• Korean Journal of Bronchoesophagology
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• v.15 no.2
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• pp.49-56
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• 2009

Purpose : To evaluate the treatment outcome for patients with locally advanced, unresectable esophageal cancer treated with relatively high dose radiation therapy(RT). Materials and Methods : From January 2000 to December 2008, 32 patients with locally advanced unresectable or medically inoperable esophageal cancer were treated with radiation therapy(RT) with or without concurrent chemotherapy. Ten patients were excluded from analysis because of distant metastasis and drop off. Patient distributions according to AJCC stages II, III IVa were 7(31.8%), 12(54.6%), 3(13.6%) respectively. The locations of tumor were cervical/upper thorax 3 (13.6%), mid thorax 13(59.1%), and lower thorax/abdominal 6(27.3%), respectively. Eleven patients received RT only, and 11 patients received cisplatin based concurrent chemoradiotherapy(CCRT). Median radiation dose was 65 Gy(range 57.6~72 Gy). Results : The median follow-up was 9.1 months(range 1.9~43.8 months). The response rates for complete response, Partial response, stable disease and Persistent disease were 6(27.3%), 11(50.0%), 4(18.2%) and 1(4.5%), respectively. Two patients(9.1%) suffered from esophageal stenosis and stents were inserted. Two patients(9.1%) had Grade 3 radiation pneumonitis and one of them expired due to acute respiratory distress syndrome(ARDS) at 36 days after completion of radiation therapy. The recurrence rate was 11(50.0%). The patterns of recurrence were persistent disease and local progression in 5(22.7%), local recurrence 3(13.7%) and concomitant local and distant recurrence in 3(13.7%). The overall survival(OS) rate was 32.1% at 2 years and 21.4% at 3 years(median 12.0 months). Disease free survival(DFS) rate was 17.3% at 2 and 3 years. All patients who had no dysphagia at diagnosis showed complete response after treatment and 100% OS at 3 years(p=0.0041). The OS for above 64.8 Gy group and 64.8 Gy or below group at 3 years were 60.6% and 9.1%(p=0.1341). The response to treatment was the only significant factor affecting OS(p=0.004). Conclusion : Relatively high dose radiation therapy in unresectable esophageal cancer tended to have a better outcome without increased complication rate. Further study with more patients is warranted to justify improved result.

• Radiation Oncology Journal
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• v.4 no.1
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• pp.55-62
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• 1986

From Nov. 1983 through Jan. 1986, 43 patients with nonsmall cell lung cancer were treated by radiation therapy at Inje Medical College Paik Hospital. 38 patients were available for the analysis of this study. 33 patients received definite irradiation with curative intent, while 5 patients received postoperative irradiation. Chemotherapy was added in 12 patients before, during and after radio-therapy. 28 patients were squamous cell carcinoma and 10 patients were adenocarcinoma. There were 29 men and 9 women (median age, 50 years; range 34 to 74 years). Stage 1 was 1 patient, Stage 11,7 patient, and Stage 111,30 patients. Among 33 patients who received radiotherapy with curative intent, follow up radiological study revealed complete response in 12 patients $(36\%)$, partial response, in 9 patients $(27\%)$, and minimal response, in 5 patients $(15\%)$, while 7 patients $(21\%)$ were nonresponders. Median survival for all patients was 6.9 months; squamous cell carcinoma, 7.3 months, adenocarcinoma, 5.9 months. Responders survived median 7 months, while nonresponders survived median 1.9 months. Improved complete response rate and survival were shown in high radiation dose group. As prognostic factors, age, initial performance status, sex, histology and tumor location were evaluated.

• Radiation Oncology Journal
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• v.16 no.2
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• pp.177-184
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• 1998

Purpose : Radiotherapy has been the mainstay of the treatment of brain metastases. We evaluated the response rate, survival and prognostic factors of patients with brain metastases treated with radiotherapy for palliative purpose. Materials and Methods : From January 1994 through April 1997, in all 42 patients, a retrospective analysis was undertaken. Of these, 33 patients received whole brain irradiation with 30Gy in 10 daily fractions with or without a boost of 10Gy in 5 daily fractions to the site of solitary lesion. Nine patients failed to complete the planned treatment Results : Of 33 patients who finished radiotherapy, complete and partial response were observed in $4(12\%)$ patients and $22(67\%)$ ones, respectively. Overall response rate was $79\%$ and median survival was 4 months. In univariate analysis, prognostic factors affecting survival were initial neurologic function class(p=0.0136), extracranial tumor activity(p=0.042), and response after radiotherapy(p=0.001). Conclusion : We confirmed that whole brain irradiation is the effective means for treating the patient with brain metastases. initial neurologic function class, extracranial tumor activity, and response alter radiotherapy were identified as prognostic factors affecting survival.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.12
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• pp.7357-7363
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• 2014

Korea had been known as safe region regarding volcanic disasters. On the other hand, Baekdu mountain experienced a large eruption one thousand years ago and the precursor phenomena for a volcanic eruption have been frequently reported these days. Therefore, a number of volcano experts, who warn of a volcanic eruption on the Korean peninsula, has increased. This paper describes the utilization plan and evolution of developing volcanic disaster response system based on spatial information and scientific modeling process for Baekdu mountain. First, the business processes for volcanic disaster response are derived based on an analysis of business system and related IT-based systems. Second, the design and development of a volcanic disaster response system are derived based on the business process. Third, a utilization plan is suggested to maximize the efficiency of the system. The application of the suggested volcanic disaster response system to NEMA, additional tests and system supplementation should be carried out. The complete volcanic disaster response system, which will be implemented based on this research, is expected to minimize the volcanic disaster damage in the area of Korea, China and Japan.

