• Journal of The Korean Society of Agricultural Engineers
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• v.62 no.3
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• pp.95-107
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• 2020

The failures of the agricultural reservoirs that most have more than 50 years, have increased due to the abnormal weather and localized heavy rains. There are many studies on the prediction of damage from reservoir collapse, however, these referenced studies focused on evaluating reservoir collapse as single unit and applyed to one and two dimensional hydrodynamic model to identify the fluid flow. This study is to estimate failure probability of spillway, sliding, bearing capacity and overflowing targeting small and medium scale agricultural reservoirs. In addition, we calculate failure probability by complex mode. Moreover, we predict downstream flood damage by reservoir failure applying three dimensional hydrodynamic model. When the reservoir destroyed, the results are as follows; (1) the flow of fluid proceeds to same stream direction and to a lower slope by potential and kinetic energy; (2) The predicted damage in downstream is evaluated that damage due to building destruction is the highest.

• Earthquakes and Structures
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• v.9 no.5
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• pp.957-981
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• 2015

Earthquakes occur as a cluster in many regions around the world where complex fault systems exist. The repeated shaking usually induces accumulative damage to affected structures. Damage accumulation in structural systems increases their level of degradation in stiffness and also reduces their strength. Many existing analytical tools of modeling RC structures lack the salient damage features that account for stiffness and strength degradation resulting from repeated earthquake loading. Therefore, these tools are inadequate to study the response of structures in regions prone to multiple earthquakes hazard. The objective of this paper is twofold: (a) develop a tool that contains appropriate damage features for the numerical analysis of RC structures subjected to more than one earthquake; and (b) conduct a parametric study that investigates the effects of multiple earthquakes on the response of RC moment resisting frame systems. For this purpose, macroscopic constitutive models of concrete and steel materials that contain the aforementioned damage features and are capable of accurately capturing materials degrading behavior, are selected and implemented into fiber-based finite element software. Furthermore, finite element models that utilize the implemented concrete and steel stress-strain hysteresis are developed. The models are then subjected to selected sets of earthquake sequences. The results presented in this study clearly indicate that the response of degrading structural systems is appreciably influenced by strong-motion sequences in a manner that cannot be predicted from simple analysis. It also confirms that the effects of multiple earthquakes on earthquake safety can be very considerable.

• Smart Structures and Systems
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• v.20 no.6
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• pp.669-682
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• 2017

The normalised version of bispectrum, the so-called bicoherence, has often proved a reliable method of damage detection on engineering applications. Indeed, higher-order spectral analysis (HOSA) has the advantage of being able to detect non-linearity in the structural dynamic response while being insensitive to ambient vibrations. Skewness in the response may be easily spotted and related to damage conditions, as the majority of common faults and cracks shows bilinear effects. The present study tries to extend the application of HOSA to damage localisation, resorting to a neural network based classification algorithm. In order to validate the approach, a non-linear finite element model of a 4-meters-long cantilever beam has been built. This model could be seen as a first generic concept of more complex structural systems, such as aircraft wings, wind turbine blades, etc. The main aim of the study is to train a Neural Network (NN) able to classify different damage locations, when fed with bispectra. These are computed using the dynamic response of the FE nonlinear model to random noise excitation.

• Journal of the Earthquake Engineering Society of Korea
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• v.7 no.4
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• pp.89-95
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• 2003

In this paper, an algorithm to locate and size damage in a complex truss structure using the time domain response is presented. Sampled response data for specific time interval is spatially expanded over the structure to obtain the mean train energy for each element of the structure. The mean strain energy for each element is, in turn, used to build a damage index that represents the ratio of the stiffness parameter of the pre-damaged to the post-damaged structure. The validity of the methodology is demonstrated using data from a numerical example of a space truss structure with simulated damage. Also in the example, the effects of noisy data on the proposed algorithm are examined by adding random noised to the response data.

• Archives of Pharmacal Research
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• v.27 no.11
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• pp.1161-1167
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• 2004

Adriblastina, a cancerostatic anthracycline antibiotic, causes considerable oxidative damage to DNA molecules. The interaction of this compound with DNA was investigated using Osteryoung square wave stripping voltammetry (OSWSV) and cyclic voltammetry (CV) at an in situ mercury film electrode. It was found that the equilibrium constant of the bonded oxidized form of the drug was 63 times bigger more important than that of the bonded reduced form. Copper forms 1 metal: 2 drug stoichiometry complex which is highly stable compared to ssDNA-drug interaction and consequently inhibited the drug biochemical damaging effects. Copper complex offered sub-nanogram determination of adriblastina in aqueous and urine media.

• Structural Engineering and Mechanics
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• v.7 no.6
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• pp.575-588
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• 1999

A boundary element method is applied to the analysis of crack trajectory in materials with complex microstructure, such as discontinuously reinforced composite materials, and systems subjected to complex loading, such as indentation. The path followed by the crack(s) has non-trivial geometry. A study of the stress intensity factors and fracture toughness of such systems must therefore be accompanied by an analysis of crack trajectory. The simulation is achieved using a dual boundary integral method in planar problems, and a single boundary integral method coupled with substructuring in axisymmetric problems. The direction of crack propagation is determined using the maximum mechanical energy release rate criterion. The method is demonstrated by application to (i) a composite material composed of components having the elastic properties of aluminium (matrix) and silicon carbide (reinforcement), and (ii) analysis of contact damage induced by the action of an indenter on brittle materials. The chief advantage of the method is the ease with which problems having complex geometry or loading (giving rise to complex crack trajectories) can be treated.

