• Molecular & Cellular Toxicology
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• 제3권3호
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• pp.208-213
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• 2007

With the help of a development and popularization of microarray technology that enable to us to simultaneously investigate the expression pattern of thousands of genes, the toxicogenomics experimenters can interpret the genome-scale interaction between genes exposed in toxicant or toxicant-related environment. The ultimate and primary goal of toxicogenomics identifies functional context among the group of genes that are differentially or similarly coexpressed under the specific toxic substance. On the other side, public reference databases with transcriptom, proteom, and biological pathway information are needed for the analysis of these complex omics data. However, due to the heterogeneous and independent nature of these databases, it is hard to individually analyze a large omics annotations and their pathway information. Fortunately, several web sites of the public database provide information linked to other. Nevertheless it involves not only approriate information but also unnecessary information to users. Therefore, the systematically integrated database that is suitable to a demand of experimenters is needed. For these reasons, we propose SOP (Search of Omics Pathway) database system which is constructed as the integrated biological database converting heterogeneous feature of public databases into combined feature. In addition, SOP offers user-friendly web interfaces which enable users to submit gene queries for biological interpretation of gene lists derived from omics experiments. Outputs of SOP web interface are supported as the omics annotation table and the visualized pathway maps of KEGG PATHWAY database. We believe that SOP will appear as a helpful tool to perform biological interpretation of genes or proteins traced to omics experiments, lead to new discoveries from their pathway analysis, and design new hypothesis for a next toxicogenomics experiments.

• 에너지공학
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• 제25권1호
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• pp.131-144
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• 2016

최근 기후변화로 인해 전 세계적인 지구온난화 피해가 심각해지면서 주요원인인 온실가스에 대한 배출 규제가 확대되고 있다. 그 중 온실가스 배출량의 약 25%를 차지하는 건물분야에 대해 정부에서는 2020년까지 BAU 대비 26.9%까지 감축하겠다는 목표를 발표하였다. 이를 달성하기 위해 건물부문의 에너지 수요를 원천적으로 저감하는 녹색건축물 활성화 방안을 추진하고 있다. 하지만 녹색건축물 활성화의 상세 이행계획 수립 및 관리, 그리고 시행에 따른 효과를 분석하기 위해서는 건물 에너지 사용량에 대한 데이터 및 관련 통계 자료가 필수적이다. 이를 위해 정부는 전국 680만동의 건물에서 사용되는 에너지 정보를 통합 관리할 수 있는 국가 건물에너지 통합관리시스템을 구축하였다. 하지만 현재 구축된 국가 건물에너지 통합관리시스템의 Database는 건축물대장 정보와 공급기관의 에너지정보를 매칭해서 사용하기 때문에 수동으로 작업이 이루어지고 있으며, 이로 인해 많은 문제들이 발생한다. 따라서 Database의 신뢰성을 확보하기 위해서는 지속적인 고도화 작업이 이루어져야 한다. 본 과제는 현재 가동 중인 국가 건물에너지 통합관리시스템의 Database를 분석하여, 시스템의 한계 및 개선방안 도출하고, 이를 통해 데이터의 신뢰성 확보 및 활용성을 증대 시키고자 하였다. 구축된 Database 분석 결과 건축물 정보와 에너지정보가 매칭된 유효데이터는 평균 85.6%이고, 미매칭된 데이터는 평균 14.4%로 나타났다. 미매칭된 데이터는 다시 건물 특성에 따른 미매칭 유형을 분석하였으며, 그 결과 건축물 정보가 없는 경우가 전체의 58.2%에 달했다. 따라서 향후 신규 구축 data의 매칭 작업 용이성 및 현재 Database에 대한 정확성 확보하기 위해서는 건축물 정보와 에너지정보 간의 주소 표준화 및 속성정보 체계를 마련할 필요가 있다. 또한 비도시지역 및 영세한 주거지역에서 사용비중이 높은 석유류 에너지원 및 향후 발전 가능성 및 활용 가능성이 높은 신재생 에너지와 같이 다른 에너지원에 대한 정보를 포함시킬 수 있도록 시스템 구축이 필요할 것으로 사료된다.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2003년도 제2차 연례학술대회 발표논문집
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• pp.66-72
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• 2003

