• Korean Journal of Pharmacognosy
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• v.48 no.1
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• pp.10-17
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• 2017

Ursi Fel's component ursodeoxycholic acid (UDCA), a traditional medicine, is used for the treatment of hepatic diseases. UDCA derivatives prepared by conjugation with antioxidant moiety such as maltol, sesamol, eugenol, mesitol and 3,4-(methylenedeoxy)aniline were expected to have various biological activity caused by synergistic effect of UDCA. Therefore, in this study, it was conducted the study of the manufacture of the UDCA derivatives and their biological activity. As a result, UDCA derivatives showed weak antioxidant activity in TBA method in vitro compared to original agents. SJ-505, SJ-502 and SJ-504 showed the effect of reducing ALT, AST, sorbitol dehydrogenase and ${\gamma}-glutamyltransferase$ in $CCl_4-induced$ liver injury experiment in vivo, even if the effects are weaker than UDCA and silymarin of the control group.

• 한국신재생에너지학회:학술대회논문집
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• 2006.11a
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• pp.447-450
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• 2006

Hydrogen separation from multi-component mixture gases by the four-bed PSA process was studied experimentally and theoretically using layered bed of activated carbon and zeolited 5A. Effects of the adsorption time, the linear velocity on the process performance were investigated. The adsorption time and linear velocity affected the purity and recovery of the product $H_2$ purity is increases according as the adsorption time and linear velocity decrease; however, $H_2$ recovery shows an opposite phenomena to the purity. PSA process simulation studied to find optimum operation condition. In the results, 50sec adsorption time, 3cm/s linear velocity might be optimal values to obtain more than 99.999% purity and 65% recovery hydrogen.

• Journal of Microbiology and Biotechnology
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• v.15 no.4
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• pp.740-744
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• 2005

Bifidobacterium has been previously shown to potentiate immune function, which was mediated through the stimulation of cytokine production by macrophage. This study was performed to further characterize the effective component of Bifidobacterium by measuring the level of interleukin (IL)-6 cytokine using the RAW 264.7 murine cell line as a macrophage model. RAW 264.7 cells were cultured for 24 h in the presence of whole cells (WCs), cell walls (CWs), and cell-free extracts (CFEs) from various strains of Bifidobacterium and other lactic acid bacteria at various concentrations. The most effective component was different depending on the strains and the concentrations used. When tested with each cell fraction from Bifidobacterium sp. BGN4, heat treatment of the cell fractions lowered the production of IL-6. Synergistic effect was obtained, especially when CWs and CFEs were combined. Sonicated WCs stimulated IL-6 production more than intact WCs. The in vitro approaches employed here should be useful in further characterization of the effects of Bifidobacterium on gastrointestinal and systemic immunity.

• Journal of Electrical Engineering and Technology
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• v.12 no.4
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• pp.1657-1662
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• 2017

Facial expression recognition systems using video devices have emerged as an important component of natural human-machine interfaces which contribute to various practical applications such as security systems, behavioral science and clinical practices. In this work, we present a new method to analyze, represent and recognize human facial expressions using a sequence of facial images. Under our proposed facial expression recognition framework, the overall procedure includes: accurate face detection to remove background and noise effects from the raw image sequences and align each image using vertex mask generation. Furthermore, these features are reduced by principal component analysis. Finally, these augmented features are trained and tested using Hidden Markov Model (HMM). The experimental evaluation demonstrated the proposed approach over two public datasets such as Cohn-Kanade and AT&T datasets of facial expression videos that achieved expression recognition results as 96.75% and 96.92%. Besides, the recognition results show the superiority of the proposed approach over the state of the art methods.

• Smart Structures and Systems
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• v.22 no.1
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• pp.57-70
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• 2018

For the long-term structural health monitoring of civil structures, the effect of ambient temperature variation has been regarded as one of the critical issues. In this study, a principal component analysis (PCA)-based algorithm is proposed to filter out temperature effects on electromechanical impedance (EMI) monitoring of prestressed tendon anchorages. Firstly, the EMI monitoring via a piezoelectric interface device is described for prestress-loss detection in the tendon anchorage system. Secondly, the PCA-based temperature filtering algorithm tailored to the EMI monitoring of the prestressed tendon anchorage is outlined. The proposed algorithm utilizes the damage-sensitive features obtained from sub-ranges of the EMI data to establish the PCA-based filter model. Finally, the feasibility of the PCA-based algorithm is experimentally evaluated by distinguishing temperature changes from prestress-loss events in a prestressed concrete girder. The accuracy of the prestress-loss detection results is discussed with respect to the EMI features before and after the temperature filtering.

