• 대한수의학회지
• /
• 제61권1호
• /
• pp.8.1-8.10
• /
• 2021

The purpose of this retrospective study was to describe cases of feline intermediateto high-grade alimentary lymphoma regarding signalment, clinical presentation, laboratory findings, response to therapy (modified 25-week University of Wisconsin-Madison [UW-25] vs. COP [cyclophosphamide, vincristine, prednisone]), toxicosis, and outcomes and to identify prognostic factors. Sixteen cats were treated with chemotherapy protocols. Response rates and survival did not differ statistically between the two protocols. The progression-free interval (PFI) and median survival time (MST) in cats achieving a response to therapy were longer than in those with no response [NR] (complete remission [CR] vs. partial remission [PR] vs. NR; PFI, 124 vs. 49 vs. 12 days, p < 0.001; MST, 361 vs. 118 vs. 16 days, p < 0.001). Clinical stage was another prognostic factor for PFI and MST. The PFI and MST in cats in stage I were longer than in those in other stages (PFI, 107 days vs. 30 days; MST, 193 days vs. 54 days). Hematologic and gastrointestinal toxicosis was mostly low grade. In comparing the modified UW-25 protocol with the COP protocol, there was not much difference in the number of neutropenic episodes and grade levels.

• Journal of Audiology & Otology
• /
• 제24권2호
• /
• pp.79-84
• /
• 2020

Background and Objectives: Hearing can be elicited in response to vibratory stimuli delivered to fluid in the external auditory meatus. To obtain a complete audiogram in subjects with normal hearing in response to pure tone vibratory stimuli delivered to fluid applied to the external meatus. Subjects and Methods: Pure tone vibratory stimuli in the audiometric range from 0.25 to 6.0 kHz were delivered to fluid applied to the external meatus of eight participants with normal hearing (15 dB or better) using a rod attached to a standard clinical bone vibrator. The fluid thresholds obtained were compared to the air conduction (AC), bone conduction (BC; mastoid), and soft tissue conduction (STC; neck) thresholds in the same subjects. Results: Fluid stimulation thresholds were obtained at every frequency in each subject. The fluid and STC (neck) audiograms sloped down at higher frequencies, while the AC and BC audiograms were flat. It is likely that the fluid stimulation audiograms did not involve AC mechanisms or even, possibly, osseous BC mechanisms. Conclusions: The thresholds elicited in response to the fluid in the meatus likely reflect a form of STC and may result from excitation of the inner ear by the vibrations induced in the fluid. The sloping fluid audiograms may reflect transmission pathways that are less effective at higher frequencies.

• 대한청각학회지
• /
• 제24권2호
• /
• pp.79-84
• /
• 2020

Background and Objectives: Hearing can be elicited in response to vibratory stimuli delivered to fluid in the external auditory meatus. To obtain a complete audiogram in subjects with normal hearing in response to pure tone vibratory stimuli delivered to fluid applied to the external meatus. Subjects and Methods: Pure tone vibratory stimuli in the audiometric range from 0.25 to 6.0 kHz were delivered to fluid applied to the external meatus of eight participants with normal hearing (15 dB or better) using a rod attached to a standard clinical bone vibrator. The fluid thresholds obtained were compared to the air conduction (AC), bone conduction (BC; mastoid), and soft tissue conduction (STC; neck) thresholds in the same subjects. Results: Fluid stimulation thresholds were obtained at every frequency in each subject. The fluid and STC (neck) audiograms sloped down at higher frequencies, while the AC and BC audiograms were flat. It is likely that the fluid stimulation audiograms did not involve AC mechanisms or even, possibly, osseous BC mechanisms. Conclusions: The thresholds elicited in response to the fluid in the meatus likely reflect a form of STC and may result from excitation of the inner ear by the vibrations induced in the fluid. The sloping fluid audiograms may reflect transmission pathways that are less effective at higher frequencies.

• 한국지리정보학회지
• /
• 제17권1호
• /
• pp.13-23
• /
• 2014

우리나라는 그간 화산 재해로부터 안전한 지역으로 알려졌다. 그러나, 최근 백두산의 화산 분화 전조현상 들이 자주 보고되고 있으며, 이에 따라 한반도의 화산 분화를 경고하는 화산 전문가들이 늘어나고 있는 실정이다. 본 논문은 백두산 화산 재해 대응 시스템의 개발방안을 기술하고 있다. 첫 번째로 소방방재청의 방재업무 체계와 관련 시스템을 분석한다. 두 번째로, 방재업무체계를 기반으로 화산 재해 대응 업무 프로세스를 도출한다. 세 번째로, 관련 재난 대응 시스템을 참고하여 화산재해 대응시스템의 시스템 아키텍처를 설계하고 필요 공간정보를 도출한다. 마지막으로, 본 논문에서 제안한 화산재해 대응시스템을 테스트하기 위하여 파일럿 시스템을 개발한다. 제안된 화산재해 대응시스템이 실제로 소방방재청에 탑재되기까지는 추가적인 검증 및 시스템 보완이 필요할 것이다. 본 연구를 기반으로 한 완성된 화산재해 대응 시스템은 우리나라와, 중국, 일본의 화산재해로 인한 피해를 최소화 할 것으로 기대된다.

