• 대한방사성의약품학회지
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• 제5권1호
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• pp.61-68
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• 2019

Purine type compounds has been recently reported to cause the death for lung cancer cell, related to microtubules-targeting agents (MTAs). Therefore it can be used to develop as theranostic radiopharmceuticals in nuclear medicine or gadolinium-based MRI imaging agents by chelate chemistry. In the study, we tried to chemically bind a DOTA chelate on the end of purine compound and obtained a specific conjugate of DOTA-purine for metal coordination. In particular, radiometal like Cu-64, for the development of MRI imaging agents, can be utilized to choice good candidates before the synthesis of gadolinium complexes. By the screening of radioisotope technique, Gd-DOTA-purine type complex was successfully prepared and showed MRI imaging for lung cancer cell into the mouse model.

• Bulletin of the Korean Chemical Society
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• 제14권2호
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• pp.287-291
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• 1993

Catalytic iminohydroacylation has been achieved by the reaction of aldimine 1 and 1,5-hexadiene (2a) with Wilkinson's complex as catalyst. Compounds 7a, 8a and 9a were obtained as final product after hydrolysis of the resulting iminohydroacylation products 4a, 5a and 6a. Depending on the reactant ratio (2/1), the ratio of products were changed dramatically : As the 2/1 ratio was increased, 7a is the major product after hydrolysis while 8a is the major with an 1/1 ratio of 2/1. The mechanism of the formation of 5a is determined by the reaction of 1 and 2b under the identical reaction conditions. Considering that 5a may not be formed from the hydroiminoacylation of 14a since 5b cannot be formed from that of conjugate diene 14b generated from isomerization of 2b, 5a must be formed from the reaction of 4a and 10 by addition-elimination mechanism.

• International Journal of Internet, Broadcasting and Communication
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• 제16권3호
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• pp.77-84
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• 2024

Aberration is still a problem for making augmented reality displays. The existing methods to solve this problem are either slow and inefficient, consume too much battery, or are too complex for straightforward implementation. There are still some problems with image quality, and users may suffer from eye strain and headaches because the images provided to each eye lack accuracy, causing the brain to receive mismatched cues between the vergence and accommodation of the eyes. In this paper, we implemented a computer simulation of an optical aberration using Zernike polynomials which are defocus, trefoil, coma, and spherical. The research showed that these optical aberrations impact the Point Spread Function (PSF) and Modulation Transfer Function (MTF). We employed the phase conjugate technique to mitigate aberrations. The findings revealed that the most significant impact on the PSF and MTF comes from the influence of spherical aberration and coma aberration.

• 대한화학회지
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• 제17권1호
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• pp.1-9
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• 1973

區區한 Diels-Alder 反應의 구조를 규명하기 위하여 Diels-Alder 反應 基 自體의 本質에 가장 가깝다고 생각한 새로운 擬似分子化合物이라는 遷移狀態의 模型을 假定하여 Mulliken의 分子化合物의 量子力學을 適用하였다. 이 擬似分子化合物은 이온성과 Radical성을 지닌 混成體이다. 이 混成體의 波動函數는 다음 식으로 표현된다. ${\psi}_{complex} = {\psi}(R,S) + {\rho}{\psi}(R^+,S^-)$ 여기 ${\rho}$는 擬似分子化合物의 極性程度를 나타내는 것이고 이 ${\rho}$가 Diene과 Dienpohile의 反應中心原子들의 自由原子價의 차 $({\Delta}F)$에 關係함을 밝혔다. 아울러 이 ${\Delta}F$量이 Brown氏의 Lp量 및 Dewar氏의 ${\Delta}E_{deloc}$量과 直線성이 있음을 알았다. Diels-Alder反應의 可能性與否를 24組의 反應組에 對하여 豫言하였다. 따라서 우리가 假定한 遷移狀態의 模型이 眞實에 가깝다고 볼 수 있으며 결국 Diels-Alder 反應은 同時附加로 융합된 ionic-Radical mechanism으로 反應이 進行한다고 볼 수 있다.

• Tribology and Lubricants
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• 제37권4호
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• pp.117-124
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• 2021

In this study, we perform a 3D CFD conjugate analysis according to the shape of the foil ramp of the air foil thrust bearing, analyze the flow characteristics inside the bearing, and compare the results corresponding to the two shapes. Air has a lower viscosity than lubricating oil. Therefore, the thrust runner of the bearing must rotate at high speed to support the load. The gap between thrust runner and foil is significantly smaller than that of the oil bearing. Hence, it is crucial to analyze the complex flow characteristics inside the bearing to predict the complex flow inside the bearing and performance of the bearing. In addition, flow characteristics may appear differently depending on the ramp shape of the bearing foil, which may affect bearing performance. In this study, we numerically analyze the main flow path of air flowing into the bearing and the secondary flow path used for cooling the bearing using the commercial CFD software ANSYS CFX and compare the flow characteristics for straight and curved foil ramp shapes. Notably, there is a difference in the speed of the flowing air according to the shape of the ramp, which affects the bearing performance.

