• Radiation Oncology Journal
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• 제17권2호
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• pp.141-145
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• 1999

목적: 방사선 치료시 유발되는 오심과 구토에 대하여 5-hydroxytriptamine 길항제인 그라니세트론을 투여하여 그 효과에 대한 임상적 효능과 방법, 사용기간, 부작용 등에 대한 기본적인 자료를 얻고자 본 연구를 시행하였다. 대상 및 방법 : 병리학적으로 암으로 확진된 18세 이상의 성인 남녀 10명(직장암 4명, 자궁경부암 2명, 자궁내막암 1명, 정상피종 1명, 폐암 1명, 백혈병 1명)을 대상으로 그라니세트론 치료의 효과를 조사하였다. 그라니세트론은 경구 투여로 2mg을 하루 1회 사용하였으며, 방사선치료 후 오심이나 구토 증상이 나타나기 시작하면 사용하여 2주간 계속적으로 투여하였다 환자의 오심의 정도, 구토 회수, 부작용 등의 증세는 방사선치료 시작일로부터 하루 한번씩 기록하여 24시간 후와 제7일 째의 결과를 분석하였다. 오심은 무증상, 경증, 증등도, 중증 등 4단계로 분류하였으며 무증상과 경증을 치료효과가 있는 것으로 판정하였다. 구토 억제에 대한 효과는 완전효과, 주효효과, 경미효과, 치료실패 등으로 구분하였고 완전효과와 주효효과를 구토가 조절된 것으로 정의하였다. 결과 : 오심에 대한 효과는 그라니세트론 투여후 제7일에 전체 10명중 9명(90$\%$)에서 증삶이 호전되었다(무증상=6명, 경증=3명). 구토증세에 대한 조절효과는 제7일에 완전효과가 70$\%$ 주효효과가 30$\%$,로 전체적인 치료효과는 100$\%$에서 구토가 조절되었으며 경미효과나 치료실패로 판정된 환자는 없었다. 부작용으로는 경도의 두통을 호소한 환자가 1명 있었고 또 다른 1명에서 경도의 어지러움증을 호소하였으나 특별한 치료없이 곧 소실되었고, 변비나 추체외로 증상은 한 예도 없었다. 결론 : 대부분의 환자(100$\%$)에서 일주일간의 그라니세트론 투여로 오심(90$\%$) 및 구토(100$\%$)의 증상을 억제할 수 있었으나 항암제와 방사선요법을 병행하는 환자나 넓은 부위를 치료하는 경우는 방사선 치료가 끝날 때까지 계속적으로 그라니세트론을 투여할 필요가 있었다. 항암제 투여시 동반되는 오심과 구토는 주요 관심의 대상으로 이에 대한 치료 방법과 효과에 대해서는 비교적 많은 연구가 이루어져 있으나, 방사선치료 시에 나타나는 이러한 증상에 관한 연구는 미흡한 실정이며 효율적인 방사선치료를 위해서는 앞으로 항구토제의 투여 방법 및 기간 등에 관한 체계적인 연구가 필요하다고 하겠다.

• Tuberculosis and Respiratory Diseases
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• 제40권4호
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• pp.367-377
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• 1993