• Journal of Korean Biological Nursing Science
• /
• 제21권4호
• /
• pp.266-274
• /
• 2019

Purpose: The aim of this research was to identify the mediating effect of sleep quality on the relationship between job stress and stress response of shift-working nurses. Methods: The participants in this study were 150 nurses who had more than 6 months of shift-working experience. A survey was conducted from May to June 2017 in a hospital in Gyeonggi-do, South Korea. The data were collected through self-report questionnaires. The collected data were analyzed using SAS 9.4 program. The analysis was based on Baron and Kenny's model to examine the mediating effects of sleep quality on the relationship between job stress and stress response of shift-working nurses. Results: In the first and second steps, job stress was identified as a significant predictor of sleep quality (β= .29, p= .001) and stress response (β = .24, p= .004). In the third step, sleep (B = .55, p< .001) was observed as a significant predictor of stress response, and the direct relationship between job stress and stress response was not significant (β= .07, p= .291). Sleep quality was found to exhibit complete mediating effect on the relationship between job stress and stress response. Conclusion: The results of this study suggest that strategies for managing the stress of shift-working nurses should include effective ways to ensure sleep quality.

• Radiation Oncology Journal
• /
• 제22권4호
• /
• pp.247-253
• /
• 2004

목적: 하인두암은 대부분 진행되어 진단이 되며 예후가 불량한 것으로 알려져 있다. 이에 4기 병기 하인두암에서 선행 항암화학요법 후 방사선치료를 시행하여 반응과 생존율에 미치는 영향을 알아보고자 하였다. 대상 및 방법: 1989년 7월부터 2000년 2월까지 원격전이가 없었던 AJCC 병기 4기의 하인두암으로 진단되어 선행 항암화학요법후 방사선치료를 받았던 18예를 대상으로 후향적 분석을 하였다. 선행화학요법은 5-FU와 cisplatln을 병용하여 3주 간격으로 모든 환자에서 2회 시행하였다. 총방사선량은 원발병소와 전이된 임파절에 $6834\~72.0$Gy까지 조사하였다(중앙값: 70.2 Gy). 결과: 추적관찰기간은 7개월에서 99개월이었다(중앙값 28개월). 3년 생존율 및 무병생존율은 각각 $41.7\%$, $31.1\%$였다. 6예($33.3\%$)에서 3년 이상 후두 보존이 가능하였다. 선행 항암화학요법 후 16예($88.8\%$)에서 부분관해를 보였고, 완전관해, 무반응은 각각 1예($5.6\%$)에서 관찰되었다. 모든 치료가 끝난 후 치료 반응으로 완전관해는 13예($72.2\%$), 부분관해가 5예($27.8\%$)로 반응률은 $100\%$였다. 생존율에 영향을 미치는 예후인자에 대한 분석에서 선행 항암화학요법과 방사선치료 후에 완전관해를 보인 군과 부분관해를 보인 군의 3년 생존율과 무병생존율이 각각 $43.1\%$ $20.0\%$와 $39.6\%$, $20.0\%$로 의미있는 차이를 보였으며(p=0.0003, p=0.002) 모든 치료가 끝난 후 최종 치료 반응만이 통계학적으로 유의성이 있었다. 결론: 4기 병기 하인두암에서 선행 항암화학요법 후의 방사선치료는 심각한 부작용없이 효과적이었다.

• Radiation Oncology Journal
• /
• 제36권1호
• /
• pp.17-24
• /
• 2018

Purpose: This study aimed to assess complications and outcomes of a new approach, that is, combining short course radiotherapy (SRT), concurrent and consolidative chemotherapies, and delayed surgery. Materials and Methods: In this single arm phase II prospective clinical trial, patients with T3-4 or N+ M0 rectal adenocarcinoma were enrolled. Patients who received induction chemotherapy or previous pelvic radiotherapy were excluded. Study protocol consisted of three-dimensional conformal SRT (25 Gy in 5 fractions in 1 week) with concurrent and consolidation chemotherapies including capecitabine and oxaliplatin. Total mesorectal excision was done at least 8 weeks after the last fraction of radiotherapy. Primary outcome was complete pathologic response and secondary outcomes were treatment related complications. Results: Thirty-three patients completed the planned preoperative chemoradiation and 26 of them underwent surgery (24 low anterior resection and 2 abdominoperineal resection). Acute proctitis grades 2 and 3 were seen in 11 (33.3%) and 7 (21.2%) patients, respectively. There were no grades 3 and 4 subacute hematologic and non-hematologic (genitourinary and peripheral neuropathy) toxicities and perioperative morbidities such as anastomose leakage. Grade 2 or higher late toxicities were observed among 29.6% of the patients. Complete pathologic response was achieved in 8 (30.8%) patients who underwent surgery. The 3-year overall survival and local control rates were 65% and 94%, respectively. Conclusion: This study showed that SRT combined with concurrent and consolidation chemotherapies followed by delayed surgery is not only feasible and tolerable without significant toxicity but also, associated with promising complete pathologic response rates.

