• BMB Reports
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• 제30권5호
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• pp.362-369
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• 1997

Multiple phosphorylation of the carboxy-terminal domain (CTD) of the largest subunit in RNA polymerase II (RNAP II) is thought to play an important role in the transcription cycle. The preinitiation complex in a partially purified complete transcription system suggested that RNA polymerase IIA containing unphosphorylated CTD is involved in complex assembly, whereas RNA polymerase IIO containing Ser and Thr phosphorylated CTD is not involved in preinitiation complex assembly. Recently a minimal transcription system was developed which requires chemically defined minimal components for its transcription: TBP, TFIIB, TFIIF, RNAP II and a supercoiled adenovirus-2 major late promoter (Ad-2 MLP). It would be using interesting to determine the consequence of CTD phosphorylation on preinitiation complex formation using the minimal transcription system. Contrary to the results from the partially purified complete transcription system, both RNA polymerase IIA and IIO are equally recruited in the preinitiation complex formation. The discrepancy may result from the two different assays used to determine complex formation, the use of chemically undefined complete and defined minimal transcription systems. This implicates that some factors in the complete transcription system are involved in the distinction between RNAP IIA and IIO in complex assembly. In addition multiple tyrosine phosphorylation of the CTD of RNAP II was prepared with c-Abl kinase and its recruiting ability in the preinitiation complex was examined. Compare with Ser and Thr phosphorylated RNAP IIO, Tyr phosphorylated RNAP IlOy forms a stable preinitiation complex in both the minimal and complete transcription systems. Based on these results, it seems that tyrosine phosphorylation of the CTD is important in the transcription cycle on the special subset of class-II promoter or has a different role in the transcription process.

• 대한안전경영과학회지
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• 제14권3호
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• pp.1-10
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• 2012

Recently, we have witnessed the definitely negative impacts of large-scale accidents happened in such areas as atomic power plants and high-speed train systems, which result in increased fear for the potential danger. The problems appear to arise due to the deficiency in the design of large-scale complex systems. One of the causes can be attributed to the design process that does not fully reflect the safety requirements in the early stage of the system development because of the substantially increased complexity. In this paper, to enhance the systems safety an integrated process is studied, which considers simultaneously both the system design process and system safety process from the beginning of the system development. In the conceptual system design phase an integrated process model is constructed by analyzing the activities of both the system design and safety processes. As a case study example, an inner city train system is described with the application of the developed process. The computer simulation of the example case is followed by the result discussed. The results obtained in the paper are expected to be the basis for the future study where a detailed process and its associated activities can be developed.

• 시스템엔지니어링학술지
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• 제8권2호
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• pp.27-36
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• 2012

In modern systems, the operational capability of the system to the user needs is expanding rapidly to accommodate the size of the system, functionality, and interfaces are becoming increasingly complex. Accordingly, the systematic practice of project management and systems engineering in the system development process, as an important element in successful systems development is recognized. EIA/ANSI 632, ISO/IEC15288, the leading international standard for systems engineering and is the leading international standard on project management PMBOK. CMMI is also contains information about the activities of project management and systems engineering and worldwide basis to assess the maturity of an organization's ability to develop system being used. But CMMI model is too complex of structure and there are many overlap parts of contents. So there are many problems for members of organization understanding all of CMMI model, applying organization and, achieving improvement activity. In this study, through the analysis and integration between the model and the related standard coverage activities essential for successful systems development in organizations that require systems engineering and project management capabilities(SEPMC) for self-assessment and continuous improvement activities to provide useful reference guideline.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2002년도 ICCAS
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• pp.94.5-94
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• 2002

The current study of complex dynamical networks is pervading all kinds of sciences today, ranging from physical to biological, even to social sciences. its impact on modern engineering and technology is prominent and will be far-reaching. Typical complex dynamical networks include the World Wide Web, the Internet, various wireless communication networks, meta-bolic networks, biological neural networks, social connection networks, scientific cooperation and citation networks, and so on. Research on fundamental properties and dynamical features of such complex networks have become overwhelm ing. This talk will provide a brief overview of some basic concepts about com plex dynamical netwo...

