• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.20 no.3
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• pp.122-128
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• 2009

Objectives : Autism is a well-known psychiatric disorder that is presumed to have a neural basis. To investigate the underlying neurofunctional abnormalities of autism, the authors performed single photon emission computed tomography (SPECT) on children with autism. Methods : Fifty-five children with untreated autism (47 boys and 8 girls, mean age=$50.6{\pm}20.28$ months) were selected from among the patients visiting the child and adolescent psychiatric clinic of Seoul National University Hospital. Psychiatrists had diagnosed the participants according to the DSM-IV criteria for autistic disorder and the Childhood Autism Rating Scale (CARS) criteria for a diagnosis of autism. All participants were examined using 99mTC-HMPAO Brain SPECT. Using statistical parametric mapping (SPM) analysis, we compared the participants' SPECT images to standardized SPECT images of normal children, which had been retrospectively selected by the authors, on a voxel by voxel basis. Voxels with a p-value less than .001 were considered to be significantly different. Results : The autistic group showed significant hypoperfusion in the right medial frontal gyrus, right precentral gyrus, and left precuneus gyrus. In addition, they showed no significant hyperperfusion areas when compared to the control group. Conclusion : The findings of hypoperfusion in the medial-frontal lobe and precuneus are accord with hemodynamic abnormalities that have been already reported. Therefore, these findings are compatible with the recently suggested "theory of mind" hypothesis and the disturbances in attention shifting that have been observed in autistic children.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.37 no.4
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• pp.267-277
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• 2019

Photogrammetry and computer vision are identical in determining the three-dimensional coordinates of images taken with a camera, but the two fields are not directly compatible with each other due to differences in camera lens distortion modeling methods and camera coordinate systems. In general, data processing of drone images is performed by bundle block adjustments using computer vision-based software, and then the plotting of the image is performed by photogrammetry-based software for mapping. In this case, we are faced with the problem of converting the model of camera lens distortions into the formula used in photogrammetry. Therefore, this study described the differences between the coordinate systems and lens distortion models used in photogrammetry and computer vision, and proposed a methodology for converting them. In order to verify the conversion formula of the camera lens distortion models, first, lens distortions were added to the virtual coordinates without lens distortions by using the computer vision-based lens distortion models. Then, the distortion coefficients were determined using photogrammetry-based lens distortion models, and the lens distortions were removed from the photo coordinates and compared with the virtual coordinates without the original distortions. The results showed that the root mean square distance was good within 0.5 pixels. In addition, epipolar images were generated to determine the accuracy by applying lens distortion coefficients for photogrammetry. The calculated root mean square error of y-parallax was found to be within 0.3 pixels.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.4 no.1
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• pp.68-75
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• 2011

The performance of peripheral devices is improving rapidly to meet the needs of users for multimedia data. Therefore, the peripheral interface with wide bandwidth and high transmission rate becomes necessary to handle large amounts of data in real time for multiple high-performance devices. PCI Express is a fast serial interface with the use of packets that are compatible with previous PCI and PCI-X. In this paper, we design and verify general peripheral interface using serial link. It includes two kinds of traffic class (TC) labels which are mapped to virtual channels (VC). The design adopts TC/VC mapping and the scheme of arbitration by priority. The design uses a packet which can be transmitted through up to four transmission lanes. The design of general peripheral interface is described in Verilog HDL and verified using ModelSim. For FPGA verification, Xilinx ISE and SPARTAN XC3S400 are used.We used Synopsys Design Compiler as a synthesis tool and the used library was MagnaChip 0.35um technology.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.30 no.1
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• pp.46-54
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• 1997