• Tuberculosis and Respiratory Diseases
• /
• 제62권5호
• /
• pp.432-436
• /
• 2007

악성 흉막 중피종(Malignant pleural mesothelioma, MPM)은 선암과의 감별이 어렵고 예후가 매우 좋지 않은 드문 암이다. MPM의 치료를 위해 많은 항암제들이 시도되었지만 그 효과는 크지 않았다. 완전관해는 거의 되지 않으며 부분 관해 역시 1/3 이하의 환자에서 기대할 수 있다. 하지만 최근 한 3상 연구를 보면 cisplatin 단독요법에 비해 pemetrexed/cisplatin 병합 항암화학요법이 반응률과 평균 생존기간을 의미있게 증가시켰다. 이에 저자들은 1차 항암화학치료에 실패한 MPM환자에서 pemetrexed/cisplatin 병합화학요법을 시도한 결과 극적인 반응을 보인 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Radiation Oncology Journal
• /
• 제36권1호
• /
• pp.25-34
• /
• 2018

Purpose: This study aimed to evaluate the initial outcomes of proton beam therapy (PBT) for hepatocellular carcinoma (HCC) in terms of tumor response and safety. Materials and Methods: HCC patients who were not indicated for standard curative local modalities and who were treated with PBT at Samsung Medical Center from January 2016 to February 2017 were enrolled. Toxicity was scored using the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. Tumor response was evaluated using modified Response Evaluation Criteria in Solid Tumors (mRECIST). Results: A total of 101 HCC patients treated with PBT were included. Patients were treated with an equivalent dose of $62-92GyE_{10}$. Liver function status was not significantly affected after PBT. Greater than 80% of patients had Child-Pugh class A and albumin-bilirubin (ALBI) grade 1 up to 3-months after PBT. Of 78 patients followed for three months after PBT, infield complete and partial responses were achieved in 54 (69.2%) and 14 (17.9%) patients, respectively. Conclusion: PBT treatment of HCC patients showed a favorable infield complete response rate of 69.2% with acceptable acute toxicity. An additional follow-up study of these patients will be conducted.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권6호
• /
• pp.2501-2504
• /
• 2014

Background: Capecitabine is an oral fluoropyrimidine derivative which is frequently used alone or in combination regimens for the treatment of metastatic breast cancer. Although overall and progression free survivals have increased in recent years with the use of new generation drugs, predictive factors that would further improve the outcomes are needed. Previous studies have demonstrated the relation between post-treatment increase in mean corpuscular volume (MCV) and predicting therapy response as well as survival. The present study investigated the clinical impact of MCV elevation in metastatic breast cancer patients treated with capecitabine. Materials and Methods: The data of a total of 82 patients from three centers followed between June 2005 and June 2013 were retrospectively analyzed. The demographic data and hormone receptor status of the patients, as well as initial examination before and after treatment and data concerning progression were recorded. MCV ${\geq}100$ fl was considered as macrocytosis. Capecitabine was given at a dose of $2500mg/m^2$ daily for 14 days every three weeks. Pre-treatment and post-treatment MCV and other parameters of complete blood count were recorded. Post-treatment initial evaluation was performed after 2 cycles of therapy. Results: The median age of the patients was 46.5 years (range 26-72 years) and 54% were premenopausal. Performance status was ECOG 0 and 1 in 81 (99%) patients. The median number of cycles for capecitabine therapy was 5 (min-max: 2-18). The median ${\Delta}MCV$ level (post-treatment values at sixth week - baseline) was 6.4. Whilst ${\Delta}MCV$ was ${\geq}6.4$ in 42 patients, it was <6.4 in 40 patients. Clinical benefit (complete response+partial response+stable disease) was observed in 37 (88%) of 42 patients with a median ${\Delta}MCV$ ${\geq}6.4$ and in 30 (75%) of 40 patients with ${\Delta}MCV$ <6.4 with no statistically significant difference (p=0.158). No significant difference was determined between the group with ${\Delta}MCV$ ${\geq}6.4$ and the group with ${\Delta}MCV$ <6.4 in terms of progression-free survival (11 vs 12 months) (p=0.55) and overall survival (20 months vs. 24 months) (p=0.11). Conclusions: The identification of new predictive markers in metastatic breast cancer is very important. In some recent studies, increase in MCV has been suggested as a marker in tumor response. In the present study, however, no significant difference was determined between tumor response and increase in MCV. Further studies including higher numbers of patients are needed to determine whether increase in MCV is a predictive marker or not.