• 한국지능시스템학회논문지
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• 제11권4호
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• pp.336-339
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• 2001

오존농도 메커니즘은 매우 복잡하고, 비선형성과 비정상성이 강하기 때문에 오존 예보시스템들은 많은 문제점을 가지고 있다. 특히 고농도 오존에 있어서 예측결과들이 성능이 좋지 않다. 본 논문은 뉴로-퍼지기법과 퍼지 클러스터링을 이용한 오존 예측시스템의 모델링 방법을 설명하고자 한다. GMDH의 전형적인 알고리즘에 기초한 동적 다항식 신경망은 데이터 분석, 비선형적이고 복잡한 시스템의 검증 그리고 동적 시스템의 예측을 위한 유용한 방법이다.

• Journal of Biosystems Engineering
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• 제24권5호
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• pp.415-424
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• 1999

This study was conducted to assess performances of the developed environmental control systems under various seasons of Korea. In all trials for the environmental control systems, the manure pit ventilation system in the windowless pig-housing with partly slatted floor was used. Consequently, under all seasons of Korea, the complex environmental control systems could comfortably maintain the indoor temperature (14.8~27.2$^{\circ}C$) , concentrations of noxious gases (CO2 gas : 631~1,874ppm, NH3 gas : 0.3~3.2ppm), air velocity (0.11~0.23m/s), air movement, and so on. Therefore, the performances of the complex environmental control systems were evaluated as proper as the intended.

• 제어로봇시스템학회논문지
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• 제2권1호
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• pp.53-59
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• 1996

An automatic verification method has been studied to determine the safety and operability of programmable logic controller (PLC) based systems. For the systematic and efficient verification, we have developed a conversion method from relay ladder logic (RLL) to the verification system description. RLL is a common representation used to document PLC programs for the sequential logic of the system such as the safety interlocks and the startup/shutdown procedures. Once the modules are developed, complex RLLs can be represented by the combination of modules. As a result we can verify complex PLC systems using the verification method including RLL modules. The developed modules are used to verify alarm systems and show that the method is valid.

• 대한수학회논문집
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• 제30권3호
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• pp.253-267
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• 2015

Given a complex submanifoldM of the projective space $\mathbb{P}$(T), the hyperplane system R on M characterizes the projective embedding of M into $\mathbb{P}$(T) in the following sense: for any two nondegenerate complex submanifolds $M{\subset}\mathbb{P}$(T) and $M^{\prime}{\subset}\mathbb{P}$(T'), there is a projective linear transformation that sends an open subset of M onto an open subset of M' if and only if (M,R) is locally equivalent to (M', R'). Se-ashi developed a theory for the differential invariants of these types of systems of linear differential equations. In particular, the theory applies to systems of linear differential equations that have symbols equivalent to the hyperplane systems on nondegenerate equivariant embeddings of compact Hermitian symmetric spaces. In this paper, we extend this result to hyperplane systems on nondegenerate equivariant embeddings of homogeneous spaces of the first kind.

• 한국지능시스템학회논문지
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• 제10권5호
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• pp.442-448
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• 2000

전통적인 동적 시스템의 제어에는 제어대상의 정확한 수학적 모델링이 필요하다. 그러나 동적 시스템의 모델링은 복잡한 상태방정식과 많은 제어파라메터들에 의해 매우 복잡한 계산과정을 필요로 한다. 그러므로, 본 논문에서는 신경회로망을 이용한 동적 시스템의 상태 공간 인식 모델을 제안하였으며, 제안된 신경회로망을 학습시키기 위하여 가우스-뉴턴 방법을 사용하였다. 본 논문에서 제안된 신경회로망 모델은 시소 시스템 인식문제를 컴퓨터 모이실험을 통해 효과적임을 보였다.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 추계학술대회 논문집
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• pp.1913-1919
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• 2007

Substantive provisions of the concept of an estimation and safety of complex technical systems are envisaged. New problems are assume orientation to use of the formalized methods of an estimation of residual resources of reliability of objects, and also development of other methodological base in creation of complex technical systems that is connected with detailed elaboration of attention to a safety at all stages of creation of systems: from designing until operation. In this connection existing large objects should be provided by the developed systems of engineering monitoring and diagnostics.