• Journal of Chest Surgery
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• 제28권9호
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• pp.851-856
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• 1995

Thymectomy has played a central role in the management of myasthenia gravis. Although both the etiology of myasthenia gravis and the reason for improvement after thymectomy remain incompletely explained, complete removal of the thymus is the logical goal of surgical treatment for this disease.From April 1989 to June 1994, maximal thymectomy was performed for 19 cases of myasthenia gravis at Chonnam National University Hospital. The results were as follows:1.Among the 19 cases, male-to-female ratio was 1:1.4, the age ranged 13 years to 71 years, and a diphasic presentation appeared with a peak in young females and a second peak in elderly males;2.Five cases were classified by modified Osserman`s classification as Group I and Group IIa and 14 cases as Group IIb and Group IIc; 3.Histologic examination of the excised thymus glands revealed normality in 5 cases [26% , thymic hyperplasia in 4 [21% , benign thymoma in 8 [42% , and malignant thymoma in 2 [11% ;4.There was no operative mortalities but two deaths occurred during the follow-up periods due to myasthenic crisis and other causes;5.The clinical improvement and the complete remission rates were 85% and 32%, respectively;6.The clinical improvement and the complete remission rates were not so good in patients with thymomas, beeing 70% and 20%, respectively; and 7.Young women with hyperplasia of the thymic tissue tended to show the best response to thymectomy.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3213-3218
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• 2012

When patients with advanced breast cancer (ABC) are treated with neoadjuvant chemotherapy (NACT), efficacy is monitored by the extent of tumor shrinkage. Since their publication in 1981, World Health Organization (WHO) guidelines have been widely practiced in clinical trials and oncologic practice, for standardized tumor response evaluation. With advances in cancer treatment and tumor imaging, a simpler criterion based on one-dimensional rather than bi-dimensional (WHO) tumor measurement, named Response Evaluation Criteria in Solid Tumors (RECIST) was introduced in 2000. Both approaches have four response categories: complete response, partial response, stable disease and progressive disease (PD). Bi-dimensional measurement data of 151 patients with ABC were analysed with WHO and RECIST criteria to compare their response categories and inter criteria reproducibility by Kappa statistics. There was 94% concordance and 9/151 patients were recategorized with RECIST including 6/12 PD cases. RECIST therefore under-estimates and delays diagnosis of PD. This is undesirable because it may delay or negate switch over to alternate therapy. Analysis was repeated with a new criteria named RECIST-Breast (RECIST-B), with a lower threshold for PD (${\geq}10%$ rather than ${\geq}20%$ increase of RECIST). This showed higher concordance of 97% with WHO criteria and re-categorization of only 4/151 patients (1/12 PD cases). RECIST-B criteria therefore have advantages of both ease of measurement and calculations combined with excellent concordance with WHO criteria, providing a practical clinical tool for response evaluation and offering good comparison with past and current clinical trials of NACT using WHO guidelines.

• 산업진흥연구
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• 제9권1호
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• pp.57-64
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• 2024

2015년 화학물질관리법 전면 개정에 따라 국내 유해화학물질 관리 패러다임이 사업장 단위에서 지역 단위로 변화하였다. 이에 2020년 지역화학사고대응계획이 수립되었으나 지자체마다 대응 범위와 기준에 대한 내용에서 조금씩 차이를 보이고 있다. 이에 본 연구는 각 지역내 수립된 화학사고대응계획을 비교 고찰함으로써 효과적인 화학사고 대응계획에 대한 시사점을 제공하고자 연구를 수행하였다. 이에 공개된 자료를 기반으로 시 단위 4개 지역의 사고 대비 현황, 화학사고 대응시스템, 주민 대피 대응 및 교육훈련의 3가지 차원에서 지역별 대응계획을 비교 분석하였다. 연구 결과, 지역별 사고 대비 및 사고 대응시스템에서는 차이가 크지 않으며, 각 지역별 사업장 특성에 연계한 대비체계는 논의가 부족했다. 또한, 주민을 위한 교육 및 훈련에서 지역간 차이가 존재했다. 앞으로 각 지자체는 지역 환경 특성에 맞는 대응 조직을 구성하고, 유관 기관 협력을 통해 민첩하고 효과적인 사고 대응을 위해 전략을 구상해야 할 것이다.

