• 한국식품위생안전성학회지
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• 제25권3호
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• pp.209-214
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• 2010

Metastasis is the primary cause of from breast cancer mortality. Cell migration and invasion play important roles in neoplastic metastasis. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix (ECM), plays an important role in cancer cell invasion. NF-${\kappa}B$ is transcription factor important in the regulation of MMP-9, as the promoter of MMP-9 gene contains binding sites for NF-${\kappa}B$. Brazilin, an active component of sappan wood (Caesalpinia sappan), decreases TPA-induced MMP-9 expression and invasion in MCF-7 cells. Also, brazilin suppressed NF-${\kappa}B$ activation in TPA-treated MCF-7 cells. Taken together, we demonstrated that the inhibition of TPA-induced MMP-9 expression and cell invasion by brazilin is mediated by the suppression of the NF-${\kappa}B$ pathway in MCF-7 cells. This result suggest brazilin provide a potential therapeutic app roach for the treatment of breast cancer.

• 한국환경과학회지
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• 제31권3호
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• pp.281-284
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• 2022

This study focused on the characteristics of manure in five beef cattle farms and two breeding farms in Hanwoo centered in Gyeongsangbuk-do province. The results of analysis and evaluation are as follows; First, the pH of manure in all the farms in this study was within the appropriate range of 8.81 to 9.45. Second, the dry matter content varied from 44.7% to 70.5% for all the farms. Third, the total nitrogen content in all the farms was 2.05-3.04%, which is higher than the reported range; however, it could play a role as a soil improvement agent when used as compost. Fourth, although the exact range of ammonia-N (VBN) content was not reported, results analyzed in all the farms showed that the level of impact on the environment was insignificant. In conclusion, soil and environment improvement effects are expected to be effective if the manure at Hanwoo farms in the Gyeongbuk area are used as compost through appropriate management.

• 한국콘텐츠학회논문지
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• 제9권10호
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• pp.482-491
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• 2009

본 연구는 유아기관에서 상용화되어 있는 지능형 로봇 iRobiQ에 탑재할 교사보조 콘텐츠 '우리반'을 기획하고 개발하는 것을 목적으로 하였다. 유아교육기관의 하루일과 중 iRobiQ가 교사보조로서 활용할 수 있는 기능을 추출하여 6개의 기능(출석, 활동, 갤러리, 배움터, 호명, 타이머)을 개발하였다. 유아가 매체를 다룰 때 수행하게 되는 주요 역할인 놀이자, 학습자, 사용자에 따라서 각각 오락적, 학습적, 도구적 요소를 충족시켜야 한다는 PLU 모델에 따라서 역할 모델에 따른 요소들을 기능에 반영하고자 하였다. 특히, 로봇은 정서적인 관계를 수행할 수 있기에 유아는 로봇을 친구(Companion)로서 접근할 수 있으며, 이에 따라서 또래 역할을 수행할 수 있는 정서적 요소들 또한 개발에 반영하였다. 유아기관에서 개발된 '우리반' 콘텐츠의 수용 양상을 살펴보기 위하여 4주간에 걸친 관찰을 수행한 결과, 교사와 유아 모두에게 긍정적인 반응을 얻었으며, 특히 유아의 경우에는 오락적, 정서적 요소에 더 많은 반응을 하였고, 로봇의 사용 방식이 점차 고정되는 교사와 달리 유아들은 끊임없이 새로운 요소를 탐색하였다. 개발 결과와 더불어서 향후 로봇 교사보조 콘텐츠를 개발할 때 고려해야 할 사항들을 논의한다.

• 지역사회간호학회지
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• 제11권1호
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• pp.231-244
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• 2000

