• Journal of Microbiology and Biotechnology
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• v.18 no.1
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• pp.138-144
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• 2008

The production of the entomopathogenic and phytotoxic cyclic depsipeptide beauvericin (BEA) was studied in submerged cultures of Fusarium oxysporum KFCC 11363P isolated in Korea. The influences of various factors on mycelia growth and BEA production were examined in both complete and chemically defined culture media. The mycelia growth and BEA production were highest in Fusarium defined medium. The optimal carbon and nitrogen sources for maximizing BEA production were glucose and $NaNO_3$, respectively. The carbon/nitrogen ratio for maximal production of BEA was investigated using response surface methodology (RSM). Equations derived by differentiation of the RSM model revealed that the production of BEA was maximal when using 108 mM glucose and 25 mM $NaNO_3$.

• Korean Journal of Head & Neck Oncology
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• v.4 no.1
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• pp.13-19
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• 1988

Brachytherapy is known to be a good modality to achieve local control as a boost treatment following limited external irradiation, which may reduce the external beam related acute radiation sickness, particularly in head and neck cancer. The authors developed iridium-192 ribbons recently to replace the radium needles. Total of 13 head and neck cancer patients had been treated with Ir-192 ribbons during last one year from October 1986 to September 1987, and the results were analysed to assess the applicability of the fabricated sources. The conclusion is as follows; 1) Iridium implant achieved 54% (7/13) of complete response and 69% (9/13) of overall response rate in head and neck cancer. 2) Iridium is superior to radium and cecium in brachytherapy because of easier to use and lesser exposure to the personnel. 3) Afterloading technique is useful to modify dose distribution, to expand treatment site and method, and to develop interstitial hyperthermia.

• Journal of Gastric Cancer
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• v.14 no.1
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• pp.1-6
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• 2014

Aerobic glycolysis has been the most important hypothesis in cancer metabolism. It seems to be related to increased bioenergetic and biosynthetic needs in rapidly proliferating cancer cells. To this end, F-18 fluorodeoxyglucose (FDG), a glucose analog, became widely popular for the detection of malignancies combined with positron emission tomography/computed tomography (PET/CT). Although the potential roles of FDG PET/CT in primary tumor detection are not fully established, it seems to have a limited sensitivity in detecting early gastric cancer and mainly signet ring or non-solid types of advanced gastric cancer. In evaluating lymph node metastases, the location of lymph nodes and the degree of FDG uptake in primary tumors appear to be important factors affecting the diagnostic accuracy of PET/CT. In spite of the limited sensitivity, the high specificity of PET/CT for lymph node metastases may play an important role in changing the extent of lymphadenectomy or reducing futile laparotomies. For peritoneal metastases, PET/CT seems to have a poorer sensitivity but a better specificity than CT. The roles of PET/CT in the evaluation of other distant metastases are yet to be known. Studies including primary tumors with low FDG uptake or peritoneal recurrence seem suffer from poorer diagnostic performance for the detection of recurrent gastric cancer. There are only a few reports using FDG PET/CT to predict response to neoadjuvant or adjuvant chemotherapy. A complete metabolic response seems to be predictive of more favorable prognosis.

• Steel and Composite Structures
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• v.19 no.5
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• pp.1145-1165
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• 2015

A behavior model for screw connections is developed to provide a better representation of the nonlinear response of thin steel plate shear walls (TSPSWs) with infill plates attached to the boundary frame members via self-drilling screws. This analytical representation is based on the load-bearing deformation relationship between the infill plate and the screw threads. The model can be easily implemented in strip models of TSPSWs where the tension field action of the infill plates is represented by a series of parallel discrete tension-only strips. Previously reported experimental results from tests of two different TSPSWs are used to provide experimental validation of the modeling approach. The beam-to-column connection behavior was also included in the analyses using a four parameter rotational spring model that was calibrated to a test of an identical frame as used for the TSPSW specimens but without the infill plates. The complete TSPSW models consisting of strips representing the infill plates, zero length elements representing the load-bearing deformation response of the screw connection at each end of the strips and the four parameter spring model at each beam-to-column connection are shown to have good agreement with the experimental results. The resulting models should enable design and analysis of TSPSWs for both new construction and retrofit of existing buildings.

• Journal of Microbiology and Biotechnology
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• v.27 no.7
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• pp.1209-1215
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• 2017

Microwave sterilization was performed to inactivate the spores of biofilms of Bacillus cereus involved in foodborne illness. The sterilization conditions, such as the amount of water and the operating temperature and treatment time, were optimized using statistical analysis based on 15 runs of experimental results designed by the Box-Behnken method. Statistical analysis showed that the optimal conditions for the inactivation of B. cereus biofilms were 14 ml of water, $108^{\circ}C$ of temperature, and 15 min of treatment time. Interestingly, response surface plots showed that the amount of water is the most important factor for microwave sterilization under the present conditions. Complete inactivation by microwaves was achieved in 5 min, and the inactivation efficiency by microwave was obviously higher than that by conventional steam autoclave. Finally, confocal laser scanning microscopy images showed that the principal effect of microwave treatment was cell membrane disruption. Thus, this study can contribute to the development of a process to control food-associated pathogens.