• Structural Engineering and Mechanics
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• 제27권5호
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• pp.555-574
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• 2007

Static response of an elastic beam on a two-parameter tensionless foundation is investigated by assuming that the beam is symmetrically subjected to a uniformly distributed load and concentrated edge loads. Governing equations of the problem are obtained and solved by pointing out that a concentrated edge foundation reaction in addition to a continuous foundation reaction along the beam axis in the case of complete contact and a discontinuity in the foundation reactions in the case of partial contact come into being as a direct result of the two-parameter foundation model. The numerical solution of the complete contact problem is straightforward. However, it is shown that the problem displays a highly non-linear character when the beam lifts off from the foundation. Numerical treatment of the governing equations is accomplished by adopting an iterative process to establish the contact length. Results are presented in figures to demonstrate the linear and non-linear behavior of the beam-foundation system for various values of the parameters of the problem comparatively.

• Asian-Australasian Journal of Animal Sciences
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• 제7권2호
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• pp.213-215
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• 1994

Poultry feeding systems are likely to change for increased efficiency of production. An experiment was conducted to compare the response of broilers to choice feeding of corn with a standard broiler ration. The treatments consisted of providing broiler feed as the only feed (SINGLE FEED) and access to corn as a choice to a complete broiler feed (CHOICE FEEDING). Weights and feed consumption were obtained at weekly intervals. Samples at the conclusion of the experiment were taken to determine the weight of abdominal fat. Results showed that there was no significant difference in term of liveweight between the two feeding regimes. However, birds given a choice of the broiler feed and corn had better feed efficiency which is reflected by the lower total feed intake. Corn intake was 23.1% of total feed intake in the choice fed birds. In term of carcass colour, birds fed corn as a choice was observed to have a deeper yellow skin colour than the birds fed with broiler feed only.

• Journal of Chest Surgery
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• 제30권1호
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• pp.72-76
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• 1997

중증 근무력증은 자가면역 반응에 의해 유발되는 비교적 드문 질환으로, 여러 가지의 치료 방법이 시행되고 있으나 현재는 완전 관해와 증상의 호전이 탁월하다는 점에서 광범위 흉선 절제술을 주된 치료의 방법으로 선택하고 있다. 본원에서는 지난 8년간 16명의 중증 근무력증 환자에 대해 흉선 절제술을 시행하여 결과를 분석하였다. 5례(31%)에서 완전 관해가 보였으며, 7례(44%)에서는 약 투여량의 감소 또는 증상의 호전을 보여 총75%에서 수술적 호전을 보았다 환자의 나이, 성별, 술전 증상의 정도, 수술적 접근 방법 및 조직학적인 결과 등을 분석하였으나 수술 후 예후와는 통계적 상관관계는 보이지 않았다.

• 대한전자공학회논문지
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• 제21권5호
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• pp.55-60
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• 1984

CMOS기술의 발전에 따라 디지탈 회로를 실현하는데 complex gate 구조를 많이 사용하게 되었다. CMOS complex gate에 대해 내부 게이트 응답과 unknown state등을 고려하여 모든 stuck-open(이하 s-op)과 stuck-on(이하 s-on) 고장을 검출할 수 있는 새로운 테스트 생성 알고리즘이 제소되었다 이 알고리즘은 minimal하고 complete한 테스트 집합을 구할 수 있게 해준다. 또한, 임의의 CMOS complex gate 회로에 대해 본 알고리즘을 적용시켜, 컴퓨터를 통해 그와 같은 테스트 집합이 구해짐을 입증하였다.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2003년도 춘계 학술발표회논문집
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• pp.216-223
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• 2003

A time-domain system identification (SI) method is developed for seismic damage assessment on structures. SI algorithms for complete measurements with respect to degrees-of-freedom are proposed. To take account of nonlinear dynamic response, an equation error in the incremental dynamic governing equation is defined for complete measurement between measured and computed acceleration. Variations of stiffness and damping parameters during earthquake vibration are chased by utilizing a constrained nonlinear optimization tool available in MATLAB. A simulation study has been carried out to identify damage event and to assess damage severity by using measured acceleration time history. Mass properties are assumed as known a priori. The effects of measurement noise on the identification are also investigated.