연구배경 : 절제가 불가능한 비소세포 폐암 환자에 대한 복합화학요법의 유용성은 아직도 분명치 않다. 그러나, cisplatin을 주축으로하는 복합화학요법의 반응율은 항암제 단독 투여시의 반응율 보다, 또한 high-dose cisplatin군의 반응율이 low-dose cisplatin군의 반응율보다 높은 것으로 최근 보고되고 있다. 복합화학요법(high VPP), 복합화학요법과 방사선 치료의 병행요법이 진행된 비소세포 폐암에서 생존율을 증가시키는지 알아보기 위해 본 연구를 시작하였다. 방법 : 조직학적으로 비소세포 폐암으로 진단된 stage III이상의 환자 35명을 대상으로 하였다. 이들중, 19명은 VP-16과 high-dose cisplatin(100 $mg/m^2$)으로 구성되는 복합화학요법 그리고 복합화학요법과 방사선 치료를 시행받았으며, 나머지 16명은 치료를 받지 않았다. 두군간의 생존율과 반응율의 차이 및 치료에 다른 부작용을 알아보기 위해 환자의 병록 일지를 검토하였다. 결과: 1) 전체적인 객관적 반응율은 한명의 완전관해를 포함하여 47%(9/19) 였다. 2) 복합화학요법과 방사선 치료를 병행하여 받은 환자군에서의 반응율은 한명의 완전관해를 포함하여 60%(6/10) 였으며, 3개월, 6개월 및 127개월 생존율은 각각 100%, 70% 및 40% 였다. 3) 복합화학요법을 받은 환자군에서의 반응율은 완전관해 없이 33%(3/9) 였으며, 3개월, 6개월 및 12개월 생존율은 각각 78%, 67% 및 33% 였다. 4) 전체적으로 치료군에서 비치료군에 비해 통계적으로 유의하게 (p<0.05) 생존기간이 연장되었다(중앙생간 307일과 95일). 5) 여러 예후인자에 따른 분석에서 운동능력이 좋을수록, stage III에서 그리고 편평상피암에서 좋은 반응율을 보였다. 6) 부작용으로서는 오성과 구토(100%), 탈모증(90%), 빈혈(79%), 백혈구 감소증 (69%), 혈소판 감소증(2%), creatinine의 증가(16%) 그리고 신경독성(5%) 등이 있었다. 결론 : 이상의 결과로 진행된 비소세포 폐암 환자에 대한 hign VPP 복합화학요법은 비치료군에 비해 치료군에서 생존율을 높이는 비교적 좋은 효과가 있으므로 좋은 적응증을 가진 환자들을 선택하여 효과적인 항암치료 및 방사선 치료를 시행하여야 할 것으로 사료된다. 그러나, hign VPP 복합화학요법에 따른 효과 개선은 본 연구 결과에선 뚜렷하지 않으므로 보다 많은 증례에서 추구 연구가 필요하리라 생각된다.

• 한국지진공학회논문집
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• 제22권6호
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• pp.345-352
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• 2018

It is inevitable to use the distinct element method in the analysis of structural dynamics for stacked stone pagoda system. However, the experimental verification of analytical results produced by the discrete element method is not sufficient yet, and the theory of distinct element method is not universal in Korea. This study introduces how to model the stacked stone pagoda system using the distinct element method, and draws some considerations in the seismic analysis procedures. First, the rocking mode and sliding mode are locally mixed in the seismic responses. Second, the vertical stiffness and the horizontal stiffness on the friction surface have the greatest influence on the seismic behavior. Third, the complete seismic analysis of stacked stone pagoda system requires a set of the horizontal, vertical, and rotational velocity time histories of the ground. However, earthquake data monitored in Korea are limited to acceleration and velocity signals in some areas.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2004년도 전력전자학술대회 논문집(2)
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• pp.479-483
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• 2004

Fuel Cell (FC) has slow response characteristic for load variation. During a load step, the inverter cannot pull more power from the fuel cell than is currently available so supplemental power must be provide by some sort of energy storage elements. In this paper, hi-directional do-dc converter for FC generation system is proposed to improve load response characteristic. The hi-directional converter interfaces the low voltage battery to the inverter dc link of FC generation system. The converter is based on a active full bridge in the primary side and on a half bridge in the secondary of a high frequency isolation transformer. The complete operating principles and simulation results in presented.

• International Journal of Control, Automation, and Systems
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• 제5권5호
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• pp.508-514
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• 2007

Properties and potential applications of the block pulse response circulant matrix (PRCM) and its singular value decomposition (SVD) are investigated in relation to MIMO control and identification. The SVD of the PRCM is found to provide complete directional as well as frequency decomposition of a MIMO system in a real matrix form. Three examples were considered: design of MIMO FIR controller, design of robust reduced-order model predictive controller, and input design for MIMO identification. The examples manifested the effectiveness and usefulness of the PRCM in the design of MIMO control and identification. irculant matrix, SVD, MIMO control, identification.

