• 한국임상수의학회지
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• 제37권1호
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• pp.1-8
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• 2020

Canine otitis externa is a common disorder in small animal practice with prevalence up to 20%. In a large percentage of cases, canine otitis externa is a chronic and recurrent disease also associated with drug-resistant bacteria that is difficult to treat with traditional antibiotics. Photodynamic therapy (PDT) is a new strategy to exterminate pathogenic microorganisms such as bacteria and fungi. The purpose of this study was to investigate the effectiveness of photodynamic therapy against canine otitis externa using three photosensitizer (PS); 5-Aminolevulinic acid (5-ALA) and Methyl aminolevulinic acid (MAL) with semiconductor laser diode (SLD, 635nm of wave length), Chlorophyll-lipoid complex (CLC) with light-emitting diode (LED, 660nm of wave length). After PDT, dogs showed improved Otitis Index Score (OTIS) in swelling, exudate, odor, and pain. A result of the cytology test revealed decrease of bacteria and malassezia count in the oil immersion field and colony forming units count. PDT was effective as a bacteriocide of methicillin-resistant Staphylococcus pseudintermedius (MRSP) and a fungicide of Malassezia pachydermatis. MAL and 5-ALA were more effective PS against canine otitis externa than CLC. These results suggest that PDT is a new strategy to exterminate pathogenic microorganisms such as bacteria and fungi. PDT can be considered as a new therapeutic approach for canine recurrent otitis externa and a countermeasure to drug resistance that is a disadvantage of traditional antibiotic and antifungal therapy.

• 한국산학기술학회논문지
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• 제19권12호
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• pp.749-757
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• 2018

본 연구는 한국 성인의 알레르기 비염에 관련된 요인들을 파악하고자, 국민건강영양조사 통계자료를 이용하여 이차자료 분석연구를 시행하였다. 본 연구의 대상자는 제 7기 1차년도 (2016) 국민건강영양조사에 참여한 19세 이상 성인 5,841명 이었다. 수집된 자료는 대상자의 알레르기 비염 유병률, 인구사회학적 특성, 건강행태 특성, 정신건강 특성 및 알레르기 질환 특성이었으며, SPSS Statistics 24 프로그램을 이용하여 복합표본 다중 로지스틱 회귀분석으로 분석하였다. 본 연구에서 대상자의 알레르기 비염 유병률은 15.4%였다. 또한, 알레르기 비염 관련요인은 성별, 연령, 결혼여부, 스트레스, 우울증, 천식 및 아토피 피부염이었다. 대상자는 성별이 남성인 경우보다 여성인 경우, 연령이 낮아지는 경우, 결혼여부가 미혼인 경우보다 기혼인 경우, 스트레스가 낮은 경우보다 높은 경우, 우울증, 천식 및 아토피 피부염이 없는 경우보다 있는 경우에 알레르기 비염 발생이 증가하였다. 본 연구결과는 국가보건통계인 국민건강영양조사 자료를 이용하여 한국 성인의 알레르기 비염을 예방하고 증상을 관리하기 위하여 관련 요인을 파악하였으며, 이를 통하여 대상자의 건강증진을 위한 정책과 중재의 기초자료를 제시하였다.

• 한방안이비인후피부과학회지
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• 제34권3호
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• pp.70-79
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• 2021

Objectives : The purpose of this study is to investigate the possibility of using herbal medicine for the management of psoriasis focusing on lipid metabolism. Methods : We reviewed studies about pathophysiology, and medical treatment of psoriasis, the relationship between psoriasis and metabolic syndrome and lipid metabolism, and herbal medicine on Pubmed and Google scholar. Results : Psoriasis is a chronic multi-organ inflammatory disease not limited to skin, and steroids, immuno-suppressants, and biological agents are used. It is known that psoriasis and metabolic syndrome act as mutual risk factors, and lipid metabolism are involved in psoriasis. The effects of various single herbal preparations and complex herbal extract, decoction on improving lipid metabolism have been consistently reported, and there was an improvement of psoriatic skin lesions and improvement of blood lipid levels through herbal medicine. Conclusions : Herbal medicine research in psoriasis has focused on the anti-inflammatory effect and the suppression effect of certain immune mediators. However, considering that psoriasis is affected by lipid metabolism and side effects of Western medicines, the use of herbal medicines for the purpose of controlling lipid metabolism in psoriasis is useful in aspects of reducing side effects of concurrent Western medicine, improving the severity of psoriasis, and managing metabolic risk factors.

