• BMB Reports
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• 제38권5호
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• pp.517-525
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• 2005

Solid phase peptide synthesis method, which was introduced by Merrifield in 1963, has spawned the concept of combinatorial chemistry. In this review, we summarize the present technologies of solid phase peptide synthesis (SPPS) that are related to combinatorial chemistry. The conventional methods of peptide library synthesis on polymer support are parallel synthesis, split and mix synthesis and reagent mixture synthesis. Combining surface chemistry with the recent technology of microelectronic semiconductor fabrication system, the peptide microarray synthesis methods on a planar solid support are developed, which leads to spatially addressable peptide library. There are two kinds of peptide microarray synthesis methodologies: pre-synthesized peptide immobilization onto a glass or membrane substrate and in situ peptide synthesis by a photolithography or the SPOT method. This review also discusses the application of peptide libraries for high-throughput bioassays, for example, peptide ligand screening for antibody or cell signaling, enzyme substrate and inhibitor screening as well as other applications.

• 한국분말재료학회지
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• 제23권2호
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• pp.143-148
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• 2016

A microfluidic reactor with computer-controlled programmable isocratic pumps and online detectors is employed as a combinatorial synthesis system to synthesize and analyze materials for fabricating CdSe quantum dots for various applications. Four reaction condition parameters, namely, the reaction temperature, reaction time, Cd/Se compositional ratio, and precursor concentration, are combined in synthesis condition sets, and the size of the synthesized CdSe quantum dots is determined for each condition. The average time corresponding to each reaction condition for obtaining the ultraviolet-visible absorbance and photoluminescence spectra is approximately 10 min. Using the data from the combinatorial synthesis system, the effects of the reaction conditions on the synthesized CdSe quantum dots are determined. Further, the data is used to determine the relationships between the reaction conditions and the CdSe particle size. This method should aid in determining and selecting the optimal conditions for synthesizing nanoparticles for diverse applications.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2004년도 Asia Display / IMID 04
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• pp.647-649
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• 2004

We have synthesized phosphor in the system CaO-$Al_2O_3-SiO_2$ by combinatorial polymerized-complex method. The application of combinatorial synthesis and characterization of luminescent materials has been enlarged to identification and optimization in interesting new phosphor. In this study, we investigated luminescent properties of above-mentioned materials by excitation and emission spectra. In $Eu^{2+}$ activated $Ca_1Al_2Si_2O_8$ phosphor emit the blue light.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2008년도 하계학술대회 논문집 Vol.9
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• pp.28-28
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• 2008

We have demonstrated the combinatorial synthesis of a variety of transparent conducting oxides using a combinatorial sputter system. The effects of a wide range of Nb or Zn doping rate on the optical and electrical properties of Indium-tin oxides (ITO) films were investigated. The Nb or Zn doped ITO films were fabricated on glass substrates, using combinatorial sputtering system which yields a linear composition spread of Nb or Zn concentration in ITO films in a controlled manner by co-sputtering two targets of ITO and $Nb_2O_5$ or ITO and ZnO. We have examined the work-function, resistivity, and optical properties of the Nb or Zn-doped ITO films. Furthermore, the effects of Hz plasma treatment on the physical properties of Ga or Zn doped ITO films synthesized by combinatorial sputter system were investigated.

• 한국재료학회지
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• 제13권12호
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• pp.785-790
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• 2003

We have synthesized some phosphors in the system $CaO-Y_2$$O_3$-$Al_2$$O_3$by combinatorial polymerized-complex method. Composition and synthetic temperature of phosphors in the library was screened from the emission intensities of individual samples under VUV excitation. In $Tb^{ 3＋}$-activated $CaO-Y_2$$O_3$-$Al_2$$O_3$, green phosphors showing good intensity were found to be X$O_3$$O_{7}$, CaYA1O$_4$, YA1O$_3$, $Y_3$$Al_{5}$$O_{12}$, $Y_4$$A1_2$$O_{9}$ .

