• Title/Summary/Keyword: Common Effect

Search Result 3,734, Processing Time 0.032 seconds

Extraction of specific common genetic network of side effect pair, and prediction of side effects for a drug based on PPI network

  • Hwang, Youhyeon;Oh, Min;Yoon, Youngmi
    • Journal of the Korea Society of Computer and Information
    • /
    • v.21 no.1
    • /
    • pp.115-123
    • /
    • 2016
  • In this study, we collect various side effect pairs which are appeared frequently at many drugs, and select side effect pairs that have higher severity. For every selected side effect pair, we extract common genetic networks which are shared by side effects' genes and drugs' target genes based on PPI(Protein-Protein Interaction) network. For this work, firstly, we gather drug related data, side effect data and PPI data. Secondly, for extracting common genetic network, we find shortest paths between drug target genes and side effect genes based on PPI network, and integrate these shortest paths. Thirdly, we develop a classification model which uses this common genetic network as a classifier. We calculate similarity score between the common genetic network and genetic network of a drug for classifying the drug. Lastly, we validate our classification model by means of AUC(Area Under the Curve) value.

Category-Based Feature Inference: Testing Causal Strength (범주기반 속성추론: 인과관계 강도의 검증)

  • JunHyoung Jo;Hyung-Chul O. Li;ShinWoo Kim
    • Science of Emotion and Sensibility
    • /
    • v.26 no.1
    • /
    • pp.55-64
    • /
    • 2023
  • This research investigated category-based feature inference when category features were connected in common cause and common effect causal networks. Previous studies that tested feature inference in causal categories showed unique inference patterns depending on causal direction, number of related features, whether the to-be-inferred feature was cause or effect, etc. However, these prior studies primarily focused on inference pattens that arise from causal relations, and few studies directly explored how the effects of causal relations vary depending on causal strength. We tested feature inference in common cause (Expt. 1) and common effect (Expt. 2) causal categories when casual strengths were either strong or weak. To this end, we had participants learn causal categories where features were causally linked and then perform feature inference task. The results showed that causal strengths as well as causal relations had important impacts on feature inference. When causal strength was strong, inference for common cause feature became weaker but that for the common effect feature became stronger. Moreover, when causal strength was strong and common cause was present, inference for the effect features became stronger, whereas the results were reversed in common effect networks. In particular, in common effect networks, casual discounting was more evident with strong causal strength. These results consistently demonstrate that participants consider not only causal relations but also causal strength in feature inference of causal categories.

Altitudinal patterns and determinants of plant species richness on the Baekdudaegan Mountains, South Korea: common versus rare species

  • Lee, Chang-Bae;Chun, Jung-Hwa;Um, Tae-Won;Cho, Hyun-Je
    • Journal of Ecology and Environment
    • /
    • v.36 no.3
    • /
    • pp.193-204
    • /
    • 2013
  • Altitudinal patterns of plant species richness and the effects of area, the mid-domain effect, climatic variables, net primary productivity and latitude on observed richness patterns along the ridge of the Baekdudaegan Mountains, South Korea were studied. Data were collected from 1,100 plots along a 200 to 1,900 m altitudinal gradient on the ridge. A total of 802 plant species from 97 families and 342 genera were recorded. Common and rare species accounted for 91% and 9%, respectively, of the total plant species. The altitudinal patterns of species richness for total, common and rare plants showed distinctly hump-shaped patterns, although the absolute altitudes of the richness peaks varied somewhat among plant groups. The mid-domain effect was the most powerful explanatory variable for total and common species richness, whereas climatic variables were better predictors for rare plant richness. No effect of latitude on species richness was observed. Our study suggests that the mid-domain effect is a better predictor for wide-ranging species such as common species, whereas climatic variables are more important factors for range-restricted species such as rare species. The mechanisms underlying these richness patterns may reflect fundamental differences in the biology and ecology of different plant groups.

The Comparative Study on the Bee-Venom Therapy and Common Acupuncture Therapy for the Acute Ankle Sprain (급성 족관절 염좌에 대한 봉독약침치료와 일반 침치료의 비교연구)

  • Lee, Hyun
    • Korean Journal of Acupuncture
    • /
    • v.21 no.4
    • /
    • pp.133-143
    • /
    • 2004
  • Objective : The purpose of this study is to compare the effect of Bee-Venom Therapy and common acupuncture therapy for the acute ankle sprain Methods : This study has been carried out for 32 cases of ankle sprain patients who have visited Cheon-an Oriental Medical Hospital from may 1, 2004 to June 30, 2004. We have treated 16 cases of them by Bee-Venom therapy(group I) and the other 16 cases by common acupuncture therapy(group II). And we have compared those two group. Results and Conclusions : 1. There were good effect on the ankle sprain in both two groups. 2. There were no significant difference at the ROM of ankle joint in both two groups. 3. Common acupuncture therapy had more quick effect on the joint of swelling. 4. In the VAS score, Bee-Venom therapy had more quick effect on total improvement of ankle sprain.

  • PDF

The Effect of Supplementation of Jackfruit Leaves (Artocarpus heterophyllus) and Mashkalai (Vigna mungo) Bran to Common Grass on the Performance of Goats

  • Islam, M.;Chowdhury, S.A.;Alam., Chowdhury
    • Asian-Australasian Journal of Animal Sciences
    • /
    • v.10 no.2
    • /
    • pp.206-209
    • /
    • 1997
  • The effect of supplementation of Jackfruit (Artocarpus heterrophyllus) tree leaves and mashkalai (Vigna mungo) barn on the intake and digestibility of freshly cut common grass by Black Bengal goats was evaluated. Twelve castrated goats of approximately 5-6 months age were randomly allocated to three dietary treatments: freshly cut common grass ad libitum, common grass+100g Jackfruit tree leaves and common grass+100g mashkalai bran. Although digestibilities of dry matter, organic matter, nitrogen and neutral detergent fibre were very similar in the grass alone and mashkalai bran supplemented goats but the values were significantly (P < 0.01) higher than those observed in the Jackfruit leaves supplemented goats. Supplementation of mashkalai bran promoted higher (p < 0.05) digestible nutrients intake with the consequent higher daily live weight gain (75 g) than those fed grass alone (31 g). It could be concluded that mashkalai bran could be a suitable supplement for goats consuming common grass in the tropics and subtropics.