• 대한본초학회지
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• 제28권1호
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• pp.65-71
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• 2013

Objectives : Asthma is a chronic, complex respiratory disease, caused by airway obstruction, airway eosinophilic inflammation(AEI), and airway hyperresponsiveness(AHR). This study was conducted to determine whether oral administration of crude water extracts of Pinellia ternate Breitenbach(PTB) has an antiasthmatic potential in the treatment of asthma in mice. Methods : Asthmatic AEI and AHR were induced by systemic sensitization to ovalbumin(OVA) by intratracheal instillation with 0.1 mg/mL suspension of diesel exhaust particles(DEP) once a week for 10 weeks in BALB/c mice. Crude PTB water extracts(50 mg/kg and 200 mg/kg) were orally administered 5 times a week for 10 weeks. Cyclosporin(10 mg/kg) was administrered the same manner as a positive control. Results : Long-term treatment with crude PTB water extracts suppressed the infiltration of inflammatory cells, including eosinophils, into airways from blood. It also reduced asthmatic AEI and AHR by attenuating the increase in the levels of cytokines such as interleukin(IL)-4, IL-5 and IL-13 in bronchoalveolar lavage fluid(BALF), as well as the levels of histamine and OVA-specific IgE in blood. However, the effect of crude PTB water extracts(200 mg/kg) was not likely to be stronger than that of cyclosporin(10 mg/kg). Conclusion : These results suggest that crude PTB water extracts have inhibitory effects on AEI and AHR in a mouse model of asthma and may act as a potential Th2 cytokine antagonist, and have a therapeutic effect on allergic asthma.

• Clinical and Experimental Pediatrics
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• 제65권5호
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• pp.230-238
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• 2022

Myocarditis was previously attributed to an epidemic viral infection. Additional harmful reagents, in addition to viruses, play a role in its etiology. Coronavirus disease 2019 (COVID-19) vaccine-induced myocarditis has recently been described, drawing attention to vaccine-induced myocarditis in children and adolescents. Its pathology is based on a series of complex immune responses, including initial innate immune responses in response to viral entry, adaptive immune responses leading to the development of antigen-specific antibodies, and autoimmune responses to cellular injury caused by cardiomyocyte rupture that releases antigens. Chronic inflammation and fibrosis in the myocardium eventually result in cardiac failure. Recent advancements in molecular biology have remarkably increased our understanding of myocarditis. In particular, microRNAs (miRNAs) are a hot topic in terms of the role of new biomarkers and the pathophysiology of myocarditis. Myocarditis has been linked with microRNA-221/222 (miR-221/222), miR-155, miR-10a^*, and miR-590. Despite the lack of clinical trials of miRNA intervention in myocarditis yet, multiple clinical trials of miRNAs in other cardiac diseases have been aggressively conducted to help pave the way for future research, which is bolstered by the success of recently U.S. Food and Drug Administration-approved small-RNA medications. This review presents basic information and recent research that focuses on myocarditis and related miRNAs as a potential novel biomarker and the therapeutics.

• 보건행정학회지
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• 제33권3호
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• pp.295-310
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• 2023