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2004년도 Asia Display / IMID 04
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• pp.650-653
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• 2004

We have synthesized some phosphors in the system MO-$Al_2O_3-SiO_2$(M=Sr, Ba) by combinatorial polymerized-complex method. Composition and synthetic temperature of phosphors in the liblary was screened from the emission intensities of individual samples under 365nm excitation. As we were screened the higher luminescent candidate composition (or candidate host lattice) at 365nm excitation, investigated whether good radiation was possible at the 405 or 465nm excitation by give the host lattice to be discovered more various change. From libraries about 2 systems, the compound to be expected in long wavelength among the compound to be screened are $Sr_4Al_{14}O_{25}$, $Sr_3Al_2O_6$, $SrAl_2Si_2O_8$, and $BaAl_2Si_2O_8$.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2003년도 International Meeting on Information Display
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• pp.836-839
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• 2003

We have synthesized some phosphors in the system $CaO-Y_{2}O_3-Al_{2}O_{3}$ by combinatorial polymerized-complex method. Composition and synthetic temperature of phosphors in the liblary was screened from the emission intensities of individual samples under VUV excitation. In $Tb^{3+}$-activated $CaO-Y_{2}O_3-Al_{2}O_{3}$, green phosphors showing good intensity were found to be $CaYAl_{3}O_{7}$, $CaYalO_{4}$, $YAlO_{3}$, $Y_{3}Al_{5}O_{12}$, $Y_{4}Al_{2}O_{9}$, $Ca_{3}Al_{2}O6$.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1995년도 Proceedings of the Korea Automation Control Conference, 10th (KACC); Seoul, Korea; 23-25 Oct. 1995
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• pp.328-331
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• 1995

A successful, computer-aided design support system can help a process designer focus on making effective design decisions, not merely tedious routine calculations. Such a system is essential to enhance quality of design in terms of economics, environmental benignity, reliability, robustness, and operability. Such a statement is even more accepted when applied to conceptual design problems, where gross design specifications are given while a combinatorial number of design alternatives exists. This paper presents an agent-based approach as a systematic and efficient way to design a design support system for the synthesis of conceptual chemical processes. An agent-based approach allows us to handle design knowledge as an object and thus greatly improve the modularity and reusability of that knowledge. Such modularity and reusability lead to the increased productivity in the development of a design support system and the increased ease in the relaxation of design decisions and the generation of design alternatives, both of which functions are critically important in dealing with the complexity and uncertainty of conceptual design problems.

• 한국세라믹학회지
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• 제41권5호
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• pp.381-387
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• 2004

현재 상용화되어 있는 PDP용 형광체의 물성에 있어서 청색 형광체는 열화, 색도변화, 휘도, 그리고 녹색 형광체는 잔광시간과 색순도, 적색 형광체의 경우에는 색순도에 대한 개선이 필요한 것으로 알려져 있다. 그 중 녹색 형광체로 Willemite 구조의 ZnSiO:Mn 형광체의 경우 발광효율은 우수하나 반면에 잔광시간이 길고 색순도(color purity)가 좋지 않다는 단점을 가지고 있다. 따라서 본 연구에서는 미세조정 조합화학기법을 이용하여 PDP에 적합한 새로운 고효율 형광체를 개발하였다. 화학적으로 정량인 가돌리늄 인산염(gadolinium phosphorous) 대신 인산을 과잉으로 첨가하여 탐색한 다음 과잉인산(excess phosphorous) 첨가 조성을 유지한 채로 가돌리늄(gadolinium)의 일정분율을 이트륨(yttrium)으로 치환하였다. 그 결과 최적 형광체 조성은 (G $d_{0.74}$ $Y_{0.11}$T $b_{0.15}$) $P_{1.15}$ $O_{{\delta}}$이였으며, 현재 상용화된 Z $n_2$ $SiO_4$:Mn 형광체에 비해 상대적으로 높은 발광효율을 나타내었으며, 잔광시간도 줄일 수 있게 되었다.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.232.1-232.1
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• 2003

Bradykinin is an autocoid related to acute and chronic pain and inflammation. The non-peptide bradykinin antagonists are of interest as novel anti-inflammatory therapeutics and some active compounds such as FR 173657, LF 16-0687, and bradyzide were reported very recently. In our search for the new bradykinin antagonists, we designed to synthesize the analogues of FR173657 with two to three amide bonds and lipophilic ring system in each molecule. (omitted)