Browse > Article
http://dx.doi.org/10.6114/jkood.2021.34.3.070

Investigation of Effective Korean Herbal Medicine for Psoriasis - Focusing on Lipid Metabolism -  

Han, Chang-Yi (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University)
Kim, Jundong (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University)
Seo, Gwang-Yeel (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University)
Kim, Kyu-Seok (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University)
Kim, Yoon-Bum (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University)
Publication Information
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology / v.34, no.3, 2021 , pp. 70-79 More about this Journal
Abstract
Objectives : The purpose of this study is to investigate the possibility of using herbal medicine for the management of psoriasis focusing on lipid metabolism. Methods : We reviewed studies about pathophysiology, and medical treatment of psoriasis, the relationship between psoriasis and metabolic syndrome and lipid metabolism, and herbal medicine on Pubmed and Google scholar. Results : Psoriasis is a chronic multi-organ inflammatory disease not limited to skin, and steroids, immuno-suppressants, and biological agents are used. It is known that psoriasis and metabolic syndrome act as mutual risk factors, and lipid metabolism are involved in psoriasis. The effects of various single herbal preparations and complex herbal extract, decoction on improving lipid metabolism have been consistently reported, and there was an improvement of psoriatic skin lesions and improvement of blood lipid levels through herbal medicine. Conclusions : Herbal medicine research in psoriasis has focused on the anti-inflammatory effect and the suppression effect of certain immune mediators. However, considering that psoriasis is affected by lipid metabolism and side effects of Western medicines, the use of herbal medicines for the purpose of controlling lipid metabolism in psoriasis is useful in aspects of reducing side effects of concurrent Western medicine, improving the severity of psoriasis, and managing metabolic risk factors.
Keywords
Psoriasis; Metabolic syndrome; Lipid metabolism; Herbal medicine;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Kim BH, Kim KI, Kang SH, Park JG, Kang DW, Nam HJ, et al. Explanation and Elaboration of the Clinical Trial Guidelines for Psoriasis Using Herbal Medicine. J Korean Med Ophthalmol Otolaryngol Dermatol. 2018;31(2):40-59.   DOI
2 Song MY, Jung HW, Park YK. Antiobesity Effect of Water Extract of Coix lacrymajobi var. mayuen in High Fat Fed C5BL/6 Mice. J Korean Med Obes Res. 2016;16(1):27-35.   DOI
3 The Society of Korean Dermatology. Textbook of Dermatology. 6th ed. Seoul; Daehan Medical book. 2015:299-314.
4 Grozdev I, Korman N, Tsankov N. Psoriasis as a systemic disease. Clin Dermatol. 2014;32(3):343-50.   DOI
5 Youn SW. Recent medical therapy for psoriasis. J Korean Med Assoc. 2019;62 (3):176-80.   DOI
6 Pietrzak A, Michalak-Stoma A, Chodorowska G, Szepietowski JC. Lipid disturbances in psoriasis: An update. Mediators of Inflammation. 2010;2010:1-13.
7 Kamiya K, Kishimoto M, Sugai J, Komine M, Ohtsuki M. Risk factors for the development of psoriasis. Int J Mol Sci. 2019;20(18):1-14.
8 Takeshita J, Grewal S, Langan SM, Mehta NN, Ogdie A, Van Voorhees AS, et al. Psoriasis and comorbid diseases: Implications for management. J Am Acad Dermatol. 2017;76(3):393-403.   DOI
9 Lee S. Psoriasis and Skin Barrier. J Ski Barrier Res. 2017;19(1):25-9.
10 Han CY, Kim JD, Kang DW, Kim KS, Kim YB. Review about using Herbal medicine on steroid tapering and steroid overuse in Skin disease. J Korean Med Ophthalmol Otolaryngol Dermatol. 2020;33(3):115-24.   DOI
11 Ogawa E. Sato Y, Minagawa A, Okuyama R. Pathogenesis of psoriasis and development of treatment. J Der. 2018;45:264-72.
12 Gisondi P, Fostini AC, Fossa I, Girolomoni G, Targher G. Psoriasis and the metabolic syndrome. Clin Dermatol. 2018;36(1):21-8.   DOI
13 Pietrzak A, Chodorowska G, Szepietowski J, Zalewska-Janowska A, Krasowska D, Hercogova J. Psoriasis and serum lipid abnormalities. Dermatol Ther. 2010;23(2): 160-73.   DOI
14 Armstrong AW, Read C. Pathophysiology, Clinical Presentation, and Treatment of Psoriasis: A Review. J Am Med Assoc. 2020;323(19):1945-60.   DOI
15 Kang DW, Han CY, Kim JD, Kim KS, Kim YB. A Proposal and Considerations for Treatment Approaches of Psoriasis. J Korean Med Ophthalmol Otolaryngol Dermatol. 2020;33(3):99-114.   DOI
16 Asad F, Khan M, Rizvi F. Atorvastatin as an adjuvant with betamethasone valerate reduces disease severity and cardiovascular risks in Psoriasis. Pakistan J Med Sci. 2017;33(6):1507-11.