Parish nursing is a community health nursing role developed in 1983 by Lutheran Chaplain Granger Westberg. An increasing emphasis on holistic care, personal responsibility for a healthy lifestyle, and changes in healthcare delivery systems have undoubtedly facilitated the establishment of an innovative nursing role in the community. Parish nurses are functioning in a variety of church congregations of various denominations. The parish nurse is a educator, a personal health counselor, a coordinator of volunteers. The parish nurses helps people relate to the complexed medical care system and assists people to integrate faith and health. The purpose of this study is to investigate what the korean parishioners want in parish nursing and what type of role expectation from parish nurse. The subjects were 1138 parishioners of 23 churches of various denominations in nationwide Korea. Data were collected by self-reported question naires from Feb 4 to June 25. 1999. The data were analyzed by using percentage. frequency. $x^2-test$. multiple Response set with SPSS program. The results are as follows: 1. Desired parish nursing contents by parish nurses are: psychological counselling(23.4%) out of private counselling. stress management(21.1 %) out of private health education. Emergency care(14.1%) out of group health education. Blood Pressure check-ups (19.0%) out of Health check ups. home visiting(44.9%) out of patient visiting method. B T. pulse, respiration and blood pressure check(15.0%) in Care to serve in home visiting. spiritual preparation to accept the death(41.7%) in hospice care, advices to choice of medical treatment using guide(50.1%) in introducing and guiding of health care facilities, pray(21.7%) in spiritual care' faith support. 2. Desired Health Teaching Content According to Period of Clients by Parish Nurse are: Vaccination(22.5%) in infant and toddler health management. sexual education(25.3%) in adolescent health management. prenatal care (29.5%) in pregnant health management. osteoporosis prevention and management (22.4%) in Middle aged health management. dementia prevention and management(25.5%) in elderly health management. 3. The expectant role from parish nurse is spiritual care faith support(14.1%). patient visiting care(13.2%), hospice care(12.9%), private counseling(12.8%), health check ups (11.1 %), volunteer organization and training out of believer(11.0%), private health education (9.3%), group health education (8.3%). 4. In Necessity of Performing Parish Nursing according to Region, Most(over 95%) responded that nursing program is needed. so there is no significance between regions. In Performing Parish Nursing in their church, Most(92.2%) responded they want to perform program. 5. In case of performing parish nursing, 52% out of the subjects responded they want to participated in parish nursing volunteer's activity, for example. to be in active to be a companion to chat(42.1%), necessity support (25.3%), donation support(25.0%), exercise support(18.2%), vehicles support (9.9%). As a result. in holistic care and spiritual care, the need of parish nursing and the role expectation from parish nurse are very high among korean believers. Therefore, I suggest parish nursing centering around Taegu and Kyungbuk province should be extended to nationwide. For extending parish nursing program. more active advertisement and research is needed. After performing parish nursing program through out the country, further comparative research between regions should be practiced and Korean parish nursing program will be developed and activated.

• Steel and Composite Structures
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• 제14권2호
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• pp.105-120
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• 2013

Flexural behavior of thin walled steel-concrete composite sections as cross sections for beams is investigated by conducting an experimental study supported by applicable analytical predictions. The experimental study consists of testing up to failure, simply supported beams of effective span 1440 mm under two point loading. The test specimens consisted of composite box and channel (with lip placed on tension side and compression side) sections, the behavior of which was compared with companion empty sections. To understand the role of shear connectors in developing the composite action, some of the composite sections were provided with novel simple bar type and conventional bolt type shear connectors in the shear zone of beams. Two RCC beams having equivalent ultimate moment carrying capacities as that of composite channel and box sections were also considered in the study. The study showed that the strength to weight ratio of composite beams is much higher than RCC beams and ductility index is also more than RCC and empty beams. The analytical predictions were found to compare fairly well with the experimental results, thereby validating the applicability of rigid plastic theory to cold-formed steel concrete composite beams.

• 한국환경과학회지
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• 제22권6호
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• pp.773-777
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• 2013

This study examined the effects of cage rearing system and backyard raising system on fatty acid profile of egg in laying hens during 9 weeks. Two hundred hens, 70-wk-old, Hy-line Brown, were used in this study and fed basal diets. 100 hens, randomly collected from facility, were transferred to cage rearing system and 100 remaining hens were moved to backyard raising system. For overall period, higher unsaturated fatty acid percentages in two different rearing systems than did saturated fatty acid (SFA) were observed. In unsaturated fatty acid compositions, both rearing system showed a higher mono unsaturated fatty acid (MUFA) contents than poly unsaturated fatty acid (PUFA) contents. Egg quality traits of laying hens reared in backyard system had considerably lower contents of SFA and higher contents of MUFA compared with eggs from cage rearing system (P<0.05). In addition, eggs from cage rearing system resulted in a significantly lower n-3 contents and higher n-6:n-3 ratios and CLA contents in comparison with backyard raising system (P<0.05). However, no significant effects of two different rearing systems on PUFA, PUFA:SFA ratio, and n-6 contents were observed during the experimental period. In conclusion, this result suggests that cage rearing system and backyard raising system will play an important role in improving egg production as functional foods.

