• Advances in aircraft and spacecraft science
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• v.3 no.3
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• pp.317-330
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• 2016

Nowadays, the interest of aerospace and automotive industries on virtual testing of medium-frequency vibrational behavior of shallow shell structures is growing. The development of software capable of predicting the vibrational response in such frequency range is still an open question because classical methods (i.e., FEM, SEA) are not fully suitable for the medium-frequency bandwidth. In this context the Variational Theory of Complex Rays (VTCR) is taking place as an ad-hoc technique to address medium-frequency problems. It is a Trefftz method based on a weak variational formulation. It allows great flexibility because any shape function that satisfies the governing equations can be used. This work further develops such theory. In particular, orthotropic materials are introduced in the VTCR formulation for shallow shell structures. A significant numerical example is proposed to show the strategy.

• Architectural research
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• v.20 no.4
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• pp.109-120
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• 2018

In the context of ever-faster urbanization, cities are becoming increasingly complex, and data collection to understand such complex relationships is becoming a very important factor. This paper focuses on the lighter weight of the method of collecting urban data, and studied how to use such complementary data collection using crowdsourcing. Especially, the method of converting mobile acceleration sensor information to urban trip information by combining with locational information was experimented. Using the parameters for transportation type classification obtained from the research, information was obtained and verified in Singapore and Zurich. The result of this study is thought to be a good example of how to combine raw data into meaningful behavior information.

• East Asian Journal of Business Economics (EAJBE)
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• v.8 no.4
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• pp.45-65
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• 2020

Purpose - This paper is to analyze the system and the models of financial analysis in the assessment of economic consistency and the creditability of borrower. To test the process of complex express-analysis, it is utilized by the concentric matrix models by using the matrix of 5×5.. Research design, data, and methodology - The estimation of economic consistency, the creditworthiness, the complex express-analysis with application of concentric matrix models were carried out on the basis of data of the report for the 2017 of corporations POSCO and in the first half of the 2018 Daewoo Shipbuilding & Marine Engineering of South Korea. Results - This paper focused on the unbalance of the corporate financial structure (capital, receivable) and the assessment of sustainability development, taking into account the liquidity, solvency, financial sustainability and economic viability of the enterprise. Conclusions - this paper also consider the theoretical means of regulating receivables. The material is presented in the pedagogical context and appendix of the conclusion.

• Clinical and Experimental Reproductive Medicine
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• v.47 no.4
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• pp.263-268
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• 2020

Autophagy, which has the literal meaning of self-eating, is a cellular catabolic process executed by arrays of conserved proteins in eukaryotes. Autophagy is dynamically ongoing at a basal level, presumably in all cells, and often carries out distinct functions depending on the cell type. Therefore, although a set of common genes and proteins is involved in this process, the outcome of autophagic activation or deficit requires scrutiny regarding how it affects cells in a specific pathophysiological context. The uterus is a complex organ that carries out multiple tasks under the influence of cyclic changes of ovarian steroid hormones. Several major populations of cells are present in the uterus, and the interactions among them drive complex physiological tasks. Mouse models with autophagic deficits in the uterus are very limited, but provide an initial glimpse at how autophagy plays a distinct role in different uterine tissues. Herein, we review recent research findings on the role of autophagy in the uterine mesenchyme in mouse models.

• Biomolecules & Therapeutics
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• v.32 no.2
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• pp.183-191
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• 2024

The Unfolded Protein Response (UPR) serves as a critical cellular mechanism dedicated to maintaining protein homeostasis, primarily within the endoplasmic reticulum (ER). This pathway diligently responds to a variety of intracellular indicators of ER stress with the objective of reinstating balance by diminishing the accumulation of unfolded proteins, amplifying the ER's folding capacity, and eliminating slow-folding proteins. Prolonged ER stress and UPR irregularities have been linked to a range of neuropsychiatric disorders, including major depressive disorder, bipolar disorder, and schizophrenia. This review offers a comprehensive overview of the UPR pathway, delineating its activation mechanisms and its role in the pathophysiology of neuropsychiatric disorders. It highlights the intricate interplay within the UPR and its profound influence on brain function, synaptic perturbations, and neural developmental processes. Additionally, it explores evolving therapeutic strategies targeting the UPR within the context of these disorders, underscoring the necessity for precision and further research to effective treatments. The research findings presented in this work underscore the promising potential of UPR-focused therapeutic approaches to address the complex landscape of neuropsychiatric disorders, giving rise to optimism for improving outcomes for individuals facing these complex conditions.