• Proceedings of the Korean Statistical Society Conference
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• 2001.11a
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• pp.143-148
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• 2001

A dataset having missing observations is often completed by using imputed values. In this paper the performances and accuracy of complete case methods and four imputation procedures are evaluated when missing values exist only on the response variables in the Weibull regression model. Our simulation results show that compared to other imputation procedures, in particular, hotdeck and Weibull regression imputation procedure can be well used to compensate for missing data. In addition an illustrative real data is given.

• Journal of Technologic Dentistry
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• v.6 no.1
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• pp.15-18
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• 1984

A denture that shifts easily in response to latterally applied forces can cause a disruption in the border seal or prevent the denture base from Correctly relating to the supporting tissue. The factors that Contribute to stability include ridge height and conformation, base adaptation, residual ridge relationships, occlusion harmony, and Muscle control. These factors can be condensed into the following categories; 1. The relationship of the denture base to the underlying tissue. 2. The relationship of occlusal harmony. 3. The relationship of the denture surface and border to the surrounding muscle. 4. The location of artificial tooth.

• Journal of the Korea Society for Simulation
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• v.12 no.2
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• pp.75-89
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• 2003

This paper describe numerical experiments with solitary beams in a self focusing Kerr medium with fast response. Through formal analogies, it compare this results on the phase sensitivity of beam collision with known predictions about one dimensional soliton interaction. For incoherent oblique beam interaction, there occurs a non-periodic coupled-mode type transfer of energy, resulting in complete transmission each beam through the other one.

• Journal of the Korean Data and Information Science Society
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• v.21 no.2
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• pp.309-316
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• 2010

Support vector quantile regression (SVQR) is capable of providing more complete description of the linear and nonlinear relationships among response and input variables. In this paper we propose a weighted SVQR for the longitudinal data. Furthermore, we introduce the generalized approximate cross validation function to select the hyperparameters which affect the performance of SVQR. Experimental results are the presented, which illustrate the performance of the proposed SVQR.

• Journal of Chest Surgery
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• v.18 no.4
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• pp.859-866
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• 1985

The characteristic features of myasthenia gravis, which are weakness of voluntary muscle and easy fatigability, result from defective neuromuscular transmission caused by an autoimmune response to acetylcholine receptor. Recently, we performed two cases of thymectomy for the treatment of myasthenia gravis, one was 50 year old man who had malignant thymoma and the other was 19 year old girl who had benign thymic hyperplasia. The former had long duration of symptoms, and showed poor postoperative result. The latter had short duration of symptoms, and showed complete remission. Herewith, we suggest that early thymectomy can give the clinical assets for myasthenia gravis. So we report these two experiences with review of literatures.

• Tuberculosis and Respiratory Diseases
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• v.48 no.5
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• pp.740-747
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• 2000

Background : To compare the efficacies and side effects of etoposide, cisplatin/cyclophosphamide, adriamycin, vincristine(VPP/CAV) with those of carboplatin etoposide(CE) in extensive stage small cell lung cancer patients. Method : Patients with extensive stage small lung cancer who has measurable disease were eligible. VPP/CAV group(n=22) was treated with cisplatin(60mg/$m^2$ iv. D1) etoposide(100mg/$m^2$ iv. D1-3), and 3 weeks later cyclophosphamide(1000mg/$m^2$ iv. D1), adriamycin( 40mg/$m^2$ iv. D1), and vincristine(1.4mg/$m^2$ iv. D1), were administered alternatively. CE group(n=22) was treated with carboplatin(325mg/$m^2$ iv. D1) and etoposide (100mg/$m^2$ iv. D1-3) ; repeated treatment was performed every 3 weeks. Result : Forty four patients were eligible for the study. The overall response rate was 61.4% (complete remission rate 0%, partial response rate 61.4%, stable disease rate 25%, progressive disease rate 13.6%), and median survival was 10.8 months. In VPP/CAV group, response rate was 54.5% (complete remission rate 0%, partial response rate 54.4%, stable disease rate 27.3%, progressive disease rate 18.2%), and, in carboplatin/etoposide group, the response rate was 68.2%(complete remission rate 0%, partial response rate 68.2%, stable disease rate 22.7%, progressive disease rate 9.1%). The median survival time was 9.5 months in the VPP/CAV group and 11 months in CE group. The toxicity of both group was moderate, and anemia was more frequent in the CE group. Conclusion : VPP/CAV regimen and CE regimen produced similar response rates and survival times in extensive stage small cell lung cancer patients. CE regimen may be effective as part of the initial therapy for extensive stage small cell lung cancer.