• Safety and Health at Work
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• v.15 no.2
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• pp.236-241
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• 2024

Background: Gasoline, a complex mixture of volatile organic compounds is classified as possibly carcinogenic to humans. Gasoline station attendants, consistently exposed to its hazardous components, may face genotoxic effects. This study aimed to assess the influence of varying work shift durations on DNA damage in gasoline station attendants. Methods: Ninety individuals from three locations in southern México were studied. Peripheral blood mononuclear cells (PBMCs) were isolated, and DNA damage was assessed using the comet assay. Demographic, occupational, and lifestyle data were collected. Statistical analyses included t-tests, ANOVA, and Pearson correlation. Results: Significant differences in DNA damage parameters were observed between exposed and unexposed groups. The impact of tobacco, alcohol, and exercise on DNA damage was negligible. Extended work shifts (12 and 24 hours) showed heightened DNA damage compared to 8-hour shifts and the unexposed group. A novel finding revealed a modest but significant correlation between DNA damage and job seniority. Conclusion: The study highlights the intricate relationship between occupational exposure to gasoline components, DNA damage, and work shift lengths. Extended shifts correlate with heightened genotoxic effects, emphasizing the importance of personalized safety measures. The significant correlation between DNA damage and job seniority introduces occupational longevity as a determinant in the genetic health of gasoline station attendants. This discovery has implications for implementing targeted interventions and preventive strategies to safeguard workers' genetic integrity throughout their years of service. The study calls for further exploration of unconsidered factors in understanding the multifactorial nature of DNA damage in this occupational setting.

• International Journal of Aeronautical and Space Sciences
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• v.18 no.2
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• pp.290-299
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• 2017

Reconfigurable flight control using various kinds of adaptive control methods has been studied since the 1970s to enhance the survivability of aircraft in case of severe in-flight failure. Early studies were mainly focused on the failure of actuators. Recently, studies of reconfigurable flight controls that can accommodate complex damage (partial wing and tail loss) in conventional aircraft were reported. However, the partial wing loss effects on the aerodynamics of conventional type aircraft are quite different to those of BWB(blended wing body) aircraft. In this paper, a reconfigurable flight control algorithm was designed using a direct model reference adaptive method to overcome the instability caused by a complex damage of a BWB aircraft. A model reference adaptive control was incorporated into the inner loop rate control system enhancing the performance of the baseline control to cope with abrupt loss of stability. Gains of the model reference adaptive control were polled out using the Liapunov's stability theorem. Outer loop attitude autopilot was designed to manage roll and pitch of the BWB UAV as well. A 6-DOF dynamic model was built-up, where the normal flight can be made to switch to the damaged state abruptly reflecting the possible real flight situation. 22% of right wing loss as well as 25% loss for both vertical tail and rudder control surface were considered in this study. Static aerodynamic coefficients were obtained via wind tunnel test. Numerical simulations were conducted to demonstrate the performance of the reconfigurable flight control system.

• Composites Research
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• v.20 no.5
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• pp.56-63
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• 2007

An approach using complex potentials is presented for analysis of composite plate with an elliptical hole or a rectilinear crack. Composite structure is susceptible to encounter impact damages, which lead to considerable decrease in its residual strength. Such impact damages could be modeled as an equivalent elliptical hole or notch-like crack. Even though finite element method is widely used to analyze stresses or fracture mechanics parameters around such damage, it is tedious to make successive FE-modeling for damage tolerance assessment under fatigue loadings. In this point of view, the solutions based on complex potentials are very simple and easy to use. The computed results are also compared and discussed with those from FEA.

• Nutrition Research and Practice
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• v.18 no.5
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• pp.587-601
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• 2024

BACKGROUND/OBJECTIVES: UV radiation is a major factor contributing to DNA damage in skin cells, including stem cells and mesenchymal stem cells, leading to the depletion of these crucial cells. This study examined whether a mixture of Indian gooseberry and barley sprout (IB) could inhibit UVB irradiation and 3-isobutyl-1-methylxanthine (IBMX)-induced photoaging and oxidative stress in the skin using HaCaT, Hs27, and B16F10 cells. MATERIALS/METHODS: The moisturizing-related factors, the collagen synthesis-related c-Jun N-terminal kinase (JNK)/c-Fos/c-Jun/matrix metalloproteinases (MMPs) pathway, and the melanogenesis-related cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/cAMP-responsive binding protein (CREB)/melanocyte inducing transcription factor (MITF)/tyrosinase-related protein (TRP)/tyrosinase activation pathways were analyzed in vitro by an enzyme-linked immunosorbent assay, real-time polymerase chain reaction, and Western blot analysis. RESULTS: The IB complex increased the hyaluronic acid and sphingomyelin levels and the collagenase inhibitory activity, enhanced hydration-related factors, including collagen, hyaluronic acid synthase (HAS), elastin, long chain base subunit 1 (LCB1) (serine palmitoyltransferase; SPT), and delta 4-desaturase sphingolipid 1 (DEGS1), modulated the inflammatory cytokines levels, antioxidant enzyme activities and the NF-κB/MMPs/cyclooxygenase-2 (COX-2) pathway in UVB-irradiated HaCaT cells, and inhibited wrinkle formation by down-regulation of the JNK/c-Fos/c-Jun/MMP pathway and up-regulation of the transforming growth factor-𝛽 receptor I (TGF𝛽R1)/small mothers against decapentaplegic homolog (Smad3)/procollagen type I pathway in UVB-irradiated Hs27 cells. Moreover, the IB complex prevented melanin production by down-regulating the PKA/CREB/MITF/TRP-1/TRP-2 pathway in IBMX-induced B16F10 cells. CONCLUSION: These findings suggest that the IB complex has the potential to serve as a safeguard, shielding the skin from UVB radiation-induced photo-damage.