• Title/Summary/Keyword: Combined effects

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Experimental Effects of Sunjeonhwadok-Tang on the Proliferation of Cancer Cells and Immunocytes - Focusing around Combined Effects of Anticarcinogen - (선전화독탕(仙傳化毒湯)이 암세포(癌細胞) 및 면역세포(免疫細胞) 증식(增殖)에 미치는 실험적(實驗的) 효과(效果) - 항암제 병용효과를 중심으로 -)

  • Chang, Wen-Lih;Kim, Jong-Han;Park, Su-Yeon;Choi, Jung-Hwa
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.18 no.1
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    • pp.104-115
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    • 2005
  • Sunjeonhwadok-Tang was a drug that treated carbuncle and cellulitis. So, the purpose of this study was to investigate effects of Sunjeonhwadok-Tang on the proliferation of cancer calls and immunocytes focusing around combined effects of anticarcinogen. We used Sunjeonhwadok-Tang extract(SHT) with freeze-dried, 8wks-old male balb/c mice and cancer cell lines(L1210, Sarcoma-180) for this Study. The proliferation of cells was tested using a colorimetric tetrazoliun assay(MTT assay). The results : 1. SHT was significantly showed cytotoxicity on the L1210 cell lines. 2. SHT was significantly increased proliferation of thymocytes and splenocytes in vitro. 3. In combined effects of SHT and vincristine(0.005 mg/kg), SHT was significantly inhibited proliferation of L1210 cell lines, but was not inhibited proliferation of Sarcoma-180 cell lines compared with positive control group. 4. In combined effects of SHT and vincristine(0.005 mg/kg), SHT was significantly increased proliferation of thymocytes and splenocytes compared with positive control group. 5. In combined effects of SHT and vincristine, SHT was significantly increased proliferation of thymocytes and splenocytes in normal mice. 6. In combined effects of SHT and vincristine, SHT was significantly inhibited proliferation of L1210 cells in L1210 cells transplanted mice 7. In combined effects of SHT and vincristine, SHT was significantly increased proliferation of L1210 cell in L1210 cells transplanted mice. The present author thought that SHT had action of anti-cancer and immuno-activity, and in combined effects of vincristine, SHT had recoverable effects on damage by anticarcinogen.

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Experimental Effects of Taklihwajung-Tang on the Proliferation of Cancer Cells and Immunocytes (탁리화중탕(托裏和中湯)이 암세포(癌細胞) 및 면역세포(免疫細胞)에 미치는 실험적(實驗的) 효과(效果))

  • Park, Su-Yeon;Kim, Jong-Han;Choi, Jung-Hwa;Lee, Jun-Hun
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.19 no.1
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    • pp.103-114
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    • 2006
  • Objective : The purpose of this study was to investigate effects of Taklihwajung-Tang on the proliferation of cancer cells land immunocytes focusing around combined effects of anticarcinogen. Materials and Method : We used Taklihwajung-Tang extract(THT) with freeze-dried, 8wks-old male balb/c mice and cancer cell lines(L1210, S-180) for this study. The proliferation of cells was tested using a colorimetric tetrazoliun assay(MIT assay). Results and Conclusion : The results of this study were obtained as follow ; 1. THT was significantly showed cytotoxicity on the L1210 cell lines and S-180 cell lines. 2. THT was significantly increased in the proliferation of thymocytes and splenocytes in vitro. 3. In combined effects of THT and vincristine(0.005mg/kg), THT was significantly inhibited proliferation of S-180 cell lines compared with positive control group. 4. In combined effects of THT and vincristine(0.005mg/kg), THT was significantly decreased in the weight of sarcoma compared with positive control group. 5. In combined effects of THT and vincristine, THT was significantly inhibited the hematological side reaction compared with positive control group. The present author thought that THT had action of anti-cancer and immune-activity, and in combined effects of vincristine, THT had recoverable effects on damage by anticarcinogen.

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Comparison of Pollutant Control in Combined Sewer Overflows and Separated Sewer Overflows using the Separation Wall (우오수분리벽을 이용한 합류식 하수관거와 분류식 우수관거의 월류수 제어효과 비교)

  • Lim, Bong-Su;Kim, Do-Young;Lee, Kuang-Chun
    • Journal of Korean Society on Water Environment
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    • v.23 no.4
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    • pp.458-466
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    • 2007
  • This study is to evaluate control effects of separation wall by surveying water quality and sewer overflows during dry and wet periods in combined sewer and separated sewer systems. Ravine water from the combined Seokgyo outfall with the separation wall was separated about four times larger than sewage flow during dry periods. The water quality of the combined Seokgyo outfall with separation wall during dry periods is flow weighed average BOD 61 mg/L, the combined Cheonseokgyo outfall without the separation wall is average BOD 71 mg/L, and the separated Pyeongsong center outfall is average BOD 41 mg/L. The BOD concentration in separated outfall form about 57% of the combined outfall, and this means the separated outfall (i.e. storm sewer) is polluted by inflow of sewage. The overflow load of the separated outfall is ten times higher than the combined outfall and its overflow load per rainfall is three times than combined outfall during the wet periods. Therefore, the control plan of overflow load is required in storm sewer. The control effects of the overflow load increased 79% by setting the separation wall in the combined sewer, and showed 27% increase without the separation wall in separated sewer, but forecasted over 80% increase of effects if the separation wall was set.

