• Radiation Oncology Journal
• /
• v.17 no.2
• /
• pp.141-145
• /
• 1999

Purpose : Granisetron is a potent, the most selective 5-HT3 receptor antagonist and is reported to b effective in treatment of radiation-induced emesis. The antiemetic efficacy and safety of oral granisteron was evaluated in patients with receiving highly emetogenic treatment by conventional fractionated irradiation. Materials and Methods : Patients with various cancers who were being treated with irradiation were accrued into the present study. The intensity of nausea was evaluated on first 24 hours and on day-7 by patients according to the degree of interference with normal daily life as followings; a) none; b) present but no interference with normal daily life (mild): c) interference with normal daily life (moderate): and d) bedridden because of nausea (severe). Non or mild state was considered to indicate successful treatment. The efficacy of antiemetic treatment was graded as follows; a) complete response; no vomiting, no worse than mild nausea and receive no rescue antiemetic therapy over the 24h period, b) major response; either one episode of vomiting or moderate/severe nausea or had received rescue medication over 24h period, or any combination of these, c) minor response; two to four episodes of vomiting over the 24h period, regardless of nausea and rescue medication, d) failure; more than four medication. The score of the most symptom was recorded and the total score over 24 hours was summarized. The complete or major response was considered to indicate successful treatment. Results : A total of 10 patients were enrolled into this study, and all were assessable for efficacy analysis. Total nausea control was achieved in 90$\%$ (9/10:none=60$\%$ plus mild=30$\%$) of total patients after 7 days. The control of vomiting by granisteron was noted in seven patients (70$\%$) of complete response and three (30$\%$) of major response with a hundred-percent successful treatment over 7 days. The minor response or treatment failure were not observed. No significant adverse events or toxicities from granisetron were recorded in patient receiving granisetron. Conclusion : We concluded that granisetron is a highly effective antiemetic agent in controlling radiotherapy-induced nausea or vomiting with a minimal toxicity profile.

• Tuberculosis and Respiratory Diseases
• /
• v.40 no.4
• /
• pp.367-377
• /
• 1993

Background: The benefits of combination chemotherapy in unresectable non-small cell lung cancer remain uncertain. But, according to the recent reports, the response rates of cisplatin-based polychemotherapy regimens are higher than those of single agent. Also, the response rates of high-dose cisplatin group are higher than those of low-dose cisplatin group. In attemp to answer the question whether treatments, combination chemotherapy (high VPP) and combination chemotherapy with radiation therapy, improve survival in advanced non-small cell lung cancer, we begin to study. Method: Thirty-five patients above stage III, diagnosed histologically as non-small cell lung cancer, were enrolled. Among them, nineteen received a combination chemotherapy consisting of VP-16 & high-dose cisplatin (100 $mg/m^2$) and/or radiation therapy. The other group (16 subjects) received no therapy. To investigate the differences of survival and response rates between two groups and the side effects related to therapy, we reviewed patients' records. Results: 1) The overall objective response rate was 47%(9/19) with one complete remission. 2) In patients who received polychemotherapy and radiation therapy, the response rate was 60%(6/10) with one complete remission and survival rates of 3 months, 6 months and 12 months were 100%, 70% and 40%. 3) In patients who received polychemotherapy, the response rate was 33% (3/9) with no complete remission and survival rates of 3 months, 6 months and 12 months were 78%, 67% and 33%. 4) Overall, treated patients survived significantly longer (p<0.05) than non-treated patients (median survival 307 days versus 95 days). 5) Analysis of the various prognostic factors disclosed that good performance status, stage III and squamous cell type showed the good response rates. 6) The toxicities were nausea and/or vomiting (100%), alopecia (90%), anemia (79%), leukopenia (69%), thrombocytopenia (2%), increased creatinine (16%) and neurotoxicity (5%). Conclusion: According to above results, there are relatively good results that high VPP combination chemotherapy in advanced non-small cell lung cancer improves survival in the treated group than in the non-treated group. Thus, it is considerd that we select the patients with proper indications and treat them with effective chemotherpy and radiation therapy. But, because improvement related to high VPP ploychemotherapy is not marked in this study, it is necessary that we should investigate follow-up studies in many cases.

• Journal of the Earthquake Engineering Society of Korea
• /
• v.22 no.6
• /
• pp.345-352
• /
• 2018

It is inevitable to use the distinct element method in the analysis of structural dynamics for stacked stone pagoda system. However, the experimental verification of analytical results produced by the discrete element method is not sufficient yet, and the theory of distinct element method is not universal in Korea. This study introduces how to model the stacked stone pagoda system using the distinct element method, and draws some considerations in the seismic analysis procedures. First, the rocking mode and sliding mode are locally mixed in the seismic responses. Second, the vertical stiffness and the horizontal stiffness on the friction surface have the greatest influence on the seismic behavior. Third, the complete seismic analysis of stacked stone pagoda system requires a set of the horizontal, vertical, and rotational velocity time histories of the ground. However, earthquake data monitored in Korea are limited to acceleration and velocity signals in some areas.

