condition. However, when the message framing is negative, consumer's evaluation is higher in mixed-joint bundle than mixed-leader bundle. The author explains this result by stating that consumers are less likely to use heuristics such as price-quality association and value discounting hypothesis(Raghubir 2004) in the negative message framing condition. Additionally, consumer's perceived risk of the teeth whitening product in the negative message framing condition can be more reduced by the bundle partner(e.g. the toothpaste) in mixed-joint bundle than mixed-leader bundle. Based on the results, marketing managers are advised to use different bundle type based on message framing of their product.

• Journal of Yeungnam Medical Science
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• v.10 no.1
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• pp.144-156
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• 1993

This study was performed to investigate the effect of octreotide on the contractility of rat vas deferens. The smooth muscle strips isolated from the prostatic portion were myographied in isolated organ bath, Electric field stimulation (monophasic square wave, duration: 1 mSec, voltage : 50 V, frequency : 5 Hz or 30 Hz, train: 10 Sec) produced reproducible contraction. The contraction was composed of two component, first phasic component (FPC) and second tonic component (STC). These contractions were abolished by tetrodotoxin ($1{\mu}M$). Octreotide inhibited the field stimulation induced contractions both FPC and STC concentration-dependently. The FPC was decreased by a desentization of purinergic receptor by pretreatment of mATP, and the STC was decreased by pretreatment of reserpine(3 mg/kg, IP) 24 hours before experiments. Octreotide reduced the field stimulation induced contraction in the presence of mATP and of reserpinized muscle strips. The inhibitory effect of octreotide was more potent at 5 Hz than at 30 Hz. Octreotide did not affect basal ton and exogenous norepinephrine- or ATP-induced contraction. These results suggest that octreotide inhibit the contractility of the isolated rat vas deferens by inhibition of the release of neurotransmitters, both ATP and norepinephrine from adrenergic nerve terminal.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.3
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• pp.390-398
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• 2020

To solve the problem of frequent component failure in guided weapons, a process of component failure in developed countries was investigated and analyzed. The suitability of component control, including risk assessment, analysis of operational impact, and the establishment of response measures, was also demonstrated. In addition, the economic effects of component control were presented by estimating the costs incurred if component control is performed in advance, after-sales, and non-management. DMSMS problems refer to losses or impending losses of an item, raw material, or software manufacturer or supplier. A problem with the discontinuation of parts occurs when the manufacturer or supplier ceases to produce and support the necessary parts, materials, or software, or when the supply of raw materials is no longer possible. Hence, it is important to recognize that failure to all parts of the system can occur.

• Journal of Korea Spatial Information System Society
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• v.3 no.1 s.5
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• pp.27-36
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• 2001

The 4S represents four systems that are commonly related to spatial information: GIS, GNSS, SIIS, ITS. The 4S technology that integrates the four systems gets more and more interests recently. In this paper, we adopt component paradigm to 4S system, apply it to the disaster control field, and design a system based on component architecture. There are many application areas to which the 4S technology can be applied. but the disaster control system is one of the most typical fields. We apply 4S technology to the disaster control fields, including fire, flood, and typhoon. Because of the characteristics of disaster control system that handles large-volume map data, component-based 4S system will take considerable effects on the improvement of disaster control works. The core functions that are common to all disaster control fields are included in 4S kernel component because of the consideration of time performance. Remaining non-common functions are implemented as separate components named as work-specific components. In our suggested system, a vehicle named as 4S-Van collects real-time information on the spot of disaster and sends image and location information to control center via wireless transmission. The control center analyzes the information together with its own spatial database or map, which was not possible in the conventional disaster control works. The control center can get desired information by sending a request of re-transmission to 4S-Van. Such method of real-time transmission supported by on-the-spot information makes the current situation judgment, decision making, and order issuance more exact, effective, and timely. The suggested system and method are expected to bring remarkable improvement on disaster control works.