• BMB Reports
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• v.57 no.3
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• pp.125-134
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• 2024

Whole-genome doubling (WGD), characterized by the duplication of an entire set of chromosomes, is commonly observed in various tumors, occurring in approximately 30-40% of patients with different cancer types. The effect of WGD on tumorigenesis varies depending on the context, either promoting or suppressing tumor progression. Recent advances in genomic technologies and large-scale clinical investigations have led to the identification of the complex patterns of genomic alterations underlying WGD and their functional consequences on tumorigenesis progression and prognosis. Our comprehensive review aims to summarize the causes and effects of WGD on tumorigenesis, highlighting its dualistic influence on cancer cells. We then introduce recent findings on WGD-associated molecular signatures and genetic aberrations and a novel subtype related to WGD. Finally, we discuss the clinical implications of WGD in cancer subtype classification and future therapeutic interventions. Overall, a comprehensive understanding of WGD in cancer biology is crucial to unraveling its complex role in tumorigenesis and identifying novel therapeutic strategies.

• Journal of architectural history
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• v.27 no.2
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• pp.51-62
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• 2018

This study examines the site and erection of the Government Complex Seoul which was a project attempted to assemble dispersed government buildings in a certain place. The study focuses on the fact that the project is situated between the 1960s' making of capital Seoul and Seoul urban planning, and the way how the project achieved symbolism in capital Seoul. The project, one of the 1960s' Major Government Buildings, led both plan of capital Seoul and transforming city Seoul. The 1960s' Major Government Building Plan had identical drive with the 1950's Major Government Building Plan, however the 1960s' had additional layer: Seoul urban planning. After restoration of the Capital building, Sejongro the capital street was planned to the site arranging government offices. The Government Complex Seoul was set to be a modern building on a site with historical context according to the plan. Because of the site, the Government Complex Seoul was constructed in aware of other buildings that represented a competitive high-rise atmosphere in the late 1960s, including the Capital building nearby. PAE International's plan was completed through a series of design modification, and it boasted a vertical aspect, unlike the horizontal-looking plan that was already won after the design competition. The Government Complex Seoul tried to acquire the symbolism in the central space of the capital Seoul and high-rised city Seoul. "The new construction method" was a requirement to achieve the height.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.38 no.6
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• pp.683-689
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• 2014

The present study conducted a parameter effect analysis of low-frequency squeal noise using a numerical simulation. The finite element program ABAQUS was used to calculate the dynamic instability based on a complex eigenvalue analysis. A total of five parameters, including the chassis, wear, piston, material property, and contact condition, were selected to identify the factor effects on a low-frequency squeal noise between 2.5 and 3.1 kHz. The present study found the dominant level of each factor through an analysis of the means in the context of the experiment design.

• Journal of Korean Academy of Nursing
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• v.40 no.3
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• pp.411-422
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• 2010

Purpose: In the present study, an analysis of the life of adolescents with complex congenital heart disease (CHD) was done using grounded theory. Consideration was given to the socio-cultural context of Korea. Methods: After approval from the institutional review board of Y hospital, 12 patients ranging in age from 14 to 35 were recruited. Data were gathered using in-depth interviews. Theoretical sampling was performed until the concepts were saturated. Results: The results confirmed the life of adolescents with complex CHD as a 'journey to finding uniqueness of oneself as a person with CHD'. The life consisted of 3 stages. In the crisis stage, participants had a feeling of threat to self-existence, and made an effort to be the same as others. In the self-recognition stage, participants who had sufficient role-performance built self-esteem while those who did not fell into self-accusation. In the self-establishment stage, participants who reached sufficiency in independence and knowledge planned the future, whereas those who did not conformed to the realities of life. Conclusion: The results of present study provide help in understanding the experiences of adolescents with CHD and provide a basis for developing nursing intervention strategies for these patients.

• Journal of English Language & Literature
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• v.56 no.6
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• pp.1191-1210
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• 2010

This article claims that English liquid consonants are characterized by the presence of complex place nodes, regardless of dialectal varieties. The primary difference between rhotic and laterals can be pursued in a phonological sense. The level of subbranching nodes is in charge of the disparities among two types of liquids: the branching immediately below the Coronal node with laterals, while branching at the secondary sublevel with rhotics. In this context, the processes of rhotic deletion and lateral vocalization can be understood as those motivated to get rid of complex place nodes. That is, those processes take place as part of phonological attrition. Next, the onset/coda asymmetry regarding liquids stems from the dispreference of vocoid at the onset position, which is readily accounted for by the series of constraints on the well-formedness on the onset, namely Harmonic Onset. The rationale of gradualness and harmonic improvement proposed by Harmonic Serialism is useful to separate the attested outputs from unattested ones across the whole gamut of English varieties. All in all, the primary benefits of our analysis can be found in the consistence in the explanation for the operations running through the sounds regarded as belonging to liquid consonants, comprising the whole range of rhotic and lateral consonants.