17 Upala S, Sanguankeo A. Effect of lifestyle weight loss intervention on disease severity in patients with psoriasis: A systematic review and meta-analysis. Int J Obes. 2015;39(8):1197-202.   DOI
18 Sarvtin MT, Hedayati MT, Shokohi T, HajHeydari Z. Serum lipids and lipoproteins in patients with psoriasis. Arch Iran Med. 2014;17(5):343-6.
19 Shih CM, Chen CC, Chu CK, Wang KH, Huang CY, Lee AW. The roles of lipoprotein in psoriasis. Int J Mol Sci. 2020;21(3):1-12.
20 Jeung CW, Jeon SW, Jo HG. Literature Review on Herbal Medicine Treatment of Psoriasis Based on Chronic Low-grade Inflammation Theory. J Korean Med Ophthalmol Otolaryngol Dermatol. 2018;31 (4):22-30.   DOI
21 Sun W, Gao Y, Yu X, Yuan Y, Yi J, Zhang Z, et al. 'Psoriasis 1' reduces psoriasis-like skin inflammation by inhibiting the VDRmediated nuclear NF-kB and STAT signaling pathways. Mol Med Rep. 2018;18(3): 2733-43.
22 Weng SW, Chen BC, Wang YC, Liu CK, Sun MF, Chang CM, et al. Traditional Chinese Medicine Use among Patients with Psoriasis in Taiwan: A Nationwide Population-Based Study. Evid Based Complement Alternat Med. 2016;2016:3164105.
23 Rouhi-Boroujeni H, Rouhi-Boroujeni H, Heidarian E, Mohammadizadeh F, RafieianKopaei M. Herbs with anti-lipid effects and their interactions with statins as a chemical anti-hyperlipidemia group drugs: A systematic review. ARYA Atheroscler. 2015;11(4):244-51.
24 Sin SM, Cha JH, Kim GT, Byun SH, Ko H. Saenggangeonbi-tang's effest on metabolic syndrome Department. J Intern Korean Med. 2008;fal:65-70.
25 Yokoi H, Mizukami H, Nagatsu A, Ohno T, Tanabe H, Inoue M. Peroxisome Proliferator- Activated Receptor g Ligands Isolated from Adlay Seed. Biol Pharm Bull. 2009;32(4):735-40.   DOI
26 Sorokin AV, Domenichiello AF, Dey AK, Yuan ZX, Goyal A, Rose SM, et al. Bioactive Lipid Mediator Profiles in Human Psoriasis Skin and Blood. J Invest Dermatol. 2018;138(7):1518-28.   DOI
27 Kim BM, Jo HG. Progress of Short-term Herbal Medicine Administration for Hypertriglyceridemia: a Case Report. J. Int. Korean Med. 2019;40(3):517-24.   DOI
28 Kim DS, Jeon BK, Mun YJ, Lee GT, Lee KK, Woo WH. Ponciri Fructus Extract Induces Lipogenesis through Transcription Factor SREBP-1 Activation. Yakhak Hoeji. 2012; 56(4):268-73.
29 Wu F, Yang X, Hu M, Shao Q, Fang K, Li J, et al. Wu-Mei-Wan prevents high-fat diet-induced obesity by reducing white adipose tissue and enhancing brown adipose tissue function. Phytomedicine. 2020;76:153258.   DOI
30 Masayuki I, Takashi S, Koh I, Kazuichi S. Chinese Herbal Medicine Yi-Gan-San Decreases the Lipid Accumulation in Mouse 3T3-L1 Adipocytes by Modulating the Activities of Transcription Factors SREBP-1c and FoxO1. Tohoku J. Exp. Med. 2009; 219:53-62.   DOI
31 Cho JG, Yang YH, Han SR, Cho AR. 3 Cases Reports of Psoriasis Treated by Damwihwan- Focused on Lipid Metabolic Abnomarilty. J Korean Med Ophthalmol Otolaryngol Dermatol 2017;30(4):167-75.   DOI
32 Lee JM, Cho SW, Kang KH, Lee SY, Yu S. The Effects of Daecheongryong-tang on transcription factors and adipogenic genes during 3T3-L1 differentiation. The Journal of Pediatrics of Korean Medicine. 2010; 24(3):92-105.
33 Xie X, Zhang L, Li X, Liu W, Wang P, Lin Y, et al. Liangxue Jiedu Formula Improves Psoriasis and Dyslipidemia Comorbidity via PI3K/Akt/mTOR Pathway. Front Pharmacol. 2021;12:1-13.
34 Rendon A, Schakel K. Psoriasis pathogenesis and treatment. Int J Mol Sci. 2019;20 (6):1-28.
35 Zuccotti E, Oliveri M, Girometta C, Ratto D, Di Iorio C, Occhinegro A, et al. Nutritional strategies for psoriasis: Current scientific evidence in clinical trials. Eur Rev Med Pharmacol Sci. 2018;22(23):8537-51.
36 Lee IW, Choi HY, Lee JH, Park SD, Kim SM, Ku SK, et al. Saeng-Kankunbi-Tang protects liver against oxidative damage through activation of ERK/Nrf2 pathway. Chin J Integr Med. 2016;22(8):619-28.   DOI
37 Yan Y, Liu W, Andres P, Pernin C, Chantalat L, Briantais P, et al. Exploratory clinical trial to evaluate the efficacy of a topical traditional Chinese herbal medicine in psoriasis vulgaris. Evid Based Complement Alternat Med. 2015;201:719641.