Combined Effects of the Essential Oil from Eucalyptus globulus with Ketoconazole against Candida and Trichophyton Species

  • Lim, Sook;Shin, Seung-Won
    • Natural Product Sciences
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    • v.14 no.1
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    • pp.27-31
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    • 2008
  • We have evaluated the combined antifungal effects of the essential oil from Eucalyptus globulus or its main component 1,8-cineole with ketoconazole. Checkerboard microtiter tests were used to analyze their effects against three Candida and six Trichophyton species. The susceptibility of the Trichophyton species to E. globulus essential oil differed distinctly. The fractional inhibitory concentration indices (FICIs) against the tested Candida species ranged between 0.09 and 0.38 for ketoconazole combined with E. globulus essential oil or 1,8-cineole, indicating significant synergism between ketoconazole and the oil samples. Similar experiments using Trichophyton species resulted in FICIs between 0.28 and 0.63, indicating relatively weaker combined effects than those observed with Candida species. Thus, the data reported here show that the anti-Candida effects of ketoconazole can be significantly improved in the presence of E. globulus essential oil or 1, 8-cineole.

Motion Analysis of Two Floating Platforms with Mooring and Hawser Lines in Tandem Moored Operation by Combined Matrix Method and Separated Matrix Method

  • KOO BON-JUN;KIM MOO-HYUN
    • Journal of Ocean Engineering and Technology
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    • v.19 no.5 s.66
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    • pp.1-15
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    • 2005
  • The motion behaviors including hydrodynamic interaction and mechanical coupling effects on multiple-body floating platforms are simulated by using a time domain hull/mooring/riser coupled dynamics analysis program. The objective of this study is to evaluate off-diagonal hydrodynamic interaction effects and mechanical coupling effects on tandem moored FPSO and shuttle taker motions. In the multiple-body floating platforms interaction, hydrodynamic coupling effects with waves and mechanical coupling effects through the connectors should be considered. Thus, in this study, the multiple-body platform motions are calculated by Combined Matrix Method (CMM) as well as Separated Matrix Method (SMM). The advantage of the combined matrix method is that it can include all the 6Nx6N full hydrodynamic and mechanical interaction effects among N bodies. Whereas, due to the larger matrix size, the calculation time of Combined Matrix Method (CMM) is longer than the Separated Matrix Method (SMM). On the other hand, Separated Matrix Method (SMM) cannot include the off-diagonal 6x6 hydrodynamic interaction coefficients although it can fully include mechanical interactions among N bodies. To evaluate hydrodynamic interaction and mechanical coupling effects, tandem moored FPSO and shuttle tanker is simulated by Combined Matrix Method (CMM) and Separated Matrix Method (SMM). The calculation results give a good agreement between Combined Matrix Method (CMM) and Separated Matrix Method (SMM). The results show that the Separated Matrix Method (SMM) is more efficient for tandem moored FPSO and shuttle tanker. In the numerical calculation, the hydrodynamic coefficients are calculated from a 3D diffraction/radiation panel program WAMIT, and wind and current forces are generated by using the respective coefficients given in the OCIMF data sheet.

Effect of Several Combined Preparation of Crude Drugs on the Adverse Effects of Anticancer Agent-Mitomycin C (항암제 Mitomycin C의 부작용에 대한 수종 복합생약의 영향)

  • Eun, Jae-Soon
    • Korean Journal of Pharmacognosy
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    • v.23 no.4
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    • pp.248-258
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    • 1992
  • The studies were conducted to investigate the combined effects of several combined preparation of crude drugs and mitomycin C(MMC). The combined effects on the proliferation of HepG2, A549, KHOS-Np, A431 and HeLa cells were estimated by MTT colorimetric assays. Sa Kunja Tang(SKT), Boyang Hwanoh Tang(BHT) and Hyulbu Choogo Tang(HCT) inhibited the proliferation of A549 and HeLa cell. The inhibitory action of MMC was increased by the combined treatment of SKT and MMC, and Sa Mul Tang(SMT) and MMC, respectively. When the mice were treated by MMC, the number of leukocyte was decreased significantly at the 3rd day, but recovered at the 7th day. In the groups of MMC treated with SKT or HCT, the number of leukocyte was increased significantly that the group of MMC treated only at the 1st and 3rd day. The combined treatment of SKT, SMT, BHT, HCT and MMC retained the spleen weight of mice at the level of normal mice, but decreased the thymus weight of mice. The combined treatment of SKT, SMT, BHT, HCT and MMC increased the number of PFC significantly than the MMC treated group. The combined treatment of SKT, SMT, BHT, HCT and MMC increased the T cell proliferation significantly thant the MMC treated group.