The Effect and the Limitation of Driven-right-leg Ground on Indirect-contact ECG measurement (간접접촉 심전도 측정에서의 오른발구동 접지의 효과와 한계)

  • Lim, Yong Gyu
    • Journal of Biomedical Engineering Research
    • /
    • v.39 no.2
    • /
    • pp.103-108
    • /
    • 2018
  • This study reviews the common-mode noise model of indirect-contact ECG measurement which uses capacitive electrode and capacitive ground, and shows the reason of the large common-mode noise in indirect-contact ECG. And then, this study shows driven-right-leg ground in indirect-contact ECG measurement, and reviews how the driven-right-leg ground reduces the common-mode noise. This study then analyzes the relation between the effective area of the indirect-contact ground and the gain of the driven-right-leg circuit. This study introduces the output voltage saturation of the driven-right-leg circuit, which occurs frequently in indirect-contact ECG measurement with the condition of the high ground impedance. This study then shows the effect of the driven-right-leg circuit saturation on the common-mode noise.

Analysis of Common Grounding Effect during the Transient State in Underground Transmission and Distribution Systems (지중송배전계통에서 과도상태시 공통접지의 영향 분석)

  • Lim, Kwang-Sik;Lee, Jong-Beom
    • The Transactions of The Korean Institute of Electrical Engineers
    • /
    • v.57 no.2
    • /
    • pp.191-197
    • /
    • 2008
  • This paper describes the effect of transient state in underground transmission and distribution lines installed together in the same tunnel. Two systems installed in the same tunnel are operated by the common grounding. This paper analyzed that how much one of the two kinds of systems influences the other systems during the transient state by EMTP/ATPDraw. Single line-to-ground fault and lightning surge were selected in transient state condition. These cases were simulated variously according to the variation of common grounding magnitude, fault location and lightning surge magnitude. It is evaluated that the analyzed results will be used for establishment and operating materials of common grounding in the same tunnel.

The Effect of Injection Pressure Variations on the Smoke and Fuel Consumption in a Small HSDI Diesel Engine with Common Rail Injection System (소형 HSDI 디젤엔진에서의 Common Rail을 이용한 분사압력 변화가 Smoke 및 연료 소모량에 미치는 영향)

  • 류명석;신범식
    • Transactions of the Korean Society of Automotive Engineers
    • /
    • v.9 no.2
    • /
    • pp.28-34
    • /
    • 2001
  • Great attentions are paid to HSDI diesel engine for passenger cars because of its high thermal efficiency. The most interesting research in HSDI diesel engine developments is focused on applying common rail system as a fuel injection equipment. In this study, a series of tests are carried out to investigate the effect of injection pressure variation on the smoke and fuel concluded in a small HSDI diesel engine with common rail system. As a result of this study it is concluded that there is an optimum rail pressure dependent on combustion system such as nozzle type, combustion chamber geometry.

  • PDF

Design of Crosstalk Compensation Circuit in TFT-LCDs (박막트랜지스터 액정표시소자의 화소간섭 보상회로설계)

  • 정윤철;박종철;김이섭
    • Journal of the Korean Institute of Telematics and Electronics B
    • /
    • v.32B no.11
    • /
    • pp.1374-1382
    • /
    • 1995
  • In TFT-LCDs, as the display size area becomes larger, and the resolution higher, we have to consider the image degradation effects due to the incorporation of the TFT-LCD parameters such as the data-line resistance, the common electrode resistance, the data-line to common parasitic capacitance, and the output characteristics of driver ICs. One of the degradation effects is crosstalk resulting from the coupling between the source bus-line and common electrode. Since a source signal which represents a large number of display data is supposed to vary frequently, the common signal level is affected through the coupling effect, resulting in the degradation of nearby pixel drive signals. Therefore, we proposed a method to compensate for this source-common electrode coupling effect, we also designed and experimented the feasibility of our crosstalk compensation circuit in the actual TFT-LCD. We saw that the newly designed compensation circuit greatly reduced the crosstalk in display pattern image.

  • PDF

Belly Sting Model Support Interference Effect of NASA Common Research Model at Low Speed Wind Tunnel (저속 풍동시험 시 NASA Common Research Model의 Belly Sting 모형 지지부에 의한 간섭효과에 관한 연구)

  • Cha, Kyunghwan;Kim, Namgyun;Ko, Sungho
    • Journal of the Korean Society for Aeronautical & Space Sciences
    • /
    • v.49 no.3
    • /
    • pp.167-174
    • /
    • 2021
  • Computational Fluid Dynamics (CFD) was performed under low-speed wind tunnel test conditions using a 29.7% scale model of the NASA common research model. A wind tunnel test was conducted to measure the aerodynamic coefficient of the CRM with Belly sting model support configuration at a low Reynolds number of 0.3×106 and it was compared with the aerodynamic coefficient of CFD analysis. In order to verify the validation of the analysis, a computational analysis under the conditions of the advance research was performed and compared. The interference effect of the Belly sting model support affected not only the fuselage but also the main and tail wings.