• Journal of Nutrition and Health
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• v.36 no.8
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• pp.828-833
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• 2003

Dially disulfide (DADS), a component of garlic (Allium sativum), has been known to exert potent chemopreventive activity against various cancers. In this study, the synergistic effect of DADS and daunorubicin on the cytotoxicity of HL-60 cells, a human leukemia cell line, was investigated. DADS at 25 M greatly potentiated daunorubicin-induced cell death, decreasing cell viabilityto50%ofthe control. Daunorubicin-induced apoptosis was accompanied by the activation of caspase-3, the degradation of poly-(ADP-ribose) polymerase (PARP) and D4-GDI, and DNA fragmentation, which were blocked by pre-treatment with acetyl-Asp-Glu-Val-Asp- dialdehyde (Ac-DEVD-CHO). Treatment that combined 25 M DADS and 100 nM daunorubicin caused a similar degree of caspase-3 activation, PARP and D4-GDI degradation, and DNA fragmentation to that caused by treatment with 250 nM daunorubicin alone. These results indicate that combined therapy using daunorubicin with DADS, a component of food, and garlic can effectively decrease the therapeutic dose of daunorubicin, preventing the severe side effects of daunorubicin.

• Journal of the Korean Society of Systems Engineering
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• v.12 no.1
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• pp.41-58
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• 2016

Reliability Centered Maintenance (RCM) introduces a systematic method and decision logic tree for utilizing previous operating experience focused on reliability and optimization of maintenance activities. In this paper RCM methodology is applied on safety injection system for APR-1400. Functional Failure Mode Effects and Criticality Analysis (FME&CA) are applied to evaluate the failure modes and the effect on the component, system and plant. Logic Tree Analysis (LTA) is used to determine the optimum maintenance tasks. The results show that increasing the condition based maintenance will reduce component failure and improve reliability and availability of the system. Also the extension of the surveillance test interval of Safety Injection Pumps (SIPs) would lead to an improved pump's availability, eliminate the unnecessary maintenance tasks and this will optimize maintenance activities.

• Progress in Superconductivity
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• v.6 no.1
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• pp.37-40
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• 2004

We investigated the effects of impurity doping on the electrical transport and magnetic properties of TEX>$(Ru, Sn)(Sr, La)<_2$$EuCeCu_2$$O_{z}$ samples. We found that Sn substitution fur Ru causes a significant decrease of the volume fraction of ferromagnetic phase, as well as a decrease of the temperature where the ferromagnetic component is observed. La substitution for Sr leads to an increase of the magnetic ordering temperature with a moderate change of ferromagnetic component. The experimental results are discussed in conjunction with the structural data, transport properties and a possible change of oxygen content.

• International Journal of Naval Architecture and Ocean Engineering
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• v.9 no.6
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• pp.677-692
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• 2017

A numerical approach based on a potential flow method is developed to simulate the unsteady interaction between propeller and rudder. In this approach, a panel method is used to solve the flow around the rudder and a vortex lattice method is used to solve the flow around the propeller, respectively. An iterative procedure is adopted to solve the interaction between propeller and rudder. The effects of one component on the other are evaluated by using induced velocities due to the other component at every time step. A fully unsteady wake alignment algorithm is implemented into the vortex lattice method to simulate the unsteady propeller flow. The Rosenhead-Moore core model is employed during the wake alignment procedure to avoid the singularities and instability. The Lamb-Oseen vortex model is adopted in the present method to decay the vortex strength around the rudder and to eliminate unrealistically high induced velocity. The present methods are applied to predict the performance of a cavitating horn-type rudder in the presence of a 6-bladed propeller. The predicted cavity patterns compare well with those observed from the experiments.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2003.10b
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• pp.40-42
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• 2003

The aim of this paper is to illustrate which factors influence the martensite grain fineness made by subsequently surface carburizing of extruded component. The effects of surface decarburizing by annealing, residual stress, initial microstructure and crystal oriental made by forward extrusion were taken into account. The available evidence suggests that the residual stress inside crystal or the crystal orientation is the main factor that results coarse martensite while cold extruded component was treated by carburizing.