• 한국산학기술학회논문지
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• 제20권7호
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• pp.423-429
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• 2019

최근에 초고속 광대역 무선통신 전송 시스템의 수신 성능 개선을 위한 다양한 기술들이 제안되고 있다. 본 논문에서는 주파수 공간 블록 부호화된 단일 측대 파형 SC (Single Carrier) FDMA (Frequency Division Multiple Access) 전송 시스템을 제안한다. 본 논문에서 제안된 주파수 공간 블록 부호화된 단일 측대 파형 SC FDMA 전송 시스템에서는 PAM (Pulse Amplitude Modulation) 신호의 DFT (Discrete Fourier Transform) 확산에 따라 생성되는 켤레 복소수 대칭을 활용하여 주파수 공간 블록 부호를 구현한다. 이를 통해 시스템 계산 복잡도를 크게 증가시키지 않으면서 단일 측대 파형 SC FDMA 전송 시스템의 성능 개선을 위한 송신 다이버시티 이득을 획득할 수 있다. 본 논문에서 제안된 주파수 공간 블록 부호화 단일 측대 파형 SC FDMA 시스템의 신호 대 잡음 비 성능이 단일 안테나 기반의 단일 측대 파형 SC FDMA 시스템보다 $10^{-2}$ 심볼 오류율 수준에서 약 4 dB 이상 개선되는 것을 실험을 통해 확인할 수 있다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2004년도 ICCAS
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• pp.277-281
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• 2004

The following paper proposes the new design of digital sine wave generator which allows users to define the phase shift of the out put sinewave according to user's demands. This new sinewave generator will have 2 outputs, cos(${\omega}_0n$) and cos(${\omega}_0n$+${\phi}$) The design of the new system starts from the construction of discrete time system with impulse response as cos(${\omega}_0n$) in a pair of conjugate complex poles and a pair of zeros at the origin and the real axis. If users want to make a phase shift of sign wave, users can change the position of zero at the real axis. The results of the experiment have shown that the new design of sign wave generator has generated sine wave with the correct phase shift according to the theory.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집D
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• pp.396-401
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• 2001

Heat transfer analysis of a iron core type linear motor for surface mounting device applications was considered in this study. In order to avoid the complex conjugate problem a fluid flow regime and a solid regime were considered separately. First, film coefficients of the moving parts were evaluated from computational fluid dynamic analysis and those of the stationary parts from the existing empirical or analytic correlations. And then, by applying them, internal and external temperatures of the linear motor pal1s were computed through finite element analysis. Both computation and measurement were carried out with respect to motor driving power. The measurement did not exhibit a linear temperature variation trend with respect to motor power while the computation revealed a linear correlation. Nonetheless, the computations agreed with the measurements within an error range of 20%. It indicates that an adequate heat transfer model for the reciprocative coil assembly may help more exact prediction.

• 동의생리병리학회지
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• 제18권4호
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• pp.1154-1158
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• 2004

The classical ABC (avidin-biotin peroxidase complex) method for immunohistochemistry in the paraffin-embedded tissues bring into being disadvantage such as low sensitivity of antigen detection and highly background. The biotinyl-tyramide conjugation recently introduced for sensitive immunohistochemistry was applied to light microscopy in paraffin-embedded pancreatic and liver tissues. The protocol consists of an indirect method in which 4-5㎛ tissue sections are reacted successively within a specific primary antibody, followed by a biotinylated secondary antibody, streptavidin-horseradich peroxidase (HRP), and then finally with biotinyl-tyramide. The labeling obtained for insulin and collagen antigen tested in pancreatic and liver tissues, respectively, was found to be highly specific with the labeling for each antigen confined to its particular cellular compartment. In this study, fish (flounder) serum was specially applied to remove nonspecific binding. Background levels and nospecific deposition of the staining were negligible. This results suggest that super-signal induction method by biotinyl-tyramide conjugate can readily applied to antigen detection of the paraffin-embedded tissues.

• 대한산업공학회지
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• 제16권2호
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• pp.135-147
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• 1990

A nuclear power plant can be viewed as a large complex man-machine system where high system reliability is obtained by ensuring that sub-systems are designed to operate at a very high level of performance. The chance of severe accident involving at least partial core-melt is very low but once it happens the consequence is very catastrophic. The prediction of risk in low probability, high-risk incidents must be examined in the contest of general engineering knowledge and operational experience. Engineering knowledge forms part of the prior information that must be quantified and then updated by statistical evidence gathered from operational experience. Recently, Bayesian procedures have been used to estimate rate of accident and to predict future risks. The Bayesian procedure has advantages in that it efficiently incorporates experts opinions and, if properly applied, it adaptively updates the model parameters such as the rate or probability of accidents. But at the same time it has the disadvantages of computational complexity. The predictive distribution for the time to next incident can not always be expected to end up with a nice closed form even with conjugate priors. Thus we often encounter a numerical integration problem with high dimensions to obtain a predictive distribution, which is practically unsolvable for a model that involves many parameters. In order to circumvent this difficulty, we propose a method of approximation that essentially breaks down a problem involving many integrations into several repetitive steps so that each step involves only a small number of integrations.