Sporulation in the fission yeast Schizosaccharomyces pombe has been regarded as an important model of cellular development and differentiation. S. pombe cells proliferate by mitosis and binary fission on growth medium. Deprivation of nutrients especially nitrogen sources, causes the cessation of mitosis and initiates sexual reproduction by malting between two sexually compatible cell types. Meiosis is then followed in a diploid cell in the absence of nitrogen source. DNA fragment complemented with the mutations of sporulation gene was isolated from the S. pombe gene library constructed in the vector, pDB 248' and designated as pDB (spo 5)1. We futher analyzed six recombinant plasmids, pDB (spo 5)2, pDB(spo 5)3, pDB(spo 5)4, pDB(spo 5)5, pDB(spo 5)6, pDB(spo 5)7, and found each plasmids is able to rescue the spo 5-2, spo 5-3, spo 5-4, spo 5-5, spo 5-6, spo 5-7, mutations, respectively. Mapping of the integrated plasmid into the homologous site of the S. pombe chromosomes demonstrated that pDB (spo 5)1, and pDB (spo 5)R1 contained the spo 5 gene. Transcipts of spo 5 gene were analyzed by Northern hybridization. Two transcripts of 3.2 kb and 25 kb were detected with 5 kb Hind III fragment containing a part of the spo 5 gene as a probe. The small mRNA (2.5 kb) appeared only when a wild-type strain was cultured in the absence of nitrogen source in which condition the large mRNA (3.2 kb) was produced constitutively. Appearance of a 2.5 kb spo 5-mRNA depends upon the function of the mei1, mei2 and mei3 genes.

• Journal of the Korean Society of Hazard Mitigation
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• v.10 no.6
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• pp.155-163
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• 2010

The past researches on flood inundation simulation mainly focused on development of numerical models based on unstructured mesh networks to improve model performances. However, despite the accurate simulation results, such models are not suitable for real-time flood inundation forecasting due to a huge computational burden in terms of geographic data processing. In addition, even though various types of vector and raster data are available to be compatible with flood inundation models for post-processes such as flood hazard mapping and flood inundation risk analysis, the unstructured mesh-based models are not effective to fully use such information due to data incommensurability. Therefore, this study aims to develop a raster-based two-dimensional inundation model; it guarantees computational efficiency because of direct application of DEM for flood inundation modeling and also has a good compatibility with various types of raster data, compared to a commercial model such as FLUMEN. We applied the model to simulate the BaekSan levee break in the Nam river during a flood period from August 10 to 13, 2002. The simulation results showed a good agreement with the field-surveyed inundation area and were also very similar with results from the FLUMEN. Moreover, the model provided physically-acceptable velocity vectors with respect to inundating and returning flows due to the difference of water level between channel and lowland.

• Korean Journal of Agricultural and Forest Meteorology
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• v.13 no.1
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• pp.35-40
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• 2011

While high-definition precipitation maps with a 270 m spatial resolution are available for South Korea, there is little information on geospatial availability of precipitation water for the famine - plagued North Korea. The restricted data access and sparse observations prohibit application of the widely used PRISM (Parameter-elevation Regressions on Independent Slopes Model) to North Korea for fine-resolution mapping of precipitation. A hybrid method which complements the PRISM grid with a sub-grid scale elevation function is suggested to estimate precipitation for remote areas with little data such as North Korea. The fine scale elevation - precipitation regressions for four sloping aspects were derived from 546 observation points in South Korea. A 'virtual' elevation surface at a 270 m grid spacing was generated by inverse distance weighed averaging of the station elevations of 78 KMA (Korea Meteorological Administration) synoptic stations. A 'real' elevation surface made up from both 78 synoptic and 468 automated weather stations (AWS) was also generated and subtracted from the virtual surface to get elevation difference at each point. The same procedure was done for monthly precipitation to get the precipitation difference at each point. A regression analysis was applied to derive the aspect - specific coefficient of precipitation change with a unit increase in elevation. The elevation difference between 'virtual' and 'real' surface was calculated for each 270m grid points across North Korea and the regression coefficients were applied to obtain the precipitation corrections for the PRISM grid. The correction terms are now added to the PRISM generated low resolution (~2.4 km) precipitation map to produce the 270 m high resolution map compatible with those available for South Korea. According to the final product, the spatial average precipitation for entire territory of North Korea is 1,196 mm for a climatological normal year (1971-2000) with standard deviation of 298 mm.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.40
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• pp.16.1-16.5
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• 2018

