• Journal of the Korea Society for Simulation
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• v.21 no.3
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• pp.71-78
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• 2012

This research discusses the application of the control variables to achieve a more precise estimation for the target response in queueing network simulation. The efficiency of control variable method in estimating the response depends upon how we choose a set of control variables strongly correlated with the response and how we construct a function of selected control variables. For a class of queuing network simulations, the random variables that drive the simulation are basically the service-time and routing probability random variables. Most of applications of control variable method focus on utilization of the service time random variables for constructing a controlled estimator. This research attempts to suggest a controlled estimator which uses these two kinds of random variables and explore the efficiency of these estimators in estimating the reponses for computer network system. Simulation experiments on this model show the promising results for application of routing probability control variables. We consider the applications of the routing probability control variables to various simulation models and combined control variables using information of service time and routing probability together in constructing a control variable as future researches.

• BMB Reports
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• v.54 no.3
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• pp.170-175
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• 2021

Atherosclerosis arising from the pro-inflammatory conditions associated with chronic kidney disease (CKD) increases major cardiovascular morbidity and mortality. Rapamycin (RAPA) is known to inhibit atherosclerosis under CKD and non-CKD conditions, but it can cause dyslipidemia; thus, the co-application of lipid-lowering agents is recommended. Atorvastatin (ATV) has been widely used to reduce serum lipids levels, but its synergistic effect with RAPA in CKD remains unclear. Here, we analyzed the effect of their combined treatment on atherosclerosis stimulated by CKD in apolipoprotein E-deficient (ApoE-/-) mice. Oil Red O staining revealed that treatment with RAPA and RAPA＋ ATV, but not ATV alone, significantly decreased the atherosclerotic lesions in the aorta and aortic sinus, compared to those seen in the control (CKD) group. The co-administration of RAPA and ATV improved the serum lipid profile and raised the expression levels of proteins involved in reverse cholesterol transport (LXRα, CYP7A1, ABCG1, PPARγ, ApoA1) in the liver. The CKD group showed increased levels of various genes encoding atherosclerosispromoting cytokines in the spleen (Tnf-α, Il-6 and Il-1β) and aorta (Tnf-α and Il-4), and these increases were attenuated by RAPA treatment. ATV and RAPA＋ATV decreased the levels of Tnf-α and Il-1β in the spleen, but not in the aorta. Together, these results indicate that, in CKD-induced ApoE-/- mice, RAPA significantly reduces the development of atherosclerosis by regulating the expression of inflammatory cytokines and the co-application of ATV improves lipid metabolism.

• Agricultural and Biosystems Engineering
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• v.7 no.1
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• pp.18-26
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• 2006

In-field site-specific nitrogen (N) management increases crop yield, reduces N application to minimize the risk of nitrate contamination of ground water, and thus reduces farming cost. Real-time N sensing and fertilization is required for efficient N management. An 'on-the-go' site-specific N management system was developed and evaluated for the supplemental N application to com (Zea mays L.). This real-time N sensing and fertilization system monitored and assessed N fertilization needs using a vision-based spectral sensor and controlled the appropriate variable N rate according to N deficiency level estimated from spectral signature of crop canopies. Sensor inputs included ambient illumination, camera parameters, and image histogram of three spectral regions (red, green, and near-infrared). The real-time sensor-based supplemental N treatment improved crop N status and increased yield over most plots. The largest yield increase was achieved in plots with low initial N treatment combined with supplemental variable-rate application. Yield data for plots where N was applied the latest in the season resulted in a reduced impact on supplemental N. For plots with no supplemental N application, yield increased gradually with initial N treatment, but any N application more than 101 kg/ha had minimal impact on yield.

• Journal of the Korean Ceramic Society
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• v.48 no.6
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• pp.600-603
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• 2011

The microstructure of particle stabilized wet foams can be tailored by using parameters including the amphiphile concentration, contact angle, and surface tension. The influence of these parameters on the porosity is satisfactorily described in terms of a combined influence of the contact angle and surface tension of the initial suspensions that are directly affected by the amphiphile concentration. The resulting macroporous structures exhibited a total porosity of 82%. The foam cells were predominantly closed due to the air bubbles of the original wet foams being completely covered.