• Journal of Korean Clinical Nursing Research
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• v.21 no.1
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• pp.92-104
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• 2015

Purpose: The purpose of this study was to identify the types of violence and coping methods experienced by general hospital nurses. Methods: Data were collected from March 17 to 24, 2014, using self-report questionnaires. Responses from 449 nurses were analyzed. Results: The majority of the respondents experienced violence from patients, visitors, doctors, and other nurses. Verbal violence was more frequent than physical threats and physical violence. Most violence happened in ERs, followed by surgical units, and ICUs. The most frequent response by nurses after violence was an emotional response, especially 'anger' ($4.01{\pm}1.059$). Based on general characteristics, the responses were significant for professional experience (F=2.935, p=.013) and work areas (F=2.290, p=.021). The most frequent coping method for nurses after violence had occurred was to 'just complete their duties as if nothing happened'. Conclusion: Most nurses are exposed to frequent violence, but they feel defenseless. These results suggest that hospital should improve the respective organizational cultures and develop promotional programs and administrative policies to prevent violence. In addition, educational programs should be provided for nurses to improve their attitudes and abilities to cope with violence. Also, hospitals should offer sufficient support, stress reduction programs and counseling programs for nurses.

• Computers and Concrete
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• v.25 no.4
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• pp.327-341
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• 2020

Advanced forms of structural design (e.g., displacement-based methods) require knowledge of the non-linear force-displacement behavior of both the overall building and individual lateral load resisting elements, i.e., walls or building cores. Similarly, understanding the non-linear behaviour of the elements in a structure can also allow for a less conservative structural response to be calculated by better understanding the cracked (i.e., effective) properties of the various RC elements. Calculating the non-linear response of an RC section typically involves using 'black box' analysis packages, wherein the user may not be in complete control nor be aware of all the intricate settings and/or decisions behind the scenes. This paper introduces a user-friendly and transparent analysis program for predicting the back-bone force displacement behavior of slender (i.e., flexure controlled) RC walls, building cores or columns. The program has been validated and benchmarked theoretically against both commonly available and widely used analysis packages and experimentally against a database of 16 large-scale RC wall test specimens. The program, which is called WHAM, is written using Microsoft Excel spreadsheets to promote transparency and allow users to further develop or modify to suit individual requirements. The program is available free-of-charge and is intended to be used as an educational tool for structural designers, researchers or students.

• Kosin Medical Journal
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• v.33 no.3
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• pp.438-445
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• 2018

Hairy cell leukemia (HCL) is a rare chronic B cell leukemia morphologically characterized by cells with an abundant cytoplasm and hair-like projections that can be found in the peripheral blood and bone marrow. The treatment for HCL is splenectomy or chemotherapy with the purine analogs pentostatin and cladribine. However, patients continue to relapse. Retreatment with the same or alternate purine analogs produces lower response rates and a shorter duration of response. Fludarabine is another purine analog widely used in treating indolent lymphoid cancers, often in combination with rituximab. Here, we report a case of HCL variant in a 60-year-old man who experienced multiple relapses after splenectomy and retreatment with cladribine. The patient was then treated with fludarabine and rituximab combination chemotherapy. After the treatment, he achieved complete remission that continued for 35 months.

• Molecules and Cells
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• v.44 no.5
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• pp.363-373
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• 2021

Immune checkpoint inhibitors have changed the paradigm of treatment options for non-small cell lung cancer (NSCLC). Monoclonal antibodies targeting programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) have gained wide attention for their application, which has been shown to result in prolonged survival. Nevertheless, only a limited subset of patients show partial or complete response to PD-1 therapy, and patients who show a response eventually develop resistance to immunotherapy. This article aims to provide an overview of the mechanisms of acquired resistance to anti-PD-1/PD-L1 therapy from the perspective of tumor cells and the surrounding microenvironment. In addition, we address the potential therapeutic targets and ongoing clinical trials, focusing mainly on NSCLC.

• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.5
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• pp.255-262
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• 2020

This study aimed to evaluate the efficacy of herbal medicine (HM) combined with chemotherapy (CT) for cervical cancer. Ten electronic databases including Pubmed, Cochrane library, Embase, Korean databases, and Chinese medical databases were systematically searched up to October 2019. All randomized controlled trials with HM combined with CT to treat cervical cancer were included. A total of 21 trials were included for analysis. Compared to the control group, HM combined with CT group significantly increased tumor response (complete and partial response) (risk ratio [RR] = 1.24, 95% CI: 1.15-1.33, p < 0.00001) and Karnofsky performance score (standardized mean difference [SMD] = 1.71, 95% CI: 1.41-2.01, p < 0.00001). Also, HM combined with CT group remarkably reduced CT toxicity. In Conclusion, our study suggests that HM might be a potential option for cervical cancer to enhance curative efficacy and reduce CT toxicity.