• 대한기계학회논문집
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• 제18권2호
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• pp.323-338
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• 1994

This paper outlines a framework for performing intelligent sensor validation for a diagnostic expert system while reasoning under uncertainty. The emphasis is on the algorithmic preprocess technique. A companion paper focusses on heuristic post-processing. Sensor validation plays a vital role in the ability of the overall system to correctly detemine the state of a plant monitored by imperfect sensors. Especially, several theoretical developments were made in understanding uncertain sensory data in statistical aspect. Uncertain information in sensory values is represented through probability assignments on three discrete states, "high", "normal", and "low", and additional sensor confidence measures in Algorithmic Sv.Upper and lower warning limits are generated from the historical learning sets, which represents the borderlines for heat rate degradation generated in the Algorithmic SV initiates a historic data base for better reference in future use. All the information generated in the Algorithmic SV initiate a session to differentiate the sensor fault from the process fault and to make an inference on the system performance. This framework for a diagnostic expert system with sensor validation and reasonig under uncertainty applies in HEATXPRT$^{TM}$, a data-driven on-line expert system for diagnosing heat rate degradation problems in fossil power plants.

• 대한전기학회논문지:전력기술부문A
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• 제54권6호
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• pp.293-305
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• 2005

This paper describes an improved Prony method in its speed, accuracy and reliability by efficiently determining the optimal sampling interval with use of DFT (discrete Fourier transformation). In the Prony method the computation time is dominated by the size of the linear prediction matrix, which is given by the number of data times the modeling order The size of the matrix in a general Prony method becomes large because of large number of data and so does the computation time. It is found that the Prony method produces satisfactory results when SNR is greater than three. The maximum sampling interval resulting minimum computation time is determined using the fact that the spectrum in DFT is inversely proportional to sampling interval. Also the process of computing the modes is made efficient by applying Hessenberg method to the companion matrix with complex shift and computing selectively only the dominant modes of interest. The proposed method is tested against the 2003 KEPCO system and found to be efficient and reliable. The proposed method may play a key role in monitoring in real time low frequency oscillations of power systems .

• Asia pacific journal of information systems
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• 제9권4호
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• pp.163-179
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• 1999

MIS personnel should not only be capable of developing technically sounded systems, but also act as the companion role of strategic management. For this reason, it is important to direct efficient human resource management for MIS personnel. For directing efficient MIS human resource management, this paper studies the relationship of major types of MIS career orientation, job satisfaction and organizational commitment based on the work area of MIS personnel, Based on the empirical analysis using questionnaires answered from MIS personnel of Korean public and private enterprises, the hypotheses of this study were proved. The result of this research shows most of the domestic MIS personnel tends to line up with technology and management favoritism for their career orientation. If an individual career orientation and his or her work area are matched, it presents higher job satisfaction. Furthermore, a group of management orientation shows higher organizational commitment than a group of technology arientation among MIS personnel with identical job satisfaction. Therefore, this study suggests that career orientation of MIS personnel affect the job satisfaction and organizational commitment. In the future, a career management system suitable to the MIS personnel should be developed to improve the effectiveness of MIS organization.

• 한국동물생명공학회지
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• 제37권1호
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• pp.2-12
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• 2022

Extracellular vesicles (EVs) are nanovesicles that carry bioactive cargoes of proteins, lipids, mRNAs, and miRNAs between living cells. Their role in cellular communication has gained the attention of several research reports globally in the last decade. EVs are critically involved in sperm functions, oocyte functions, fertilization, embryonic development, and pregnancy. The review summarizes the state-of-the-art of EVs research in the diagnostic and therapeutic (theranostic) potentials of the EVs during the pregnancy that might provide a solution for gestational disturbances such as implantation failure, maternal health problems, gestational diabetes, and preeclampsia. EVs can be found in all biological fluids of the fetus and the mother and would provide a non-invasive and excellent tool for diagnostic purposes. Moreover, we provide the current efforts in manufacturing and designing targeted therapeutics using synthetic and semi-synthetic nanovesicles mimicking the natural EVs for efficient drug delivery during pregnancy.