• Proceedings of the KIPE Conference
• /
• 2004.07b
• /
• pp.479-483
• /
• 2004

Fuel Cell (FC) has slow response characteristic for load variation. During a load step, the inverter cannot pull more power from the fuel cell than is currently available so supplemental power must be provide by some sort of energy storage elements. In this paper, hi-directional do-dc converter for FC generation system is proposed to improve load response characteristic. The hi-directional converter interfaces the low voltage battery to the inverter dc link of FC generation system. The converter is based on a active full bridge in the primary side and on a half bridge in the secondary of a high frequency isolation transformer. The complete operating principles and simulation results in presented.

• International Journal of Control, Automation, and Systems
• /
• v.5 no.5
• /
• pp.508-514
• /
• 2007

Properties and potential applications of the block pulse response circulant matrix (PRCM) and its singular value decomposition (SVD) are investigated in relation to MIMO control and identification. The SVD of the PRCM is found to provide complete directional as well as frequency decomposition of a MIMO system in a real matrix form. Three examples were considered: design of MIMO FIR controller, design of robust reduced-order model predictive controller, and input design for MIMO identification. The examples manifested the effectiveness and usefulness of the PRCM in the design of MIMO control and identification. irculant matrix, SVD, MIMO control, identification.

• Structural Engineering and Mechanics
• /
• v.23 no.6
• /
• pp.599-613
• /
• 2006

A method for the dynamical analysis of FE discretized uncertain linear and nonlinear structures is presented. This method is based on the moment equation approach, for which the differential equations governing the response first and second-order statistical moments must be solved. It is shown that they require the cross-moments between the response and the random variables characterizing the structural uncertainties, whose governing equations determine an infinite hierarchy. As a consequence, a closure scheme must be applied even if the structure is linear. In this sense the proposed approach is approximated even for the linear system. For nonlinear systems the closure schemes are also necessary in order to treat the nonlinearities. The complete set of equations obtained by this procedure is shown to be linear if the structure is linear. The application of this procedure to some simple examples has shown its high level of accuracy, if compared with other classical approaches, such as the perturbation method, even for low levels of closures.

• Proceedings of the Computational Structural Engineering Institute Conference
• /
• 1996.10a
• /
• pp.159-167
• /
• 1996

This paper describes the theory and verification of a method which utilizes the free decay response of a structure to determine its vibration parameters. The theory of the method is base on the formulation of a system matrix, contains information characterizing the complete set of modal parameters of the system, and its eigen-solution problem. The applicability of the method is verified by simulated free decay response data of a cantilever bean The method described was used to determined the parameters related to the first five generated modes of vibration of a cantilever beam. It involves two very close natural frequencies which could not be identified using a frequency sweep test(peak amplitude) because of interference between modes.

• Proceedings of the Korea Concrete Institute Conference
• /
• 2006.05a
• /
• pp.446-449
• /
• 2006

Several experimental investigations have been carried out to study the behavior of reinforced concrete columns with short lap splices. However, very few analytical models have been developed for the analysis of such columns subjected to earthquakes. As nonlinear analysis procedures become more common in practice (such as those outlined in the Guidelines for Seismic Rehabilitation of Buildings published by the Federal Emergency Management Agency in the United States), the need for an accurate and reliable representation of the nonlinear response of strength degrading systems becomes more important. In this study, an analytical model for estimating the complete response of reinforced concrete columns with short lap splices is presented. The model is based on local bond stress-slip relationships and is validated against independent experimental data from cyclic loading tests on reinforced concrete columns with typical construction details of the 1960s. In this paper a simple equation for calculating the bar stress at splice failure is presented. Use of the proposed equation resulted in excellent agreement between the measured and calculated strength at splice failure.

• Ocean Systems Engineering
• /
• v.8 no.2
• /
• pp.201-221
• /
• 2018

In this paper a comprehensive study for the structural control of Jacket platform with Magneto-Rheological (MR) damper is presented. The control is implemented as a closed loop feedback of the applied voltage in the MR Damper using fuzzy logic. Nine cases of combinations with MR damper are presented to complete the work. The selection of the MR damper (RD 1005-3) is based on the operating parameters (i.e., the range of frequency and displacement). Bingham model is used to obtain the control forces. The damping co-efficient of the model is obtained using empirical relationship between the voltage in the MR damper and input velocity from the structural members. The force acting on the structure is obtained from Morison equation using P-M spectrum. The results show that the reliable control was obtained when there was a continuous connection of multiple MR dampers with the lower levels of the structure. Independent MR dampers at different levels provided control within a range, while the MR dampers placed at alternate positions gave very high control.

• English Language & Literature Teaching
• /
• v.13 no.4
• /
• pp.1-32
• /
• 2007

This study took a cross-sectional, quantitative approach and profiled EFL students' awareness of the writing process and of teacher feedback. The subjects were 113 college students aged 19-26 years from non-English majors, who were enrolled in three sections of a required English course. According to the scores gained from the essay writing assignment, they were divided into two groups (proficient and less-proficient writers) and responded to an in-class survey. Major findings were that: (1) the vast majority of both groups did not find English writing enjoyable; (2) longer comments gave rise to substantial changes to the students' revisions; (3) the less-proficient writers were shown to benefit from revision significantly more than the proficient writers; (4) Both groups of writers utilized multiple strategies to process teacher feedback and preferred to receive teacher comments using complete sentences rather than phrases or single words; and (5) teacher's marks on grammar and vocabulary claimed to be most conducive to EFL writing development. Several important implications for EFL writing instruction and for future studies are suggested.