Background: The long-term care (LTC) group has higher rates of chronic disease and disability registration compared to the general older people population. There is a need to provide integrated medical services and care for LTC group. Consequently, this study aimed to identify medical usage patterns based on the ratings of LTC and the characteristics of benefits usage in the LTC group. Methods: This study employed the National Health Insurance Service Database to analyze the effects of demographic and LTC-related characteristics on medical usage from 2015 to 2019 using a repeated measures analysis. A longitudinal logit model was applied to binary data, while a linear mixed model was utilized for continuous data. Results: In the case of LTC ratings, a positive correlation was observed with overall medical usage. In terms of LTC benefit usage characteristics, a higher overall level of medical usage was found in the group using home care benefits. Detailed analysis by medical institution classification revealed a maintained correlation between care ratings and the volume of medical usage. However, medical usage by classification varied based on the characteristics of LTC benefit usage. Conclusion: This study identified a complex interaction between LTC characteristics and medical usage. Predicting the requisite medical services based on the LTC rating presented a challenge. Consequently, it becomes essential for the LTC group to continuously monitor medical and care needs, even after admission into the LTC system. To facilitate this, it is crucial to devise an LTC rating system that accurately reflects medical needs and to broaden the implementation of integrated medical-care policies.

• Journal of Periodontal and Implant Science
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• 제27권3호
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• pp.533-547
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• 1997

과학기술이 발전함에 따라 치주과학 영역에서도 1960년 이후 1980년대에 걸쳐 괄목할 만한 학문적 발전이 이루어졌으며 1990년에는 이에 의거한 치주질환의 예방 및 조절방법이 개발되어 사용되고 있다. 미래의 치주처치전략은 대상 지역의 특성과 보건환경에 따라 달라지므로 여기에서는 한국내 치주치료요구도와 치주치료 담당 일반치과의와 치주전문의의 수, 처치 내용에 대해 점검하고 현재의 치주처치 추세를 검토한 후 향후의 치료전략에 대해 언급하고자 한다. 1980년도 역학조사에 의하면 전체 인구의 82%가 치주질환(치은염+치주염), 35세 성인 인구의 30-40%가량이 치주염에 이환되어 있고 15세 청소년 인구중 0.1%가 유년형치주염에 이환되고 있다. 평균 수명이 증가하면서 65세 이상의 노년층도 전인구의 6%(성인 50%), 2000년도에는 6.9%(성인 52%)로 증가하고 치아보유율도 증가하므로 치주질환 치료요구도는 상승하리라 전망된다. 현재 한국내 치주전공 과정을 거친 치과의사는 약 780인 정도이다, 1996년 류의 연구에 의하면 이들도 대부분 일반치과의(개원의, 공증보건의 포함)로서 진료하고 있으며 의료보험하에서의 치주치료의 비중은 매우 낮다(4.66%). 포괄적 치주적 검사도 보편적이지 않고 대학병원급의 극히 일부에서만 이행되고 있는 실정이다. 향후의 치주질환이 처치전략에는 의료보험 운용시 치주적 배려와 간편한 치주검사과정을 통한 조기진단 및 조기치료, 진행기질환 및 난치성질환자의 치주전문으로의 의뢰가 포함될 것이며 각 환자에게는 개별적이며 임상시험 결과에 근거하는 evidence-based approach에 의한 치료선정 과정이 활용되리라 전망한다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권1호
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• pp.69-73
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• 2012

Cancer is a complex disease and the genetic susceptibility to it could be an outcome of the inherited difference in the capacity of xenobiotic metabolizing enzymes. Glutathione-S-transferases (GSTs) are phase II metabolizing enzymes whose various genotypes have been associated with increased risk of different types of cancer. Null mutations caused by the deletion of the entire gene result in the absence of the enzymatic activity and increase in the risk of developing cancer including chronic myeloid leukaemia (CML). In the present case-control study we evaluated the effect of null mutations in GSTM1 and GSTT1 genes on the risk of developing CML. The study included 75 CML patients (43 males and 32 females; age (mean ${\pm}$ S.D) $42.3{\pm}13.4$ years) and unrelated non-malignant controls (76 male and 48 females; age (mean ${\pm}$ S.D) $41.5{\pm}12.9$). The distribution of GSTM1 and GSTT1 genotypes in CML patients and controls was assessed by multiplex-PCR method. Logistic regression was used to assess the relationship between GSTM1 and GSTT1 genotypes and risk of CML. Chi-square test was used to evaluate the trend in modulating the risk to CML by one or more potential high risk genotype. Although GSTM1 null genotype frequency was higher in CML patients (41%) than in the controls (35%), it did not reached a statistical significance (OD = 1.32, 95% CI: 0.73-2.40; P value = 0.4295). The frequency of GSTT1 null genotypes was higher in the CML patients (36%) than in the controls (21%) and the difference was found to be statistically significant (OD = 2.12, 95% CI: 1.12-4.02; P value = 0.0308). This suggests that the presence of GSTT1genotype may have protective role against the CML. We found a statistically significant (OD = 3.09, 95% CI: 1.122-8.528; P value = 0.0472) interaction between the GSTM1 and GSTT1 null genotypes and thus individuals carrying null genotypes of both GSTM1 and GSTT1 genes are at elevated risk of CML.