Toxicogenomics is now emerging as one of the most important genomics application because the toxicity test based on gene expression profiles is expected more precise and efficient than current histopathological approach in pre-clinical phase. One of the challenging points in Toxicogenomics is the construction of intelligent database management system which can deal with very heterogeneous and complex data from many different experimental and information sources. Here we present a new Toxicogenomics database developed as a part of 'Toxicogenomics for Efficient Safety Test (TEST) project'. The TEST database is especially focused on the connectivity of heterogeneous data and intelligent query system which enables users to get inspiration from the complex data sets. The database deals with four kinds of information; compound information, histopathological information, gene expression information, and annotation information. Currently, TEST database has Toxicogenomics information fer 12 molecules with 4 efficacy classes; anti cancer, antibiotic, hypotension, and gastric ulcer. Users can easily access all kinds of detailed information about there compounds and simultaneously, users can also check the confidence of retrieved information by browsing the quality of experimental data and toxicity grade of gene generated from our toxicology annotation system. Intelligent query system is designed for multiple comparisons of experimental data because the comparison of experimental data according to histopathological toxicity, compounds, efficacy, and individual variation is crucial to find common genetic characteristics .Our presented system can be a good information source for the study of toxicology mechanism in the genome-wide level and also can be utilized fur the design of toxicity test chip.

• Journal of Multimedia Information System
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• 제7권2호
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• pp.175-188
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• 2020

The paper focuses on conception and development of complex systems composed mainly by a pump syringe subsystem and an electronically injector that facilitates patients saving data operation for medical staff use. We successfully developed conventional approaches for medical system staff requirements, such as system boundary conditions. Decisions at a given level are studied. We propose a complex system architecture, based mainly on patients collected data and ordered stepper injection parameters. System is successfully simulated and prototyped. Design and implement tests are accomplished, the proposed system ensures both the electric syringe pump and the electric injector operation. In addition, this new system introduces several additional options as patient database development and automation injection operation. Development and software operating tests to create a visualization control interface are validated. The solution performs syringe function and electronic injector. User can manage a syringe in two C modes of technology. We propose a program composed of two linked parts. If an error such radiologist bad target selection is made, an image with lower intrinsic quality emerges. Developed Shoot syringe different electronic cards are simulated and prototyped, in addition, maps are driven, prototype. All tests results are accomplished.

• Interdisciplinary Bio Central
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• 제4권4호
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• pp.13.1-13.6
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• 2012

The advanced glycation endproducts receptor (AGER) is a multiligand signal transduction receptor. One of its ligands, S100b molecules activates vascular smooth muscle cells and endothelial cells via its receptor, thus triggering activation of signaling cascades and generation of cytokines and proinflammatory molecules. Ubiquitin-conjugating enzyme Ubc9 is an E2 conjugating enzyme that transfers the activated small ubiquitin-related modifier to protein substrates, and thus it plays a critical role in SUR-Mylation-mediated cellular pathways. Previous studies have shown that both AGE-R and Ubc9 play roles in diverse cellular signaling pathways. However, until recently, little attention has been paid to interactions between AGE-R and Ubc9. In this study, sequence database searches allowed us to identify a potential interaction motif between AGE-R and Ubc9. The subsequent biochemical and molecular biological analysis suggested that there may be specificity in AGE-R and Ubc9 complex signaling in atherosclerosis and cancer cells in a cell-type specific manner. Although the determinant for specificity in AGE-R and Ubc9 complex signaling in cancer cells and atherosclerosis is yet to be determined, this study provides the basis to develop a specific therapeutic application of AGE-R, SURM (small ubiquitin-related modifier)-1, and Ubc9 complex activation pathways in atherosclerosis, diabetes, cancer and inflammatory diseases.

• Journal of Ecology and Environment
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• 제34권3호
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• pp.323-331
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• 2011

Biodiversity and the community composition of micro-eukaryotic organisms were investigated in the Upo wetland in Korea using molecular analysis. Molecular identification was performed using cytochrome oxidase I (COI) and small subunit ribosomal DNA (SSU rDNA). The genomic DNA was isolated directly from soil samples. The COI and SSU rDNA regions were amplified using universal primers and then sequenced after cloning. In a similarity search of the obtained sequences with BLAST in the Genbank database, the closely related sequences from NCBI were used to identify the amplified sequences. A total of six eukaryotic groups (Annelida, Arthropoda, Rotifera, Chlorophyta, Bacillariophyta, and Stramenopiles) with COI and six groups (Annelida, Arthropoda, Rotifera, Alveolata, Fungi, and Apicomplexa) with SSU rDNA genes were determined in the Upo wetland. Among 38 taxa in 20 genera, which are closely related to the amplified sequences, 10 genera (50%) were newly reported in Korea and five genera (25%) were shown to be distributed in the Upo wetland. This approach is applicable to the development of an efficient method for monitoring biodiversity without traditional taxonomic processes and is expected to produce more accurate results in depositing molecular barcode data in the near future.