Background: Proliferative verrucous leukoplakia (PVL) is an oral potentially malignant disorder, characterized by multifocal expression, progressive clinical evolution, and a high rate of malignant transformation. Evidence-based information regarding optimal PVL management is lacking, due to the paucity of data. The present report describes a case of PVL associated with HPV-16 infection and epithelial dysplasia treated by diode laser surgery, and the outcome of disease clinical remission over a 2-year follow-up period. Case report: A 61-year-old Caucasian male with oral verrucous hyperkeratosis presented for diagnosis. The lesions were localized on the maxillary gingiva and palatal alveolar ridge. Multiple biopsy specimens have been taken by mapping the keratotic lesion area. Microscopic examination was compatible with a diagnosis of PVL with focal mild dysplasia, localized in the right maxillary gingiva. Polymerase chain reaction (PCR) was done for human papillomavirus (HPV) detection which revealed presence of HPV DNA, and the genotype revealed HPV 16 in the sample. The PVL in the right gingival area was treated on an outpatient basis by excision with a diode laser. This approach resulted in good clinical response and decreased morbidity over a 2-year follow-up period. Conclusions: This case illustrates the benefit of a conservative approach by diode laser treatment than wide surgical excision for management of the PVL lesions associated with mild dysplasia and HPV-16 infection.

• The Korean Journal of Food And Nutrition
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• v.15 no.2
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• pp.112-118
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• 2002

Sporulation in the fission yeast Schizosaccharomyces pombe has been regarded as an important model of cellular development and differentiation. S. pombe cells proliferate by mitosis and binary fission on growth medium. Deprivation of nutrients especially nitrogen sources, causes the cessation of mitosis and initiates sexual reproduction by matting between two sexually compatible cell types. Meiosis is then followed in a diploid cell in the absence of nitrogen source. DNA fragment complemented with the mutations of sporulation gene was isolated from the S. pombe gene library constructed in the vector, pDB 248' and designated as pDB(spo5)1. We futher analyzed six recombinant plasmids, pDB(spo5)2, pDB(spo5)3, pDB(spo5)4, pDB(spo5)5, pDB (spo5)6, pDB(spo5)7 and found each of these plasmids is able to rescue the spo5-2, spo5-3, spo5-4, spo5-5, spo5-6, spo5-7 mutations, respectively. Mapping of the integrated plasmid into the homologous site of the S. pombe chromosomes demonstrated that pDB(spo5)1, and pDB(spu5)Rl contained the spo5 gene. Transcripts of spo5 gene were analyzed by Northern hybridization. Two transcripts of 3.2 kb and 2.5kb were detected with 5kb Hind Ⅲ fragment containing a part of the spo5 gene as a probe. The small mRNA(2.5kb) appeared only when a wild-type strain was cultured in the absence of nitrogen source in which condition the large mRNA (3.2kb) was produced constitutively. Appearance of a 2.5kb spo5-mRNA depends upon the function of the meil, mei2 and mei3 genes.

• Investigative Magnetic Resonance Imaging
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• v.13 no.1
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• pp.31-39
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• 2009

Purpose : This study proposes the keyhole method in order to improve the time resolution of the proton resonance frequency(PRF) MR temperature monitoring technique. The values of Root Mean Square (RMS) error of measured temperature value and Signal-to-Noise Ratio(SNR) obtained from the keyhole and full phase encoded temperature images were compared. Materials and Methods : The PRF method combined with GRE sequence was used to get MR temperature images using a clinical 1.5T MR scanner. It was conducted on the tissue-mimic 2% agarose gel phantom and swine's hock tissue. A MR compatible coaxial slot antenna driven by microwave power generator at 2.45GHz was used to heat the object in the magnetic bore for 5 minutes followed by a sequential acquisition of MR raw data during 10 minutes of cooling period. The acquired raw data were transferred to PC after then the keyhole images were reconstructed by taking the central part of K-space data with 128, 64, 32 and 16 phase encoding lines while the remaining peripheral parts were taken from the 1st reference raw data. The RMS errors were compared with the 256 full encoded self-reference temperature image while the SNR values were compared with the zero filling images. Results : As phase encoding number at the center part on the keyhole temperature images decreased to 128, 64, 32 and 16, the RMS errors of the measured temperature increased to 0.538, 0.712, 0.768 and 0.845$^{\circ}C$, meanwhile SNR values were maintained as the phase encoding number of keyhole part is reduced. Conclusion : This study shows that the keyhole technique is successfully applied to temperature monitoring procedure to increases the temporal resolution by standardizing the matrix size, thus maintained the SNR values. In future, it is expected to implement the MR real time thermal imaging using keyhole method which is able to reduce the scan time with minimal thermal variations.