• The Journal of the Korea Contents Association
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• v.12 no.6
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• pp.92-99
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• 2012

According to the scale of mobile applications has been expanded, the high coupled application combined mobile and web service are growing. The growth of mobile application's size means that predicting design for variability should be involved. If mobile application's change is occurred, application should be reinstalled totally. However this reinstallation can raise side-effects in case of high-coupling application. Therefore, this paper proposes a technique of customization for changing web service protocol as the mobile applications are connected with web service in android platform. Proposed protocol customization technique is consist of selection and plug-in technique.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2010.10a
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• pp.248-251
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• 2010

Smart Phones from a PC using the Internet using a multimedia data service provides a scalable and user convenience is provided in the form of an application. Wired and wireless communications, especially with the reduction of royalty free WiFi or the Internet to download the application program on the PC you're using on the Smart Phone. In this paper, the location API in Android-based Smart Phone, using GPS coordinates identified in the latitude and longitude coordinates can be transferred to the server, Android Smart Phone to know the possibility of retracing the location. You are smart trace back information from the user application program design, development, and real-time GPS location signals combined backtrack to read the GPS location in Google Earth application is to study the trace back.

• Journal of the Optical Society of Korea
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• v.17 no.1
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• pp.86-90
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• 2013

Various methods have been proposed for enhancing the contrast of laser speckle contrast image (LSCI) in subcutaneous blood flow measurements. However, the LSCI still suffers from low image contrast due to tissue turbidity. Herein, a physicochemical tissue optical clearing (PCTOC) method was employed to enhance the contrast of LSCI. Ex vivo and in vivo experiments were performed with porcine skin samples and male ICR mice, respectively. The ex vivo LSCIs were obtained before and 90 min after the application of the PCTOC and in vivo LSCIs were obtained for 60 min after the application of the PCTOC. In order to obtain the skin recovery images, saline was applied for 30 min after the application of the PCTOC was completed. The visible appearance of the tubing under ex vivo samples and the in vivo vasculature gradually enhanced over time. The LSCI increased as a function of time after the application of the PCTOC in both ex vivo and in vivo experiments, and properly recovered to initial conditions after the application of saline in the in vivo experiment. The LSCI combined with the PCTOC was greatly enhanced even in deep vasculature. It is expected that similar results will be obtained in in vivo human studies.

• Journal of Environmental Science International
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• v.8 no.2
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• pp.145-150
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• 1999

To estimate the thermal effect of the vegetation canopy on the surface sublayer environment numerically, we used the combined model of Pielke's1) single layer model for vegetation and Deardorff's2) Force restore method(FRM) for soil layer. Application of present combined model to three surface conditions, ie., unsaturated bare soil, saturated bare soil and saturated vegetation canopy, showed followings; The diurnal temperature range of saturated vegetation canopy is only 20K, while saturated bare soil and unsaturated bare soil surface are 30K, 35K, respectively. The maximum temperature of vegetation canopy occurs at noon, about 2 hours earlier than that of the non-vegetation cases. The peak latent heat fluxes of vegetation canopy is simulated as a 600Wm-2 at 1300 LST. They have higher values during afternoon than beforenoon. Furthermore, the energy redistribution ratios to latent heat fluxes also increased in the late afternoon. Therefore, oasis effect driving from the vegetation canopy is reinforced during late afternoon compared with the non-vegetated conditions.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2005.09a
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• pp.294-299
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• 2005

We have studied unbound docking for 12 protein-protein complexes using conformational space annealing (CSA) combined along with statistical pair potentials. The CSA, a powerful global optimization tool, is used to search the conformational space represented by a translational vector and three Euler amgles between two proteins. The energy function consists of three statistical pair-wise energy terms; one from the distance-scaled finite ideal-gas reference state (DFIRE) approach by Zhou and the other two derived from residue-residue contacts. The residue-residue contact terms describe both attractive and repulsive interactions between two residues in contact. The performance of the CSA docking is compared with that of ZDOCK, a well-established protein-protein docking method. The results show that the application of CSA to the protein-protein docking is quite successful, indicating that the CSA combined with a good scoring function is a promising method for the study of protein-protein interaction.

• International Journal of Precision Engineering and Manufacturing
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• v.3 no.4
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• pp.64-71
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• 2002

Recently, mechanical systems such as a high-speed vehicles and railway trains moving on flexible beam structures have become a very important issue to consider. Using the general approach proposed in the first part of this paper, it is possible to predict motion of the constrained mechanical system and the elastic structure, with various kinds of foundation supporting conditions. Combined differential-algebraic equation of motion derived from both multibody dynamics theory and finite element method can be analyzed numerically using a generalized coordinate partitioning algorithm. To verify the validity of this approach, results from the simply supported elastic beam subjected to a moving load are compared with the exact solution from a reference. Finally, parametric study is conducted for a moving vehicle model on a simply supported 3-span bridge.