• 한국사회복지학
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• 제69권2호
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• pp.117-141
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• 2017

본 연구의 목적은 우울진입에 영향을 미치는 요인이 세대별로 어떤 차이가 있는지를 살펴보고 생애 주기별 우울 예방의 실천적 전략을 제시하는 것이다. 이를 위해 한국복지패널의 3~10차 조사 자료를 결합하여, 성년층과 중년층, 노년층의 우울진입 영향요인을 이산시간위험모델을 통해 분석하였다. 분석결과, 3세대 공통적으로 여자가 남자보다, 자아존중감이 낮을수록, 수입 만족도와 가족관계 만족도가 낮을수록 우울진입 가능성이 높았다. 또한 세대별로 차이를 나타낸 변수는 연령과 교육수준, 건강상태, 만성질환유무, 취업여부, 권역별지역, 여가생활 만족도였다. 성년(20~39세)의 경우 나이가 적을수록, 만성질환이 있는 경우에, 미취업자가 취업자보다 우울진입 가능성이 높다. 반면 중년층(40~64세)의 경우 나이가 많을수록, 건강상태가 좋지 않은 경우에, 만성질환이 없는 경우에, 여가생활 만족도가 낮은 경우에 우울진입 가능성이 높다. 마지막으로 노년층(65세 이상)은 교육수준이 높을수록, 건강상태가 좋지 않은 경우에, 도농 복합군이 서울보다, 여가생활 만족도가 낮을수록 우울진입 가능성이 높다. 이러한 결과를 바탕으로 우울진입을 예방하기 위해 세대별로 드러난 특성이 반영된 지원방안을 마련할 필요가 있음을 제시하였다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2008년도 학술발표회 논문집
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• pp.694-698
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• 2008

In hydrology, it is a difficult task to deal with multivariate time series such as modeling streamflows of an entire complex river system. Normal distribution based model such as MARMA (Multivariate Autorgressive Moving average) has been a major approach for modeling the multivariate time series. There are some limitations for the normal based models. One of them might be the unfavorable data-transformation forcing that the data follow the normal distribution. Furthermore, the high dimension multivariate model requires the very large parameter matrix. As an alternative, one might be decomposing the multivariate data into independent components and modeling it individually. In 1985, Lins used Principal Component Analysis (PCA). The five scores, the decomposed data from the original data, were taken and were formulated individually. The one of the five scores were modeled with AR-2 while the others are modeled with AR-1 model. From the time series analysis using the scores of the five components, he noted "principal component time series might provide a relatively simple and meaningful alternative to conventional large MARMA models". This study is inspired from the researcher's quote to develop a multivariate simulation model. The multivariate simulation model is suggested here using Principal Component Analysis (PCA) and Independent Component Analysis (ICA). Three modeling step is applied for simulation. (1) PCA is used to decompose the correlated multivariate data into the uncorrelated data while ICA decomposes the data into independent components. Here, the autocorrelation structure of the decomposed data is still dominant, which is inherited from the data of the original domain. (2) Each component is resampled by block bootstrapping or K-nearest neighbor. (3) The resampled components bring back to original domain. From using the suggested approach one might expect that a) the simulated data are different with the historical data, b) no data transformation is required (in case of ICA), c) a complex system can be decomposed into independent component and modeled individually. The model with PCA and ICA are compared with the various statistics such as the basic statistics (mean, standard deviation, skewness, autocorrelation), and reservoir-related statistics, kernel density estimate.