• 디지털산업정보학회논문지
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• 제7권1호
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• pp.1-9
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• 2011

In this paper, Wireless sensor network technology applied to various greenhouse agro-industry items such as horticulture and local specialty etc., we was constructed automatic control system for optimum growth environment by measuring growth status and environmental change. existing monitoring systems of greenhouse gather information about growth environment depends on the temperature. but in this system, Can be efficient collection and control of information to construct wireless sensor network by growth measurement sensor and environment monitoring sensor inside of the greenhouse. The system is consists of sensor manager for information processing, an environment database that stores information collected from sensors, the GUI of show the greenhouse status, it gather soil and environment information to soil and environment(including weather) sensors, growth measurement sensor. In addition to support that soil information service shows the temperature, moisture, EC, ph of soil to user through the interaction of obtained data and Complex Growth Environment information service for quality and productivity can prevention and response by growth disease or disaster of greenhouse agro-industry items how temperature, humidity, illumination acquiring informationin greenhouse(strawberry, ginseng). To verify the executability of the system, constructing the complex growth environment measurement system using wireless sensor network in greenhouse and we confirmed that it is can provide our optimized growth environment information.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집B
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• pp.42-47
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• 2001

Analyzing the ECG signal, we can find heart disease, for example, arrhythmia and myocardial infarction, etc. Particularly, detecting arrhythmia is more important, because serious arrhythmia can take away the life from patients within ten minutes. In this paper, we would like to introduce the signal processing for ECG analysis and the device made for wireless communication of ECG data. In the signal processing, the wavelet transform decomposes the ECG signal into high and low frequency components using wavelet function. Recomposing the high frequency bands including QRS complex, we can detect QRS complex and eliminate the noise from the original ECG signal. To recognize the ECG signal pattern, we adopted the polynomial approximation partially and statistical method. The ECG signal is divided into small parts based on QRS complex, and then, each part is approximated to the polynomials. Comparing the approximated ECG pattern with the database, we can detect and classify the heart disease. The ECG detection device consists of amplifier, filters, A/D converter and RF module. After amplification and filtering, the ECG signal is fed through the A/D converter to be digitalized. The digital ECG data is transmitted to the personal computer through the RF transceiver module and serial port.

• 한국표면공학회지
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• 제43권2호
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• pp.111-120
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• 2010

In this study, the effects of multi-complex agents addition on characteristics of electroless Ni plating solution are investigated. The species and the concentration of complexing agents are major factors to control the deposition rate, P concentration, and surface morphology of plating films. Adipic acid increases the deposition rate in regardless of single- or mutli-complex agent addition. However, lactic acid effectively increases the deposition rate in case of multi-addition as the complex agents with adipic or sodium succinate acid. In addition, sodium citric acid and malic acid show good stabilizing effects of plating solution and lowering the deposition rate, because they have high complexibility. Therefore, it is suggested that the development of Ni-P plating solution suitable for diverse usages can be carried out systematically using the database from this study.

• 한국태양에너지학회 논문집
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• 제31권3호
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• pp.29-35
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• 2011

This study draws economic expense factors according to the influence of generation resulted from slipstream and the arrangement of the complex when arranging and designing the complex for offshore windpower development as a model of 50MW offshore wind farm and conducts economics analysis. According to the result of the analysis, O (Optimize) arrangement was the one that has the highest generation for having the best windpower resources in terms of design and being least affected by slipstream; however, the arrangement requires expensive submarine cables and high installation cost. Therefore, according to the analysis of economics, it was thought that 50MW complex should have less economics as BC ratio 0.95 than the series arrangement of main wind direction and I+80 series arrangement would be rather more economical. This economics evaluation provides comparison according to the arrangement of the development complex considering the uncertainty of the electricity price and gross construction cost. And it is expected that the result of economics evaluation would greatly differ by installation capacity, and the reason is that the cost of electric infrastructure takes up a higher portion than the gross construction cost of the development complex. The only way to compensate this part is to make the windpower development complex larger. It seems that it will be necessary to enhance spot applicability to evaluate economics afterwards and pay consistent attention to and conduct follow-up research on the economics evaluation of the complex construction.