• Radiation Oncology Journal
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• 제27권1호
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• pp.10-14
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• 2009

목적: 식도암에서 수술 후 방사선치료 및 방사선 단독 치료의 효과를 검증하고 예후 인자를 알아보고자 하였다. 대상 및 방법: 1989년부터 2006년까지 방사선치료를 받은 132명의 환자를 후향적으로 분석하였다. 35명은 제2병기 88명은 제3병기 9명은 제4병기 환자였다. 상부 식도암이 18명, 하부 식도암이 33명이었으며 중등부 식도암이 81명이었다. 60명에서는 방사선 단독 치료를 시행하였고 72명은 수술 후 방사선치료를 받았다. 8명에서는 40 Gy 이하를 조사하였으며 78명에서는 40내지 50 Gy를 조사하였다. 나머지 46명은 50내지 60 Gy를 조사 받았으며 수술 후 방사선치료를 받은 대부분의 환자는 45 Gy를 조사받았다. 결과: 전체 환자의 2년 및 5년 생존율은 24% 및 5%이었고 중앙 생존기간은 11개월이었다. 수술 후 방사선치료군의 2년 및 5년 생존율은 19% 및 8%, 방사선 단독치료군의 2년 및 5년 생존율은 18% 및 2%이었다. 제2병기, 제3 병기 및 제4병기 환자의 2년 및 5년 생존율은 각각 43% 및 15, 22% 및 2, 0% 및 0% 이었으며 이는 통계적으로 유의하였다. 상부, 중등부, 하부 식도암의 2년 생존율은 각각 19, 29, 22%이었으며 통계적으로 유의한 차이는 나타나지 않았다. 방사선 단독치료군에서 13명(22%)은 완전관해를, 40명(67%)은 부분관해를 보였고 7명(12%)은 반응을 보이지 않았다. 완전관해를 보인 환자군이 부분관해를 보인 환자군보다 더 나은 2년 생존율을 나타내었다(31% vs 17%). 결론: 식도암에서 방사선치료는 효과적이고 유용한 치료 방법이었으며 병기 및 방사선치료에의 반응 정도가 유의한 예후인자이었다. 그러나 식도암의 장기 생존율 및 예후가 만족스럽지 못하므로 더욱 효과적인 치료 방법의 개발이 향후 필요하리라 사료된다.

• Radiation Oncology Journal
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• 제13권3호
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• pp.233-241
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• 1995

Purpose : To analyse clinical outcome and prognostic factors according to treatment modality, this paper report our experience of retrospective study of patients with esophageal cancer Materials and Methods : One hundred and ten patients with primary esophageal cancer who were treated in Presbyterian Medical Center from May 1985 to December 1992. We analysed these patients retrospectively with median follow up time of 28 months, one hundred and four patients($95{\%}$) were followed up from 15 to 69 months. In methods, twenty-eight patients were treated with median radiation dose irradiated 54.3Gy only. Fifty-six patients were treated with combined chemoradiotherapy. Sixteen cases of these patients were treated with concurrent chemoradiation and the other patients(forty cases) were treated sequential chemoradiotherapy. In concurrent chemoradiotherapy group, patients received 5-FU continuous IV infusion for 4 days. Cisplatin IV bolus. and concurrent esophageal irradiation to 30 Gy. After that patients received 5-FU continuous IV, Cisplatin bolus injection and Mitomycin-C bolus IV, Bleomycin continuous IV, and irradiation to 20 Gy. In sequential chemoradiotherapy group, the chemotherapy consisted of 5-FU 1,000mg/$m^2$ administered as a continuous 24 hour intravenous infusion during five days and Cisplatin 80-100mg/$m^2$ bolus injected, or Bleomycin, Vinblastine, Cisplatin, Methotrexate were used of 1 or 2 cycles. After preoperative concurrentm chemoradiation twenty-six patients underwent radical esophagectomy. Results : Ninety-three patients could be examined for response assessment, By treatment modality, response rates were $85.1{\%}$ for radiation alone group and $86.3{\%}$ for combined chemoradiation group. But in operation group, after one cycle of concurrent chemoradiation treatment, response rate was $61.9{\%}$. The pathologic complete response were $15.4{\%}$ in operation group. Overall median survival was II months and actuarial 5-year survival rate was $8{\%}$. The median survival interval was 6 months for radiation alone group, 11 months for combined chemoradiation group and 19 months for operation group. And also median survival was 19 months for complete responder group that 8 months for noncomplete responder group. In univariative analysis, statistically significant prognostic factors were tumor size, clinical stage, tumor response, and operation. In multivariative analysis, significantly better survival was associated with clinical stage, tumor response, radiation dose, and operation. Conclusion : Compared with radiotherapy alone, combined multimodality may improve the median survival in patients with localized carcinoma of the esophagus and toxicity is acceptable.