• Structural Engineering and Mechanics
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• 제23권6호
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• pp.599-613
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• 2006

A method for the dynamical analysis of FE discretized uncertain linear and nonlinear structures is presented. This method is based on the moment equation approach, for which the differential equations governing the response first and second-order statistical moments must be solved. It is shown that they require the cross-moments between the response and the random variables characterizing the structural uncertainties, whose governing equations determine an infinite hierarchy. As a consequence, a closure scheme must be applied even if the structure is linear. In this sense the proposed approach is approximated even for the linear system. For nonlinear systems the closure schemes are also necessary in order to treat the nonlinearities. The complete set of equations obtained by this procedure is shown to be linear if the structure is linear. The application of this procedure to some simple examples has shown its high level of accuracy, if compared with other classical approaches, such as the perturbation method, even for low levels of closures.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1996년도 가을 학술발표회 논문집
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• pp.159-167
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• 1996

This paper describes the theory and verification of a method which utilizes the free decay response of a structure to determine its vibration parameters. The theory of the method is base on the formulation of a system matrix, contains information characterizing the complete set of modal parameters of the system, and its eigen-solution problem. The applicability of the method is verified by simulated free decay response data of a cantilever bean The method described was used to determined the parameters related to the first five generated modes of vibration of a cantilever beam. It involves two very close natural frequencies which could not be identified using a frequency sweep test(peak amplitude) because of interference between modes.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2006년도 춘계학술발표회 논문집(I)
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• pp.446-449
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• 2006

Several experimental investigations have been carried out to study the behavior of reinforced concrete columns with short lap splices. However, very few analytical models have been developed for the analysis of such columns subjected to earthquakes. As nonlinear analysis procedures become more common in practice (such as those outlined in the Guidelines for Seismic Rehabilitation of Buildings published by the Federal Emergency Management Agency in the United States), the need for an accurate and reliable representation of the nonlinear response of strength degrading systems becomes more important. In this study, an analytical model for estimating the complete response of reinforced concrete columns with short lap splices is presented. The model is based on local bond stress-slip relationships and is validated against independent experimental data from cyclic loading tests on reinforced concrete columns with typical construction details of the 1960s. In this paper a simple equation for calculating the bar stress at splice failure is presented. Use of the proposed equation resulted in excellent agreement between the measured and calculated strength at splice failure.

• Ocean Systems Engineering
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• 제8권2호
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• pp.201-221
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• 2018

In this paper a comprehensive study for the structural control of Jacket platform with Magneto-Rheological (MR) damper is presented. The control is implemented as a closed loop feedback of the applied voltage in the MR Damper using fuzzy logic. Nine cases of combinations with MR damper are presented to complete the work. The selection of the MR damper (RD 1005-3) is based on the operating parameters (i.e., the range of frequency and displacement). Bingham model is used to obtain the control forces. The damping co-efficient of the model is obtained using empirical relationship between the voltage in the MR damper and input velocity from the structural members. The force acting on the structure is obtained from Morison equation using P-M spectrum. The results show that the reliable control was obtained when there was a continuous connection of multiple MR dampers with the lower levels of the structure. Independent MR dampers at different levels provided control within a range, while the MR dampers placed at alternate positions gave very high control.

• 영어어문교육
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• 제13권4호
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• pp.1-32
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• 2007

This study took a cross-sectional, quantitative approach and profiled EFL students' awareness of the writing process and of teacher feedback. The subjects were 113 college students aged 19-26 years from non-English majors, who were enrolled in three sections of a required English course. According to the scores gained from the essay writing assignment, they were divided into two groups (proficient and less-proficient writers) and responded to an in-class survey. Major findings were that: (1) the vast majority of both groups did not find English writing enjoyable; (2) longer comments gave rise to substantial changes to the students' revisions; (3) the less-proficient writers were shown to benefit from revision significantly more than the proficient writers; (4) Both groups of writers utilized multiple strategies to process teacher feedback and preferred to receive teacher comments using complete sentences rather than phrases or single words; and (5) teacher's marks on grammar and vocabulary claimed to be most conducive to EFL writing development. Several important implications for EFL writing instruction and for future studies are suggested.