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Effects of Combined Exercise and Creatine Intake to Muscular Function and Pain in Back Pain Patients (복합운동과 크레아틴 복용이 요통환자의 근기능과 통증에 미치는 영향)

  • Jeong, Dong-Hyuk;Kim, Soo-Keun;Seo, Jeong-Hun
    • Korean Journal of Exercise Nutrition
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    • v.13 no.3
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    • pp.193-201
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    • 2009
  • The purpose of this study was to examine the effects of combined exercise and creatine consumption to muscular function and pain in 24 middle-aged men in back pain patients. The patients were categorized into three groups; 8 patients underwent combined exercise alone, 8 patients underwent creatine consumption as well as combined exercise and the control group was 8 patients without these options. The follow-up period was 10 weeks doing aerobic exercise, resistance exercise or creatine consumption. The group that underwent creatine intake as well as combined exercise simultaneously showed significant increase on the 0°, 12°, 24°, 36°, 48°, 60° and 72° of back muscular power in the muscular function changes compared to control group, furthermore, it showed statistically significant improvement on the 24°, 36°, 48° and 60° in the combined exercise group compared to control group. However, between the group that underwent creatine consumption as well as combined exercise and the group that underwent combined exercise, the back muscular power was high in the all angles, but it was not statistically significant. The group that performed both creatine consumption and combined exercise showed pain relief relatively, comparing with either combined exercise or control group and the pain was also alleviated in the combined exercise group.

Effects of Kigong Theraphy in Cocentration of Catecholamines and Cortisol and some Tests on Testing-Stressed (기공외기요법(氣功外氣療法)의 항(抗) 스트레스 효과(效果) 연구(硏究))

  • Kim Ki-Ok
    • Journal of Korean Medical Ki-Gong Academy
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    • v.1 no.1
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    • pp.95-109
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    • 1996
  • To investigate anti-stress effects of Manual Kigong, Manual-Apparatus Combined Kikong, and Systemic Kigong, this experiments were performed changing of plasma catecholaminess and serum cortisol measured. Also using D.I.T.I(Digital Infrared Thermongraphy Imaging), Pulse Analyzer, Electric Current on Neurometer, and Digital Flicker on Testing-Stressed. And following results were abtained. 1) Menual-Appartus Combined Kikong decreased significantly increasing concentration of plasma epinephrine and norepinephrine level in Testing-stressed. 2) Manual Kigong decreased increasing concentration of serum cortisol level in Testing-stressed. 3) Manual Kigong and Manual-Aparatues Combined Kikong increased decreasing thermomerty on the palm's center caused Testing-stressed. 4) All of three treats are small change in SET(Systolic Ejection Time) by Pulse Analyzer caused Testing-stressed. 5) More changes of Electric Current on the Neurometer Diagnosis caused Testing-stressed are as followed. Manual-Apparatus Combined Kikong >Systemic Kigong >Manual Kigong From the results, it may be concluded that Manual-Apparatus Combined Kikong Theraphy having more anti-stress effects than Manual Theraphy. Systemic Kigong Therapy.

A Study on the Fin Efficiency of Continuous Fin with Combined Heat and Mass Transfer (열과 물질 전달을 수반하는 연속휜의 휜효율에 관한 연구)

  • 정세환
    • Journal of Advanced Marine Engineering and Technology
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    • v.22 no.4
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    • pp.445-450
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    • 1998
  • In the present paper the effects of combined heat and mass transfer on the fin efficiency were calculated. Sector method was used for calculating the fin efficiency of the continuous fin. The parameter Lewis No. and C which describe the combined heat and mass transfer is derived by using the heat and mass transfer analogy and effects of Lewis No. and C on the fin efficiencies were calculated.

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A Study on the Complex Effects of Streetscape Components on Visual Preference (도시가로경관요소가 시각적 선호에 미치는 복합적 영향에 관한 연구)

  • 변재상;정수정;임승빈
    • Journal of the Korean Institute of Landscape Architecture
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    • v.27 no.2
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    • pp.9-18
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    • 1999
  • In this study the relative effects among trees, cars, wires and building facades on visual preference are measured with the photo-montage scenes, which were synthesized by computer graphic programs. In addition to these experiments, the interaction of each elements of streetscapes have been investigated. The results of this study can be summarized as follows ; (1) It was found that trees had a remarkable positive effect on preference for streetscapes, wires had a moderate negative effect, cars had a trivial effect and the effects of building facades were medium. (2) It was investigated that the building of residential type was most preferred among commercial, residential, and office building types. The next preferred building facade was the commercial type. (3) The interaction of each element of streetscapes also have effects on preference. Especially, it was found that the combined effects of building-wire and building-cars were more notable than other combined effects of two elements.

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